[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr3:47,911,521-50,921,261

Best TWAS P=4.87e-26 · Best GWAS P=4.6e-24 conditioned to 0.0343

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
59	GTEx	Skin Sun Exposed Lower leg	MST1	0.07	0.00	enet	10	0.01	4.1e-02	9.897	10.6	4.9e-26	0.85	0.03	0.88	TRUE
24	GTEx	Brain Hypothalamus	MST1	0.32	0.13	lasso	3	0.12	9.4e-04	9.897	10.3	6.4e-25	0.90	0.03	0.82	FALSE
28	GTEx	Cells Transformed fibroblasts	APEH	0.13	0.12	lasso	15	0.12	1.3e-09	9.923	10.3	7.9e-25	0.98	0.03	0.97	FALSE
75	NTR	Blood	AMT	0.02	0.01	lasso	13	0.02	5.1e-06	-8.522	10.0	1.4e-23	0.83	0.13	0.87	FALSE
92	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APEH	0.02	0.02	blup	49	0.02	2.5e-03	9.810	10.0	1.9e-23	0.95	0.01	0.90	FALSE
54	GTEx	Nerve Tibial	MST1	0.27	0.03	lasso	8	0.10	1.9e-07	5.098	9.8	1.1e-22	0.80	0.05	0.95	FALSE
51	GTEx	Muscle Skeletal	FAM212A	0.05	0.08	lasso	3	0.07	4.9e-07	10.012	-9.8	1.3e-22	-0.97	0.02	0.98	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	APEH	0.04	0.03	lasso	2	0.03	3.9e-04	9.365	9.8	1.3e-22	0.75	0.04	0.77	FALSE
84	YFS	Blood	APEH	0.11	0.05	enet	46	0.06	1.3e-19	10.012	9.7	2.3e-22	0.78	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MST1	0.16	0.05	blup	314	0.07	4.0e-09	9.324	9.6	1.0e-21	0.71	0.08	0.92	FALSE
56	GTEx	Nerve Tibial	RHOA-IT1	0.05	0.02	enet	14	0.03	4.7e-03	9.897	9.6	1.1e-21	0.85	0.07	0.69	FALSE
68	GTEx	Thyroid	MST1	0.18	0.01	enet	11	0.05	8.1e-05	5.923	9.4	6.2e-21	0.73	0.02	0.97	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	MST1	0.20	0.07	bslmm	307	0.08	8.8e-11	9.401	9.2	5.9e-20	0.56	0.92	0.08	FALSE
36	GTEx	Esophagus Mucosa	APEH	0.16	0.08	lasso	4	0.12	1.2e-08	5.923	9.0	1.6e-19	0.77	0.07	0.93	FALSE
72	METSIM	Adipose	APEH	0.09	0.06	enet	22	0.07	3.7e-11	9.324	8.9	4.3e-19	0.76	0.09	0.91	FALSE
95	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GMPPB	0.09	0.05	enet	7	0.04	1.5e-03	9.369	8.9	5.0e-19	0.63	0.01	0.42	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	BSN-AS2	0.07	0.10	lasso	6	0.09	3.5e-12	-8.649	8.9	6.6e-19	0.58	1.00	0.00	FALSE
69	GTEx	Thyroid	RHOA-IT1	0.05	0.05	lasso	5	0.04	5.2e-04	-8.527	8.8	2.2e-18	0.61	0.34	0.48	FALSE
66	GTEx	Testis	GPX1	0.08	0.00	lasso	6	0.04	1.0e-02	9.907	-8.7	3.4e-18	-0.78	0.04	0.78	FALSE
45	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	-6.602	-8.5	1.5e-17	-0.84	0.11	0.68	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	-6.757	-7.9	2.0e-15	-0.68	0.99	0.01	FALSE
58	GTEx	Skin Not Sun Exposed Suprapubic	MST1	0.12	0.09	enet	34	0.11	1.5e-06	10.113	7.9	2.5e-15	0.73	0.02	0.97	FALSE
