[Hub]/) : Traits : Crohns Disease (2017) :

chr5:95,519,506-97,065,386

Best TWAS P=4.7e-15 · Best GWAS P=5.12e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ERAP2 0.58 0.76 enet 51 0.79 4.2e-153 7.6 7.5 5.5e-14 0.96 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous ERAP2 0.49 0.57 enet 28 0.61 5.4e-62 7.8 7.6 4.1e-14 0.98 0.01 0.99 FALSE
3 GTEx Adipose Visceral Omentum ERAP2 0.46 0.50 enet 24 0.53 1.4e-31 7.6 7.4 1.0e-13 0.98 0.02 0.98 FALSE
4 GTEx Adrenal Gland ERAP2 0.59 0.68 enet 28 0.66 4.3e-31 7.5 7.5 4.9e-14 0.97 0.02 0.98 FALSE
5 GTEx Artery Aorta ERAP2 0.55 0.60 lasso 11 0.63 8.7e-44 7.5 7.7 1.9e-14 0.98 0.02 0.98 FALSE
6 GTEx Artery Coronary ERAP2 0.64 0.65 lasso 18 0.64 1.4e-27 7.5 7.5 5.2e-14 0.97 0.02 0.98 FALSE
7 GTEx Artery Tibial LNPEP 0.08 0.08 lasso 9 0.07 1.7e-06 7.6 7.6 2.3e-14 0.99 0.02 0.98 FALSE
8 GTEx Artery Tibial ERAP2 0.52 0.68 enet 18 0.68 3.4e-71 7.5 7.6 3.2e-14 0.97 0.02 0.98 FALSE
9 GTEx Artery Tibial AC008865.1 0.09 0.07 enet 17 0.06 1.5e-05 7.6 7.0 2.9e-12 0.94 0.03 0.97 FALSE
10 GTEx Brain Caudate basal ganglia ERAP2 0.62 0.61 lasso 11 0.60 4.9e-21 7.6 7.5 4.5e-14 0.97 0.02 0.98 FALSE
11 GTEx Brain Cerebellar Hemisphere ERAP2 0.47 0.48 lasso 12 0.45 5.9e-13 7.7 7.8 5.5e-15 0.99 0.02 0.98 FALSE
12 GTEx Brain Cerebellum ERAP2 0.49 0.34 lasso 15 0.35 3.4e-11 7.5 7.4 1.4e-13 0.98 0.02 0.98 FALSE
13 GTEx Brain Cortex ERAP2 0.60 0.51 lasso 10 0.53 3.3e-17 7.6 7.7 1.0e-14 0.99 0.02 0.98 FALSE
14 GTEx Brain Frontal Cortex BA9 ERAP2 0.23 0.19 enet 26 0.19 9.9e-06 6.2 6.6 5.5e-11 0.90 0.07 0.93 FALSE
15 GTEx Brain Hippocampus ERAP2 0.52 0.40 enet 31 0.39 3.6e-10 7.6 7.2 7.2e-13 0.89 0.02 0.98 FALSE
16 GTEx Brain Hypothalamus ERAP2 0.58 0.54 lasso 16 0.53 1.0e-14 7.8 7.8 5.8e-15 1.00 0.02 0.98 FALSE
17 GTEx Brain Nucleus accumbens basal ganglia ERAP2 0.59 0.56 lasso 5 0.56 3.9e-18 7.7 7.8 6.1e-15 0.99 0.01 0.99 FALSE
18 GTEx Brain Putamen basal ganglia ERAP2 0.30 0.23 enet 17 0.18 5.3e-05 7.7 7.5 5.2e-14 0.99 0.02 0.98 FALSE
19 GTEx Breast Mammary Tissue ERAP2 0.48 0.57 lasso 12 0.56 7.1e-34 7.5 7.5 5.9e-14 0.97 0.02 0.98 FALSE
20 GTEx Breast Mammary Tissue (Male) ERAP2 0.32 0.32 lasso 12 0.35 6.3e-09 7.8 7.8 9.0e-15 0.99 0.02 0.98 FALSE
21 GTEx Breast Mammary Tissue (Female) ERAP2 0.48 0.42 enet 23 0.41 1.6e-13 7.6 7.5 9.3e-14 0.92 0.02 0.98 FALSE
22 GTEx Cells Transformed fibroblasts ERAP2 0.64 0.73 lasso 10 0.75 2.0e-82 7.5 7.7 1.7e-14 0.98 0.02 0.98 FALSE
