Hub : Genes

SFMBT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1300 0.0400 1.6e-11 0.099 0.105 0.117 0.108 0.110 4.1e-12 1.0e-12 4.4e-14 5.1e-13 2.9e-13
2 GTEx Adipose Subcutaneous 0.1040 0.0380 2.7e-04 0.022 NA 0.021 NA 0.026 5.6e-03 NA 7.1e-03 NA 2.8e-03
3 GTEx Artery Aorta 0.1580 0.0560 3.5e-05 0.105 NA 0.084 NA 0.010 2.1e-06 NA 2.3e-05 NA 8.9e-02
4 GTEx Colon Transverse 0.3450 0.0820 1.2e-06 0.184 NA 0.156 NA 0.161 3.9e-09 NA 6.9e-08 NA 4.4e-08
5 GTEx Nerve Tibial 0.2054 0.0639 2.8e-05 0.103 NA 0.068 NA 0.033 1.0e-07 NA 1.4e-05 NA 2.0e-03
6 GTEx Ovary 0.2450 0.0880 5.0e-03 0.102 NA 0.146 NA 0.139 1.8e-03 NA 2.0e-04 NA 2.8e-04
7 GTEx Pituitary 0.1590 0.0760 1.9e-03 0.014 NA 0.017 NA 0.015 1.4e-01 NA 1.2e-01 NA 1.3e-01
8 GTEx Thyroid 0.1270 0.0440 5.6e-07 0.086 NA 0.098 NA 0.091 4.2e-07 NA 6.3e-08 NA 1.9e-07
9 METSIM Adipose 0.0360 0.0167 4.2e-03 0.037 0.022 0.026 0.020 0.028 3.0e-06 2.6e-04 7.6e-05 3.9e-04 3.5e-05
10 ROSMAP Brain Pre-frontal Cortex 0.0749 0.0357 1.0e-04 0.019 0.024 0.003 0.025 0.017 1.5e-03 4.3e-04 1.1e-01 2.9e-04 2.2e-03
11 TCGA Kidney Renal Clear Cell Carcinoma 0.4016 0.1208 0.0e+00 0.166 0.142 0.151 NA 0.168 2.9e-18 9.8e-16 1.1e-16 NA 1.9e-18
12 TCGA Kidney Renal Papillary Cell Carcinoma 0.1730 0.0720 2.8e-07 0.143 0.116 0.124 NA 0.139 1.5e-08 3.7e-07 1.4e-07 NA 2.5e-08
13 TCGA Brain Lower Grade Glioma 0.1344 0.0600 9.2e-09 0.028 0.069 0.057 NA 0.059 3.0e-04 3.0e-08 4.2e-07 NA 2.9e-07
14 TCGA Liver Hepatocellular Carcinoma 0.1740 0.1240 1.0e-03 0.082 0.055 0.040 NA 0.065 1.1e-04 1.3e-03 5.7e-03 NA 5.5e-04
15 TCGA Lung Adenocarcinoma 0.0376 0.0290 6.5e-03 0.007 0.015 0.029 NA 0.017 4.4e-02 6.0e-03 2.1e-04 NA 3.8e-03
16 TCGA Prostate Adenocarcinoma 0.2721 0.1288 8.6e-09 0.068 0.062 0.061 NA 0.064 1.3e-07 4.7e-07 5.7e-07 NA 2.9e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 3.8 6.1 15.6 -3.4 -2.4 -2.4 1.1 -1.9 -2.4 -4.0 -3.0 -3.4 -2.8 -0.3 -0.7 -3.2 -2.0 0.7 -2.1
Bipolar Disorder or Schizophrenia 4.6 11.3 41.4 -4.9 -1.5 -2.5 -0.4 -0.8 -2.1 -6.4 -4.2 -2.9 -4.4 -2.8 -3.2 -4.2 -2.8 2.3 -2.8
Depressed Affect (Nagel 2018) 2.7 5.6 14.9 -0.5 2.3 0.8 -3.9 1.4 1.8 -1.7 -1.5 2.5 -1.8 -3.5 -3.5 2.3 1.9 3.2 2.5
Depression (Nagel 2018) 1.7 2.5 10.5 -1.9 -0.6 -1.6 -1.2 -0.8 -1.1 -3.0 -1.5 -0.8 -3.2 -1.4 -1.6 -0.4 0.2 1.8 0.3
Intelligence (Savage-Jansen 2018) 3.9 12.0 38.9 3.5 -2.6 -0.1 3.9 -1.7 -1.2 6.2 3.0 -1.2 4.2 5.3 5.5 0.8 0.5 -5.1 -0.1
Neuroticism (Nagel 2018) 4.1 9.5 22.2 -3.3 1.2 -1.2 -4.1 0.1 0.0 -4.6 -3.7 0.6 -4.0 -4.4 -4.7 0.9 1.4 4.6 1.8
Schizophrenia (2018) 3.3 6.8 25.7 -3.5 -0.0 -1.3 -1.4 0.5 -0.8 -5.1 -3.0 -1.0 -3.3 -3.3 -3.6 -2.8 -2.0 2.4 -1.8
Schizophrenia vs Biploar Disorder 1.2 1.5 4.5 0.8 2.1 1.9 -1.0 2.1 1.4 0.2 0.3 1.8 0.1 -1.6 -1.5 -0.3 -0.7 0.1 -0.4
Worry (Nagel 2018) 7.5 15.8 48.5 -5.4 0.2 -2.6 -4.0 -0.7 -1.4 -7.0 -5.1 -1.1 -5.8 -5.1 -5.6 -0.8 0.3 5.6 0.9
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 -0.3 -0.1 -0.7 -0.1 -0.7 -0.6 -0.4 -0.7 -0.4 0.3 0.2 0.2 0.6 0.5 0.6 0.6
Alzheimer’s Disease (in father) 1.1 1.2 3.1 0.6 1.8 0.2 -1.5 1.0 1.2 -0.3 -0.0 1.7 -1.1 -1.1 -1.1 1.2 1.0 0.9 1.0
Alzheimer’s Disease (including proxy) 0.4 0.5 1.4 -0.4 0.4 -1.2 -0.5 -0.7 -0.4 -0.9 -0.8 0.1 -0.7 0.2 0.1 1.0 1.1 0.6 1.1
Crohns Disease (2017) 4.3 9.4 26.5 -3.3 -4.1 -4.4 1.4 -5.2 -5.0 -1.8 -3.1 -4.3 -2.5 2.4 2.0 -0.5 1.5 -1.1 1.0
Irritable Bowel Disease (IBD) 1.9 4.6 11.9 -3.5 -0.6 -2.6 -1.6 -2.5 -2.2 -2.7 -3.4 -1.6 -2.4 -1.1 -1.4 0.5 1.8 2.0 1.8
Ulcerative Colitis (UC) 3.2 6.0 16.1 -1.9 2.7 0.2 -3.7 1.0 1.4 -2.1 -2.2 1.8 -1.3 -3.6 -3.8 1.8 1.8 4.0 2.2
Major Depression (MDD) 3.1 3.8 9.7 -2.2 0.9 -0.9 -2.6 0.2 0.1 -3.1 -2.0 0.2 -2.6 -3.0 -3.1 0.3 0.5 2.7 0.9
Reaction Time 0.2 0.4 1.3 0.8 1.1 0.9 -0.2 1.0 0.9 0.4 0.5 1.1 -0.2 -0.3 -0.3 0.3 -0.1 -0.3 -0.1
Verbal and Numeric Reasoning (VNR) 3.9 9.4 28.5 3.1 -2.3 -0.7 2.8 -1.8 -0.9 5.3 2.4 -0.6 3.9 4.8 4.9 2.0 1.7 -4.2 1.2
Breast Cancer 0.4 0.9 4.1 1.0 -0.4 0.5 0.8 -0.1 0.1 1.8 0.7 -0.0 2.0 1.2 1.3 0.7 0.2 -0.8 0.1
Ovarian Cancer 0.3 0.3 1.3 0.6 -0.1 0.5 0.7 0.7 0.3 -0.3 0.7 -0.2 0.4 0.2 0.1 -0.6 -1.2 0.3 -1.0
Prostate Cancer 0.8 1.1 3.2 -1.3 0.3 -0.5 -1.5 -0.2 -0.2 -1.6 -1.5 0.2 -1.8 -1.4 -1.3 0.1 0.6 1.1 0.8
Age at First Birth 1.5 2.2 7.5 1.2 -0.5 -0.6 -0.3 -0.6 -0.3 2.1 1.1 1.0 -0.4 1.3 1.4 2.5 2.7 -1.6 2.4
Bipolar Disorder (2011) 6.3 6.1 24.2 -3.8 -1.1 -3.1 -1.3 -1.6 -1.7 -4.9 -3.8 -1.8 -3.2 -1.7 -1.9 -0.9 0.0 2.5 0.5
Body Mass Index (BMI) (2010) 0.7 1.0 3.1 1.4 0.5 0.5 -0.2 0.4 0.7 1.8 1.0 1.0 1.2 0.6 0.7 1.6 1.1 -0.7 1.1
Coronary Artery Disease (CAD) 0.4 0.4 2.0 -0.1 1.0 1.4 -0.1 0.7 1.0 0.1 0.1 0.5 0.7 -0.5 -0.6 -0.4 -0.6 0.6 -0.6
Crohns Disease (2012) 4.3 6.9 17.5 -2.3 -3.8 -3.5 2.1 -4.1 -4.2 -1.5 -2.0 -3.8 -1.8 2.6 2.4 -1.0 0.5 -1.1 -0.0
Mean Putamen Volume 0.3 0.4 1.7 -0.8 -0.4 -0.9 -0.2 -0.3 -0.7 -1.3 -0.4 -0.4 -1.0 -0.4 -0.4 -0.2 -0.3 -0.1 0.1
Fasting Glucose 1.8 2.2 6.2 1.1 1.1 2.3 0.3 2.5 1.6 0.5 0.6 0.8 1.6 -1.5 -1.1 -1.8 -1.2 -0.1 -2.5
HbA1C 1.9 2.1 6.3 1.3 2.5 1.2 -1.4 1.8 2.0 0.5 0.7 2.4 0.5 -1.2 -1.0 1.3 0.6 1.5 1.1
HDL Cholesterol 3.3 5.4 16.1 -2.4 -2.8 -4.0 -0.1 -3.7 -2.9 -1.1 -2.9 -2.0 -1.3 1.6 1.4 1.3 2.8 -0.6 2.4