44	GTEx	Esophagus Muscularis	NICN1-AS1	0.09	0.04	enet	14	0.06	2.3e-04	9.870	7.9	3.0e-15	0.84	0.06	0.90	FALSE
12	GTEx	Artery Tibial	MST1R	0.06	0.02	lasso	5	0.02	1.5e-02	-4.483	-7.9	3.2e-15	-0.75	0.12	0.42	FALSE
108	The Cancer Genome Atlas	Stomach Adenocarcinoma	USP4	0.05	0.03	blup	44	0.04	3.5e-04	7.207	7.9	3.4e-15	0.66	0.12	0.30	FALSE
50	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	9.897	-7.7	1.5e-14	-0.85	0.06	0.76	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRAIP	0.02	0.01	enet	8	0.01	3.1e-02	-7.092	-7.7	1.5e-14	-0.57	0.01	0.71	FALSE
16	GTEx	Brain Cerebellar Hemisphere	MST1R	0.30	0.08	enet	25	0.10	1.8e-03	-4.483	-7.5	8.7e-14	-0.69	0.20	0.34	FALSE
37	GTEx	Esophagus Mucosa	RNF123	0.07	0.03	enet	9	0.04	1.8e-03	-6.634	-7.3	2.0e-13	-0.64	0.49	0.21	FALSE
43	GTEx	Esophagus Muscularis	GPX1	0.13	0.05	lasso	14	0.06	1.1e-04	9.881	-7.3	2.0e-13	-0.82	0.08	0.91	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	-6.655	-7.3	2.9e-13	-0.69	0.56	0.18	FALSE
40	GTEx	Esophagus Muscularis	NICN1	0.11	0.03	enet	22	0.07	2.7e-05	9.923	7.3	2.9e-13	0.85	0.04	0.96	FALSE
8	GTEx	Artery Coronary	CCDC71	0.21	0.05	lasso	4	0.05	1.1e-02	7.195	7.2	4.4e-13	0.65	0.07	0.33	FALSE
46	GTEx	Heart Left Ventricle	AMT	0.07	0.02	lasso	7	0.02	4.6e-02	-8.489	-7.2	7.1e-13	-0.42	0.23	0.04	FALSE
73	METSIM	Adipose	MST1	0.06	0.03	lasso	8	0.03	2.0e-05	5.098	7.1	9.3e-13	0.56	0.77	0.10	FALSE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBA7	0.02	0.01	blup	30	0.02	5.3e-03	-6.628	7.1	1.5e-12	0.63	0.04	0.59	FALSE
96	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBA7	0.13	0.16	lasso	6	0.15	1.1e-08	-6.664	7.0	2.8e-12	0.70	0.18	0.82	FALSE
21	GTEx	Brain Cerebellum	GPX1	0.31	0.09	enet	19	0.23	2.0e-07	9.933	-7.0	3.4e-12	-0.80	0.04	0.95	FALSE
76	NTR	Blood	QRICH1	0.01	0.00	blup	276	0.01	1.6e-04	5.123	-7.0	3.6e-12	-0.66	0.36	0.50	FALSE
49	GTEx	Lung	MST1	0.13	0.05	lasso	6	0.03	1.1e-03	5.923	6.9	4.2e-12	0.56	0.09	0.48	FALSE
62	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	-6.628	6.9	4.3e-12	0.66	0.25	0.50	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	TCTA	0.04	0.04	blup	24	0.03	3.6e-04	-8.522	-6.9	6.1e-12	-0.41	0.26	0.05	FALSE
105	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UBA7	0.11	0.14	enet	7	0.11	2.7e-05	-6.628	6.8	1.2e-11	0.66	0.14	0.79	FALSE
30	GTEx	Cells Transformed fibroblasts	UBA7	0.07	0.06	enet	5	0.04	7.5e-04	-6.602	6.7	2.6e-11	0.66	0.95	0.01	FALSE
17	GTEx	Brain Cerebellar Hemisphere	FAM212A	0.25	0.17	lasso	21	0.20	8.1e-06	4.592	-6.7	2.7e-11	-0.55	0.42	0.13	FALSE