23 GTEx Colon Sigmoid ERAP2 0.55 0.57 lasso 16 0.55 3.7e-23 7.6 7.5 5.2e-14 0.97 0.02 0.98 FALSE
24 GTEx Colon Transverse ERAP2 0.41 0.55 lasso 12 0.55 1.2e-30 7.8 7.8 6.4e-15 1.00 0.01 0.99 FALSE
25 GTEx Esophagus Gastroesophageal Junction LNPEP 0.15 0.07 lasso 10 0.08 5.5e-04 7.5 7.1 1.1e-12 0.92 0.03 0.83 FALSE
26 GTEx Esophagus Gastroesophageal Junction ERAP2 0.41 0.49 lasso 11 0.48 2.5e-19 7.5 7.5 4.7e-14 0.97 0.02 0.98 FALSE
27 GTEx Esophagus Gastroesophageal Junction AC008865.1 0.15 0.11 lasso 11 0.13 1.6e-05 7.6 6.6 4.8e-11 0.87 0.03 0.86 FALSE
28 GTEx Esophagus Mucosa ERAP2 0.53 0.65 enet 26 0.64 1.4e-54 7.6 7.5 5.9e-14 0.97 0.02 0.98 FALSE
29 GTEx Esophagus Muscularis LNPEP 0.14 0.15 enet 16 0.16 3.0e-10 7.5 7.3 3.6e-13 0.95 0.02 0.98 FALSE
30 GTEx Esophagus Muscularis ERAP2 0.58 0.63 lasso 20 0.60 1.1e-44 7.5 7.6 3.0e-14 0.98 0.02 0.98 FALSE
31 GTEx Esophagus Muscularis AC008865.1 0.14 0.14 enet 16 0.15 3.1e-09 7.5 7.1 1.4e-12 0.94 0.02 0.98 FALSE
32 GTEx Heart Atrial Appendage ERAP2 0.54 0.60 lasso 6 0.61 5.5e-34 7.6 7.7 1.3e-14 0.99 0.02 0.98 FALSE
33 GTEx Heart Left Ventricle ERAP2 0.43 0.47 lasso 9 0.47 4.7e-28 7.6 7.5 9.6e-14 0.96 0.02 0.98 FALSE
34 GTEx Liver ERAP2 0.57 0.61 lasso 9 0.59 3.6e-20 7.8 7.7 9.7e-15 1.00 0.01 0.99 FALSE
35 GTEx Lung ERAP2 0.54 0.65 enet 26 0.70 1.3e-73 7.5 7.7 2.0e-14 0.98 0.02 0.98 FALSE
36 GTEx Muscle Skeletal ERAP2 0.47 0.58 enet 34 0.58 1.3e-70 7.5 7.5 7.5e-14 0.97 0.02 0.98 FALSE
37 GTEx Nerve Tibial ERAP2 0.53 0.68 enet 25 0.67 1.2e-62 7.5 7.5 5.7e-14 0.97 0.02 0.98 FALSE
38 GTEx Ovary ERAP2 0.61 0.43 enet 30 0.50 3.0e-14 7.5 7.4 1.3e-13 0.97 0.02 0.98 FALSE
39 GTEx Pancreas ERAP2 0.38 0.44 lasso 12 0.46 3.0e-21 7.6 7.6 2.1e-14 0.97 0.02 0.98 FALSE
40 GTEx Pituitary ERAP2 0.66 0.63 lasso 17 0.60 2.1e-18 7.6 7.6 3.7e-14 0.97 0.02 0.98 FALSE
41 GTEx Prostate ERAP2 0.56 0.62 lasso 13 0.54 5.0e-16 7.5 7.5 5.0e-14 0.97 0.02 0.98 FALSE
42 GTEx Skin Not Sun Exposed Suprapubic ERAP2 0.49 0.61 lasso 9 0.60 7.2e-41 7.6 7.5 4.4e-14 0.97 0.02 0.98 FALSE
43 GTEx Skin Sun Exposed Lower leg ERAP2 0.44 0.52 enet 34 0.52 4.0e-50 7.6 7.8 4.7e-15 0.96 0.02 0.98 TRUE
44 GTEx Small Intestine Terminal Ileum ERAP2 0.55 0.60 lasso 12 0.59 3.6e-16 7.7 7.7 1.3e-14 1.00 0.01 0.99 FALSE
45 GTEx Spleen ERAP2 0.66 0.61 enet 33 0.63 1.3e-20 7.5 7.3 2.8e-13 0.96 0.02 0.98 FALSE
46 GTEx Stomach ERAP2 0.42 0.47 enet 29 0.50 1.8e-27 7.6 7.4 9.8e-14 0.96 0.02 0.98 FALSE
