[Hub]/) : Traits : Crohns Disease (2012) :

chr22:21,075,537-22,685,340

Best TWAS P=1.22e-09 · Best GWAS P=1.22e-09 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex UBE2L3 0.10 0.12 enet 16 0.11 9.7e-14 6.0 5.8 7.8e-09 0.94 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous CCDC116 0.15 0.12 lasso 7 0.13 1.7e-10 6.0 -5.8 6.9e-09 -0.94 0.02 0.98 FALSE
3 GTEx Adipose Visceral Omentum CCDC116 0.09 0.05 lasso 3 0.03 1.4e-02 5.7 -5.7 1.3e-08 -0.96 0.03 0.94 FALSE
4 GTEx Artery Aorta CCDC116 0.18 0.18 lasso 10 0.18 5.5e-10 5.6 -5.6 1.6e-08 -0.96 0.03 0.97 FALSE
5 GTEx Artery Coronary CCDC116 0.16 0.06 lasso 4 0.09 5.6e-04 5.9 -5.4 5.3e-08 -0.93 0.03 0.94 FALSE
6 GTEx Artery Tibial CCDC116 0.14 0.15 lasso 5 0.14 2.7e-11 5.9 -5.9 4.6e-09 -0.96 0.02 0.98 FALSE
7 GTEx Brain Cerebellum CCDC116 0.25 0.16 lasso 4 0.10 6.5e-04 5.7 -5.7 1.4e-08 -0.96 0.03 0.94 FALSE
8 GTEx Brain Cortex CCDC116 0.17 0.17 lasso 2 0.15 7.3e-05 5.9 -5.9 3.3e-09 -0.96 0.02 0.94 FALSE
9 GTEx Breast Mammary Tissue CCDC116 0.15 0.12 enet 20 0.13 5.1e-07 5.7 -5.2 2.2e-07 -0.81 0.03 0.96 FALSE
10 GTEx Esophagus Gastroesophageal Junction CCDC116 0.20 0.08 lasso 8 0.12 6.0e-05 5.7 -5.9 3.0e-09 -0.96 0.03 0.95 FALSE
11 GTEx Esophagus Mucosa CCDC116 0.10 0.06 lasso 4 0.06 8.7e-05 5.7 -5.8 6.9e-09 -0.96 0.03 0.97 FALSE
12 GTEx Esophagus Muscularis CCDC116 0.15 0.20 lasso 1 0.19 6.5e-12 5.6 -5.6 1.9e-08 -0.96 0.04 0.96 FALSE
13 GTEx Heart Atrial Appendage CCDC116 0.11 0.03 lasso 3 0.05 1.8e-03 5.7 -5.7 1.2e-08 -0.92 0.03 0.94 FALSE
14 GTEx Lung CCDC116 0.12 0.15 lasso 2 0.14 5.3e-11 5.8 -5.8 5.9e-09 -0.95 0.02 0.98 FALSE
15 GTEx Nerve Tibial CCDC116 0.22 0.25 enet 9 0.29 1.8e-20 5.9 -5.9 3.1e-09 -0.96 0.02 0.98 FALSE
16 GTEx Ovary CCDC116 0.54 0.15 lasso 10 0.20 1.5e-05 5.9 -5.7 1.3e-08 -0.81 0.02 0.82 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic CCDC116 0.12 0.05 lasso 5 0.02 2.1e-02 5.6 -6.1 1.4e-09 -0.92 0.02 0.93 FALSE
18 GTEx Skin Sun Exposed Lower leg CCDC116 0.07 0.08 enet 8 0.08 6.6e-07 5.9 -5.3 1.2e-07 -0.87 0.02 0.98 FALSE
19 GTEx Thyroid CCDC116 0.10 0.07 lasso 4 0.07 3.7e-06 5.9 -5.9 3.9e-09 -0.96 0.02 0.98 FALSE
20 GTEx Thyroid HIC2 0.07 0.00 lasso 4 0.00 5.9e-01 5.9 5.9 3.8e-09 0.96 0.03 0.64 FALSE
21 GTEx Whole Blood UBE2L3 0.06 0.00 enet 22 0.01 4.0e-02 5.8 5.2 1.9e-07 0.72 0.03 0.90 FALSE
22 METSIM Adipose CCDC116 0.06 0.07 enet 22 0.08 4.6e-12 5.7 -5.4 5.3e-08 -0.89 0.03 0.97 FALSE
23 YFS Blood UBE2L3 0.13 0.25 bslmm 330 0.25 1.3e-82 5.7 5.8 5.7e-09 0.96 0.02 0.98 FALSE
24 The Cancer Genome Atlas Bladder Urothelial Carcinoma CCDC116 0.03 0.02 enet 12 0.02 5.1e-03 6.1 -5.1 2.7e-07 -0.86 0.01 0.76 FALSE
25 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCDC116 0.05 0.06 lasso 1 0.05 1.3e-03 6.1 -6.1 1.2e-09 -1.00 0.01 0.86 TRUE
26 The Cancer Genome Atlas Glioblastoma Multiforme CCDC116 0.10 0.06 blup 39 0.07 4.4e-03 6.1 -6.1 1.3e-09 -0.94 0.01 0.83 FALSE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCDC116 0.02 0.02 lasso 2 0.02 1.4e-03 5.7 -5.8 7.5e-09 -0.91 0.02 0.84 FALSE
28 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma YDJC 0.04 0.00 blup 34 0.02 4.0e-02 5.8 5.5 4.3e-08 0.91 0.01 0.66 FALSE
29 The Cancer Genome Atlas Brain Lower Grade Glioma CCDC116 0.07 0.12 blup 40 0.11 1.2e-12 5.8 -5.4 7.4e-08 -0.92 0.02 0.98 FALSE
30 The Cancer Genome Atlas Brain Lower Grade Glioma YDJC 0.08 0.14 blup 34 0.15 2.9e-16 5.8 5.9 3.7e-09 0.94 0.02 0.98 FALSE
31 The Cancer Genome Atlas Pancreatic Adenocarcinoma CCDC116 0.07 0.02 blup 40 0.03 1.5e-02 5.9 -5.7 1.4e-08 -0.92 0.01 0.78 FALSE
32 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CCDC116 0.11 0.14 enet 14 0.12 2.3e-05 5.9 -6.0 1.6e-09 -0.96 0.02 0.98 FALSE
33 The Cancer Genome Atlas Thyroid Carcinoma CCDC116 0.05 0.07 blup 40 0.07 4.6e-07 5.8 -5.5 3.2e-08 -0.93 0.02 0.98 FALSE