LDL Cholesterol 2.8 4.5 11.8 2.8 0.0 2.0 2.4 1.3 1.3 3.4 3.2 0.8 3.1 2.0 2.2 -0.3 -1.2 -2.3 -1.4
Lupus 0.6 0.9 2.0 -0.1 -1.0 -1.0 0.9 -1.4 -1.4 0.4 -0.1 -1.4 -0.1 1.4 1.1 -0.0 0.5 -1.1 0.3
Neuroticism (2016) 2.2 3.1 8.9 -2.7 -0.4 -1.8 -1.7 -1.2 -1.2 -3.0 -2.6 -0.8 -2.9 -1.4 -1.6 0.1 0.9 1.4 0.9
Primary Biliary Cirrhosis 1.0 1.4 5.3 1.1 -1.1 0.1 1.3 -0.6 -0.8 1.9 1.2 -0.5 0.8 1.6 1.7 -0.2 -0.0 -2.3 -0.4
Rheumatoid Arthritis 1.0 1.4 4.0 1.2 -0.8 -0.1 1.0 -0.6 -0.5 1.7 1.7 -0.3 1.0 1.8 1.9 0.5 0.7 -2.0 0.3
Schizophrenia (2014) 3.7 8.1 29.4 -3.8 0.1 -1.5 -1.1 0.5 -0.9 -5.4 -3.2 -1.4 -3.6 -3.5 -3.8 -3.5 -2.7 2.3 -2.4
Triglycerides 0.6 1.0 3.3 1.0 0.1 1.4 0.6 1.2 0.8 0.7 1.4 0.2 1.0 -0.2 -0.1 -1.1 -1.8 -0.5 -1.6
Type 2 Diabetes (T2D) (2012) 4.4 5.0 13.9 3.2 2.3 3.7 -0.6 3.6 3.0 0.2 3.0 2.7 0.5 -1.6 -1.0 -0.8 -2.1 -0.5 -1.7
Ulcerative Colitis 5.9 8.5 24.6 -2.3 3.0 0.6 -4.4 1.1 1.6 -3.0 -2.5 1.8 -1.9 -4.4 -4.6 1.8 1.7 5.0 2.3
Blood Eosinophil Count 3.1 23.7 55.4 7.4 5.3 6.8 -1.5 6.5 6.6 6.0 7.3 6.9 3.3 -1.2 -0.5 3.4 0.3 -0.3 0.8
Blood Platelet Count 0.7 7.6 29.9 3.2 1.1 3.2 2.0 2.1 1.6 5.5 3.0 1.3 5.4 1.2 1.4 -1.2 -2.1 -2.6 -1.9
Blood Red Count 1.5 14.7 58.4 -4.5 1.6 -1.6 -2.5 0.8 -0.4 -7.6 -3.8 -1.0 -4.7 -5.1 -5.4 -3.8 -2.8 4.7 -2.6
Blood White Count 1.4 10.5 22.2 3.9 2.2 4.3 2.3 4.1 3.1 2.5 4.7 1.6 3.9 0.0 0.3 -2.8 -4.7 -1.4 -4.3
Heel T-Score 2.3 18.3 48.2 6.9 4.7 6.4 0.8 6.1 5.7 4.1 6.8 5.1 3.4 -0.2 0.3 0.7 -2.5 -0.7 -2.1
BMI 4.8 27.6 65.8 7.5 5.5 7.3 -0.6 5.3 7.0 8.1 6.0 6.4 7.2 0.7 1.3 4.8 1.6 -0.7 1.7
Height 8.1 156.1 372.5 -15.8 -10.6 -19.3 -4.3 -17.4 -14.6 -13.2 -15.6 -10.4 -17.1 2.5 1.2 6.4 13.6 4.7 12.4
Waist Hip Ratio (WHR) 2.8 12.4 42.6 -1.2 0.7 1.0 1.7 2.6 0.6 -5.3 1.8 -1.5 -3.8 -2.3 -2.4 -6.4 -6.5 1.3 -6.5
Systolic Blood Pressure 1.3 6.3 14.2 2.9 2.9 3.8 -1.8 2.8 3.4 3.6 2.3 3.5 1.5 -1.4 -1.2 2.5 1.2 0.9 1.6
Smoking Status 4.6 11.0 29.9 4.9 2.6 5.0 0.6 3.5 3.6 5.5 4.6 3.2 5.0 0.4 1.0 0.9 -1.0 -2.3 -0.9
Allergy or Eczema 0.1 0.2 0.9 0.3 0.3 -0.5 0.3 0.1 -0.0 -0.9 0.2 -0.3 0.6 0.2 0.3 -0.2 -0.4 0.1 -0.5
Cardiovascular Disease 1.6 5.1 13.5 3.2 2.6 3.7 -0.9 2.5 2.8 3.4 2.7 3.0 1.2 -0.3 0.0 2.2 0.9 -0.4 1.0
Hypothyroidism (self reported) 0.1 0.2 0.9 -0.5 -0.2 -0.4 -0.2 -0.5 -0.1 0.1 -0.9 0.0 0.5 0.3 0.3 0.4 0.9 -0.3 0.8
Respiratory disease 0.6 1.4 4.6 1.1 1.7 1.2 -1.0 2.2 1.9 -0.5 0.7 1.9 -0.3 -1.3 -1.1 0.5 -0.3 0.3 -0.0
Type 2 Diabetes (T2D) (2018) 3.1 5.9 14.8 3.9 2.5 3.5 0.9 2.9 2.9 3.0 3.6 2.3 3.1 0.5 1.0 0.2 -1.4 -0.9 -1.4
Lung FEV1/FVC ratio 0.9 4.7 19.4 0.3 0.4 -0.2 -2.2 -1.2 0.2 3.1 0.2 1.3 -1.1 0.1 0.1 4.3 4.4 1.0 4.1
Lung FVC 0.1 0.7 5.4 0.3 0.5 0.9 -0.7 0.6 0.8 2.3 0.8 0.8 -0.5 -0.7 -0.5 0.4 0.4 0.6 0.3
Neuroticism 3.9 9.4 24.5 -3.1 1.5 -1.2 -4.1 0.4 0.1 -5.0 -3.8 0.6 -4.2 -4.5 -4.6 0.6 1.0 4.2 1.5
Chronotype (morning person) 1.1 2.5 5.2 1.9 1.6 1.5 -0.9 1.4 2.2 2.1 1.6 2.0 2.3 -0.3 -0.2 2.1 1.0 0.5 1.3
Hair Pigment 0.1 3.8 11.8 1.3 3.4 3.1 -1.4 2.9 2.6 0.6 1.1 2.9 1.4 -1.8 -1.6 0.9 -0.3 1.3 0.2
Tanning 0.5 6.4 24.1 3.6 0.6 0.9 1.1 -0.5 1.3 4.9 2.9 1.5 4.1 2.7 3.0 2.5 1.5 -2.8 1.4
Hand grip strength (left) 5.5 14.4 32.7 -5.0 -5.3 -4.9 1.6 -5.6 -5.7 -3.5 -4.8 -5.6 -2.9 1.9 1.6 -2.3 0.5 -0.6 -0.2
Number of treatments/medications taken 1.5 2.8 8.8 1.5 2.5 3.0 -1.0 2.4 2.3 1.9 1.4 2.2 0.8 -1.4 -1.2 0.4 -0.5 0.3 -0.2
Average weekly spirits intake 2.0 2.5 7.5 2.7 1.0 2.2 0.2 1.8 1.8 2.2 1.9 2.1 1.9 0.5 0.6 0.9 0.1 -1.4 0.3
Sensitivity / hurt feelings 0.7 1.3 4.2 -0.8 1.2 0.1 -1.6 0.6 0.0 -1.7 -0.9 0.5 -1.1 -2.0 -2.1 -0.1 0.1 1.4 0.2
Frequency of depressed mood in last 2 weeks 2.5 3.4 8.8 -1.5 1.3 -0.2 -2.7 0.6 0.8 -2.5 -1.3 0.8 -2.7 -2.8 -2.8 0.9 0.8 3.0 1.1
Hearing difficulty/problems: Yes 0.4 0.7 3.4 1.1 0.7 1.2 0.1 0.6 0.4 0.3 1.5 0.5 -1.8 0.1 0.0 -0.1 -0.2 -0.8 -0.2
Relative age of first facial hair 0.5 1.1 3.5 0.1 -0.6 -0.4 1.4 -0.9 -1.4 0.2 0.4 -1.3 1.0 1.1 1.1 -1.2 -0.9 -1.9 -1.0
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.2 -0.4 0.6 0.4 0.2 0.2 -0.3 -0.7 0.1 -0.5 -0.6 -0.5 -0.5 -1.1 -1.1 0.4 -1.1
Ever used hormone-replacement therapy (HRT) 1.5 1.9 6.6 0.4 -0.3 1.1 1.6 0.9 0.1 1.0 1.3 -0.5 1.5 0.3 0.4 -2.3 -2.5 -1.2 -2.6
Ever had hysterectomy (womb removed) 0.3 0.3 1.1 0.2 -0.1 0.2 0.6 -0.6 -0.8 1.1 0.3 -0.6 -0.9 0.5 0.4 -0.5 -0.1 -0.8 -0.3
Systolic blood pressure, automated reading 2.0 5.8 11.9 2.0 3.2 3.4 -2.4 2.7 3.3 2.6 1.3 3.5 1.2 -2.0 -1.8 2.4 1.4 1.6 1.8
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 4.1 1.6 0.7 2.0 1.1 1.2 0.9 0.7 1.6 0.4 0.4 0.6 0.6 -0.5 -1.2 -0.2 -1.2
Angina 0.1 0.1 0.6 -0.4 0.3 0.3 -0.5 0.1 0.2 -0.1 -0.4 0.2 -0.8 -0.4 -0.3 0.4 0.4 0.3 0.5
Medication for hormone replacement therapy 2.1 2.4 8.3 1.3 -0.5 1.7 2.0 1.1 0.3 0.9 1.5 -0.7 1.0 0.5 0.6 -2.4 -2.8 -1.1 -2.9
Vitamin and mineral supplements 2.2 3.0 7.0 0.8 2.3 2.4 -0.9 2.7 2.3 -0.8 0.8 1.6 1.2 -2.2 -2.1 -0.7 -1.7 1.9 -1.2
Supplements: Zinc 0.3 0.3 0.9 1.0 0.4 0.7 0.2 0.8 0.4 0.5 0.9 0.1 -0.0 -0.2 -0.1 -0.6 -0.7 -0.4 -0.8
Medication: Co-codamol 1.2 1.4 4.9 0.5 -0.5 0.8 1.5 0.4 -0.2 0.3 1.5 -0.7 0.3 0.5 0.6 -2.0 -2.1 -1.3 -2.2
