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chr5:95,519,506-97,065,386

Best TWAS P=4.7e-15 · Best GWAS P=5.12e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
43	GTEx	Skin Sun Exposed Lower leg	ERAP2	0.44	0.52	enet	34	0.52	4.0e-50	7.6	7.8	4.7e-15	0.96	0.02	0.98	TRUE
50	GTEx	Uterus	ERAP2	0.66	0.58	lasso	3	0.63	2.5e-16	7.8	7.8	5.0e-15	1.00	0.01	0.99	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ERAP2	0.47	0.48	lasso	12	0.45	5.9e-13	7.7	7.8	5.5e-15	0.99	0.02	0.98	FALSE
16	GTEx	Brain Hypothalamus	ERAP2	0.58	0.54	lasso	16	0.53	1.0e-14	7.8	7.8	5.8e-15	1.00	0.02	0.98	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	ERAP2	0.59	0.56	lasso	5	0.56	3.9e-18	7.7	7.8	6.1e-15	0.99	0.01	0.99	FALSE
24	GTEx	Colon Transverse	ERAP2	0.41	0.55	lasso	12	0.55	1.2e-30	7.8	7.8	6.4e-15	1.00	0.01	0.99	FALSE
83	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ERAP2	0.66	0.53	enet	13	0.53	1.0e-16	7.6	7.8	7.1e-15	0.96	0.01	0.99	FALSE
20	GTEx	Breast Mammary Tissue (Male)	ERAP2	0.32	0.32	lasso	12	0.35	6.3e-09	7.8	7.8	9.0e-15	0.99	0.02	0.98	FALSE
34	GTEx	Liver	ERAP2	0.57	0.61	lasso	9	0.59	3.6e-20	7.8	7.7	9.7e-15	1.00	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ERAP2	0.53	0.56	enet	26	0.56	1.5e-31	7.8	7.7	9.9e-15	0.96	0.01	0.99	FALSE
13	GTEx	Brain Cortex	ERAP2	0.60	0.51	lasso	10	0.53	3.3e-17	7.6	7.7	1.0e-14	0.99	0.02	0.98	FALSE
78	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERAP2	0.60	0.56	lasso	8	0.60	4.5e-29	7.5	7.7	1.0e-14	0.98	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERAP2	0.52	0.75	enet	23	0.76	1.1e-239	7.5	7.7	1.2e-14	0.97	0.02	0.98	FALSE
32	GTEx	Heart Atrial Appendage	ERAP2	0.54	0.60	lasso	6	0.61	5.5e-34	7.6	7.7	1.3e-14	0.99	0.02	0.98	FALSE
44	GTEx	Small Intestine Terminal Ileum	ERAP2	0.55	0.60	lasso	12	0.59	3.6e-16	7.7	7.7	1.3e-14	1.00	0.01	0.99	FALSE
49	GTEx	Thyroid	ERAP2	0.49	0.65	lasso	9	0.65	1.9e-65	7.6	7.7	1.5e-14	0.98	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERAP2	0.47	0.62	enet	26	0.60	6.7e-63	7.6	7.7	1.6e-14	0.95	0.01	0.99	FALSE
22	GTEx	Cells Transformed fibroblasts	ERAP2	0.64	0.73	lasso	10	0.75	2.0e-82	7.5	7.7	1.7e-14	0.98	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ERAP2	0.56	0.71	enet	13	0.72	3.1e-57	7.5	7.7	1.8e-14	0.98	0.01	0.99	FALSE
5	GTEx	Artery Aorta	ERAP2	0.55	0.60	lasso	11	0.63	8.7e-44	7.5	7.7	1.9e-14	0.98	0.02	0.98	FALSE
35	GTEx	Lung	ERAP2	0.54	0.65	enet	26	0.70	1.3e-73	7.5	7.7	2.0e-14	0.98	0.02	0.98	FALSE
