Best TWAS P=1.18e-20 · Best GWAS P=8.3e-56 conditioned to 2.83e-28
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CARD6 | 0.27 | 0.12 | lasso | 8 | 0.12 | 2.5e-10 | 7.8 | -8.2 | 2.1e-16 | 0.21 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | CARD6 | 0.20 | 0.05 | lasso | 10 | 0.05 | 4.8e-05 | 7.8 | -5.5 | 4.6e-08 | 0.07 | 0.72 | 0.01 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | CARD6 | 0.18 | 0.17 | lasso | 2 | 0.18 | 4.2e-13 | 7.8 | -8.0 | 1.1e-15 | 0.15 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | PTGER4 | 0.05 | 0.06 | lasso | 3 | 0.04 | 3.9e-04 | -9.0 | 9.3 | 1.2e-20 | -0.30 | 0.50 | 0.13 | TRUE |
| 5 | GTEx | Esophagus Muscularis | CARD6 | 0.17 | 0.00 | enet | 19 | 0.02 | 1.3e-02 | 2.5 | -5.2 | 2.4e-07 | -0.06 | 0.13 | 0.04 | FALSE |
| 6 | GTEx | Nerve Tibial | CARD6 | 0.23 | 0.14 | lasso | 5 | 0.12 | 7.4e-09 | 7.8 | -7.4 | 1.3e-13 | 0.13 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | CARD6 | 0.13 | 0.07 | lasso | 2 | 0.07 | 4.2e-06 | 7.5 | -7.8 | 7.8e-15 | 0.16 | 0.90 | 0.00 | FALSE |
| 8 | METSIM | Adipose | CARD6 | 0.16 | 0.08 | bslmm | 453 | 0.10 | 4.0e-14 | 7.5 | -6.6 | 3.7e-11 | 0.12 | 1.00 | 0.00 | FALSE |
| 9 | YFS | Blood | PRKAA1 | 0.02 | 0.01 | lasso | 7 | 0.01 | 1.5e-04 | -6.8 | -6.0 | 2.7e-09 | 0.31 | 0.67 | 0.01 | TRUE |
| 10 | YFS | Blood | RPL37 | 0.02 | 0.00 | blup | 445 | 0.01 | 1.4e-03 | -5.2 | -5.3 | 1.4e-07 | 0.15 | 0.11 | 0.02 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CARD6 | 0.03 | 0.02 | enet | 6 | 0.01 | 2.1e-03 | 7.8 | -7.6 | 2.6e-14 | 0.19 | 0.00 | 0.98 | FALSE |