87	YFS	Blood	UBA7	0.16	0.24	lasso	6	0.23	4.0e-75	-6.678	6.7	2.7e-11	0.66	1.00	0.00	FALSE
61	GTEx	Spleen	RNF123	0.13	0.13	lasso	5	0.10	1.3e-03	-6.655	-6.7	2.8e-11	-0.67	0.16	0.31	FALSE
41	GTEx	Esophagus Muscularis	RNF123	0.15	0.14	enet	17	0.14	1.2e-08	-6.664	-6.7	2.9e-11	-0.67	1.00	0.00	FALSE
48	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	-6.664	-6.7	3.0e-11	-0.77	0.44	0.52	FALSE
102	The Cancer Genome Atlas	Lung Adenocarcinoma	UBA7	0.03	0.04	enet	9	0.02	1.8e-03	-6.682	6.6	3.2e-11	0.66	0.16	0.80	FALSE
19	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	4.674	-6.6	3.7e-11	-0.63	0.79	0.17	FALSE
39	GTEx	Esophagus Mucosa	FAM212A	0.19	0.26	enet	24	0.27	4.4e-18	-6.558	-6.6	3.7e-11	-0.66	1.00	0.00	FALSE
67	GTEx	Thyroid	RNF123	0.09	0.13	lasso	9	0.12	2.7e-09	-6.757	-6.6	4.1e-11	-0.66	1.00	0.00	FALSE
107	The Cancer Genome Atlas	Stomach Adenocarcinoma	UBA7	0.04	0.05	lasso	1	0.04	1.0e-03	-6.602	6.6	4.1e-11	0.66	0.08	0.68	FALSE
32	GTEx	Colon Transverse	UBA7	0.28	0.30	lasso	2	0.30	1.1e-14	-6.607	6.6	4.6e-11	0.66	1.00	0.00	FALSE
104	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CAMKV	0.07	0.05	enet	9	0.06	2.3e-03	-6.634	-6.6	4.7e-11	-0.59	0.01	0.73	FALSE
60	GTEx	Skin Sun Exposed Lower leg	FAM212A	0.05	0.07	enet	16	0.06	1.1e-05	-6.558	-6.6	4.9e-11	-0.66	0.96	0.03	FALSE
20	GTEx	Brain Cerebellum	FAM212A	0.27	0.35	lasso	5	0.34	9.7e-11	-6.602	-6.5	6.6e-11	-0.67	0.99	0.01	FALSE
34	GTEx	Esophagus Gastroesophageal Junction	MST1R	0.18	0.02	lasso	9	0.06	2.4e-03	-5.002	-6.5	9.0e-11	-0.56	0.10	0.39	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBA7	0.08	0.09	lasso	5	0.09	3.4e-10	-6.602	6.5	9.4e-11	0.66	0.18	0.82	FALSE
77	NTR	Blood	UBA7	0.02	0.03	lasso	4	0.03	1.6e-09	-6.602	6.5	1.0e-10	0.64	1.00	0.00	FALSE
38	GTEx	Esophagus Mucosa	UBA7	0.04	0.07	enet	8	0.05	4.5e-04	-6.634	6.4	1.4e-10	0.65	0.76	0.06	FALSE
93	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBA7	0.02	0.02	blup	30	0.02	3.8e-03	-6.634	6.3	2.1e-10	0.68	0.05	0.28	FALSE
64	GTEx	Testis	RBM6	0.28	0.14	enet	19	0.17	7.7e-08	-5.002	6.3	2.6e-10	0.51	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	RNF123	0.08	0.11	lasso	4	0.07	2.2e-04	-6.602	-6.3	3.4e-10	-0.66	0.64	0.23	FALSE
70	GTEx	Vagina	RBM6	0.24	0.22	enet	27	0.21	1.5e-05	4.554	6.2	4.1e-10	0.53	0.72	0.14	FALSE
53	GTEx	Nerve Tibial	RNF123	0.24	0.16	lasso	5	0.15	1.0e-10	-6.757	-6.2	4.8e-10	-0.66	1.00	0.00	FALSE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMIGO3	0.01	0.00	enet	13	0.01	5.7e-03	-0.072	-6.2	5.2e-10	-0.78	0.01	0.49	FALSE
