Hub : Genes

AL133458.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.111	0.0450	2.7e-03	0.016	NA	0.014	NA	0.012	1.7e-02	NA	2.5e-02	NA	3.3e-02
2	GTEx	Brain Cerebellar Hemisphere	0.294	0.1000	2.1e-03	0.003	NA	-0.002	NA	-0.005	2.7e-01	NA	3.6e-01	NA	4.5e-01
3	GTEx	Brain Cerebellum	0.423	0.0960	2.3e-05	0.318	NA	0.304	NA	0.306	3.9e-10	NA	1.1e-09	NA	1.0e-09
4	GTEx	Cells Transformed fibroblasts	0.158	0.0440	1.7e-05	0.145	NA	0.138	NA	0.089	5.6e-11	NA	1.7e-10	NA	3.4e-07
5	GTEx	Esophagus Mucosa	0.149	0.0650	6.5e-03	0.011	NA	0.021	NA	0.020	6.1e-02	NA	1.3e-02	NA	1.6e-02
6	GTEx	Lung	0.167	0.0437	4.5e-06	0.089	NA	0.093	NA	0.116	2.3e-07	NA	1.4e-07	NA	3.9e-09
7	GTEx	Skin Not Sun Exposed Suprapubic	0.126	0.0560	8.4e-03	0.054	NA	0.009	NA	0.014	6.6e-04	NA	9.9e-02	NA	5.4e-02
8	GTEx	Skin Sun Exposed Lower leg	0.134	0.0460	2.3e-04	0.083	NA	0.032	NA	0.000	2.2e-07	NA	1.0e-03	NA	3.0e-01
9	GTEx	Thyroid	0.092	0.0390	5.0e-03	0.066	NA	0.063	NA	0.073	8.8e-06	NA	1.4e-05	NA	2.9e-06
10	GTEx	Whole Blood	0.197	0.0460	1.4e-08	0.142	NA	0.182	NA	0.173	4.8e-13	NA	1.4e-16	NA	9.0e-16

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.1	0.5	0.2	-0.3	0.3	0.1	-0.3	0.5	-0.5	0.2
Bipolar Disorder or Schizophrenia	0.3	0.6	1.8	0.6	0.1	0.6	-1.3	0.6	0.7	0.0	1.3	-0.3	1.0
Depressed Affect (Nagel 2018)	4.0	8.5	12.5	-2.1	-3.2	-3.5	3.5	-2.8	-2.5	-2.5	-3.4	-2.2	-3.1
Depression (Nagel 2018)	0.5	0.8	3.0	-0.2	-1.0	-1.5	1.0	-0.0	-0.1	-1.7	-0.7	-0.3	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.5	0.9	-0.5	-0.1	-0.5	0.8	0.7	0.7	0.3	1.2	0.2
Neuroticism (Nagel 2018)	5.7	13.4	19.2	-2.7	-4.2	-3.7	4.2	-3.2	-3.1	-3.9	-4.4	-2.8	-3.9
Schizophrenia (2018)	0.3	0.7	2.2	0.8	-0.3	0.7	-1.5	0.5	0.8	0.3	1.2	0.1	1.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.6	-0.3	-0.7	0.1	0.3	0.4	-0.1	0.8	-0.0	0.1	-0.0
Worry (Nagel 2018)	4.4	9.3	19.5	-2.7	-3.1	-2.2	3.0	-2.6	-2.4	-4.4	-3.5	-3.0	-3.0
Alzheimer’s Disease (in mother)	0.8	0.9	4.2	0.4	0.5	-0.5	-0.2	0.1	1.3	0.9	0.9	2.0	0.9
Alzheimer’s Disease (in father)	0.7	0.7	1.8	0.8	1.2	0.9	-0.1	0.4	1.0	0.1	1.0	0.7	1.3
Alzheimer’s Disease (including proxy)	0.9	1.3	3.6	0.7	1.3	0.2	-0.5	0.4	1.4	0.8	1.4	1.9	1.4
Crohns Disease (2017)	31.0	68.0	85.5	-6.8	-9.0	-8.5	8.9	-6.9	-8.1	-8.3	-9.1	-7.2	-9.2
Irritable Bowel Disease (IBD)	21.3	50.7	65.1	-6.8	-6.7	-6.4	7.6	-5.8	-7.3	-7.7	-7.6	-7.0	-8.1
Ulcerative Colitis (UC)	5.6	10.5	16.8	-3.4	-1.7	-1.8	3.3	-2.4	-3.7	-4.0	-3.4	-4.1	-3.6
Major Depression (MDD)	0.2	0.2	1.3	-0.4	-0.5	-0.1	-1.1	-0.0	-0.2	-0.3	0.0	-0.6	-0.2
Reaction Time	0.5	1.0	2.4	-1.1	-0.7	-0.3	0.9	-0.6	-1.1	-1.6	-0.8	-1.2	-1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.2	0.7	0.4	0.6	-1.1	1.1	0.9	0.4	1.1	0.9	0.7
Breast Cancer	0.9	2.2	4.6	-0.5	-1.9	-2.0	2.1	-1.2	-1.2	-0.3	-1.9	-0.5	-1.7
Ovarian Cancer	1.3	1.7	4.6	2.1	0.3	-0.2	-1.0	1.8	1.1	1.4	0.8	1.6	1.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.6	2.3	6.5	-1.2	-2.5	-1.5	1.5	-1.5	-1.6	-0.3	-1.5	-1.1	-1.6
Bipolar Disorder (2011)	0.1	0.1	0.4	0.6	-0.4	-0.2	-0.1	0.2	0.2	0.1	0.3	0.3	0.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.9	-0.5	1.0	0.3	-0.3	-0.1	0.3	-0.2	0.4	-0.1	0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.4	-0.3	-0.6	0.1	0.3	-0.2	-0.2	0.3	-0.0	-0.1	-0.5
Crohns Disease (2012)	21.1	33.9	51.8	-4.0	-7.2	-6.8	6.2	-4.9	-5.9	-5.1	-6.3	-4.8	-6.3
Mean Putamen Volume	0.5	0.6	1.7	-0.5	-0.8	-0.0	0.5	-0.3	-1.2	-0.9	-0.7	-1.3	-0.8
Fasting Glucose	0.3	0.4	1.7	-0.3	-1.2	-1.3	-0.5	0.1	0.1	-0.3	0.7	-0.1	-0.0
HbA1C	0.1	0.1	0.6	-0.5	-0.4	0.3	0.1	0.1	-0.8	0.2	0.3	-0.3	-0.5
HDL Cholesterol	1.1	1.9	3.6	1.0	0.8	1.2	-1.6	1.1	1.7	0.8	1.6	1.4	1.9
LDL Cholesterol	1.1	1.7	3.7	-1.4	-0.3	-0.7	1.0	-0.4	-1.6	-1.9	-1.5	-1.4	-1.7
Lupus	2.0	3.1	7.8	-0.7	-2.3	-1.4	2.8	-0.9	-1.7	-1.2	-1.9	-1.5	-2.0
Neuroticism (2016)	1.3	1.8	4.0	-0.3	-2.0	-1.7	1.4	-1.5	-0.5	-1.7	-1.8	-0.3	-1.0