39	GTEx	Pancreas	ERAP2	0.38	0.44	lasso	12	0.46	3.0e-21	7.6	7.6	2.1e-14	0.97	0.02	0.98	FALSE
7	GTEx	Artery Tibial	LNPEP	0.08	0.08	lasso	9	0.07	1.7e-06	7.6	7.6	2.3e-14	0.99	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ERAP2	0.46	0.70	lasso	9	0.70	6.4e-110	7.5	7.6	2.3e-14	0.98	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	ERAP2	0.55	0.72	enet	21	0.74	4.7e-130	7.5	7.6	2.5e-14	0.97	0.01	0.99	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	ERAP2	0.57	0.68	enet	21	0.69	8.0e-93	7.6	7.6	2.6e-14	0.96	0.02	0.98	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ERAP2	0.44	0.68	lasso	2	0.68	3.6e-106	7.6	7.6	2.7e-14	0.97	0.01	0.99	FALSE
30	GTEx	Esophagus Muscularis	ERAP2	0.58	0.63	lasso	20	0.60	1.1e-44	7.5	7.6	3.0e-14	0.98	0.02	0.98	FALSE
54	NTR	Blood	ERAP2	0.33	0.63	enet	35	0.63	7.1e-269	7.5	7.6	3.0e-14	0.98	0.02	0.98	FALSE
8	GTEx	Artery Tibial	ERAP2	0.52	0.68	enet	18	0.68	3.4e-71	7.5	7.6	3.2e-14	0.97	0.02	0.98	FALSE
48	GTEx	Testis	ERAP2	0.39	0.44	lasso	4	0.45	6.5e-22	7.6	7.6	3.2e-14	0.98	0.02	0.98	FALSE
55	NTR	Blood	LNPEP	0.10	0.15	enet	22	0.16	3.3e-49	7.5	7.6	3.3e-14	0.95	0.02	0.98	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERAP2	0.63	0.73	lasso	12	0.74	5.5e-124	7.5	7.6	3.4e-14	0.97	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	ERAP2	0.50	0.72	lasso	7	0.74	5.1e-115	7.5	7.6	3.6e-14	0.97	0.01	0.99	FALSE
40	GTEx	Pituitary	ERAP2	0.66	0.63	lasso	17	0.60	2.1e-18	7.6	7.6	3.7e-14	0.97	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Stomach Adenocarcinoma	ERAP2	0.69	0.76	enet	12	0.74	3.3e-78	7.6	7.6	3.7e-14	0.97	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	ERAP2	0.49	0.57	enet	28	0.61	5.4e-62	7.8	7.6	4.1e-14	0.98	0.01	0.99	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	ERAP2	0.49	0.61	lasso	9	0.60	7.2e-41	7.6	7.5	4.4e-14	0.97	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERAP2	0.51	0.73	enet	19	0.75	3.3e-126	7.5	7.5	4.4e-14	0.96	0.02	0.98	FALSE
10	GTEx	Brain Caudate basal ganglia	ERAP2	0.62	0.61	lasso	11	0.60	4.9e-21	7.6	7.5	4.5e-14	0.97	0.02	0.98	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	ERAP2	0.41	0.49	lasso	11	0.48	2.5e-19	7.5	7.5	4.7e-14	0.97	0.02	0.98	FALSE
4	GTEx	Adrenal Gland	ERAP2	0.59	0.68	enet	28	0.66	4.3e-31	7.5	7.5	4.9e-14	0.97	0.02	0.98	FALSE
41	GTEx	Prostate	ERAP2	0.56	0.62	lasso	13	0.54	5.0e-16	7.5	7.5	5.0e-14	0.97	0.02	0.98	FALSE
6	GTEx	Artery Coronary	ERAP2	0.64	0.65	lasso	18	0.64	1.4e-27	7.5	7.5	5.2e-14	0.97	0.02	0.98	FALSE