Medication: Metformin 1.3 1.8 4.5 2.0 2.0 2.1 -0.3 1.7 1.8 1.6 1.7 1.7 1.4 -0.2 0.0 0.8 0.0 0.2 -0.1
Diabetes (father) 3.1 3.8 10.0 2.9 2.2 2.2 0.7 3.2 3.0 1.2 2.5 2.5 2.0 -0.1 0.0 -0.1 -1.8 -0.1 -1.2
Diabetes (mother) 1.3 1.7 5.8 1.6 0.4 1.7 1.4 1.2 0.6 0.1 1.5 -0.0 0.8 0.2 0.3 -1.7 -2.4 -0.5 -2.4
Severe depression (siblings) 1.0 1.2 3.1 -1.4 -1.2 -1.0 0.9 -1.1 -1.2 -0.9 -0.4 -1.7 -1.6 0.6 0.5 -1.3 -0.9 -0.2 -0.8
Pack years adult smoking proportion 5.3 8.1 17.4 1.2 3.8 3.9 -2.7 4.2 4.0 -0.6 1.3 3.2 0.3 -4.2 -4.0 0.0 -1.3 3.2 -0.7
Impedance of leg (right) 2.5 12.3 30.6 -4.3 -3.9 -5.3 1.6 -3.0 -4.5 -5.5 -3.0 -4.5 -3.9 0.1 -0.3 -4.1 -2.5 -0.1 -2.5
Leg fat-free mass (left) 1.1 5.8 27.4 -0.6 -0.5 -1.1 -1.6 -2.7 -0.8 1.2 -1.3 0.1 -1.4 1.4 1.2 4.5 5.2 0.7 4.8
Trunk fat percentage 0.2 0.7 2.4 0.4 1.1 0.3 -1.1 0.4 0.9 0.0 -0.2 0.9 -0.1 -0.9 -0.9 1.2 0.9 1.6 0.8
Hand grip strength (right) 5.3 14.4 35.0 -4.6 -5.2 -5.4 1.0 -5.9 -5.8 -3.0 -5.2 -5.2 -2.5 2.1 1.7 -0.9 2.0 -0.8 1.2
Townsend deprivation index at recruitment 3.9 5.4 13.8 3.6 2.4 3.7 0.5 3.0 3.3 2.7 2.9 2.5 3.1 0.1 0.3 0.5 -1.1 -1.2 -0.9
Current tobacco smoking 0.8 1.3 3.5 1.8 0.9 1.6 0.2 1.2 1.1 1.9 1.8 1.0 1.8 -0.0 0.2 0.2 -0.6 -0.6 -0.6
Average weekly fortified wine intake 4.0 4.7 13.4 -2.8 -2.0 -3.7 -0.4 -3.4 -2.2 -1.7 -2.6 -1.8 -1.6 1.1 1.0 1.6 2.8 0.8 2.3
Maternal smoking around birth 2.9 4.2 10.6 2.3 2.9 3.2 -0.1 3.2 2.5 0.2 2.3 2.1 0.7 -1.7 -1.6 -1.0 -2.4 0.7 -1.9
Fed-up feelings 1.9 3.5 7.5 0.6 2.5 1.7 -2.7 2.1 2.1 -0.4 0.2 2.4 -1.1 -2.7 -2.7 1.3 0.8 2.1 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 6.2 -1.3 0.1 -0.8 -1.5 -0.4 -0.5 -1.8 -1.0 -0.3 -2.5 -1.6 -1.7 0.4 0.6 1.6 0.8
Relative age voice broke 2.4 3.7 11.7 1.7 -1.2 0.4 2.7 -0.7 -0.7 2.6 1.7 -0.9 2.3 2.9 3.0 -0.8 -0.8 -3.4 -1.0
Taking other prescription medications 0.8 1.2 2.6 0.6 1.6 1.2 -1.4 1.3 1.1 0.1 0.7 1.5 -0.9 -1.5 -1.4 0.8 0.4 0.7 0.5
Age when periods started (menarche) 2.4 5.7 22.5 -0.5 -0.9 -2.3 -1.1 -2.6 -1.3 2.4 -1.4 0.1 -0.1 1.9 1.7 4.1 4.7 -0.6 4.6
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 5.4 1.0 0.1 1.3 1.5 1.2 0.6 0.8 1.2 0.2 -0.3 0.3 0.2 -2.0 -2.3 -1.1 -2.2
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.0 10.2 2.9 2.4 2.9 -0.1 2.7 2.7 2.7 3.2 2.6 1.2 -0.4 -0.1 0.8 -0.5 -0.3 -0.3
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 0.0 0.1 0.2 -0.5 -0.1 -0.1 -0.6 -0.5 -0.1 -0.7 -0.5 -0.4 0.3 0.4 0.7 0.3
Qualifications: CSEs or equivalent 0.9 1.2 3.0 -0.0 1.4 0.4 -1.6 0.9 1.1 -1.1 -0.7 1.3 -0.4 -1.7 -1.7 0.7 0.4 1.7 0.7
Serious illness, injury or assault to yourself 1.8 2.2 6.2 -1.3 -1.7 -0.7 1.4 -1.1 -1.8 -1.0 -0.7 -2.3 -1.6 0.4 0.3 -2.5 -1.8 -0.4 -1.9
High blood pressure 0.7 1.9 5.7 1.1 1.7 2.4 -1.4 1.4 1.6 2.1 0.6 1.8 0.6 -1.0 -0.9 1.3 0.9 0.3 1.1
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.9 -0.4 0.1 -0.2 0.5 0.2 -0.4 -1.7 -0.1 -0.8 -0.2 -0.4 -0.4 -1.4 -1.4 0.2 -1.4
Multivitamins +/- minerals 2.3 3.0 9.4 0.8 -2.0 -1.0 1.9 -1.8 -1.4 1.9 1.0 -1.2 -0.1 2.9 3.1 0.4 0.8 -2.9 0.3
Stomach or abdominal pain in last month 1.6 2.0 5.5 -1.6 -0.7 -0.1 0.0 -0.2 -1.0 -2.1 -0.9 -1.3 -2.3 -1.3 -1.5 -2.4 -1.8 0.6 -1.6
Supplements: Glucosamine 0.2 0.3 1.1 -0.2 -0.4 -1.1 0.2 -0.7 -0.5 0.7 0.6 -0.1 -0.4 0.5 0.7 0.3 0.3 -0.7 0.3
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 2.5 -0.1 -1.4 -0.5 1.3 -0.7 -1.2 -0.1 0.4 -1.3 -1.1 0.9 0.9 -1.5 -0.9 -1.6 -1.3
Medication: Atenolol 1.1 1.3 3.5 1.6 0.8 1.9 -0.1 1.8 1.6 1.5 1.4 1.0 1.2 -0.7 -0.5 -0.2 -0.8 -0.4 -0.9
Medication: Levothyroxine sodium 0.4 0.8 3.5 -0.5 -0.2 -0.8 -0.8 -0.6 -0.3 0.3 -0.9 0.4 -0.1 0.2 0.2 1.4 1.9 -0.2 1.8
Sitting height 6.0 42.5 87.2 -8.6 -4.3 -9.3 -3.9 -8.6 -6.2 -6.9 -8.9 -4.2 -8.3 0.0 -0.6 4.5 8.1 3.9 7.7
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 0.3 0.2 -0.1 -0.4 0.3 0.1 -0.1 0.5 0.3 0.1 -0.5 -0.4 0.4 0.0 0.6 0.1
High blood pressure (mother) 0.7 1.0 3.0 -1.1 0.6 0.9 0.0 0.6 0.5 -1.2 -0.3 -0.5 -0.4 -1.1 -1.2 -1.7 -1.7 0.9 -1.5
Body mass index (BMI) 3.6 15.3 39.6 5.5 4.7 6.3 -0.7 4.4 5.3 5.9 4.5 4.7 4.7 -0.4 0.1 2.6 0.4 -0.2 0.5
Impedance of leg (left) 2.5 12.3 35.3 -4.2 -3.5 -4.9 1.3 -2.7 -4.2 -5.9 -3.0 -4.3 -4.2 -0.4 -0.8 -4.3 -2.8 0.2 -2.8
Leg predicted mass (left) 1.1 5.8 27.5 -0.6 -0.5 -1.2 -1.5 -2.8 -0.9 1.2 -1.3 0.0 -1.5 1.5 1.3 4.5 5.2 0.7 4.8
Trunk fat mass 0.4 1.7 7.3 -0.3 0.5 -0.6 -1.4 -1.0 0.1 0.2 -0.8 0.4 -0.9 -0.1 -0.2 2.5 2.7 1.5 2.4
Waist circumference 0.7 2.7 9.0 1.8 2.5 3.0 -0.4 2.3 2.5 1.0 2.0 1.6 0.2 -1.0 -0.9 0.2 -0.7 1.2 -0.8
Number of incorrect matches in round 3.3 5.4 16.3 -4.0 -1.1 -2.7 -1.1 -1.8 -2.1 -4.0 -3.9 -2.0 -2.3 -1.6 -1.9 -1.1 0.1 2.1 0.2
Past tobacco smoking 3.6 6.6 17.1 -3.9 -1.9 -3.5 -1.2 -2.3 -2.7 -4.1 -3.5 -2.3 -3.8 -1.4 -1.7 -0.9 0.4 2.3 0.4
Alcohol usually taken with meals 3.1 5.0 11.4 -3.2 -3.3 -2.8 1.1 -3.0 -3.1 -2.1 -2.5 -3.4 -2.0 1.2 1.0 -1.5 -0.0 0.0 -0.5
Nervous feelings 4.4 8.3 29.6 -3.5 0.6 -1.3 -3.1 0.6 -0.1 -5.4 -3.3 -0.2 -3.3 -4.3 -4.5 -0.9 -0.5 4.2 0.1
Frequency of tenseness / restlessness in last 2 weeks 3.6 5.6 13.9 -2.7 1.8 -0.2 -3.2 0.7 0.5 -3.4 -2.3 0.7 -2.8 -3.6 -3.7 0.7 0.7 3.6 1.3
