[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr5:129,797,129-132,900,729

Best TWAS P=1.1e-33 · Best GWAS P=5.59e-36 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
80	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	10.9	-12.1	1.1e-33	-0.76	0.03	0.96	TRUE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-9.3	-9.2	3.8e-20	-0.65	0.15	0.31	TRUE
59	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-10.0	-8.7	2.6e-18	-0.71	0.13	0.22	TRUE
12	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	-5.9	-7.0	2.9e-12	-0.39	0.52	0.12	TRUE
73	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	6.9	-7.0	3.6e-12	-0.65	0.90	0.03	TRUE
108	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	-4.3	-5.6	2.1e-08	-0.41	0.96	0.00	TRUE
13	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	10.8	-11.6	5.0e-31	-0.82	0.45	0.55	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	10.8	-11.4	7.3e-30	-0.78	0.10	0.84	FALSE
28	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	10.6	-11.2	5.1e-29	-0.77	0.16	0.72	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	10.6	-11.0	3.1e-28	-0.78	0.49	0.15	FALSE
33	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	10.6	-11.0	6.0e-28	-0.82	0.96	0.04	FALSE
61	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	9.8	10.9	7.5e-28	0.83	0.09	0.91	FALSE
40	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	10.6	-10.8	3.9e-27	-0.84	0.68	0.32	FALSE
70	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	10.9	-10.8	4.6e-27	-0.77	0.30	0.69	FALSE
26	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-9.3	-10.7	1.2e-26	-0.79	1.00	0.00	FALSE
69	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	10.6	-10.6	2.6e-26	-0.84	0.90	0.10	FALSE
75	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	10.6	-10.6	2.7e-26	-0.84	0.50	0.50	FALSE
56	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	9.8	-10.6	2.8e-26	-0.83	0.27	0.73	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	12.2	10.5	7.2e-26	0.87	0.00	0.89	FALSE
78	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	-6.1	10.4	3.1e-25	0.67	0.68	0.32	FALSE
68	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-9.3	-10.4	3.6e-25	-0.69	0.21	0.65	FALSE
57	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	10.8	-10.3	7.0e-25	-0.84	1.00	0.00	FALSE
67	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	9.6	10.3	9.9e-25	0.77	0.24	0.68	FALSE
91	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-9.3	-10.1	7.1e-24	-0.78	0.03	0.91	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	9.5	10.1	7.6e-24	0.76	0.66	0.34	FALSE
85	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	10.6	-10.0	1.9e-23	-0.80	1.00	0.00	FALSE
66	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	-5.2	-9.9	4.0e-23	-0.66	0.76	0.21	FALSE
7	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	9.8	9.8	1.2e-22	0.77	0.57	0.41	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	-10.0	-9.7	1.9e-22	-0.70	0.14	0.12	FALSE
64	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	9.6	9.7	2.2e-22	0.76	0.40	0.51	FALSE
35	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	9.8	9.7	2.8e-22	0.77	0.52	0.45	FALSE
58	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	10.6	9.7	3.4e-22	0.81	0.07	0.81	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf56	0.03	0.01	blup	98	0.02	4.2e-03	-6.2	9.6	7.5e-22	0.73	0.08	0.49	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	10.6	-9.4	5.5e-21	-0.74	0.04	0.92	FALSE
11	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	9.6	9.4	6.4e-21	0.77	0.80	0.20	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-9.3	-9.3	9.4e-21	-0.70	0.03	0.51	FALSE
10	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	9.4	9.3	1.3e-20	0.77	0.15	0.70	FALSE