18	GTEx	Brain Putamen basal ganglia	ERAP2	0.30	0.23	enet	17	0.18	5.3e-05	7.7	7.5	5.2e-14	0.99	0.02	0.98	FALSE
23	GTEx	Colon Sigmoid	ERAP2	0.55	0.57	lasso	16	0.55	3.7e-23	7.6	7.5	5.2e-14	0.97	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ERAP2	0.58	0.76	enet	51	0.79	4.2e-153	7.6	7.5	5.5e-14	0.96	0.02	0.98	FALSE
37	GTEx	Nerve Tibial	ERAP2	0.53	0.68	enet	25	0.67	1.2e-62	7.5	7.5	5.7e-14	0.97	0.02	0.98	FALSE
19	GTEx	Breast Mammary Tissue	ERAP2	0.48	0.57	lasso	12	0.56	7.1e-34	7.5	7.5	5.9e-14	0.97	0.02	0.98	FALSE
28	GTEx	Esophagus Mucosa	ERAP2	0.53	0.65	enet	26	0.64	1.4e-54	7.6	7.5	5.9e-14	0.97	0.02	0.98	FALSE
84	The Cancer Genome Atlas	Skin Cutaneous Melanoma	LNPEP	0.18	0.17	lasso	1	0.13	2.3e-04	7.5	7.5	6.1e-14	0.99	0.01	0.94	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	ERAP2	0.60	0.66	lasso	6	0.66	4.6e-50	7.5	7.5	6.8e-14	0.97	0.01	0.99	FALSE
81	The Cancer Genome Atlas	Rectum Adenocarcinoma	ERAP2	0.57	0.64	enet	19	0.67	8.4e-21	7.5	7.5	7.4e-14	0.97	0.01	0.99	FALSE
36	GTEx	Muscle Skeletal	ERAP2	0.47	0.58	enet	34	0.58	1.3e-70	7.5	7.5	7.5e-14	0.97	0.02	0.98	FALSE
82	The Cancer Genome Atlas	Soft Tissue Sarcoma	ERAP2	0.59	0.60	lasso	8	0.65	2.6e-50	7.5	7.5	8.6e-14	0.97	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ERAP2	0.38	0.49	enet	11	0.54	7.6e-31	7.5	7.5	9.0e-14	0.98	0.01	0.99	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	ERAP2	0.47	0.71	lasso	8	0.71	2.3e-130	7.6	7.5	9.2e-14	0.97	0.02	0.98	FALSE
21	GTEx	Breast Mammary Tissue (Female)	ERAP2	0.48	0.42	enet	23	0.41	1.6e-13	7.6	7.5	9.3e-14	0.92	0.02	0.98	FALSE
33	GTEx	Heart Left Ventricle	ERAP2	0.43	0.47	lasso	9	0.47	4.7e-28	7.6	7.5	9.6e-14	0.96	0.02	0.98	FALSE
46	GTEx	Stomach	ERAP2	0.42	0.47	enet	29	0.50	1.8e-27	7.6	7.4	9.8e-14	0.96	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ERAP2	0.50	0.58	enet	24	0.62	4.4e-27	7.5	7.4	9.9e-14	0.97	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	ERAP2	0.46	0.50	enet	24	0.53	1.4e-31	7.6	7.4	1.0e-13	0.98	0.02	0.98	FALSE
51	GTEx	Vagina	ERAP2	0.52	0.46	enet	40	0.48	8.8e-13	6.6	7.4	1.0e-13	0.94	0.04	0.96	FALSE
52	GTEx	Whole Blood	ERAP2	0.37	0.36	lasso	12	0.36	3.4e-34	7.5	7.4	1.0e-13	0.94	0.02	0.98	FALSE
38	GTEx	Ovary	ERAP2	0.61	0.43	enet	30	0.50	3.0e-14	7.5	7.4	1.3e-13	0.97	0.02	0.98	FALSE
12	GTEx	Brain Cerebellum	ERAP2	0.49	0.34	lasso	15	0.35	3.4e-11	7.5	7.4	1.4e-13	0.98	0.02	0.98	FALSE