71	GTEx	Whole Blood	UBA7	0.03	0.04	lasso	2	0.01	1.5e-02	-6.634	6.2	7.0e-10	0.64	0.46	0.08	FALSE
35	GTEx	Esophagus Mucosa	RBM6	0.18	0.21	enet	18	0.23	3.0e-15	-5.417	6.2	7.9e-10	0.55	1.00	0.00	FALSE
29	GTEx	Cells Transformed fibroblasts	RNF123	0.08	0.09	enet	14	0.06	1.7e-05	-6.678	-6.1	8.5e-10	-0.69	0.81	0.17	FALSE
22	GTEx	Brain Cortex	RNF123	0.23	0.05	enet	33	0.04	2.4e-02	-6.655	-6.1	1.2e-09	-0.49	0.25	0.07	FALSE
10	GTEx	Artery Tibial	NICN1	0.20	0.17	enet	27	0.23	3.0e-18	-1.040	6.1	1.3e-09	0.72	0.88	0.12	FALSE
85	YFS	Blood	COL7A1	0.01	0.01	bslmm	247	0.01	8.0e-04	4.997	6.0	1.5e-09	0.51	0.03	0.92	FALSE
3	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	4.646	6.0	1.8e-09	0.55	1.00	0.00	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	C3orf62	0.02	0.00	blup	31	0.02	6.4e-03	-1.548	-6.0	1.9e-09	-0.68	0.01	0.33	FALSE
7	GTEx	Artery Coronary	RBM6	0.14	0.14	enet	23	0.15	1.0e-05	-6.757	6.0	2.7e-09	0.61	0.95	0.02	FALSE
14	GTEx	Brain Caudate basal ganglia	RNF123	0.13	0.04	enet	20	0.02	1.2e-01	-6.657	-6.0	2.7e-09	-0.68	0.20	0.29	FALSE
23	GTEx	Brain Frontal Cortex BA9	GPX1	0.16	0.06	lasso	6	0.15	7.9e-05	-1.599	-5.9	3.1e-09	-0.65	0.06	0.80	FALSE
90	The Cancer Genome Atlas	Colon Adenocarcinoma	UBA7	0.11	0.06	enet	5	0.05	7.6e-04	-6.682	5.9	3.3e-09	0.49	0.11	0.88	FALSE
11	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	-6.607	-5.9	4.2e-09	-0.67	0.98	0.02	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	RBM6	0.25	0.29	lasso	23	0.30	2.2e-11	4.554	5.8	6.1e-09	0.57	1.00	0.00	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	USP4	0.08	0.05	lasso	2	0.09	8.7e-04	-1.548	-5.8	7.7e-09	-0.70	0.11	0.62	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBA7	0.05	0.04	enet	7	0.05	1.6e-05	-6.652	5.8	9.0e-09	0.65	0.15	0.84	FALSE
13	GTEx	Artery Tibial	IP6K1	0.03	0.00	enet	22	0.01	2.5e-02	-4.750	-5.7	9.5e-09	-0.60	0.17	0.33	FALSE
63	GTEx	Spleen	QRICH1	0.24	0.21	enet	26	0.19	1.3e-05	-2.216	-5.7	9.8e-09	-0.56	0.26	0.54	FALSE
55	GTEx	Nerve Tibial	NICN1-AS1	0.15	0.11	lasso	5	0.13	1.1e-09	-0.947	5.7	1.1e-08	0.74	0.28	0.72	FALSE
6	GTEx	Artery Aorta	SEMA3F	0.12	0.03	enet	20	0.06	3.6e-04	-4.443	-5.7	1.3e-08	-0.53	0.13	0.64	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	-6.620	-5.7	1.6e-08	-0.67	0.06	0.18	FALSE
31	GTEx	Colon Transverse	RBM6	0.29	0.33	enet	43	0.36	4.6e-18	4.532	5.6	2.4e-08	0.47	1.00	0.00	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	MST1R	0.08	0.07	enet	10	0.09	2.6e-10	-5.379	-5.6	2.6e-08	-0.52	0.26	0.74	FALSE