90	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	-6.9	-9.3	1.4e-20	-0.59	0.53	0.11	FALSE
79	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	8.2	-9.2	3.4e-20	-0.69	0.27	0.68	FALSE
14	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	9.5	9.2	3.7e-20	0.77	0.49	0.51	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-6.7	-9.0	2.0e-19	-0.74	0.19	0.81	FALSE
77	NTR	Blood	C5orf56	0.01	0.01	blup	439	0.01	1.7e-03	-9.9	-9.0	3.2e-19	-0.49	0.24	0.12	FALSE
84	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-6.7	-8.9	5.2e-19	-0.78	1.00	0.00	FALSE
74	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	8.2	-8.6	7.6e-18	-0.70	0.60	0.37	FALSE
43	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-6.2	8.5	1.7e-17	0.69	0.22	0.11	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	9.5	8.5	2.5e-17	0.65	0.04	0.95	FALSE
65	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	7.0	-8.5	2.8e-17	-0.73	0.05	0.90	FALSE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-5.6	-8.4	4.4e-17	-0.68	0.06	0.71	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-6.6	-8.3	8.4e-17	-0.78	0.41	0.58	FALSE
49	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	-6.4	8.3	9.6e-17	0.55	0.36	0.19	FALSE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	10.6	-8.3	1.0e-16	-0.71	0.43	0.17	FALSE
93	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-6.6	-8.3	1.0e-16	-0.76	0.88	0.12	FALSE
19	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-6.4	8.2	1.7e-16	0.73	0.36	0.33	FALSE
32	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	9.8	8.2	1.8e-16	0.69	0.98	0.02	FALSE
105	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	-9.3	-8.1	4.9e-16	-0.52	0.08	0.70	FALSE
46	GTEx	Nerve Tibial	SLC22A5	0.17	0.11	lasso	9	0.09	5.5e-07	-5.2	-7.9	2.5e-15	-0.43	0.81	0.15	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	UQCRQ	0.21	0.01	enet	30	0.04	2.0e-02	-8.7	-7.8	4.4e-15	-0.42	0.08	0.24	FALSE
72	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	9.5	7.8	6.2e-15	0.67	0.97	0.03	FALSE
71	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-6.1	7.5	6.0e-14	0.61	0.16	0.73	FALSE
37	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-6.7	7.5	7.6e-14	0.72	0.87	0.13	FALSE
52	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-6.7	7.5	8.5e-14	0.70	0.85	0.14	FALSE
104	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-5.7	-7.3	2.8e-13	-0.69	0.66	0.32	FALSE
48	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	7.0	7.3	3.5e-13	0.69	0.89	0.09	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-6.0	7.2	4.2e-13	0.63	0.42	0.38	FALSE
87	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-6.2	-7.2	8.2e-13	-0.56	1.00	0.00	FALSE
22	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	10.6	-7.1	9.9e-13	-0.72	0.02	0.96	FALSE
42	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-6.5	7.0	2.1e-12	0.68	1.00	0.00	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-6.1	-6.9	5.2e-12	-0.56	1.00	0.00	FALSE
29	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-6.7	6.9	5.9e-12	0.67	0.92	0.04	FALSE
60	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-5.7	6.8	7.2e-12	0.63	0.99	0.00	FALSE
44	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-6.7	6.8	1.0e-11	0.68	0.95	0.05	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A5	0.06	0.04	blup	93	0.04	8.9e-06	-1.8	6.8	1.4e-11	0.42	0.45	0.34	FALSE
109	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	-5.9	-6.8	1.5e-11	-0.49	0.09	0.10	FALSE
15	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-6.5	6.7	2.0e-11	0.67	1.00	0.00	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-6.6	6.7	2.6e-11	0.66	0.87	0.07	FALSE
4	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-6.7	6.7	2.7e-11	0.66	1.00	0.00	FALSE