Hearing difficulty/problems with background noise 0.9 1.5 8.1 -0.6 1.3 0.1 -1.4 0.5 0.2 -1.6 -0.6 0.2 -2.8 -1.7 -1.7 0.2 0.1 1.5 0.4
Hair/balding pattern: Pattern 2 0.2 0.2 0.7 0.5 0.2 -0.0 -0.2 0.3 0.3 0.5 0.4 0.7 0.2 0.3 0.3 0.8 0.7 -0.2 0.8
Had menopause 0.6 0.8 2.2 -0.4 0.7 0.3 -1.5 0.5 0.7 0.4 -0.8 0.9 0.2 -1.4 -1.4 0.8 0.8 1.0 1.0
Had other major operations 0.2 0.2 0.7 0.0 -0.8 -0.3 0.6 -0.3 -0.3 0.4 0.3 -0.6 -0.2 0.5 0.5 -0.2 -0.3 -0.6 -0.3
Forced vital capacity (FVC) 2.7 10.4 23.1 -4.6 -2.2 -4.4 -1.9 -4.1 -3.2 -3.6 -4.4 -2.6 -4.8 -0.4 -0.8 1.5 3.3 2.7 3.1
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.5 11.3 3.1 2.2 3.2 0.2 3.1 2.5 2.6 3.4 2.6 0.9 -0.6 -0.3 -0.0 -1.4 -0.5 -1.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.3 0.5 0.4 0.9 0.9 0.7 0.5 0.5 1.1 0.2 -0.3 0.4 0.3 -0.7 -1.2 -0.1 -1.0
Qualifications: None of the above 5.2 11.1 26.6 2.8 4.9 4.1 -3.8 4.6 4.4 1.7 1.4 5.2 0.6 -3.8 -3.6 2.7 1.1 1.7 1.9
Financial difficulties in last 2 years 0.6 0.8 3.3 1.1 1.3 1.8 0.1 1.2 1.2 0.3 1.3 0.5 0.2 -0.5 -0.4 -0.4 -1.0 0.3 -0.8
Mouth/teeth dental problems 0.5 0.8 2.2 -1.0 -1.5 -1.2 0.8 -1.3 -1.2 0.2 -0.7 -0.9 -0.2 1.2 1.3 -0.2 0.3 -0.0 0.1
Heart attack 1.0 1.3 2.6 1.6 1.4 1.5 -0.5 1.2 1.6 1.6 1.4 1.4 1.3 -0.4 -0.1 0.9 0.3 0.1 0.4
Allergy 0.5 1.1 3.9 0.0 -1.5 -0.2 0.8 -1.4 -0.9 2.0 0.1 -0.7 0.8 1.5 1.4 0.4 0.9 -1.0 0.7
Pain all over the body in last month 1.7 1.8 5.6 1.4 1.4 1.8 0.4 2.4 2.2 -0.2 1.8 1.7 0.6 -0.5 -0.2 -0.6 -1.7 -0.1 -1.4
Diabetes (self-reported) 3.4 5.2 12.4 3.5 2.5 3.3 0.4 3.0 2.9 3.0 3.5 2.7 2.3 0.2 0.6 0.6 -0.9 -0.8 -0.8
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 4.0 -1.4 0.9 -0.4 -1.7 0.2 0.0 -1.7 -1.4 0.3 -0.6 -2.0 -2.0 0.3 0.4 1.9 0.6
Medication: Ramipril 1.3 1.6 3.3 1.1 1.8 1.8 -1.3 1.1 1.7 0.8 1.1 1.8 0.3 -0.8 -0.6 1.8 1.1 0.7 1.3
Medication: Simvastatin 0.2 0.3 1.3 0.7 0.5 0.4 -0.2 0.2 0.4 1.0 0.3 0.5 1.1 0.1 0.1 0.7 0.5 -0.1 0.4
Fluid intelligence score 3.7 7.7 24.3 2.6 -2.5 -1.2 3.1 -1.9 -1.1 3.9 2.4 -1.1 2.2 4.8 4.9 1.6 1.3 -4.0 0.8
Illnesses of siblings 1.0 1.4 3.9 -0.0 -1.6 -1.0 1.8 -1.3 -1.3 0.2 0.0 -1.4 0.5 2.0 1.9 -0.8 -0.6 -1.0 -0.8
Neuroticism score 3.7 7.8 19.5 -1.7 2.5 0.2 -4.3 1.3 1.3 -3.2 -2.2 1.8 -2.9 -4.4 -4.4 1.7 1.5 4.3 2.1
Weight 0.7 3.7 17.6 0.3 0.6 -0.1 -1.4 -1.6 0.2 1.6 -0.4 0.7 -0.7 0.9 0.9 4.0 4.2 0.8 3.8
Impedance of arm (right) 3.9 18.3 54.3 -5.5 -4.7 -7.1 0.6 -4.2 -5.4 -7.4 -4.5 -4.9 -5.6 -0.2 -0.7 -3.0 -0.9 1.0 -1.0
Arm fat percentage (right) 1.5 5.7 13.7 3.4 3.1 3.7 -0.6 3.0 3.5 2.9 2.7 3.0 2.8 -0.7 -0.5 1.4 -0.1 0.3 -0.0
Trunk fat-free mass 2.2 12.7 44.0 -2.7 -2.2 -3.6 -1.4 -5.4 -3.2 0.0 -2.9 -1.8 -3.4 2.3 2.1 4.9 6.6 0.4 6.0
Hip circumference 0.5 2.2 8.7 0.7 0.3 0.4 -0.6 -1.3 0.1 2.6 -0.4 0.3 0.7 1.1 1.0 2.8 2.9 0.2 2.6
Time employed in main current job 3.2 3.7 10.1 2.1 2.2 2.8 0.1 3.2 2.3 1.0 2.2 1.9 2.0 -1.3 -1.2 -1.2 -2.3 -0.3 -2.0
Alcohol intake versus 10 years previously 1.1 1.7 5.6 2.2 0.6 0.7 -0.1 0.7 0.8 2.4 1.6 1.4 1.7 0.7 0.8 1.5 1.0 -1.3 1.2
Father’s age at death 1.0 1.3 3.3 -1.1 -1.2 -1.8 1.4 -1.3 -1.4 -1.1 -0.9 -1.3 0.7 1.3 1.2 -1.0 -0.4 -0.7 -0.9
Worrier / anxious feelings 7.7 14.5 38.4 -6.2 -2.1 -3.9 -2.3 -2.9 -3.8 -5.8 -5.6 -3.1 -5.7 -3.1 -3.6 -1.8 0.2 3.7 0.5
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 6.5 -1.8 -0.1 -0.7 -1.2 -0.5 -0.8 -1.9 -1.2 -0.5 -2.5 -1.4 -1.5 0.1 0.4 2.0 0.6
Falls in the last year 0.7 0.9 1.9 0.9 0.9 1.4 1.0 0.8 0.5 1.1 1.2 0.1 0.9 0.3 0.4 -1.0 -1.3 -0.8 -1.4
Hair/balding pattern: Pattern 3 0.8 1.1 3.9 1.0 -1.2 -0.2 1.5 -0.5 -0.5 1.2 0.8 -0.6 0.2 1.6 1.7 -0.5 -0.6 -2.0 -0.7
Number of live births 0.0 0.1 0.2 -0.2 0.4 -0.2 -0.2 0.1 0.2 0.3 0.3 0.1 0.3 -0.1 -0.1 0.4 0.2 -0.0 0.3
Forced expiratory volume in 1-second (FEV1) 2.7 9.1 18.7 -4.0 -2.3 -4.1 -1.6 -4.2 -3.0 -2.2 -3.6 -2.3 -4.3 0.3 -0.1 2.0 3.7 2.4 3.4
Pulse rate 2.2 3.7 13.6 -1.7 -0.3 0.0 1.1 0.7 -0.1 -3.0 -0.6 -1.2 -2.1 -1.1 -1.3 -3.7 -3.6 0.5 -3.2
Happiness 2.5 3.1 8.6 -2.3 -0.9 -2.4 -1.5 -1.1 -0.8 -2.9 -2.6 -0.2 -2.3 -0.8 -1.1 1.1 1.7 1.7 1.9
Noisy workplace 0.7 0.9 2.3 1.1 1.1 1.5 -0.8 1.4 1.2 0.9 0.6 1.5 0.2 -0.9 -0.8 0.4 0.0 0.0 0.1
Qualifications: A levels/AS levels or equivalent 2.3 5.2 14.2 -2.3 -3.2 -3.8 1.3 -3.7 -2.7 -0.0 -1.5 -2.5 -0.0 2.8 2.7 0.6 1.9 -1.3 1.4
Serious illness, injury or assault of a close relative in last 2 years 3.6 4.1 9.9 -1.8 -2.8 -1.8 2.2 -2.2 -2.7 -1.2 -1.1 -3.1 -1.3 1.3 1.0 -2.9 -1.9 -1.3 -2.1
Mouth/teeth dental problems: Dentures 2.0 3.3 7.0 1.4 2.5 1.7 -2.2 2.3 2.4 0.4 0.9 2.6 0.5 -2.1 -2.1 1.9 1.0 1.3 1.4
Asthma 0.6 1.1 3.7 1.4 1.2 1.2 -0.5 1.9 1.7 0.3 1.1 1.5 -0.1 -1.0 -0.8 -0.1 -0.7 -0.3 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.5 -0.0 -0.1 0.3 -0.1 0.2 0.0 0.3 -0.3 0.3 0.7 0.1 0.1 0.2 0.2 -0.5 0.3
Medication: Cholesterol lowering 0.6 0.9 3.8 1.5 0.5 1.1 0.1 0.5 0.6 2.0 1.0 0.8 1.4 0.5 0.6 0.8 0.6 -0.9 0.5
Depression (self-reported) 2.6 3.1 8.6 -2.5 0.9 -0.3 -2.0 0.4 0.0 -2.8 -1.9 -0.1 -2.0 -2.6 -2.7 -0.3 -0.1 2.9 0.4
Medication: Lansoprazole 1.1 1.2 4.5 -1.0 -1.3 -0.6 1.1 -0.6 -1.2 -0.4 -0.6 -1.4 -0.7 0.2 0.1 -2.1 -1.6 -0.5 -1.8