Primary Biliary Cirrhosis	1.9	2.7	6.6	-1.7	-1.4	-1.6	2.6	-1.8	-0.6	-2.2	-1.6	-0.8	-1.2
Rheumatoid Arthritis	3.5	4.8	8.5	-1.6	-1.9	-1.8	2.0	-1.1	-2.4	-2.3	-2.9	-2.9	-2.4
Schizophrenia (2014)	0.3	0.7	2.2	0.5	0.1	1.0	-1.1	0.4	0.9	0.2	1.5	0.2	1.1
Triglycerides	2.5	4.1	7.5	-2.5	-1.7	-1.4	1.4	-1.5	-2.2	-2.7	-2.2	-2.0	-2.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.7	-0.9	0.3	0.3	0.7	0.1	-0.7	-1.1	-0.1	-1.3	-0.6
Ulcerative Colitis	4.8	7.0	9.6	-2.8	-2.6	-2.3	2.8	-2.1	-2.5	-3.1	-2.5	-2.8	-2.9
Blood Eosinophil Count	0.3	2.3	11.2	-1.1	0.1	1.9	1.1	-0.7	-0.5	-3.4	-0.8	-2.0	-0.4
Blood Platelet Count	0.0	0.5	1.6	-0.9	-0.6	-0.5	-0.7	-1.3	-0.6	-0.7	-0.5	-0.3	-0.6
Blood Red Count	0.1	1.1	2.4	1.4	0.7	1.0	-0.5	0.7	1.4	1.1	0.3	1.6	1.2
Blood White Count	1.9	14.0	18.9	3.8	3.5	2.8	-4.3	4.3	4.1	2.3	3.6	3.8	4.3
Heel T-Score	0.3	2.0	3.9	1.3	1.2	1.9	-2.0	1.7	1.0	0.6	1.3	0.9	1.6
BMI	0.5	2.6	5.2	1.1	2.1	2.3	-1.8	2.1	0.8	2.0	1.4	0.6	0.9
Height	0.0	0.4	1.4	0.4	-1.1	-1.2	0.1	0.4	0.4	-0.5	-0.2	0.3	0.2
Waist Hip Ratio (WHR)	0.7	2.9	5.6	-2.0	-1.5	-1.5	1.7	-1.5	-1.6	-2.4	-1.3	-1.6	-1.8
Systolic Blood Pressure	0.2	0.9	3.5	0.5	-1.9	-1.1	0.7	0.5	-0.3	-1.6	-0.7	-0.5	-0.1
Smoking Status	0.4	1.1	3.7	1.1	0.4	-0.3	0.1	0.3	1.9	0.4	0.7	1.9	1.0
Allergy or Eczema	1.8	4.8	10.7	-1.8	-1.2	-0.2	3.3	-2.0	-2.0	-2.3	-2.8	-2.7	-2.2
Cardiovascular Disease	1.6	5.4	9.5	-1.8	-3.0	-3.1	2.9	-0.8	-2.4	-1.9	-2.2	-1.6	-2.4
Hypothyroidism (self reported)	48.3	111.0	144.0	-8.5	-11.5	-12.0	10.3	-10.0	-10.9	-9.2	-11.7	-9.0	-11.6
Respiratory disease	1.3	2.8	7.4	2.7	1.7	2.5	0.3	1.2	1.8	1.5	0.9	1.0	1.7
Type 2 Diabetes (T2D) (2018)	3.9	7.2	16.3	-3.0	-3.1	-2.5	2.0	-2.6	-2.1	-4.0	-2.4	-2.0	-2.5
Lung FEV1/FVC ratio	0.1	0.7	2.2	0.8	0.8	-0.6	-0.4	1.3	0.9	0.4	0.6	1.5	0.6
Lung FVC	0.5	2.3	4.3	-1.8	-1.2	-0.3	1.4	-1.7	-2.1	-0.7	-1.1	-2.0	-1.8
Neuroticism	3.7	9.0	14.7	-2.0	-3.8	-2.8	3.2	-2.6	-2.3	-3.5	-3.7	-2.4	-3.0
Chronotype (morning person)	0.1	0.3	1.5	-0.1	-0.2	0.5	-1.2	-0.2	-0.4	0.6	0.0	0.4	-0.2
Hair Pigment	0.0	0.1	0.3	-0.3	0.0	-0.4	-0.3	0.5	-0.2	-0.5	0.3	-0.2	0.2
Tanning	0.3	3.5	13.7	0.6	2.7	3.7	-1.4	1.9	1.2	0.7	1.9	0.4	1.5
Hand grip strength (left)	0.4	1.0	2.5	1.2	0.4	1.5	-1.4	1.6	0.1	1.1	0.9	-0.2	0.4
Number of treatments/medications taken	7.3	13.2	17.7	-3.6	-4.0	-3.9	2.6	-4.0	-3.5	-4.2	-3.2	-3.2	-3.8
Average weekly spirits intake	0.2	0.3	1.0	-0.3	0.7	-1.0	0.3	-0.3	0.6	-0.8	0.0	0.3	0.3
Sensitivity / hurt feelings	1.8	3.2	4.6	-1.4	-1.8	-2.0	1.7	-1.3	-1.6	-2.1	-1.9	-1.9	-1.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.9	0.4	-0.5	-0.1	0.8	0.1	0.1	-1.4	-0.5	-0.3	0.1
Hearing difficulty/problems: Yes	0.3	0.4	2.4	-0.3	0.9	1.6	-0.4	-0.1	-0.1	-0.7	0.4	-0.2	-0.0
Relative age of first facial hair	1.3	2.7	4.8	2.0	2.2	1.5	-1.0	1.8	1.9	0.9	1.2	1.6	1.9
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.6	-0.4	-1.3	-1.4	1.6	-1.1	-1.1	-0.7	-1.4	-1.3	-1.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.2	-0.9	-1.2	-1.8	1.1	-1.1	-1.2	-1.3	-1.1	-1.0	-1.0
Ever had hysterectomy (womb removed)	1.9	2.2	4.3	-2.1	-1.6	-1.9	1.1	-1.5	-1.3	-0.8	-1.6	-0.9	-1.5
Systolic blood pressure, automated reading	0.1	0.4	1.6	0.5	-1.2	-1.0	0.6	0.0	-0.1	-0.6	-0.5	-0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	-0.3	0.1	-0.1	-0.1	-0.1	1.1	-0.1	0.9	0.5	0.6
Angina	0.2	0.3	1.4	-0.3	0.8	1.2	-0.4	0.7	0.1	0.3	0.3	-0.4	0.3
Medication for hormone replacement therapy	1.5	1.7	3.1	-1.2	-1.7	-0.7	1.0	-1.3	-1.8	-1.3	-0.7	-1.3	-1.5
Vitamin and mineral supplements	0.3	0.4	1.5	-0.0	0.7	0.7	-1.2	-0.2	0.6	-0.7	0.4	0.4	0.4
Supplements: Zinc	0.4	0.4	1.0	0.7	0.4	1.0	0.0	1.0	-0.8	0.4	0.3	-0.7	-0.1
Medication: Co-codamol	0.3	0.4	1.9	-1.4	0.3	0.4	0.0	-0.6	-0.6	0.0	0.0	-0.6	-0.6
Medication: Metformin	5.3	7.4	11.7	-2.9	-2.7	-1.8	2.4	-3.4	-2.2	-3.4	-2.8	-2.2	-2.8
Diabetes (father)	0.1	0.2	0.7	0.1	-0.5	-0.0	0.4	0.1	-0.2	-0.8	0.2	-0.5	-0.5
Diabetes (mother)	0.1	0.2	0.9	0.4	0.6	-0.3	-0.0	0.3	-0.3	1.0	-0.1	-0.1	-0.1
