[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr5:39,986,432-41,555,158

Best TWAS P=1.18e-20 · Best GWAS P=8.3e-56 conditioned to 2.83e-28

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Cells Transformed fibroblasts	PTGER4	0.05	0.06	lasso	3	0.04	3.9e-04	-9.0	9.3	1.2e-20	-0.30	0.50	0.13	TRUE
9	YFS	Blood	PRKAA1	0.02	0.01	lasso	7	0.01	1.5e-04	-6.8	-6.0	2.7e-09	0.31	0.67	0.01	TRUE
2	GTEx	Artery Tibial	CARD6	0.20	0.05	lasso	10	0.05	4.8e-05	7.8	-5.5	4.6e-08	0.07	0.72	0.01	TRUE
1	GTEx	Adipose Subcutaneous	CARD6	0.27	0.12	lasso	8	0.12	2.5e-10	7.8	-8.2	2.1e-16	0.21	1.00	0.00	FALSE
3	GTEx	Cells Transformed fibroblasts	CARD6	0.18	0.17	lasso	2	0.18	4.2e-13	7.8	-8.0	1.1e-15	0.15	1.00	0.00	FALSE
7	GTEx	Skin Sun Exposed Lower leg	CARD6	0.13	0.07	lasso	2	0.07	4.2e-06	7.5	-7.8	7.8e-15	0.16	0.90	0.00	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	CARD6	0.03	0.02	enet	6	0.01	2.1e-03	7.8	-7.6	2.6e-14	0.19	0.00	0.98	FALSE
6	GTEx	Nerve Tibial	CARD6	0.23	0.14	lasso	5	0.12	7.4e-09	7.8	-7.4	1.3e-13	0.13	1.00	0.00	FALSE
8	METSIM	Adipose	CARD6	0.16	0.08	bslmm	453	0.10	4.0e-14	7.5	-6.6	3.7e-11	0.12	1.00	0.00	FALSE
10	YFS	Blood	RPL37	0.02	0.00	blup	445	0.01	1.4e-03	-5.2	-5.3	1.4e-07	0.15	0.11	0.02	FALSE
5	GTEx	Esophagus Muscularis	CARD6	0.17	0.00	enet	19	0.02	1.3e-02	2.5	-5.2	2.4e-07	-0.06	0.13	0.04	FALSE