Prospective memory result 2.5 3.1 11.5 -2.7 -1.0 -2.0 -1.0 -1.4 -1.8 -3.4 -2.6 -1.1 -2.8 -1.0 -1.3 -0.4 0.6 1.0 0.5
Lung cancer (father) 0.7 0.9 2.8 -0.7 0.9 -0.4 -1.2 0.6 0.7 -0.8 -0.9 0.4 -0.2 -1.7 -1.7 -0.2 -0.1 1.6 -0.0
Illnesses of mother 0.5 0.7 1.6 0.6 -0.4 -0.4 0.1 -0.6 -0.2 1.3 0.3 0.3 0.2 1.0 1.1 1.3 1.3 -1.1 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.8 8.9 22.6 -4.1 -2.3 -3.8 -1.4 -4.3 -3.3 -2.1 -3.7 -2.8 -4.8 0.2 -0.2 1.4 3.3 2.1 2.9
Pulse wave Arterial Stiffness index 0.8 1.0 3.6 1.0 0.5 1.9 0.8 1.1 1.2 1.3 1.3 0.8 1.2 0.7 0.7 -0.0 -0.7 -0.3 -0.5
Impedance of arm (left) 3.5 16.1 55.1 -5.2 -4.0 -6.7 0.4 -3.5 -4.6 -7.4 -4.5 -4.3 -5.4 -0.6 -1.1 -2.9 -1.1 1.5 -1.1
Arm fat mass (right) 0.8 3.3 7.1 2.3 2.2 2.3 -0.9 1.2 2.3 2.7 1.7 2.1 1.6 0.0 0.2 2.6 1.8 0.4 1.6
Trunk predicted mass 2.2 12.8 44.6 -2.6 -2.2 -3.7 -1.4 -5.4 -3.2 0.1 -2.8 -1.8 -3.3 2.4 2.1 4.9 6.7 0.4 6.0
Standing height 8.0 79.8 196.0 -11.1 -8.8 -14.0 -1.7 -13.1 -11.2 -9.0 -10.6 -8.6 -11.9 3.0 1.9 3.7 8.9 2.2 7.9
Length of working week for main job 2.7 2.9 7.6 2.0 2.4 2.5 -1.3 2.0 2.4 1.2 1.4 2.8 0.6 -0.9 -0.9 1.9 0.9 0.4 1.2
Exposure to tobacco smoke at home 0.3 0.4 1.2 -0.9 -0.4 -0.5 0.0 -1.0 -0.6 -0.4 -1.0 -0.6 -1.1 0.2 0.1 0.0 0.3 -0.2 0.5
Breastfed as a baby 0.9 1.1 4.1 0.9 -1.0 0.1 1.2 -0.4 -0.2 1.2 0.2 -0.0 0.7 1.9 2.0 0.5 0.7 -1.9 0.4
Tense / ‘highly strung’ 2.8 4.7 13.8 -3.0 0.1 -1.9 -2.5 -0.7 -0.7 -3.7 -3.0 -0.6 -2.3 -2.6 -2.7 0.4 1.0 3.1 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 10.9 -2.4 0.9 -0.7 -2.2 0.7 0.5 -3.3 -2.1 0.1 -1.7 -3.0 -3.2 -0.6 -0.1 2.8 0.2
Hair/balding pattern: Pattern 4 0.9 2.2 6.2 1.5 -0.9 0.5 1.3 -0.4 0.2 2.5 1.5 0.0 2.1 2.3 2.5 1.0 0.9 -1.9 0.5
Birth weight of first child 2.4 4.4 11.9 -1.7 -3.1 -3.5 1.2 -3.3 -3.2 -1.3 -1.7 -2.7 -0.6 2.1 2.0 0.2 1.2 -0.6 0.6
Peak expiratory flow (PEF) 1.1 2.5 7.3 -1.5 -0.5 -1.4 -1.5 -1.4 -0.3 -1.0 -1.4 -0.0 -2.2 -0.1 -0.2 2.3 2.7 1.9 2.7
Pulse wave reflection index 3.1 3.8 7.6 2.4 1.9 2.4 -0.4 1.7 2.6 2.6 2.0 2.6 2.0 0.7 1.0 2.8 1.5 0.0 1.6
Ever highly irritable/argumentative for 2 days 1.8 2.2 9.7 2.1 -0.0 1.3 0.9 0.5 0.8 3.1 2.2 0.8 1.1 1.5 1.8 1.0 0.4 -1.9 0.3
Loud music exposure frequency 0.6 0.6 1.6 -1.0 0.0 0.3 -0.4 0.1 -0.4 -1.0 -1.3 -0.6 -0.6 -1.1 -1.2 -1.2 -0.8 0.6 -0.7
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 4.6 -1.2 -1.5 -2.1 0.6 -1.5 -1.4 -1.2 -1.1 -1.4 -0.2 0.9 0.9 -0.3 0.3 -0.1 0.0
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.1 -1.0 -0.4 0.0 0.1 -0.3 -0.8 -2.0 -0.8 -1.3 -1.2 -0.9 -1.1 -1.9 -1.6 -0.1 -1.4
Blood clot in the leg (DVT) 0.8 1.0 2.4 0.2 1.4 0.1 -1.1 1.0 1.1 -1.1 0.2 1.5 -1.6 -0.8 -0.6 1.2 0.4 1.2 0.8
Medication: Paracetamol 1.6 2.6 8.2 -1.6 -1.2 -0.4 0.7 -0.4 -1.2 -2.1 -1.4 -1.7 -2.3 -0.8 -1.0 -2.9 -2.4 0.0 -2.2
Headache pain in last month 3.4 5.8 18.0 -3.7 -1.2 -2.9 -1.0 -2.3 -2.2 -4.2 -3.6 -2.1 -3.8 -0.9 -1.2 -0.4 0.9 2.2 0.7
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 4.7 -1.4 -2.0 -2.2 1.3 -1.5 -1.9 -1.8 -0.9 -2.1 -1.2 0.8 0.7 -1.7 -1.1 -0.7 -1.1
Glaucoma (self-reported) 0.8 0.9 2.0 -0.2 1.2 0.7 -0.4 1.3 0.7 -1.3 0.7 0.4 -0.6 -1.4 -1.4 -1.0 -1.2 0.8 -0.9
Gout (self-reported) 8.4 11.5 36.2 -0.8 4.4 2.4 -4.5 3.9 3.1 -2.4 -0.7 3.4 -2.2 -6.0 -5.9 0.2 -0.6 4.4 0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.4 -0.3 -0.0 -0.5 -0.4 -0.5 -0.1 0.3 -0.8 0.3 0.1 0.3 0.3 0.9 1.2 -0.3 1.2
Medication: Amlodipine 1.2 1.7 6.2 0.5 1.8 2.5 -0.8 1.9 1.8 1.5 0.7 1.5 0.5 -1.4 -1.4 -0.1 -0.6 0.7 -0.2
Medication: Ventolin 100micrograms inhaler 0.6 0.8 3.3 -0.6 -0.3 0.4 0.0 0.5 -0.3 -0.4 -0.8 -0.7 0.3 -1.0 -1.1 -1.8 -1.6 -0.3 -1.3
Birth weight 5.3 11.5 27.9 -3.8 -3.4 -4.8 -0.6 -5.3 -4.5 -2.4 -4.0 -3.5 -5.0 1.3 1.0 1.6 3.6 0.5 3.1
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.2 0.6 0.6 -0.1 -0.6 1.1 0.9 -0.6 0.7 1.1 -0.7 -0.7 -0.4 0.7 0.1 0.6 0.2
High blood pressure (siblings) 0.4 0.6 1.6 0.3 1.1 1.2 -1.0 1.0 1.0 0.4 0.2 1.0 -0.4 -1.2 -1.1 0.4 0.2 0.2 0.3
Forced vital capacity (FVC), Best measure 3.1 11.5 29.0 -5.0 -2.5 -4.5 -1.5 -4.4 -3.8 -3.6 -4.6 -3.3 -5.4 -0.3 -0.8 0.8 3.0 2.4 2.6
Body fat percentage 0.5 1.9 4.2 1.9 2.0 2.0 -0.6 1.7 2.0 1.6 1.3 1.8 1.4 -0.6 -0.5 1.0 0.2 0.8 0.1
Leg fat percentage (right) 1.7 6.2 14.4 3.7 2.6 3.8 0.6 2.9 3.0 3.8 3.2 2.4 3.7 0.2 0.4 0.4 -1.1 -0.8 -1.1
Arm fat-free mass (right) 1.1 5.7 26.1 -1.0 -0.6 -1.3 -1.4 -3.1 -1.2 1.1 -1.5 -0.3 -1.6 1.4 1.3 4.2 5.1 0.6 4.7
Exposure to tobacco smoke outside home 0.6 0.8 2.1 0.1 1.2 0.5 -1.4 0.9 0.9 -0.2 -0.7 0.8 -0.5 -1.4 -1.4 0.6 0.4 0.8 0.6
Comparative body size at age 10 1.1 3.1 10.6 2.8 0.3 1.9 1.5 0.7 1.0 3.2 2.7 0.9 1.7 1.9 2.2 0.5 -0.2 -2.0 -0.4
Number of full brothers 1.1 1.4 4.0 1.2 0.6 1.0 1.2 0.8 1.0 1.8 1.5 0.7 2.0 1.1 1.2 -0.2 -0.8 -1.7 -0.8
Worry too long after embarrassment 1.3 2.1 5.5 -1.8 0.7 -0.7 -1.9 -0.0 -0.2 -2.0 -1.2 -0.3 -1.9 -2.3 -2.4 -0.0 0.0 2.3 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 7.3 -2.2 0.2 -0.8 -1.3 -0.1 -0.2 -2.7 -1.8 -0.6 -2.0 -1.8 -1.9 -0.6 -0.1 2.5 0.0