76	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ERAP2	0.47	0.58	enet	29	0.63	9.8e-55	7.5	7.4	1.4e-13	0.94	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ERAP2	0.64	0.56	blup	71	0.56	7.9e-28	7.5	7.3	2.2e-13	0.90	0.01	0.99	FALSE
45	GTEx	Spleen	ERAP2	0.66	0.61	enet	33	0.63	1.3e-20	7.5	7.3	2.8e-13	0.96	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	ERAP2	0.66	0.60	lasso	8	0.57	5.7e-21	7.5	7.3	3.1e-13	0.97	0.01	0.99	FALSE
29	GTEx	Esophagus Muscularis	LNPEP	0.14	0.15	enet	16	0.16	3.0e-10	7.5	7.3	3.6e-13	0.95	0.02	0.98	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LNPEP	0.06	0.03	blup	70	0.04	1.5e-03	5.7	7.2	5.5e-13	0.94	0.05	0.87	FALSE
59	YFS	Blood	ERAP2	0.55	0.73	enet	39	0.78	0.0e+00	6.5	7.2	6.0e-13	0.94	0.99	0.01	FALSE
15	GTEx	Brain Hippocampus	ERAP2	0.52	0.40	enet	31	0.39	3.6e-10	7.6	7.2	7.2e-13	0.89	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Esophageal Carcinoma	ERAP2	0.51	0.46	enet	18	0.51	1.2e-18	7.5	7.2	8.3e-13	0.94	0.01	0.99	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	LNPEP	0.15	0.07	lasso	10	0.08	5.5e-04	7.5	7.1	1.1e-12	0.92	0.03	0.83	FALSE
88	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ERAP2	0.53	0.61	enet	26	0.63	5.0e-22	7.5	7.1	1.3e-12	0.95	0.01	0.99	FALSE
31	GTEx	Esophagus Muscularis	AC008865.1	0.14	0.14	enet	16	0.15	3.1e-09	7.5	7.1	1.4e-12	0.94	0.02	0.98	FALSE
9	GTEx	Artery Tibial	AC008865.1	0.09	0.07	enet	17	0.06	1.5e-05	7.6	7.0	2.9e-12	0.94	0.03	0.97	FALSE
53	METSIM	Adipose	ERAP2	0.26	0.33	enet	60	0.35	2.7e-55	6.5	6.9	3.9e-12	0.92	0.99	0.01	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LNPEP	0.04	0.03	blup	73	0.02	7.6e-04	7.6	6.8	8.3e-12	0.85	0.02	0.93	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	LNPEP	0.23	0.18	lasso	12	0.27	3.9e-34	7.6	6.7	1.9e-11	0.84	0.02	0.98	FALSE
47	GTEx	Testis	LNPEP	0.16	0.14	lasso	4	0.13	1.5e-06	6.2	6.6	4.7e-11	0.87	0.02	0.97	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	AC008865.1	0.15	0.11	lasso	11	0.13	1.6e-05	7.6	6.6	4.8e-11	0.87	0.03	0.86	FALSE
14	GTEx	Brain Frontal Cortex BA9	ERAP2	0.23	0.19	enet	26	0.19	9.9e-06	6.2	6.6	5.5e-11	0.90	0.07	0.93	FALSE
79	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LNPEP	0.13	0.07	blup	73	0.09	2.9e-04	5.7	6.3	2.4e-10	0.86	0.02	0.82	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	AC008865.1	0.05	0.00	bslmm	458	0.02	8.2e-04	7.7	-5.8	5.8e-09	-0.70	0.02	0.90	FALSE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	LNPEP	0.09	0.02	blup	73	0.05	4.9e-06	7.7	5.6	2.2e-08	0.67	0.01	0.98	FALSE