47 GTEx Testis LNPEP 0.16 0.14 lasso 4 0.13 1.5e-06 6.2 6.6 4.7e-11 0.87 0.02 0.97 FALSE
48 GTEx Testis ERAP2 0.39 0.44 lasso 4 0.45 6.5e-22 7.6 7.6 3.2e-14 0.98 0.02 0.98 FALSE
49 GTEx Thyroid ERAP2 0.49 0.65 lasso 9 0.65 1.9e-65 7.6 7.7 1.5e-14 0.98 0.02 0.98 FALSE
50 GTEx Uterus ERAP2 0.66 0.58 lasso 3 0.63 2.5e-16 7.8 7.8 5.0e-15 1.00 0.01 0.99 FALSE
51 GTEx Vagina ERAP2 0.52 0.46 enet 40 0.48 8.8e-13 6.6 7.4 1.0e-13 0.94 0.04 0.96 FALSE
52 GTEx Whole Blood ERAP2 0.37 0.36 lasso 12 0.36 3.4e-34 7.5 7.4 1.0e-13 0.94 0.02 0.98 FALSE
53 METSIM Adipose ERAP2 0.26 0.33 enet 60 0.35 2.7e-55 6.5 6.9 3.9e-12 0.92 0.99 0.01 FALSE
54 NTR Blood ERAP2 0.33 0.63 enet 35 0.63 7.1e-269 7.5 7.6 3.0e-14 0.98 0.02 0.98 FALSE
55 NTR Blood LNPEP 0.10 0.15 enet 22 0.16 3.3e-49 7.5 7.6 3.3e-14 0.95 0.02 0.98 FALSE
56 ROSMAP Brain Pre-frontal Cortex LNPEP 0.23 0.18 lasso 12 0.27 3.9e-34 7.6 6.7 1.9e-11 0.84 0.02 0.98 FALSE
57 ROSMAP Brain Pre-frontal Cortex ERAP2 0.47 0.71 lasso 8 0.71 2.3e-130 7.6 7.5 9.2e-14 0.97 0.02 0.98 FALSE
58 ROSMAP Brain Pre-frontal Cortex AC008865.1 0.05 0.00 bslmm 458 0.02 8.2e-04 7.7 -5.8 5.8e-09 -0.70 0.02 0.90 FALSE
59 YFS Blood ERAP2 0.55 0.73 enet 39 0.78 0.0e+00 6.5 7.2 6.0e-13 0.94 0.99 0.01 FALSE
60 The Cancer Genome Atlas Bladder Urothelial Carcinoma ERAP2 0.47 0.62 enet 26 0.60 6.7e-63 7.6 7.7 1.6e-14 0.95 0.01 0.99 FALSE
61 The Cancer Genome Atlas Breast Invasive Carcinoma ERAP2 0.52 0.75 enet 23 0.76 1.1e-239 7.5 7.7 1.2e-14 0.97 0.02 0.98 FALSE
62 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ERAP2 0.38 0.49 enet 11 0.54 7.6e-31 7.5 7.5 9.0e-14 0.98 0.01 0.99 FALSE
63 The Cancer Genome Atlas Colon Adenocarcinoma ERAP2 0.60 0.66 lasso 6 0.66 4.6e-50 7.5 7.5 6.8e-14 0.97 0.01 0.99 FALSE
64 The Cancer Genome Atlas Esophageal Carcinoma ERAP2 0.51 0.46 enet 18 0.51 1.2e-18 7.5 7.2 8.3e-13 0.94 0.01 0.99 FALSE
65 The Cancer Genome Atlas Glioblastoma Multiforme ERAP2 0.66 0.60 lasso 8 0.57 5.7e-21 7.5 7.3 3.1e-13 0.97 0.01 0.99 FALSE
66 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ERAP2 0.46 0.70 lasso 9 0.70 6.4e-110 7.5 7.6 2.3e-14 0.98 0.01 0.99 FALSE
67 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma LNPEP 0.04 0.03 blup 73 0.02 7.6e-04 7.6 6.8 8.3e-12 0.85 0.02 0.93 FALSE
68 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ERAP2 0.51 0.73 enet 19 0.75 3.3e-126 7.5 7.5 4.4e-14 0.96 0.02 0.98 FALSE
69 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ERAP2 0.56 0.71 enet 13 0.72 3.1e-57 7.5 7.7 1.8e-14 0.98 0.01 0.99 FALSE