Wheeze or whistling in the chest in last year 1.6 2.9 8.5 -0.4 2.0 1.3 -2.3 1.6 1.3 -1.6 -0.6 1.4 -2.0 -2.9 -2.8 0.3 0.1 2.2 0.4
Number of children fathered 0.4 0.5 2.1 0.4 -0.4 0.4 0.7 -0.1 0.2 1.2 0.5 0.1 1.5 1.1 1.2 0.5 0.2 -0.1 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.3 -0.4 -0.1 -1.2 -0.3 -0.6 -0.5 -1.5 -1.1 -0.4 -1.2 0.3 0.2 0.8 0.8 0.9 1.0
Age at first live birth 0.7 1.3 4.1 -1.1 -1.8 -2.0 0.1 -1.8 -1.8 -0.5 -1.0 -1.4 -0.7 0.7 0.6 0.2 1.0 0.0 0.6
Pulse wave peak to peak time 2.0 2.3 8.2 -1.7 -1.2 -2.9 -0.7 -2.0 -2.1 -1.9 -2.0 -1.4 -1.9 -0.3 -0.4 0.2 1.2 0.3 0.9
Health satisfaction 0.5 0.6 2.5 1.3 0.8 1.6 -0.0 1.1 0.9 0.7 1.2 0.9 -0.3 -0.3 -0.3 0.2 -0.5 0.1 -0.2
Shortness of breath walking on level ground 1.9 2.2 5.9 1.5 2.1 2.2 -1.0 2.4 2.2 0.7 1.3 2.3 0.4 -1.2 -1.1 0.8 -0.0 0.8 0.2
Qualifications: College or University degree 1.8 5.8 13.8 -3.1 -2.8 -3.7 1.5 -3.3 -3.1 -2.7 -2.0 -3.2 -3.0 1.9 1.6 -1.1 0.2 -0.6 -0.0
Eye problems/disorders: None of the above 2.7 3.1 7.7 1.6 -2.2 0.3 2.5 -0.4 -0.5 2.2 1.3 -1.0 2.0 2.4 2.5 -1.1 -1.1 -2.8 -1.3
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.7 -1.1 0.4 -0.5 -1.1 -0.1 0.0 -1.2 -1.2 -0.0 -0.6 -1.3 -1.3 0.3 0.4 1.1 0.5
Emphysema/chronic bronchitis 1.4 1.5 3.3 -1.7 -0.3 -1.8 -1.4 -1.1 -1.0 -1.4 -1.4 -0.5 -1.7 -0.9 -1.0 0.7 1.5 0.6 1.4
Medication for pain relief, constipation, heartburn 0.7 1.1 4.0 0.8 -0.8 -0.9 1.4 -0.8 -0.5 0.8 0.8 -0.5 1.5 2.0 2.0 0.3 0.4 -1.1 0.1
Neck or shoulder pain in last month 0.3 0.4 1.0 0.7 0.6 0.8 -0.6 1.0 0.8 0.1 0.8 1.0 -0.1 -0.6 -0.6 0.4 0.0 0.5 -0.0
Medication: Blood pressure 2.7 4.9 10.2 1.3 3.2 2.8 -2.5 2.2 2.9 1.7 0.8 3.1 0.8 -1.9 -1.8 2.6 1.7 2.0 2.0
Angina (self-reported) 0.2 0.3 0.6 -0.5 0.4 0.5 -0.7 0.2 0.3 -0.1 -0.5 0.3 -0.8 -0.6 -0.6 0.5 0.4 0.6 0.5
Migraine (self-reported) 2.2 2.7 7.0 -2.4 -1.1 -2.5 -0.7 -1.9 -1.9 -2.6 -2.6 -1.7 -1.8 -0.5 -0.8 -0.5 0.6 1.0 0.5
Medication: Ibuprofen 0.2 0.3 1.3 0.3 0.3 0.6 -0.3 0.6 0.5 0.9 -0.0 0.8 1.1 0.0 0.1 0.6 0.3 -0.4 0.5
Medication: Allopurinol 5.3 7.0 20.8 0.0 3.7 2.3 -3.5 3.3 2.5 -1.7 -0.1 2.8 -1.5 -4.6 -4.5 0.5 -0.3 3.1 0.3
Medication: Omeprazole 0.6 0.7 1.8 0.5 1.3 0.9 -0.9 1.1 1.0 0.5 0.7 1.0 -0.8 -1.3 -1.3 0.2 -0.1 0.3 0.0
Medication: Seretide 50 evohaler 1.5 1.7 4.3 0.3 2.1 1.1 -1.7 1.5 1.9 0.1 0.2 1.6 0.4 -1.8 -1.8 0.8 0.4 1.5 0.5
Mean time to correctly identify matches 0.2 0.5 1.9 0.6 1.0 0.7 -0.5 1.0 1.0 0.5 0.2 1.4 0.2 -0.4 -0.3 0.7 0.4 -0.3 0.4
Heart disease (mother) 0.2 0.3 1.1 -0.0 -1.0 -0.3 0.5 -0.5 -1.0 0.5 -0.3 -0.8 -0.3 0.3 0.2 -0.5 -0.3 -0.1 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 3.9 1.7 0.8 2.0 -0.1 1.5 1.6 1.5 1.1 1.0 1.9 -0.6 -0.5 0.1 -0.9 0.5 -0.7
Whole body fat mass 0.4 1.5 5.9 1.1 1.3 0.8 -1.0 0.1 1.1 1.5 0.5 1.2 0.2 0.1 0.1 2.4 2.1 0.8 1.9
Leg fat mass (right) 0.9 3.4 10.4 2.5 2.0 2.6 -0.5 1.2 2.1 3.2 1.8 2.0 2.1 0.4 0.5 2.2 1.4 -0.1 1.2
Arm predicted mass (right) 1.2 6.4 28.0 -1.2 -0.8 -1.6 -1.4 -3.4 -1.4 1.0 -1.7 -0.6 -1.8 1.6 1.5 4.3 5.3 0.6 4.8
Pulse rate, automated reading 3.7 12.1 51.0 0.3 -1.4 1.2 4.7 1.4 -0.5 -1.2 2.2 -2.5 0.3 1.1 1.0 -6.8 -7.1 -2.0 -7.1
Alcohol intake frequency. 0.4 1.0 3.9 -0.2 0.9 0.5 -1.2 1.1 0.6 -0.9 -0.3 0.7 -0.5 -2.0 -2.0 -0.7 -0.8 0.9 -0.5
Comparative height size at age 10 5.9 32.5 80.1 -7.0 -5.6 -8.9 -1.7 -8.0 -6.6 -5.9 -6.4 -5.0 -8.3 1.3 0.7 2.8 5.9 1.7 5.5
Number of full sisters 1.1 1.3 3.4 0.9 1.8 1.5 -1.2 1.6 1.6 0.7 0.6 1.5 0.2 -1.2 -1.1 1.1 0.4 0.8 0.8
Suffer from ‘nerves’ 4.3 6.7 19.1 -2.3 1.6 -0.2 -3.4 1.0 0.6 -3.7 -2.7 0.8 -3.2 -4.2 -4.4 0.2 0.3 4.1 0.8
Overall health rating 0.5 1.0 2.9 0.2 1.0 1.2 -1.1 1.1 0.7 -0.4 0.7 0.9 -1.6 -1.6 -1.7 -0.2 -0.3 1.1 -0.2
Chest pain or discomfort 1.2 1.7 7.1 -1.6 -0.1 -0.4 -0.6 -0.1 -0.5 -2.7 -1.5 -0.6 -2.5 -1.4 -1.5 -1.1 -0.7 1.5 -0.4
Had major operations 2.4 2.9 11.6 1.3 -0.8 1.2 2.4 0.4 -0.2 1.3 1.9 -0.8 0.2 1.8 1.8 -1.9 -1.9 -3.4 -1.9
Age at last live birth 0.1 0.2 0.6 -0.4 -0.4 -0.8 0.3 -0.4 -0.7 -0.6 -0.1 -0.5 -0.5 0.4 0.3 -0.2 0.2 0.1 -0.1
Family relationship satisfaction 2.7 3.3 9.3 -2.1 -2.2 -2.3 0.6 -2.0 -2.2 -3.0 -2.0 -2.2 -2.8 0.5 0.3 -1.3 -0.2 -0.2 -0.3
Leg pain on walking 1.7 2.1 6.1 1.5 2.5 2.5 -0.7 1.9 1.9 1.1 1.7 2.0 -0.1 -1.1 -1.0 0.6 -0.4 0.4 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 3.1 -0.2 -0.2 0.3 0.6 0.3 -0.0 -0.4 0.2 -0.6 0.8 -0.4 -0.3 -1.7 -1.7 0.2 -1.7
Commuting to job workplace: Car/motor vehicle 0.9 1.1 3.1 -0.9 -1.1 -1.8 0.2 -1.6 -1.7 -0.1 -1.2 -1.3 -0.8 0.9 0.7 0.3 0.9 -0.4 0.8
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 6.8 -0.3 -0.3 -1.3 -1.0 -0.8 -0.2 0.9 -0.4 0.8 -0.1 0.5 0.6 2.3 2.6 -0.3 2.5
Medication: Aspirin 0.5 0.6 3.1 0.4 1.1 1.8 -0.5 0.9 0.7 0.6 -0.2 0.5 0.9 -1.0 -0.9 -0.3 -0.4 0.3 -0.2
Supplements: Vitamin C 1.1 1.3 4.0 -1.1 -1.6 -2.0 0.0 -1.8 -1.6 0.1 -1.3 -1.2 -0.6 0.7 0.5 0.2 1.1 -0.7 1.0
Knee pain experienced in last month 0.6 0.9 3.2 1.5 0.6 1.7 -0.2 1.0 0.9 1.8 1.5 0.9 1.0 -0.2 -0.1 0.4 -0.2 0.0 -0.2
Hypertension (Self-reported) 1.1 3.0 7.4 1.5 2.4 2.7 -1.6 2.0 2.3 2.3 1.0 2.5 0.7 -1.2 -1.1 1.7 1.0 0.5 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.3 -0.5 -0.4 0.1 -0.1 -0.0 -0.1 -0.3 -0.2 -0.4 -0.2 -0.2 -0.5 -0.5 0.1 -0.5