65	GTEx	Testis	MON1A	0.08	0.06	enet	13	0.05	2.4e-03	-4.443	5.6	2.7e-08	0.50	0.41	0.07	FALSE
91	The Cancer Genome Atlas	Glioblastoma Multiforme	AMIGO3	0.18	0.02	enet	24	0.07	2.9e-03	-0.072	-5.5	2.8e-08	-0.69	0.02	0.25	FALSE
9	GTEx	Artery Tibial	RBM6	0.24	0.31	enet	24	0.30	5.8e-24	4.646	5.5	3.9e-08	0.50	1.00	0.00	FALSE
57	GTEx	Skin Not Sun Exposed Suprapubic	RBM6	0.16	0.17	enet	24	0.23	1.2e-12	4.554	5.5	4.6e-08	0.49	1.00	0.00	FALSE
74	METSIM	Adipose	RNF123	0.03	0.02	lasso	12	0.02	2.0e-04	-6.682	-5.4	5.6e-08	-0.55	0.86	0.01	FALSE
89	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC36	0.10	0.05	enet	18	0.07	4.7e-05	4.914	-5.4	5.9e-08	-0.42	0.23	0.17	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	UBA7	0.03	0.01	blup	30	0.02	2.0e-03	-6.664	5.4	7.2e-08	0.62	0.07	0.31	FALSE
52	GTEx	Nerve Tibial	IP6K2	0.12	0.04	enet	14	0.07	1.8e-05	4.318	-5.4	7.5e-08	-0.52	0.15	0.21	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	RBM6	0.08	0.06	blup	79	0.07	4.3e-08	-4.483	5.4	7.8e-08	0.48	0.06	0.93	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	RNF123	0.04	0.05	lasso	3	0.05	1.4e-06	-6.757	-5.3	1.1e-07	-0.63	0.97	0.02	FALSE
5	GTEx	Adipose Visceral Omentum	GPX1	0.11	0.01	lasso	3	0.03	1.2e-02	10.118	-5.3	1.5e-07	-0.68	0.04	0.76	FALSE
47	GTEx	Lung	TCTA	0.09	0.01	enet	10	0.03	3.3e-03	-8.649	-5.2	1.6e-07	-0.31	0.06	0.10	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	MST1R	0.02	0.00	blup	278	0.01	4.5e-02	-5.002	-5.2	1.8e-07	-0.60	0.64	0.08	FALSE
42	GTEx	Esophagus Muscularis	MST1R	0.05	0.00	lasso	5	0.05	3.6e-04	4.525	-5.2	1.9e-07	-0.58	0.20	0.42	FALSE
86	YFS	Blood	DAG1	0.01	0.00	bslmm	305	0.00	2.6e-02	9.401	5.2	2.0e-07	0.36	0.03	0.07	FALSE
26	GTEx	Breast Mammary Tissue	RNF123	0.11	0.07	enet	14	0.02	3.2e-02	-6.655	-5.2	2.2e-07	-0.59	0.50	0.30	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	SEMA3F	0.07	0.11	bslmm	275	0.10	4.9e-13	-4.676	5.2	2.2e-07	0.37	1.00	0.00	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	MST1R	0.03	0.01	blup	32	0.03	3.1e-04	-5.379	-5.2	2.4e-07	-0.51	0.22	0.12	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	GPX1	0.23	0.25	lasso	10	0.30	1.5e-39	-0.953	-5.2	2.5e-07	-0.68	1.00	0.00	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	RBM6	0.14	0.19	blup	79	0.20	1.4e-19	4.516	5.2	2.5e-07	0.46	0.06	0.93	FALSE
18	GTEx	Brain Cerebellum	RBM6	0.25	0.41	enet	32	0.33	2.1e-10	4.525	5.1	2.9e-07	0.46	1.00	0.00	FALSE
25	GTEx	Brain Nucleus accumbens basal ganglia	RBM6	0.20	0.19	enet	29	0.22	2.0e-06	4.646	5.1	2.9e-07	0.45	0.87	0.04	FALSE