[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr6:166,651,581-167,841,508

Best TWAS P=4.46e-23 · Best GWAS P=3.74e-22 conditioned to 0.0313

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Lung	RNASET2	0.21	0.13	lasso	10	0.13	4.0e-10	-9.3	-9.9	4.5e-23	-0.87	0.04	0.96	TRUE
6	GTEx	Esophagus Mucosa	RNASET2	0.29	0.31	lasso	9	0.32	1.6e-21	-9.1	-9.7	4.5e-22	-0.80	0.57	0.43	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	RNASET2	0.05	0.03	lasso	3	0.03	9.2e-05	-9.1	-9.6	5.9e-22	-0.78	0.22	0.54	FALSE
24	NTR	Blood	RNASET2	0.28	0.42	lasso	13	0.43	5.3e-155	-9.2	-9.6	1.1e-21	-0.83	0.24	0.76	FALSE
29	The Cancer Genome Atlas	Esophageal Carcinoma	RNASET2	0.17	0.11	lasso	3	0.09	8.7e-04	-9.1	-9.5	1.4e-21	-0.76	0.14	0.56	FALSE
23	METSIM	Adipose	RNASET2	0.09	0.09	lasso	4	0.12	8.7e-18	-9.3	-9.4	3.7e-21	-0.77	0.17	0.83	FALSE
25	YFS	Blood	RNASET2	0.45	0.60	enet	24	0.61	1.8e-260	-9.3	-9.3	9.9e-21	-0.82	0.19	0.81	FALSE
20	GTEx	Whole Blood	AL133458.1	0.20	0.14	enet	7	0.18	1.4e-16	-8.9	-9.2	2.3e-20	-0.79	0.24	0.76	FALSE
19	GTEx	Whole Blood	RNASET2	0.20	0.18	enet	23	0.18	3.4e-16	-9.3	-9.2	3.6e-20	-0.79	0.16	0.84	FALSE
15	GTEx	Skin Sun Exposed Lower leg	AL133458.1	0.13	0.08	enet	10	0.03	1.0e-03	-9.3	-9.1	1.1e-19	-0.80	0.15	0.85	FALSE
35	The Cancer Genome Atlas	Rectum Adenocarcinoma	RNASET2	0.14	0.19	lasso	3	0.15	2.1e-04	-9.0	-9.0	2.0e-19	-0.68	0.03	0.53	FALSE
16	GTEx	Stomach	RNASET2	0.22	0.12	lasso	6	0.16	6.5e-08	-7.7	-9.0	2.1e-19	-0.60	0.28	0.62	FALSE
2	GTEx	Brain Cerebellar Hemisphere	AL133458.1	0.29	0.00	enet	19	0.00	3.6e-01	-9.3	-9.0	3.4e-19	-0.70	0.07	0.69	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNASET2	0.07	0.05	lasso	4	0.04	5.1e-09	-9.1	-8.9	3.8e-19	-0.67	0.64	0.36	FALSE
5	GTEx	Cells Transformed fibroblasts	AL133458.1	0.16	0.14	enet	13	0.14	1.7e-10	-9.1	8.9	3.9e-19	0.77	0.19	0.81	FALSE
8	GTEx	Esophagus Mucosa	FGFR1OP	0.10	0.07	lasso	4	0.03	4.4e-03	9.0	8.9	4.1e-19	0.97	0.01	0.98	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RNASET2	0.13	0.09	lasso	9	0.10	1.4e-11	-9.0	-8.9	4.5e-19	-0.68	0.66	0.34	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	RNASET2	0.06	0.04	lasso	2	0.03	2.6e-04	-8.9	-8.9	4.8e-19	-0.69	0.22	0.28	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RNASET2	0.09	0.08	lasso	2	0.08	2.9e-09	-8.9	-8.9	6.6e-19	-0.69	0.65	0.35	FALSE
4	GTEx	Cells Transformed fibroblasts	RNASET2	0.29	0.30	enet	31	0.29	1.0e-21	-9.1	8.7	3.8e-18	0.79	0.22	0.78	FALSE
14	GTEx	Skin Sun Exposed Lower leg	RNASET2	0.32	0.23	enet	48	0.24	3.3e-20	-9.1	-8.7	3.9e-18	-0.80	0.17	0.83	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNASET2	0.24	0.15	lasso	3	0.14	5.6e-15	-9.0	-8.6	5.6e-18	-0.66	0.64	0.36	FALSE
3	GTEx	Brain Cerebellum	AL133458.1	0.42	0.32	lasso	6	0.31	1.0e-09	-9.1	-8.5	1.7e-17	-0.67	0.46	0.52	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	AL133458.1	0.13	0.05	lasso	2	0.01	5.4e-02	8.3	-8.3	1.3e-16	-0.84	0.08	0.75	FALSE
11	GTEx	Nerve Tibial	RNASET2	0.19	0.07	lasso	8	0.09	4.4e-07	8.3	-8.2	2.1e-16	-0.86	0.21	0.79	FALSE
10	GTEx	Lung	AL133458.1	0.17	0.09	lasso	5	0.12	3.9e-09	-6.3	-8.1	6.6e-16	-0.74	0.10	0.90	FALSE
22	METSIM	Adipose	FGFR1OP	0.05	0.00	blup	606	0.02	1.5e-03	1.4	7.5	6.4e-14	0.68	0.03	0.92	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	RNASET2	0.14	0.07	enet	25	0.08	3.6e-05	9.6	-7.5	8.7e-14	-0.76	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RNASET2	0.08	0.05	enet	12	0.07	2.0e-06	-8.9	-7.4	1.2e-13	-0.72	0.15	0.84	FALSE
17	GTEx	Thyroid	RNASET2	0.16	0.06	enet	33	0.04	3.8e-04	9.0	-7.2	4.5e-13	-0.71	0.03	0.96	FALSE
18	GTEx	Thyroid	AL133458.1	0.09	0.07	lasso	5	0.07	2.9e-06	-6.3	-7.2	4.5e-13	-0.72	0.70	0.29	FALSE
7	GTEx	Esophagus Mucosa	AL133458.1	0.15	0.01	enet	12	0.02	1.3e-02	-8.9	-6.9	5.7e-12	-0.72	0.18	0.49	FALSE
1	GTEx	Adipose Subcutaneous	AL133458.1	0.11	0.02	enet	18	0.01	2.5e-02	8.3	-6.8	1.3e-11	-0.69	0.06	0.84	FALSE
21	METSIM	Adipose	CCR6	0.06	0.02	lasso	3	0.04	5.6e-07	5.0	5.5	3.1e-08	0.75	0.60	0.36	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	RNASET2	0.12	0.05	enet	7	0.08	2.4e-05	-9.0	-5.3	9.2e-08	-0.32	0.15	0.14	FALSE