[Hub]/) : Traits : Crohns Disease (2017) :

chr3:52,242,902-53,860,103

Best TWAS P=4.55e-09 · Best GWAS P=7.93e-09 conditioned to 0.303

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RFT1 0.21 0.22 lasso 3 0.22 5.7e-26 5.2 5.2 2.5e-07 0.87 0.06 0.94 FALSE
2 GTEx Adipose Subcutaneous RFT1 0.21 0.19 enet 24 0.17 3.7e-14 5.2 5.2 1.6e-07 0.86 0.04 0.96 FALSE
3 GTEx Adipose Visceral Omentum RFT1 0.16 0.15 enet 12 0.10 1.0e-05 5.2 5.4 7.6e-08 0.84 0.04 0.96 FALSE
4 GTEx Adrenal Gland RFT1 0.15 0.02 enet 11 0.03 4.0e-02 5.2 5.3 9.0e-08 0.93 0.01 0.95 FALSE
5 GTEx Artery Coronary RFT1 0.38 0.33 lasso 5 0.34 2.6e-12 5.2 5.1 2.8e-07 0.88 0.04 0.96 FALSE
6 GTEx Brain Frontal Cortex BA9 RFT1 0.23 0.10 enet 17 0.10 1.4e-03 5.2 5.3 1.5e-07 0.85 0.02 0.93 FALSE
7 GTEx Brain Nucleus accumbens basal ganglia RFT1 0.26 0.16 lasso 4 0.10 1.1e-03 5.2 5.1 3.1e-07 0.87 0.02 0.92 FALSE
8 GTEx Breast Mammary Tissue RFT1 0.24 0.14 lasso 8 0.15 3.1e-08 5.8 5.8 7.3e-09 0.99 0.00 1.00 FALSE
9 GTEx Breast Mammary Tissue (Male) RFT1 0.23 0.12 enet 8 0.13 5.5e-04 5.2 5.5 3.7e-08 0.94 0.01 0.87 FALSE
10 GTEx Cells Transformed fibroblasts RFT1 0.22 0.21 enet 16 0.22 2.8e-16 5.2 5.4 5.9e-08 0.94 0.01 0.99 FALSE
11 GTEx Colon Sigmoid RFT1 0.55 0.45 enet 15 0.43 1.0e-16 5.2 5.3 1.1e-07 0.91 0.03 0.97 FALSE
12 GTEx Esophagus Gastroesophageal Junction RFT1 0.43 0.37 enet 18 0.34 7.0e-13 5.2 5.5 4.4e-08 0.92 0.02 0.98 FALSE
13 GTEx Lung RFT1 0.24 0.23 enet 12 0.23 2.7e-17 5.2 5.3 1.1e-07 0.91 0.03 0.97 FALSE
14 GTEx Muscle Skeletal RFT1 0.17 0.16 enet 17 0.15 3.0e-14 5.2 5.9 4.6e-09 0.91 0.03 0.97 TRUE
15 GTEx Nerve Tibial RFT1 0.35 0.31 enet 17 0.27 1.9e-19 5.2 5.2 1.8e-07 0.89 0.04 0.96 FALSE
16 GTEx Nerve Tibial SFMBT1 0.21 0.10 enet 11 0.07 1.4e-05 5.2 -5.2 2.7e-07 -0.88 0.03 0.97 FALSE
17 GTEx Skin Sun Exposed Lower leg RFT1 0.18 0.16 enet 7 0.13 1.1e-10 5.2 5.2 2.2e-07 0.88 0.03 0.96 FALSE
18 GTEx Small Intestine Terminal Ileum RFT1 0.20 0.20 enet 19 0.11 2.2e-03 5.2 5.2 2.5e-07 0.86 0.03 0.90 FALSE
19 GTEx Spleen RFT1 0.23 0.22 enet 7 0.13 3.6e-04 5.2 5.2 2.2e-07 0.88 0.03 0.89 FALSE
20 GTEx Testis RFT1 0.20 0.12 enet 8 0.10 2.9e-05 5.2 5.5 4.5e-08 0.95 0.01 0.98 FALSE
21 GTEx Thyroid RFT1 0.36 0.33 enet 17 0.35 2.4e-27 5.2 5.6 2.4e-08 0.93 0.02 0.98 FALSE
22 METSIM Adipose RFT1 0.13 0.19 lasso 7 0.18 7.8e-27 5.2 5.2 2.6e-07 0.88 0.06 0.94 FALSE
23 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RFT1 0.15 0.21 lasso 8 0.22 1.4e-24 5.2 5.3 1.2e-07 0.91 0.05 0.95 FALSE
24 The Cancer Genome Atlas Thyroid Carcinoma RFT1 0.25 0.30 lasso 4 0.29 3.8e-28 5.2 5.1 2.9e-07 0.87 0.06 0.93 FALSE