Illnesses of father: Heart disease 0.3 0.4 1.6 -0.6 -0.5 0.4 0.6 -0.4 -0.6 0.7 -0.3 -0.9 1.2 0.3 0.1 -0.8 -0.7 -0.2 -0.6
Illnesses of siblings: Diabetes 0.3 0.4 1.6 0.3 -0.3 0.0 0.3 -0.4 -0.3 0.9 0.4 0.3 -1.3 0.8 0.8 0.5 0.6 -0.6 0.5
Smoking status: Previous 3.0 4.4 10.5 3.2 1.7 3.0 0.7 1.9 2.4 3.1 2.9 2.1 3.1 1.1 1.3 1.0 -0.1 -1.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 4.2 8.7 17.8 -4.0 -1.8 -3.9 -1.6 -3.8 -2.8 -3.8 -4.2 -2.5 -4.2 -0.3 -0.6 1.2 3.0 2.2 2.7
Whole body fat-free mass 1.6 9.1 37.1 -1.8 -1.3 -2.5 -1.6 -4.3 -2.2 0.5 -2.2 -1.0 -2.7 1.8 1.6 4.8 6.1 0.6 5.5
Leg fat-free mass (right) 1.0 5.4 25.2 -0.8 -0.5 -1.1 -1.6 -2.8 -1.0 0.9 -1.5 -0.1 -1.8 1.2 1.1 4.2 5.0 0.9 4.6
Arm fat percentage (left) 1.5 6.1 14.0 3.3 3.4 3.7 -0.8 3.2 3.7 2.7 2.6 3.1 2.8 -1.0 -0.7 1.4 -0.1 0.8 -0.0
Average weekly red wine intake 0.4 0.7 1.6 0.1 -0.8 0.3 1.3 -0.5 -0.6 0.5 -0.3 -1.2 1.1 1.0 1.0 -0.7 -0.8 -1.0 -0.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.2 -1.0 -0.3 -1.4 -0.0 -1.5 -0.7 -0.1 -0.7 -0.7 -0.2 0.6 0.4 0.6 1.0 0.1 1.0
Mood swings 4.6 8.3 19.3 -0.4 3.3 1.6 -4.4 2.3 2.9 -2.1 -1.0 3.3 -1.9 -4.1 -4.0 2.7 2.0 4.1 2.6
Loneliness, isolation 3.9 5.4 14.2 -0.2 2.8 0.2 -3.8 0.8 1.5 -0.9 -1.1 2.4 -2.0 -2.7 -2.6 3.1 2.8 2.7 3.2
Long-standing illness, disability or infirmity 1.4 2.2 5.6 1.6 2.1 2.4 -0.7 1.9 2.1 1.6 2.1 1.8 0.7 -0.9 -0.7 1.0 0.0 0.9 0.0
Ever had bowel cancer screening 1.8 2.1 5.5 -1.7 -0.5 -2.3 -0.8 -1.9 -1.8 -1.0 -1.3 -1.0 -2.0 0.2 0.1 1.3 2.1 0.6 1.9
Diabetes diagnosed by doctor 3.2 5.3 12.8 3.6 2.0 3.2 1.0 2.6 2.6 3.3 3.6 2.2 2.9 0.8 1.2 0.4 -1.0 -1.1 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.4 0.9 1.2 0.9 -0.7 1.1 1.2 0.8 1.0 1.1 1.0 -0.7 -0.6 0.8 0.2 0.5 0.1
Friendships satisfaction 2.4 3.0 8.8 -2.4 -1.5 -2.1 -1.0 -1.5 -1.4 -2.9 -3.0 -0.9 -2.4 -0.5 -0.7 0.3 1.4 1.4 1.4
Qualifications: nursing, teaching 4.2 6.5 17.0 -0.9 -3.7 -2.7 3.6 -3.0 -2.6 0.6 0.2 -3.0 0.3 4.0 4.1 -1.2 -0.5 -2.8 -1.1
Commuting to job workplace: Walk 2.9 3.1 10.7 1.5 -0.0 1.7 1.9 1.6 0.8 0.3 2.2 0.1 1.3 0.4 0.5 -2.7 -3.3 -1.8 -3.1
Eye problems/disorders: Cataract 1.6 1.9 5.2 -2.0 1.1 -1.4 -1.5 -0.6 -0.6 -2.0 -1.6 -0.2 -2.3 -1.3 -1.4 0.4 0.9 1.5 1.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.7 1.6 1.1 1.4 -0.1 0.9 1.1 1.4 1.5 1.3 0.5 0.2 0.3 0.9 0.4 -0.6 0.2
Medication for cholesterol 1.5 2.3 5.8 -1.8 0.4 -1.8 -1.8 -0.8 -0.3 -2.4 -2.2 0.3 -1.0 -1.1 -1.1 1.2 1.7 2.0 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.8 8.1 -0.4 1.3 0.2 -2.6 0.9 1.0 -1.6 -1.0 1.6 -1.2 -2.2 -2.3 2.0 1.5 2.8 1.8
Back pain experienced in last month 1.2 1.7 5.2 1.1 0.8 0.5 -1.5 0.6 1.1 1.8 1.2 1.7 -0.3 -0.6 -0.5 2.3 1.9 0.2 2.0
Mineral and other dietary supplements 1.2 1.6 4.9 -1.2 0.6 0.1 -0.9 0.5 0.3 -2.2 -1.4 -0.1 -0.9 -1.9 -2.0 -1.2 -1.1 1.7 -0.8
Breast cancer (self-reported) 0.3 0.4 1.3 -0.3 -1.1 -0.4 0.6 -0.7 -1.0 -0.1 -0.5 -1.1 0.4 0.4 0.2 -0.9 -0.4 -0.5 -0.4
Asthma (self-reported) 0.6 1.1 4.0 1.3 1.2 1.2 -0.5 2.0 1.7 0.0 1.0 1.4 -0.1 -1.1 -0.9 -0.2 -0.9 -0.1 -0.6
Osteoporosis (self-reported) 0.3 0.3 0.9 -1.0 -0.6 -0.3 0.7 -0.5 -0.6 -0.0 -0.2 -0.8 -0.1 0.4 0.3 -0.9 -0.6 -0.1 -0.8
Osteoarthritis (self-reported) 0.3 0.4 1.7 0.9 -0.0 0.9 0.1 0.2 0.2 1.3 1.0 0.2 0.8 -0.0 0.0 -0.0 -0.3 -0.7 -0.2
Medication: Aspirin 0.4 0.5 2.3 0.1 1.1 1.5 -0.7 0.8 0.7 0.4 -0.3 0.5 0.8 -1.1 -1.0 -0.2 -0.3 0.5 -0.1
Medication: Gliclazide 0.7 0.8 2.0 1.4 0.5 1.4 0.8 0.7 0.9 0.8 1.3 0.3 1.4 0.6 0.7 -0.3 -0.7 -0.5 -0.9
Illnesses of father: None of the above (group 1) 0.4 0.5 1.1 -0.2 -1.0 -1.0 0.5 -0.9 -0.6 -0.5 -0.2 -0.8 -0.8 0.8 0.9 -0.3 0.3 -1.0 -0.1
Smoking status: Current 1.1 1.8 5.0 2.0 1.0 2.0 0.2 1.4 1.4 2.2 1.9 1.2 2.0 -0.0 0.2 0.3 -0.6 -0.7 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.5 -1.5 -1.3 -1.5 0.4 -1.9 -1.5 0.1 -0.8 -1.5 -1.8 0.8 0.6 0.1 0.7 0.4 0.6
Whole body water mass 1.5 8.7 36.3 -1.6 -1.3 -2.3 -1.5 -4.1 -2.0 0.7 -2.0 -0.9 -2.4 1.9 1.7 4.8 6.0 0.6 5.5
Leg predicted mass (right) 1.0 5.5 25.6 -0.7 -0.5 -1.1 -1.6 -2.8 -0.9 1.0 -1.4 -0.1 -1.7 1.2 1.1 4.3 5.1 0.9 4.6
Arm fat mass (left) 0.9 3.7 7.8 2.5 2.4 2.5 -0.9 1.4 2.5 2.8 1.8 2.3 1.8 0.0 0.2 2.6 1.7 0.6 1.5
Number of self-reported non-cancer illnesses 0.5 0.9 3.5 -0.9 1.0 0.5 -1.5 0.6 0.2 -0.2 -0.9 0.4 -0.9 -1.9 -1.9 0.0 0.1 1.2 0.3
Average weekly champagne plus white wine intake 0.7 1.0 3.8 0.2 -0.6 -0.3 0.5 -1.0 -0.5 1.9 -0.2 -0.2 1.1 1.4 1.4 1.0 1.4 -1.1 1.1
Miserableness 2.4 4.2 9.5 0.8 2.6 2.7 -2.7 2.4 2.5 0.4 -0.3 2.3 0.1 -3.1 -3.0 1.1 0.3 2.5 0.8
Guilty feelings 1.8 2.7 8.5 -2.0 0.5 -1.0 -1.8 -0.0 -0.5 -2.9 -2.2 -0.3 -2.3 -2.4 -2.4 -0.4 -0.1 2.0 0.4
Wears glasses or contact lenses 1.1 1.3 4.5 -0.0 -1.1 -1.2 -0.5 -1.0 -0.5 1.5 -1.1 0.2 0.5 0.7 0.6 1.7 2.1 -0.6 2.0
Ever taken oral contraceptive pill 1.9 2.1 4.9 2.0 2.1 2.2 -0.3 1.6 2.2 1.5 1.9 1.8 1.4 -0.2 -0.0 1.3 0.0 0.5 0.3
Hearing aid user 3.0 3.4 7.8 2.3 2.2 2.0 -1.6 2.1 2.4 2.2 1.7 2.8 1.7 -1.2 -1.0 1.9 1.0 0.4 1.2
Mother’s age at death 2.3 2.9 9.9 -1.6 -2.2 -3.1 0.1 -2.3 -2.2 -1.5 -1.7 -1.4 -1.8 1.2 1.1 0.7 1.8 -0.3 1.4