Severe depression (siblings)	0.1	0.1	0.5	-0.3	0.1	-0.3	-0.7	0.3	0.6	-0.3	0.1	0.3	0.3
Pack years adult smoking proportion	0.2	0.3	1.7	1.3	-0.3	-0.4	0.4	0.6	-0.0	0.2	-0.3	-0.2	0.2
Impedance of leg (right)	0.1	0.5	1.8	-0.7	-1.2	-0.4	0.8	-0.4	-0.5	-1.3	-0.2	-0.6	-0.1
Leg fat-free mass (left)	0.0	0.2	0.7	0.5	0.1	0.1	0.0	0.8	-0.3	0.7	-0.8	-0.3	-0.5
Trunk fat percentage	0.6	2.5	4.8	0.6	1.7	1.9	-2.1	1.7	1.0	2.2	1.7	1.1	1.1
Hand grip strength (right)	0.3	0.9	5.1	-0.2	-0.2	0.5	0.4	0.4	-1.3	-0.7	-0.5	-2.3	-1.0
Townsend deprivation index at recruitment	0.5	0.7	2.8	-0.2	-1.0	-1.7	-0.1	-0.9	-0.2	0.7	-0.8	0.8	-0.5
Current tobacco smoking	0.6	1.0	2.8	1.4	0.1	-0.7	-0.1	0.6	1.0	1.5	0.8	1.7	0.6
Average weekly fortified wine intake	0.2	0.2	0.7	0.8	-0.2	0.1	-0.3	-0.0	0.5	0.8	0.5	0.4	0.3
Maternal smoking around birth	0.6	0.9	3.9	0.4	-1.5	-2.0	0.6	0.3	0.2	0.1	-1.0	0.9	-0.4
Fed-up feelings	0.8	1.5	2.7	-0.7	-1.1	-1.4	1.3	-1.6	-1.0	-1.3	-1.4	-0.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	0.2	-0.5	-0.7	0.6	-0.1	0.3	-0.6	-0.2	-0.0	0.2
Relative age voice broke	1.0	1.6	3.9	1.8	2.0	1.1	0.0	1.3	1.3	1.1	0.6	1.3	1.1
Taking other prescription medications	14.0	21.7	28.3	-3.5	-5.3	-5.1	4.6	-4.7	-4.6	-4.2	-5.2	-4.0	-5.0
Age when periods started (menarche)	1.0	2.4	8.4	-0.7	-1.0	-2.9	1.8	-2.2	-0.7	-0.8	-1.7	-0.9	-1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	-0.3	-0.9	-1.3	0.8	0.0	-0.9	-0.8	-0.8	-0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.2	7.9	1.9	2.5	2.8	-1.6	1.7	2.4	0.8	2.0	1.7	2.4
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.8	0.6	-1.3	-1.2	1.7	-0.3	-0.8	-0.5	-1.0	-0.4	-0.7
Qualifications: CSEs or equivalent	0.7	0.9	3.0	-0.2	-0.5	-0.3	0.7	-0.5	-1.6	-0.0	-0.7	-1.7	-1.4
Serious illness, injury or assault to yourself	0.1	0.2	0.4	0.2	0.6	0.4	-0.3	0.3	0.6	0.5	0.2	0.0	0.5
High blood pressure	0.9	2.5	4.3	-1.5	-1.6	-1.7	1.8	-0.6	-2.1	-1.2	-1.4	-1.6	-2.0
Hayfever, allergic rhinitis or eczema	2.6	5.6	10.2	-1.6	-2.1	-0.9	3.2	-1.7	-2.5	-2.3	-3.0	-2.9	-2.5
Multivitamins +/- minerals	0.2	0.3	0.9	0.9	-0.3	-0.6	0.7	0.5	0.2	0.8	-0.1	0.2	0.4
Stomach or abdominal pain in last month	0.6	0.7	2.6	-0.4	0.3	-1.0	1.2	-0.4	-1.1	-0.3	-0.2	-1.6	-0.5
Supplements: Glucosamine	1.3	1.6	3.6	-0.8	-0.8	0.3	1.4	-0.9	-1.8	-1.1	-1.9	-1.5	-1.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.7	0.9	1.2	1.3	-1.0	1.3	1.1	1.6	1.5	0.5	0.9
Medication: Atenolol	0.3	0.4	1.5	-0.2	-0.2	-0.8	-0.6	-0.2	0.8	-1.2	-0.2	0.9	0.3
Medication: Levothyroxine sodium	33.7	57.1	84.6	-7.2	-8.2	-9.2	6.2	-7.9	-7.5	-6.5	-8.1	-6.1	-7.9
Sitting height	0.3	2.4	6.6	-0.5	-2.6	-1.0	0.9	-1.6	-1.3	-1.4	-2.1	-1.4	-1.5
Chronic bronchitis/emphysema (father)	0.4	0.5	2.3	-1.1	0.5	1.5	-0.7	0.3	0.5	-0.5	0.3	0.0	0.3
High blood pressure (mother)	0.3	0.4	2.0	0.0	0.7	1.4	-0.3	0.5	0.3	-0.6	0.4	-0.7	0.4
Body mass index (BMI)	0.2	1.0	4.1	0.4	1.1	1.1	-0.9	1.4	0.2	2.0	0.5	0.4	0.2
Impedance of leg (left)	0.0	0.2	0.7	-0.2	-0.5	0.4	-0.0	-0.2	0.5	-0.8	0.6	0.1	0.8
Leg predicted mass (left)	0.0	0.2	0.7	0.5	0.1	0.2	-0.0	0.9	-0.2	0.7	-0.7	-0.2	-0.5
Trunk fat mass	0.3	1.5	3.6	0.5	1.2	1.6	-1.6	1.5	0.6	1.9	1.0	0.7	0.5
Waist circumference	0.1	0.4	1.1	-0.7	-0.6	-0.4	0.4	-0.1	-0.8	0.7	-0.7	-0.2	-1.1
Number of incorrect matches in round	0.3	0.5	1.9	0.6	-0.3	-0.5	1.4	-0.4	-0.7	0.9	-0.7	-0.5	-0.4
Past tobacco smoking	0.2	0.4	0.9	0.2	0.1	0.7	-0.8	0.7	-0.9	0.6	0.8	-1.0	-0.1
Alcohol usually taken with meals	0.5	0.8	3.1	0.6	-1.4	-1.8	-0.0	0.3	-0.5	0.7	-0.7	0.5	-1.0
Nervous feelings	0.9	1.6	4.0	0.1	-1.1	-0.5	1.3	-0.7	-1.1	-1.8	-1.4	-2.0	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.7	0.3	0.9	1.3	0.3	0.9	-0.1	-0.3	0.4	-0.5	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.1	0.4	1.1	0.6	-0.9	-0.2	1.0	-0.4	0.9	1.0	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	-0.4	0.6	0.2	-0.5	1.1	-0.7	-0.7	0.2	-1.0	-0.1