70 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma LNPEP 0.06 0.03 blup 70 0.04 1.5e-03 5.7 7.2 5.5e-13 0.94 0.05 0.87 FALSE
71 The Cancer Genome Atlas Brain Lower Grade Glioma ERAP2 0.63 0.73 lasso 12 0.74 5.5e-124 7.5 7.6 3.4e-14 0.97 0.01 0.99 FALSE
72 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ERAP2 0.53 0.56 enet 26 0.56 1.5e-31 7.8 7.7 9.9e-15 0.96 0.01 0.99 FALSE
73 The Cancer Genome Atlas Lung Adenocarcinoma ERAP2 0.55 0.72 enet 21 0.74 4.7e-130 7.5 7.6 2.5e-14 0.97 0.01 0.99 FALSE
74 The Cancer Genome Atlas Lung Adenocarcinoma LNPEP 0.09 0.02 blup 73 0.05 4.9e-06 7.7 5.6 2.2e-08 0.67 0.01 0.98 FALSE
75 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ERAP2 0.44 0.68 lasso 2 0.68 3.6e-106 7.6 7.6 2.7e-14 0.97 0.01 0.99 FALSE
76 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ERAP2 0.47 0.58 enet 29 0.63 9.8e-55 7.5 7.4 1.4e-13 0.94 0.01 0.99 FALSE
77 The Cancer Genome Atlas Pancreatic Adenocarcinoma ERAP2 0.64 0.56 blup 71 0.56 7.9e-28 7.5 7.3 2.2e-13 0.90 0.01 0.99 FALSE
78 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ERAP2 0.60 0.56 lasso 8 0.60 4.5e-29 7.5 7.7 1.0e-14 0.98 0.01 0.99 FALSE
79 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma LNPEP 0.13 0.07 blup 73 0.09 2.9e-04 5.7 6.3 2.4e-10 0.86 0.02 0.82 FALSE
80 The Cancer Genome Atlas Prostate Adenocarcinoma ERAP2 0.50 0.72 lasso 7 0.74 5.1e-115 7.5 7.6 3.6e-14 0.97 0.01 0.99 FALSE
81 The Cancer Genome Atlas Rectum Adenocarcinoma ERAP2 0.57 0.64 enet 19 0.67 8.4e-21 7.5 7.5 7.4e-14 0.97 0.01 0.99 FALSE
82 The Cancer Genome Atlas Soft Tissue Sarcoma ERAP2 0.59 0.60 lasso 8 0.65 2.6e-50 7.5 7.5 8.6e-14 0.97 0.01 0.99 FALSE
83 The Cancer Genome Atlas Skin Cutaneous Melanoma ERAP2 0.66 0.53 enet 13 0.53 1.0e-16 7.6 7.8 7.1e-15 0.96 0.01 0.99 FALSE
84 The Cancer Genome Atlas Skin Cutaneous Melanoma LNPEP 0.18 0.17 lasso 1 0.13 2.3e-04 7.5 7.5 6.1e-14 0.99 0.01 0.94 FALSE
85 The Cancer Genome Atlas Stomach Adenocarcinoma ERAP2 0.69 0.76 enet 12 0.74 3.3e-78 7.6 7.6 3.7e-14 0.97 0.01 0.99 FALSE
86 The Cancer Genome Atlas Testicular Germ Cell Tumors ERAP2 0.50 0.58 enet 24 0.62 4.4e-27 7.5 7.4 9.9e-14 0.97 0.01 0.99 FALSE
87 The Cancer Genome Atlas Thyroid Carcinoma ERAP2 0.57 0.68 enet 21 0.69 8.0e-93 7.6 7.6 2.6e-14 0.96 0.02 0.98 FALSE
88 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma ERAP2 0.53 0.61 enet 26 0.63 5.0e-22 7.5 7.1 1.3e-12 0.95 0.01 0.99 FALSE