47	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-6.7	6.7	2.9e-11	0.66	1.00	0.00	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-6.1	-6.6	3.4e-11	-0.52	0.15	0.72	FALSE
76	NTR	Blood	ACSL6	0.01	0.00	bslmm	399	0.00	2.8e-02	-1.6	-6.6	3.5e-11	-0.49	0.17	0.31	FALSE
27	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	-6.4	6.6	3.8e-11	0.68	0.25	0.14	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-6.2	-6.6	3.9e-11	-0.57	1.00	0.00	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-5.7	-6.6	4.0e-11	-0.62	1.00	0.00	FALSE
18	GTEx	Brain Frontal Cortex BA9	AC034220.3	0.31	0.20	lasso	14	0.21	3.3e-06	-6.4	6.6	4.3e-11	0.70	0.42	0.49	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-6.6	-6.6	4.8e-11	-0.66	0.45	0.06	FALSE
6	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-6.7	6.6	5.0e-11	0.66	0.66	0.14	FALSE
5	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-6.5	6.5	6.4e-11	0.66	0.52	0.14	FALSE
63	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-6.5	6.5	6.8e-11	0.66	0.90	0.01	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	SLC22A5	0.15	0.00	enet	24	0.05	1.4e-02	-6.4	6.5	8.2e-11	0.55	0.10	0.17	FALSE
34	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	-6.4	6.5	9.0e-11	0.66	0.97	0.01	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-6.3	6.4	1.4e-10	0.59	0.60	0.33	FALSE
51	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-5.7	6.3	2.2e-10	0.63	0.70	0.04	FALSE
17	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	-6.5	6.3	3.8e-10	0.65	0.98	0.02	FALSE
62	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	-6.4	6.2	6.2e-10	0.65	0.26	0.07	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-5.8	-6.2	7.2e-10	-0.52	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-6.2	-6.2	7.6e-10	-0.52	0.84	0.01	FALSE
41	GTEx	Lung	AC004041.2	0.13	0.08	lasso	9	0.08	8.8e-07	-6.1	-6.1	1.0e-09	-0.47	0.96	0.01	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	LYRM7	0.03	0.01	enet	10	0.02	7.5e-04	-4.3	6.1	1.0e-09	0.24	0.01	0.86	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	-7.0	-6.1	1.2e-09	-0.62	0.80	0.07	FALSE
99	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	-5.7	-6.1	1.2e-09	-0.54	0.04	0.38	FALSE
39	GTEx	Lung	RAD50	0.12	0.09	lasso	11	0.08	1.3e-06	-6.1	-6.1	1.4e-09	-0.44	0.92	0.02	FALSE
8	GTEx	Artery Aorta	HINT1	0.07	0.07	enet	8	0.06	4.7e-04	-6.0	-6.0	1.8e-09	-0.20	0.18	0.05	FALSE
92	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A4	0.02	0.02	lasso	1	0.02	3.0e-03	-6.0	-6.0	1.8e-09	-0.57	0.24	0.09	FALSE
38	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	-6.7	5.9	3.5e-09	0.62	1.00	0.00	FALSE
45	GTEx	Nerve Tibial	LYRM7	0.05	0.02	enet	11	0.04	7.0e-04	-6.0	5.9	4.7e-09	0.22	0.52	0.05	FALSE
97	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	-5.7	-5.8	9.0e-09	-0.55	0.13	0.09	FALSE
25	GTEx	Cells Transformed fibroblasts	HINT1	0.10	0.06	lasso	2	0.05	2.1e-04	-5.8	-5.7	9.5e-09	-0.26	0.76	0.02	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	HINT1	0.07	0.04	lasso	2	0.01	1.8e-02	-5.7	-5.7	1.3e-08	-0.21	0.02	0.92	FALSE
50	GTEx	Pancreas	P4HA2	0.22	0.21	lasso	13	0.20	5.3e-09	-2.9	5.7	1.6e-08	0.45	0.93	0.04	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	HINT1	0.02	0.03	lasso	4	0.02	1.1e-03	-5.6	5.5	2.9e-08	0.24	0.30	0.08	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C5orf56	0.07	0.01	blup	98	0.03	3.2e-04	-6.2	5.4	6.1e-08	0.51	0.15	0.45	FALSE
9	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	-6.7	5.3	1.0e-07	0.56	0.60	0.08	FALSE
16	GTEx	Brain Cerebellar Hemisphere	AC116366.6	0.21	0.24	lasso	5	0.24	9.9e-07	-4.7	5.2	1.5e-07	0.63	0.42	0.23	FALSE
36	GTEx	Esophagus Muscularis	LYRM7	0.10	0.03	lasso	4	0.01	4.0e-02	-4.6	5.2	2.5e-07	0.17	0.44	0.03	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ACSL6	0.13	0.07	enet	47	0.08	1.9e-10	-7.8	-5.1	2.9e-07	-0.34	1.00	0.00	FALSE