Had menopause	1.2	1.6	3.7	-1.4	-0.9	-1.9	0.8	-1.5	-0.8	-1.8	-1.1	-0.6	-1.0
Had other major operations	0.5	0.6	1.1	-0.6	-0.8	-1.0	0.8	-1.1	-0.9	0.1	-0.6	-0.6	-0.8
Forced vital capacity (FVC)	0.2	0.7	2.1	-0.8	-0.6	0.3	1.0	-0.2	-1.0	-0.6	-0.7	-1.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.6	1.6	1.4	2.4	-1.6	1.4	1.9	0.5	1.7	1.5	1.9
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.8	-0.0	-2.0	-1.6	1.5	0.1	-1.1	-0.9	-1.5	-1.9	-1.3
Qualifications: None of the above	0.3	0.6	1.5	0.8	1.0	-0.6	0.2	0.5	1.1	-0.2	0.2	1.2	1.0
Financial difficulties in last 2 years	0.2	0.3	0.9	0.4	-0.6	1.0	-0.0	-0.6	0.4	0.7	0.2	0.2	0.3
Mouth/teeth dental problems	3.4	5.2	9.8	1.5	1.8	3.1	-3.0	2.4	2.1	1.4	2.4	2.1	2.4
Heart attack	1.8	2.3	4.6	-1.5	-2.0	-1.7	1.1	-1.6	-0.7	-2.2	-1.9	-0.5	-1.2
Allergy	1.3	3.0	8.5	0.2	1.3	-0.2	-2.9	1.1	1.8	1.1	2.4	2.5	1.5
Pain all over the body in last month	0.7	0.7	1.7	-0.6	-0.9	-1.2	1.3	-0.9	-0.6	-0.4	-1.1	0.2	-0.6
Diabetes (self-reported)	3.0	4.7	6.6	-2.4	-2.4	-2.1	2.3	-2.6	-1.4	-2.5	-2.2	-1.3	-2.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.2	-0.4	0.0	-0.0	1.3	-0.6	-1.4	-1.2	-1.1	-1.5	-1.1
Medication: Ramipril	0.1	0.1	0.6	0.2	0.3	-0.8	0.3	0.0	0.2	-0.2	0.1	0.5	-0.1
Medication: Simvastatin	0.2	0.3	1.3	-0.6	-0.6	-0.3	0.5	-0.5	0.4	-1.1	0.1	0.6	0.2
Fluid intelligence score	0.7	1.5	3.6	1.0	0.9	1.1	-1.9	1.7	1.2	0.8	1.2	1.2	1.0
Illnesses of siblings	0.2	0.3	1.3	-1.1	-0.4	0.5	-0.3	-0.1	-0.5	-1.0	0.2	-0.4	0.0
Neuroticism score	2.3	4.8	8.1	-0.6	-2.6	-2.8	2.5	-2.2	-1.5	-2.4	-2.8	-1.4	-2.1
Weight	0.1	0.4	1.8	0.2	0.2	0.6	-0.3	0.9	-0.3	1.3	-0.4	-0.0	-0.4
Impedance of arm (right)	0.3	1.5	3.0	1.5	0.5	-0.1	-1.1	0.9	1.7	0.2	1.5	1.7	1.7
Arm fat percentage (right)	0.6	2.4	5.4	1.1	1.6	1.5	-1.8	2.0	1.0	2.3	1.6	1.2	1.0
Trunk fat-free mass	0.2	1.3	3.0	-0.3	-1.1	-0.6	1.4	-0.3	-1.4	-0.0	-1.7	-1.2	-1.7
Hip circumference	0.3	1.3	6.0	1.3	0.4	0.6	-1.1	1.4	0.6	2.5	0.4	1.2	0.3
Time employed in main current job	0.9	1.0	2.1	-0.1	1.5	1.3	-1.1	1.1	0.7	-0.6	1.3	-0.1	1.1
Alcohol intake versus 10 years previously	3.5	5.2	9.4	-2.4	-0.9	-0.9	2.2	-1.9	-2.8	-2.8	-2.3	-3.1	-2.4
Father’s age at death	0.4	0.6	1.4	0.3	-0.4	-1.2	-0.9	0.1	0.7	-1.1	0.6	0.9	0.6
Worrier / anxious feelings	1.0	2.0	4.0	0.0	-1.7	-2.0	1.6	-1.1	-0.6	-1.8	-1.8	-0.6	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.0	0.8	-0.5	-0.4	0.8	0.1	-1.0	0.3	-0.4	-0.5	-0.6
Falls in the last year	0.5	0.6	2.6	0.7	-0.7	-1.6	0.7	-0.6	-0.5	0.2	-0.9	-0.3	-0.8
Hair/balding pattern: Pattern 3	1.3	2.0	3.8	0.6	1.6	1.1	-1.2	1.1	1.6	0.7	2.0	1.9	1.5
Number of live births	0.8	1.1	5.0	-0.0	1.6	2.2	-0.7	-0.2	1.1	0.5	1.1	0.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.3	-0.4	0.2	0.7	0.4	-0.6	-0.5	-0.5	-0.8	-0.6
Pulse rate	0.2	0.3	0.9	0.9	0.8	0.5	-0.5	0.9	0.1	0.4	0.3	-0.2	0.5
Happiness	0.5	0.7	2.0	-0.3	-0.9	-0.6	0.8	-0.2	-0.7	-1.4	-0.8	-0.8	-0.9
Noisy workplace	0.2	0.3	1.2	-0.4	-0.5	-0.3	1.1	-0.4	-0.5	0.0	-0.3	-0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.7	0.6	1.0	1.2	-1.6	1.4	0.2	1.3	1.0	0.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	5.0	-1.6	-1.6	-2.2	1.3	-1.4	-0.9	-1.0	-1.7	-0.6	-1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	1.5	-0.9	-0.3	-1.2	1.0	-0.4	-0.8	-1.2	-0.9	-1.0	-1.0
Asthma	0.2	0.4	1.4	1.2	-0.3	0.6	1.2	-0.1	0.0	0.1	-0.8	-0.6	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	0.1	-0.5	0.9	0.6	0.1	-0.7	-1.2	-0.3	-1.2	-0.8
Medication: Cholesterol lowering	0.1	0.2	0.7	-0.4	0.1	0.4	-0.3	-0.5	0.3	-0.8	0.3	0.1	0.5
Depression (self-reported)	0.3	0.4	0.9	-0.8	0.1	0.7	0.5	-0.5	-0.7	-0.3	-0.3	-0.8	-0.9
Medication: Lansoprazole	0.7	0.8	2.9	1.0	0.8	0.7	-0.5	1.1	0.5	1.7	0.8	0.1	0.9
Prospective memory result	0.5	0.6	1.4	-0.8	-0.9	-0.9	0.3	-0.5	-0.6	-1.2	-0.8	-0.7	-0.4
Lung cancer (father)	2.7	3.1	5.0	0.9	1.4	1.0	-2.1	0.9	2.2	2.0	2.2	2.0	2.0