Financial situation satisfaction 1.6 2.0 4.6 1.8 2.0 2.2 -0.9 1.6 2.0 0.6 1.5 2.1 0.6 -0.6 -0.5 1.6 0.6 0.8 0.9
Tinnitus: Yes, now most or all of the time 2.4 2.8 8.0 -0.5 2.2 1.4 -1.9 1.9 1.0 -2.1 -1.1 1.5 -1.2 -2.8 -2.8 -0.6 -0.9 1.7 -0.5
Commuting to job workplace: Public transport 0.6 0.8 2.1 0.1 -1.2 -0.4 1.3 -0.7 -0.9 -0.2 0.2 -0.9 -0.2 1.2 1.3 -0.8 -0.6 -1.5 -0.7
Eye problems/disorders: Glaucoma 0.8 1.0 2.7 -0.5 1.6 0.7 -0.7 1.1 0.5 -1.2 0.2 0.5 -0.9 -1.5 -1.5 -0.7 -0.8 1.0 -0.7
Medication: Blood pressure 0.2 0.4 3.2 0.7 0.4 1.3 0.0 0.5 0.5 1.8 0.6 0.3 0.3 -0.1 -0.1 0.1 0.0 -0.5 -0.1
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.7 1.2 1.2 1.8 0.8 1.6 1.3 1.3 1.9 0.8 1.4 -0.1 0.1 -0.9 -1.7 -0.4 -1.7
Supplements: Fish oil (including cod liver oil) 1.1 1.4 4.9 0.9 0.4 -0.1 -0.3 -0.1 0.2 1.7 1.2 0.9 0.6 1.1 1.1 2.2 2.0 -0.7 1.9
High cholesterol (Self-reported) 0.9 1.6 3.3 1.4 1.6 1.3 -1.4 1.3 1.2 1.6 0.8 1.8 0.5 -1.0 -1.0 1.5 1.0 0.3 1.1
Medication: Bendroflumethiazide 0.9 1.4 4.5 1.4 1.0 1.4 -0.5 1.1 1.7 2.1 1.6 1.4 1.5 -0.2 -0.1 1.2 0.6 0.2 0.6
Medication: Paracetamol 0.6 1.0 4.1 -1.4 0.0 -0.4 -0.4 -0.1 -0.4 -1.3 -1.3 -0.7 -2.0 -1.1 -1.2 -1.1 -0.8 0.7 -0.7
Medication: Lisinopril 2.3 2.9 8.5 1.5 2.2 2.9 -1.2 2.6 2.6 1.3 0.7 2.2 1.7 -1.8 -1.6 0.2 -0.6 0.6 -0.3
Medication: Atorvastatin 0.3 0.4 1.3 0.8 0.7 1.1 -0.3 0.7 0.3 0.8 0.7 0.6 -0.7 -0.5 -0.4 -0.0 -0.2 0.1 -0.2
Illnesses of father: High blood pressure 1.0 1.2 3.6 -0.3 1.4 1.0 -1.5 0.9 0.5 -0.3 -0.4 1.1 -1.2 -1.7 -1.9 0.4 0.3 1.7 0.6
Alcohol drinker status: Never 1.8 2.2 6.9 -0.8 1.7 0.7 -2.2 1.4 1.4 -1.0 -0.6 1.6 -0.4 -2.6 -2.6 0.6 0.2 2.0 0.5
Ever smoked 3.2 5.5 16.4 3.4 0.8 2.5 2.0 1.3 1.5 4.0 3.0 1.2 3.7 2.2 2.4 0.1 -0.7 -3.1 -0.9
Basal metabolic rate 1.3 7.3 31.2 -1.3 -1.0 -1.9 -1.4 -3.7 -1.7 0.8 -1.8 -0.7 -2.1 1.7 1.6 4.5 5.6 0.6 5.0
Leg fat percentage (left) 1.9 7.0 17.6 3.9 3.1 4.2 0.2 3.2 3.4 3.7 3.3 2.8 3.7 -0.2 0.1 0.5 -1.0 -0.5 -1.0
Arm fat-free mass (left) 1.2 6.0 26.6 -1.1 -0.7 -1.4 -1.4 -3.2 -1.3 1.0 -1.5 -0.4 -1.7 1.5 1.4 4.3 5.2 0.6 4.7
Number of operations (self-reported) 0.8 1.1 4.3 0.3 -0.7 0.6 1.5 0.2 -0.3 0.1 0.4 -0.8 -0.8 0.9 1.0 -1.6 -1.5 -2.1 -1.5
Average weekly beer plus cider intake 0.8 1.2 3.2 0.0 1.8 0.9 -1.6 1.2 1.1 -0.6 -0.0 1.4 0.1 -1.6 -1.5 0.8 0.4 1.2 0.7
Irritability 1.1 1.9 3.8 0.9 1.8 1.4 -1.6 1.0 1.6 1.2 0.2 1.9 1.2 -0.9 -0.7 1.9 1.4 1.2 1.5
Risk taking 0.4 0.6 2.4 0.4 0.8 1.5 0.7 0.7 0.5 -0.2 0.8 0.1 -0.4 0.0 0.1 -1.1 -1.2 -0.2 -1.3
Ever had prostate specific antigen (PSA) test 1.3 1.5 4.7 -1.1 0.7 -0.5 -1.8 -0.2 0.3 -0.7 -1.4 0.9 -0.3 -0.9 -0.8 1.8 2.2 1.4 2.1
Fractured/broken bones in last 5 years 0.5 0.6 1.7 0.2 1.2 1.0 -0.9 0.6 1.0 0.8 0.1 1.3 0.3 -0.6 -0.5 1.1 0.9 0.3 0.9
Age started oral contraceptive pill 1.9 2.4 6.0 -1.6 -0.8 -2.4 -1.4 -1.5 -0.8 -1.1 -1.7 -0.1 -2.0 -0.2 -0.3 2.0 2.4 0.9 2.4
Diastolic blood pressure, automated reading 1.9 6.0 12.8 0.6 3.5 3.3 -2.1 3.4 3.1 -0.7 0.7 2.5 -0.8 -3.6 -3.6 -0.3 -1.5 3.2 -0.9
Ever depressed for a whole week 0.0 0.1 0.4 -0.2 -0.0 0.1 0.3 0.2 0.6 0.1 0.2 0.2 0.1 0.1 0.1 -0.0 -0.4 0.4 -0.1
Unable to work because of sickness or disability 0.9 1.2 2.8 0.1 1.4 1.5 -0.8 1.5 1.3 -0.1 0.7 1.0 -0.3 -1.7 -1.6 -0.5 -1.0 1.0 -0.8
Commuting to job workplace: Cycle 0.2 0.2 1.0 -0.0 -0.2 -0.4 -0.4 -0.3 -0.1 0.6 0.3 0.2 0.3 0.1 0.0 0.8 1.0 -0.3 1.0
Myopia 2.9 4.2 14.7 1.9 -1.9 0.1 2.9 -0.8 -1.0 2.6 1.7 -1.1 1.5 3.0 3.1 -0.9 -1.0 -3.8 -1.2
Vascular/heart problems diagnosed by doctor 0.8 2.2 7.1 -1.3 -2.0 -2.7 1.3 -1.7 -1.9 -2.1 -0.9 -2.0 -0.5 1.1 1.0 -1.2 -0.6 -0.3 -0.9
Cholesterol lowering medication 0.2 0.3 0.9 0.7 1.0 0.7 -0.6 0.7 0.5 0.7 0.6 0.7 -0.4 -0.6 -0.5 0.5 0.2 0.0 0.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.8 -0.1 0.7 0.4 -1.0 0.5 0.3 0.2 -0.1 0.5 -1.3 -1.3 -1.3 -0.0 0.0 0.2 0.1
Pain experienced in last month 0.5 0.9 2.2 -0.7 -0.5 -0.4 1.2 -0.5 -0.5 -0.6 -1.1 -1.1 1.2 0.7 0.7 -1.5 -1.2 -0.8 -1.1
Supplements: Calcium 1.6 1.8 4.0 -0.9 -2.0 -1.4 0.7 -1.9 -1.6 -0.0 -0.7 -1.4 -1.4 1.8 1.6 0.6 1.4 -1.1 1.2
Basal cell carcinoma (self-reported) 2.1 2.5 5.4 -2.3 -1.7 -1.9 0.9 -1.6 -2.1 -2.3 -1.7 -2.2 -1.7 0.4 0.1 -1.7 -1.2 0.0 -0.9
Heart attack/myocardial infarction (self-reported) 1.0 1.3 3.0 1.6 1.4 1.6 -0.6 1.5 1.7 1.4 1.4 1.4 1.3 -0.7 -0.4 0.7 0.0 0.3 0.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.3 0.3 1.3 0.1 -0.8 1.0 1.1 -1.1 0.4 1.4 -1.5 -0.6 -0.4 1.0 0.2 1.0 0.5
Heart disease (siblings) 0.2 0.2 0.6 -0.3 0.0 -0.3 -0.5 -0.6 -0.5 -0.1 -0.6 -0.2 -0.6 -0.3 -0.3 0.3 0.8 -0.1 0.7
Alcohol drinker status: Previous 0.8 0.9 2.2 1.4 1.0 1.5 -0.2 1.1 1.5 0.7 1.1 1.3 1.0 -0.2 -0.0 0.8 -0.1 0.7 0.1
Pack years of smoking 5.0 7.3 16.3 1.0 3.7 3.3 -3.1 3.7 3.7 -0.6 0.9 3.3 0.1 -4.0 -3.9 0.7 -0.4 3.2 0.1
Impedance of whole body 3.5 17.9 59.4 -5.5 -4.1 -6.5 0.7 -3.4 -4.8 -7.7 -4.5 -4.8 -5.5 -0.9 -1.4 -4.0 -2.2 1.3 -2.1
Leg fat mass (left) 1.0 3.8 9.8 2.6 2.4 2.8 -0.8 1.5 2.4 3.1 1.8 2.3 2.1 0.1 0.3 2.3 1.5 0.2 1.3
Arm predicted mass (left) 1.1 5.7 26.3 -0.7 -0.5 -1.1 -1.3 -3.0 -1.1 1.3 -1.1 -0.2 -1.5 1.6 1.5 4.4 5.1 0.5 4.7