Illnesses of mother	0.8	0.9	2.5	1.3	0.3	0.4	-0.9	0.6	0.9	1.6	0.3	1.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	0.5	-0.5	-0.1	0.5	0.6	-0.2	-0.3	-0.5	-0.2	-0.3
Pulse wave Arterial Stiffness index	0.2	0.2	1.0	-0.5	-0.2	-0.6	-0.2	-1.0	0.5	-0.4	-0.0	0.3	-0.0
Impedance of arm (left)	0.2	0.9	2.0	0.9	0.1	-0.0	-1.1	0.5	1.3	-0.3	1.3	1.0	1.4
Arm fat mass (right)	0.3	1.3	4.6	1.0	0.9	1.0	-1.1	1.7	0.3	2.1	0.8	0.6	0.3
Trunk predicted mass	0.3	1.5	3.3	-0.3	-1.2	-0.7	1.5	-0.3	-1.5	0.0	-1.8	-1.2	-1.7
Standing height	0.1	1.3	2.9	-0.2	-1.6	-1.0	1.0	-0.9	-0.8	-1.0	-1.7	-0.9	-1.3
Length of working week for main job	2.2	2.4	4.7	0.8	2.0	0.1	-1.6	0.6	1.9	2.2	1.1	2.1	1.8
Exposure to tobacco smoke at home	3.5	4.0	8.0	-2.4	-1.6	-1.1	2.1	-2.1	-2.0	-1.6	-1.9	-2.8	-1.9
Breastfed as a baby	0.5	0.6	1.3	0.9	0.8	1.0	-1.1	-0.0	0.7	0.8	0.1	1.1	0.4
Tense / ‘highly strung’	2.7	4.5	10.5	-2.5	-1.9	-1.4	1.4	-2.1	-1.8	-3.2	-1.9	-2.2	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	5.5	-0.5	-1.7	-2.3	1.2	-1.4	-0.7	-1.3	-1.8	-0.5	-1.3
Hair/balding pattern: Pattern 4	0.5	1.1	2.8	0.6	-0.2	1.6	1.7	-0.9	-0.8	-0.3	-1.4	-1.0	-1.0
Birth weight of first child	0.1	0.2	0.6	-0.0	0.8	-0.1	-0.6	-0.3	0.5	-0.4	0.0	0.4	0.2
Peak expiratory flow (PEF)	0.2	0.4	1.0	0.9	-0.2	0.3	-0.0	1.0	0.6	1.0	0.1	0.6	0.4
Pulse wave reflection index	0.3	0.3	1.0	-0.8	-0.5	-0.8	0.3	-1.0	0.3	-0.0	-0.3	0.5	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.6	-0.5	-0.4	0.5	0.6	-0.3	-0.6	-0.3	-0.3	-0.5
Loud music exposure frequency	0.4	0.4	1.1	-0.6	-0.7	-1.1	0.3	0.1	-1.0	-0.2	-0.6	-0.6	-0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.1	-1.0	-0.9	0.8	0.5	0.6	-1.7	0.3	-0.4	-1.8	-1.3
Mouth/teeth dental problems: Bleeding gums	4.5	5.9	13.8	-0.6	-2.4	-3.7	3.0	-2.5	-1.9	-1.7	-3.0	-1.5	-2.4
Blood clot in the leg (DVT)	1.0	1.3	4.8	0.9	2.2	0.3	-0.5	0.6	1.3	1.5	0.6	1.5	0.8
Medication: Paracetamol	2.3	3.9	6.7	-1.1	-2.6	-2.4	2.3	-1.4	-1.5	-2.3	-2.2	-1.4	-1.8
Headache pain in last month	0.9	1.5	3.7	-0.2	-1.6	-1.9	1.6	-0.5	-0.7	-0.9	-1.7	-0.2	-1.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.3	-0.4	-0.5	0.8	-0.0	-0.4	-0.1	-0.5	-0.5	-0.6
Glaucoma (self-reported)	0.1	0.2	0.9	0.2	-0.6	-0.0	0.3	0.3	0.1	-0.9	-0.3	0.1	-0.3
Gout (self-reported)	0.3	0.4	0.9	-0.2	0.3	-0.6	-0.6	0.2	0.8	-0.9	-0.0	1.0	0.5
Hypothyroidism/myxoedema (self-reported)	37.7	73.6	100.0	-7.1	-9.5	-10.0	8.1	-8.5	-8.6	-7.5	-9.7	-7.0	-9.3
Medication: Amlodipine	0.7	1.0	2.8	1.0	1.4	1.0	-0.8	1.7	-0.1	1.1	0.8	-0.1	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.5	-0.1	0.3	0.8	-0.1	-0.8	1.0	-0.8	-0.6	-0.5
Birth weight	0.1	0.3	1.1	0.2	1.1	0.9	0.4	0.2	0.2	0.2	0.1	-0.7	0.4
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.5	-0.4	-0.2	0.1	1.3	-0.5	-1.6	-0.0	-1.1	-1.5	-1.2
High blood pressure (siblings)	0.3	0.5	1.0	0.9	1.0	-0.1	-0.8	0.7	0.8	0.3	0.0	0.9	0.2
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	0.2	-0.9	-0.0	0.9	0.3	-0.5	-0.3	-0.7	-0.8	-0.7
Body fat percentage	0.5	1.8	3.5	0.3	1.5	1.7	-1.8	1.6	0.7	1.9	1.3	0.8	0.8
Leg fat percentage (right)	0.2	0.7	1.9	-0.2	0.9	1.4	-0.8	1.3	-0.1	1.2	0.5	0.1	0.1
Arm fat-free mass (right)	0.2	0.9	2.0	-0.7	-0.8	-0.2	0.9	-0.1	-1.3	0.1	-1.4	-1.3	-1.4
Exposure to tobacco smoke outside home	3.7	4.9	7.4	-1.7	-2.7	-2.4	2.2	-1.7	-2.1	-2.2	-2.3	-2.4	-2.4
Comparative body size at age 10	2.0	5.5	11.4	1.2	2.5	1.8	-2.0	1.7	2.5	3.4	2.2	2.9	2.5
Number of full brothers	0.3	0.4	1.4	-0.1	-0.5	-0.3	0.7	0.2	-0.2	-1.2	-1.0	-0.6	-0.1
Worry too long after embarrassment	2.9	4.9	6.6	-1.1	-2.4	-2.3	2.1	-1.8	-2.2	-2.4	-2.6	-2.4	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	4.4	-1.0	-1.3	-1.3	1.2	-2.1	-0.8	-1.1	-1.5	-0.9	-1.3
Wheeze or whistling in the chest in last year	0.5	0.8	2.4	1.6	1.2	0.0	-0.0	1.2	0.9	0.5	0.5	0.7	1.0
Number of children fathered	0.2	0.2	0.7	-0.4	-0.6	0.8	0.3	-0.2	-0.4	0.9	-0.1	-0.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	5.8	0.1	-1.9	-2.4	1.8	-0.0	-1.8	0.1	-2.4	-1.0	-1.6
Age at first live birth	0.3	0.6	1.4	0.9	0.2	0.4	-0.7	0.2	0.9	1.0	0.7	0.7	1.2
Pulse wave peak to peak time	0.2	0.3	0.9	0.4	0.2	0.8	0.2	0.9	-0.7	0.3	-0.1	-0.5	-0.1
Health satisfaction	0.2	0.2	0.8	0.9	-0.5	-0.6	0.2	0.8	-0.1	-0.3	-0.4	-0.3	-0.1
Shortness of breath walking on level ground	0.9	1.0	3.2	0.8	0.9	1.2	-1.8	1.1	0.6	0.9	1.2	0.4	0.7
Qualifications: College or University degree	0.4	1.2	2.4	0.9	1.0	1.4	-1.5	1.5	1.0	0.5	1.1	0.9	1.0
Eye problems/disorders: None of the above	1.2	1.4	2.9	1.0	1.4	1.0	-1.2	1.7	1.3	0.9	0.9	1.1	1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.6	0.6	-0.9	0.5	-0.1	0.7	0.6	0.2	0.9	0.1
Emphysema/chronic bronchitis	2.4	2.7	4.7	1.5	2.2	1.4	-1.6	1.1	2.0	1.1	1.8	1.4	2.0
Medication for pain relief, constipation, heartburn	2.7	4.6	6.6	1.5	2.1	2.2	-2.4	2.3	2.2	1.8	2.4	1.9	2.6
Neck or shoulder pain in last month	0.4	0.5	2.5	-0.1	-1.3	-1.6	0.4	-0.9	-0.1	-0.3	-0.5	-0.1	-0.2
Medication: Blood pressure	0.2	0.3	0.5	-0.5	-0.6	-0.7	0.1	-0.7	-0.7	-0.3	-0.6	-0.2	-0.7
Angina (self-reported)	0.2	0.2	1.1	-0.3	0.8	1.0	-0.1	0.5	-0.0	0.1	0.1	-0.6	0.2
Migraine (self-reported)	0.6	0.8	4.1	0.6	-1.2	-2.0	0.8	-0.1	-0.1	0.3	-0.9	0.5	-0.4
Medication: Ibuprofen	0.4	0.5	1.8	0.1	-0.6	0.7	0.6	0.2	-0.6	-1.3	-0.3	-0.8	-0.8
Medication: Allopurinol	0.3	0.4	2.0	-0.1	-0.6	-1.4	0.2	-0.6	-0.0	-1.0	-0.7	0.1	-0.1
Medication: Omeprazole	0.6	0.7	2.2	0.8	1.1	0.9	-0.7	1.5	0.1	0.8	0.3	0.4	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.5	-0.6	-0.2	-0.1	0.1	-0.6	0.6	-0.4	0.1	-0.5
Mean time to correctly identify matches	2.0	3.8	7.7	-2.8	-1.0	-0.9	1.6	-1.9	-2.4	-2.2	-1.4	-2.1	-2.3
Heart disease (mother)	1.9	2.3	5.9	-1.4	-1.1	-2.0	0.2	-0.7	-1.6	-2.4	-1.0	-2.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.9	-0.2	1.0	0.8	-0.7	0.0	0.3	0.2	0.5	-0.5	0.7
Whole body fat mass	0.3	1.1	3.2	0.4	0.9	1.2	-1.3	1.4	0.4	1.8	0.8	0.5	0.3
Leg fat mass (right)	0.1	0.5	1.8	0.1	0.6	0.9	-0.6	1.3	-0.1	1.4	0.1	0.1	-0.1
Arm predicted mass (right)	0.2	1.2	2.7	-0.6	-1.0	-0.5	1.2	-0.2	-1.4	-0.0	-1.6	-1.4	-1.6
Pulse rate, automated reading	0.1	0.2	1.2	0.5	-1.1	-0.8	-0.1	0.4	-0.0	0.0	0.2	-0.1	-0.1
Alcohol intake frequency.	0.4	1.0	2.7	-1.2	0.2	0.2	1.4	-0.8	-1.0	-0.8	-0.7	-1.6	-0.8
Comparative height size at age 10	0.3	1.5	4.4	-1.0	-2.1	-1.4	0.5	-1.6	-0.7	-0.9	-1.3	-0.4	-1.2
Number of full sisters	3.4	4.2	6.4	2.3	2.2	0.6	-1.7	1.0	2.5	2.3	2.1	2.5	2.3
Suffer from ‘nerves’	2.2	3.5	8.6	-1.2	-2.2	-1.2	1.5	-1.4	-1.5	-2.9	-2.1	-2.0	-1.8
Overall health rating	0.7	1.4	8.2	0.3	-1.1	-2.9	1.4	-1.0	-0.2	-0.1	-1.3	0.4	-0.4
Chest pain or discomfort	0.3	0.5	2.1	0.5	1.4	1.0	-0.8	-0.0	0.5	0.1	0.2	-0.2	0.7
Had major operations	0.4	0.5	1.1	-0.7	-0.5	-0.5	1.0	-0.8	-0.4	-0.6	-0.9	-0.1	-0.8
Age at last live birth	0.6	0.9	2.0	1.2	1.2	0.1	-0.5	0.4	0.9	1.4	0.8	1.1	0.9
Family relationship satisfaction	0.3	0.3	1.3	0.0	0.4	0.6	-1.1	0.2	0.4	0.4	0.8	0.3	0.7
Leg pain on walking	0.2	0.3	0.8	0.9	-0.3	-0.5	-0.2	-0.2	0.8	0.4	0.1	0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	4.2	-1.8	0.1	1.1	0.9	-1.1	-1.4	-0.2	-0.8	-2.1	-1.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.1	0.2	0.3	0.1	0.1	-0.1	0.6	0.3	0.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.5	0.8	0.3	0.2	-1.0	1.2	0.7	-0.1	0.6	1.1	1.1
Medication: Aspirin	2.5	3.3	6.0	-1.7	-1.4	-1.9	1.9	-2.5	-1.9	-1.0	-2.0	-1.4	-2.1
Supplements: Vitamin C	0.1	0.2	0.5	-0.2	0.1	0.3	0.5	0.1	-0.6	0.2	-0.0	-0.5	-0.7
Knee pain experienced in last month	1.2	1.8	3.4	-0.6	-1.8	-1.1	1.4	-1.0	-1.6	-1.2	-1.3	-1.4	-1.6
Hypertension (Self-reported)	0.8	2.3	3.9	-1.7	-1.5	-1.4	1.7	-0.6	-2.0	-1.1	-1.1	-1.6	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.6	0.2	0.4	0.3	-0.2	-0.6	-0.5	-0.5	-0.6	-0.3
Illnesses of father: Heart disease	2.1	2.9	4.8	-1.9	-1.3	-0.6	1.9	-1.1	-2.2	-0.7	-2.0	-2.1	-2.1
Illnesses of siblings: Diabetes	0.1	0.2	0.6	0.8	-0.1	0.2	0.3	0.4	0.0	0.4	0.4	-0.6	0.3
Smoking status: Previous	0.2	0.3	0.7	-0.1	0.4	-0.1	0.1	-0.6	0.8	-0.6	-0.5	0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.7	-0.1	-1.3	-0.1	1.2	0.2	-0.7	-1.3	-1.3	-0.9	-1.1
Whole body fat-free mass	0.1	0.5	1.7	-0.0	-0.5	-0.2	0.8	0.2	-0.9	0.3	-1.3	-0.8	-1.1
Leg fat-free mass (right)	0.0	0.2	0.6	0.6	0.3	0.5	-0.2	0.8	0.1	0.7	-0.4	-0.1	-0.2
Arm fat percentage (left)	0.6	2.4	4.9	0.9	1.7	1.6	-1.9	1.9	0.9	2.2	1.6	1.1	1.0
Average weekly red wine intake	0.2	0.3	0.8	0.2	-0.8	-0.6	0.5	-0.2	-0.5	0.5	-0.5	-0.1	-0.9
Handedness (chirality/laterality): Left-handed	3.2	3.8	5.1	2.1	1.9	1.3	-2.1	2.3	1.7	2.1	2.1	1.7	2.0
Mood swings	0.5	1.0	2.6	0.4	-0.9	-1.6	1.5	-0.9	-0.2	0.1	-1.6	0.1	-0.8
Loneliness, isolation	8.0	11.1	17.9	-2.1	-3.7	-3.8	4.2	-3.3	-3.0	-2.6	-3.8	-2.7	-3.3
Long-standing illness, disability or infirmity	10.0	15.3	19.6	-3.2	-4.1	-4.4	4.4	-4.2	-3.6	-3.3	-4.3	-3.4	-4.0
Ever had bowel cancer screening	0.6	0.8	2.6	-1.3	-0.5	-0.9	0.2	-1.6	-0.7	-0.5	-0.4	-0.7	-0.9
Diabetes diagnosed by doctor	4.1	6.7	9.4	-2.7	-2.9	-2.6	2.7	-3.0	-1.8	-3.1	-2.7	-1.6	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.7	0.0	-0.4	0.4	-0.4	-0.6	0.0	-0.1	-0.3	-0.4
Friendships satisfaction	0.2	0.2	0.5	0.7	-0.1	-0.4	-0.5	0.2	0.6	-0.1	0.3	0.5	0.5
Qualifications: nursing, teaching	1.1	1.6	3.7	0.1	1.4	0.5	-1.5	-0.0	1.9	0.4	1.3	1.8	1.8
Commuting to job workplace: Walk	1.1	1.2	2.1	-0.7	-1.5	-0.9	0.9	-1.2	-1.0	-1.2	-1.2	-1.1	-1.1
Eye problems/disorders: Cataract	0.6	0.7	1.6	-1.1	-0.8	-0.2	0.5	-1.0	-0.9	-1.0	0.0	-1.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	5.0	-1.2	-1.5	-1.2	1.6	-2.2	-1.4	-0.2	-1.1	-1.4	-1.3
Medication for cholesterol	3.2	4.8	7.3	1.9	2.5	2.7	-2.2	1.7	2.5	2.0	2.1	2.0	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.3	-1.1	-0.3	-1.6	0.1	-1.8	-0.6	-1.3	-1.1	-0.4	-1.1
Back pain experienced in last month	1.1	1.7	3.6	1.6	1.5	1.5	-1.2	1.9	0.9	0.5	1.3	-0.2	1.3
Mineral and other dietary supplements	1.8	2.4	4.2	0.4	2.1	1.6	-1.3	1.4	1.6	1.4	1.9	1.7	1.6
Breast cancer (self-reported)	0.6	0.7	1.7	0.7	0.9	0.4	-1.1	0.3	1.3	0.6	0.7	0.6	1.2
Asthma (self-reported)	0.2	0.5	2.0	1.0	-0.4	0.5	1.4	-0.2	-0.0	-0.2	-0.9	-0.7	0.2
Osteoporosis (self-reported)	0.4	0.5	1.7	-0.5	-0.2	-1.3	0.5	0.0	-0.1	-1.1	-0.9	-0.2	-0.2
Osteoarthritis (self-reported)	0.4	0.5	1.3	-0.8	-0.5	0.4	0.3	-0.4	-0.9	-1.1	-0.5	-0.9	-0.9
Medication: Aspirin	3.2	4.2	6.9	-1.8	-1.7	-2.0	2.2	-2.6	-2.0	-1.4	-2.4	-1.6	-2.4
Medication: Gliclazide	3.7	4.1	5.0	-2.1	-2.1	-1.8	2.2	-2.2	-2.0	-2.0	-2.1	-1.5	-2.1
Illnesses of father: None of the above (group 1)	0.6	0.8	2.3	1.0	1.0	0.3	-0.8	0.2	0.7	1.5	0.8	0.7	1.0
Smoking status: Current	0.4	0.7	1.8	1.2	-0.3	-0.8	0.2	0.6	0.9	1.1	0.6	1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.6	0.7	0.5	0.5	-0.9	1.6	0.5	0.9	0.8	0.5	0.8
Whole body water mass	0.1	0.6	1.7	-0.1	-0.6	-0.3	0.8	0.1	-0.9	0.2	-1.3	-0.8	-1.2
Leg predicted mass (right)	0.0	0.3	0.7	0.7	0.4	0.5	-0.3	0.8	0.2	0.8	-0.4	-0.0	-0.2
Arm fat mass (left)	0.3	1.1	4.7	0.8	0.8	0.9	-1.1	1.4	0.3	2.2	0.7	0.6	0.2
Number of self-reported non-cancer illnesses	7.3	12.6	15.6	-2.5	-3.5	-3.9	3.6	-3.3	-3.9	-3.4	-3.6	-3.6	-4.0
Average weekly champagne plus white wine intake	0.2	0.3	1.8	-0.2	-0.4	-0.0	-1.3	0.5	0.1	-0.1	0.3	0.4	-0.3
Miserableness	2.3	4.0	7.2	-0.8	-2.3	-2.3	2.5	-2.0	-1.7	-1.6	-2.7	-1.1	-2.1
Guilty feelings	1.5	2.3	7.6	0.3	-2.2	-2.8	1.7	-1.6	0.2	-0.3	-1.6	1.2	-0.7
Wears glasses or contact lenses	0.3	0.4	1.2	-0.9	0.2	-0.9	-0.6	-1.1	0.3	0.2	-0.0	0.6	-0.3
Ever taken oral contraceptive pill	0.6	0.7	1.6	-0.9	-0.8	0.3	1.0	-1.3	-0.2	-1.2	-0.7	-0.6	-0.5
Hearing aid user	5.6	6.4	9.4	2.8	2.3	3.1	-2.7	2.6	2.1	2.0	2.7	1.8	2.9
Mother’s age at death	0.4	0.5	1.4	0.3	1.1	1.2	0.2	0.4	0.5	0.8	1.0	0.5	0.1
Financial situation satisfaction	2.5	3.1	5.3	-2.3	-1.6	-1.1	1.7	-1.9	-1.8	-2.2	-1.3	-1.7	-1.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.6	-0.2	-0.5	-0.8	0.3	-0.3	0.1	-0.5	0.0	0.4	0.1
Commuting to job workplace: Public transport	0.3	0.3	0.9	0.2	-0.4	-0.5	-0.9	0.8	-0.5	-0.9	0.3	-0.1	-0.0
Eye problems/disorders: Glaucoma	0.5	0.6	1.9	-0.3	-0.7	-0.5	1.1	-0.4	-0.7	-1.4	-0.7	-0.9	-0.9
Medication: Blood pressure	1.0	1.9	3.7	-1.3	-0.9	-1.6	1.5	-1.0	-1.9	-0.6	-1.0	-1.9	-1.5
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.7	0.2	1.6	2.2	-1.0	1.1	2.1	0.7	2.0	1.1	1.7
Supplements: Fish oil (including cod liver oil)	1.9	2.4	3.4	-0.7	-1.6	-1.4	1.8	-1.7	-1.4	-1.7	-1.8	-1.7	-1.4
High cholesterol (Self-reported)	0.4	0.7	3.1	-0.5	-1.0	-1.8	0.6	-0.4	0.2	-1.2	-0.4	0.4	0.1
Medication: Bendroflumethiazide	0.2	0.3	1.2	-0.1	-0.0	-0.5	0.1	0.0	-1.1	0.0	-0.1	-1.0	-0.4
Medication: Paracetamol	2.6	4.0	8.4	-1.2	-2.9	-2.7	2.2	-1.1	-1.5	-2.2	-2.1	-1.5	-1.8
Medication: Lisinopril	0.4	0.5	0.9	-1.0	-0.7	0.2	0.7	-0.4	-0.7	-0.3	-0.9	-0.6	-0.8
Medication: Atorvastatin	1.2	1.5	2.8	-1.3	-0.8	-1.0	0.3	-1.0	-1.5	-1.3	-1.1	-1.7	-1.6
Illnesses of father: High blood pressure	0.5	0.6	1.3	-0.8	-1.1	-0.2	0.8	-0.2	-1.0	-0.9	-1.1	-0.5	-0.8
Alcohol drinker status: Never	1.1	1.3	4.0	-0.3	-2.0	-1.0	1.6	-0.7	-1.1	0.2	-1.1	-0.9	-1.1
Ever smoked	0.3	0.5	1.6	-0.2	0.1	-0.7	0.4	-0.5	1.1	-0.7	-0.3	1.3	0.4
Basal metabolic rate	0.1	0.4	1.2	-0.0	-0.4	-0.0	0.5	0.4	-0.8	0.5	-1.1	-0.7	-1.0
Leg fat percentage (left)	0.3	1.2	3.0	0.0	1.3	1.7	-1.2	1.5	0.4	1.6	0.9	0.5	0.6
Arm fat-free mass (left)	0.1	0.7	1.9	-0.3	-0.7	-0.6	0.9	0.0	-1.0	0.3	-1.4	-0.7	-1.3
Number of operations (self-reported)	0.5	0.7	3.0	-1.7	-0.0	-0.9	-0.3	-0.9	-0.9	-0.5	0.1	-0.7	-0.7
Average weekly beer plus cider intake	0.3	0.4	1.5	-0.4	1.0	1.2	-0.7	0.2	0.3	-0.3	0.3	-0.0	0.7
Irritability	1.8	3.0	7.1	-0.5	-1.6	-2.4	2.0	-1.9	-1.4	-1.4	-2.7	-0.6	-1.7
Risk taking	0.3	0.5	1.7	-0.1	-0.1	-1.3	1.0	-0.8	-0.1	0.3	-0.8	0.3	-0.6
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.4	0.4	0.3	1.8	-1.0	0.6	0.1	1.8	1.3	0.2	0.0
Fractured/broken bones in last 5 years	0.6	0.8	3.8	-0.9	-0.2	-0.2	1.2	-0.3	-0.2	-1.9	-0.9	-0.4	-0.8
Age started oral contraceptive pill	2.4	3.0	14.4	-0.6	-2.7	-3.8	1.4	-1.2	-0.5	-1.1	-1.5	-0.1	-0.9
Diastolic blood pressure, automated reading	0.1	0.2	0.9	0.2	-0.5	-0.9	-0.8	0.2	-0.2	-0.6	-0.2	0.0	0.1
Ever depressed for a whole week	1.7	2.1	4.4	-0.4	-2.1	-1.8	1.0	-1.4	-1.3	-1.0	-1.6	-1.5	-1.7
Unable to work because of sickness or disability	0.5	0.6	1.3	-0.3	-0.2	-1.0	1.1	-1.0	-0.3	-1.0	-0.9	-0.5	-0.6
Commuting to job workplace: Cycle	0.3	0.4	1.2	0.4	0.5	0.8	-0.2	0.3	0.7	0.6	0.5	1.1	0.8
Myopia	0.9	1.3	4.9	0.7	1.1	2.2	-1.8	0.7	0.4	-0.2	1.2	-0.4	1.1
Vascular/heart problems diagnosed by doctor	1.2	3.2	5.0	1.8	1.7	1.7	-2.0	1.1	2.2	1.3	1.7	1.7	2.2
Cholesterol lowering medication	2.9	4.3	6.8	-1.6	-2.5	-2.6	2.6	-1.9	-1.5	-2.4	-2.1	-1.2	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.4	0.8	1.6	1.1	-1.0	1.4	0.2	1.1	0.7	0.3	0.9
Pain experienced in last month	0.4	0.6	3.0	0.4	0.6	0.1	-0.8	0.1	0.8	1.0	0.3	1.7	0.3
Supplements: Calcium	1.1	1.2	3.1	0.6	-1.5	-1.8	1.5	-0.6	-0.1	-0.4	-1.7	0.3	-0.7
Basal cell carcinoma (self-reported)	4.9	5.8	10.9	1.4	2.7	3.3	-1.8	2.3	2.6	2.0	2.7	2.2	2.4
Heart attack/myocardial infarction (self-reported)	1.6	2.1	3.9	-1.5	-2.0	-1.6	1.1	-1.5	-0.7	-1.9	-1.7	-0.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.4	0.8	1.9	0.0	-0.1	0.2	1.2	1.4	0.4	1.4	0.7
Heart disease (siblings)	0.1	0.1	0.4	-0.3	0.6	-0.4	0.1	-0.1	0.3	-0.2	-0.2	-0.3	-0.1
Alcohol drinker status: Previous	0.2	0.3	0.7	0.1	0.8	0.5	-0.1	-0.1	0.8	0.6	0.3	0.5	0.6
Pack years of smoking	0.1	0.2	0.5	0.7	-0.4	-0.5	0.3	0.1	-0.5	0.0	-0.5	-0.7	-0.2
Impedance of whole body	0.1	0.3	0.9	0.3	-0.4	-0.1	-0.4	0.0	0.7	-0.7	0.8	0.5	1.0
Leg fat mass (left)	0.2	0.8	2.2	0.2	0.8	1.2	-0.9	1.4	0.2	1.5	0.4	0.3	0.2
Arm predicted mass (left)	0.1	0.6	1.6	-0.4	-0.5	-0.4	0.8	0.1	-1.1	0.3	-1.3	-0.9	-1.3