TWAS hub - FGFR1OP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0990	0.0440	0.00840	0.065	NA	0.024	NA	0.029	3.6e-05	NA	9.9e-03	NA	4.5e-03
2	METSIM	Adipose	0.0514	0.0188	0.00047	-0.001	0.016	0.002	0.014	0.000	5.0e-01	1.5e-03	1.4e-01	3.2e-03	3.9e-01
3	NTR	Blood	0.0304	0.0108	0.00027	0.021	0.013	0.015	0.023	0.019	1.5e-07	3.9e-05	7.6e-06	4.5e-08	4.9e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hypothyroidism (self reported)	25.6	58.7	104.0	10.2	7.8	3.3
Crohns Disease (2017)	22.4	49.3	79.8	8.9	7.5	3.4
Hypothyroidism/myxoedema (self-reported)	20.9	40.7	69.9	8.4	6.7	2.6
Medication: Levothyroxine sodium	17.5	29.7	49.7	7.0	5.6	2.9
Irritable Bowel Disease (IBD)	14.9	35.6	62.6	7.9	5.4	3.9
Crohns Disease (2012)	12.7	20.5	40.8	6.4	4.3	1.5
Taking other prescription medications	7.9	12.2	20.2	4.5	3.5	2.1
Loneliness, isolation	6.3	8.7	13.3	3.5	3.6	0.7
Long-standing illness, disability or infirmity	6.3	9.7	14.0	3.7	3.7	1.3
Worry (Nagel 2018)	5.2	11.0	18.6	4.3	2.5	2.9
Medication: Metformin	5.2	7.3	8.7	3.0	2.8	2.2
Alcohol intake versus 10 years previously	5.2	7.8	10.7	2.6	3.3	2.5
Neuroticism (Nagel 2018)	4.9	11.5	19.0	4.4	3.4	2.0
Hearing aid user	4.9	5.5	8.3	-2.9	-2.7	-1.0
Number of self-reported non-cancer illnesses	4.7	8.2	11.7	3.4	3.4	1.2
Number of treatments/medications taken	4.6	8.3	13.7	3.7	2.0	2.7
Ulcerative Colitis (UC)	4.3	8.0	15.0	3.9	1.2	2.7
Type 2 Diabetes (T2D) (2018)	4.3	8.1	9.9	3.1	2.8	2.6
Lung cancer (father)	4.1	4.8	6.0	-2.4	-2.3	-1.8
Tense / ‘highly strung’	4.1	6.7	8.4	2.4	2.9	2.5
Medication: Paracetamol	3.7	6.1	9.4	3.1	2.7	1.3
Depressed Affect (Nagel 2018)	3.6	7.6	13.2	3.0	3.6	0.8
Basal cell carcinoma (self-reported)	3.4	4.1	6.1	-2.5	-2.4	-0.6
Suffer from ‘nerves’	3.3	5.1	8.4	2.9	2.0	1.8
Ulcerative Colitis	3.2	4.7	8.2	2.9	0.6	2.4
Length of working week for main job	3.2	3.6	8.0	-2.8	-0.9	-1.4
Age started oral contraceptive pill	3.2	4.0	6.3	2.2	2.5	-0.9
Neuroticism	2.9	7.1	10.5	3.2	2.6	1.9
Comparative body size at age 10	2.9	8.1	11.4	-3.3	-3.4	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	5.2	2.2	0.7	-2.3
Diabetes diagnosed by doctor	2.9	4.7	7.1	2.7	1.8	2.0
Rheumatoid Arthritis	2.8	3.8	6.6	2.1	2.6	0.7
Medication: Paracetamol	2.8	4.4	8.5	2.9	2.0	0.9
Triglycerides	2.7	4.5	6.5	2.5	0.9	2.5
Heart attack	2.6	3.3	6.1	1.8	2.5	0.9
Neuroticism score	2.6	5.4	9.1	2.5	3.0	1.0
Exposure to tobacco smoke outside home	2.6	3.5	3.9	2.0	1.7	1.9
Cholesterol lowering medication	2.6	3.9	6.6	2.6	2.1	0.9
Diabetes (self-reported)	2.5	3.8	6.8	2.6	1.5	1.5
Worry too long after embarrassment	2.5	4.3	6.4	2.5	2.2	1.2
Medication for cholesterol	2.5	3.8	10.1	-3.2	-1.1	-0.3
Financial situation satisfaction	2.5	3.1	7.9	1.1	-0.2	2.8
Primary Biliary Cirrhosis	2.4	3.4	4.6	2.0	2.2	1.3
Medication: Gliclazide	2.3	2.6	5.9	2.4	0.4	1.3
Lupus	2.2	3.3	4.9	2.2	2.1	0.7
Heart disease (mother)	2.2	2.7	3.5	1.5	1.9	1.5
Neuroticism (2016)	2.0	2.9	4.3	2.1	1.9	1.0
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	5.2	2.3	1.6	0.1
Medication for pain relief, constipation, heartburn	2.0	3.5	7.5	-2.7	-1.6	-0.7
Miserableness	2.0	3.4	7.1	1.7	2.7	0.4
Fractured/broken bones in last 5 years	2.0	2.6	3.4	1.6	1.4	1.8
Heart attack/myocardial infarction (self-reported)	2.0	2.6	4.6	1.7	2.1	0.7
Supplements: Glucosamine	1.9	2.4	4.6	2.1	1.0	1.3
Worrier / anxious feelings	1.9	3.6	5.9	2.0	2.4	1.1
Exposure to tobacco smoke at home	1.9	2.2	3.6	1.9	0.4	1.7
Supplements: Fish oil (including cod liver oil)	1.9	2.5	4.2	2.1	-0.4	1.8
Medication: Atorvastatin	1.9	2.4	7.0	0.4	2.7	0.0
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.9	-1.2	-2.2	-0.6
Sensitivity / hurt feelings	1.8	3.1	4.7	2.2	1.8	1.2
Number of full sisters	1.8	2.2	3.4	-1.7	-0.6	-1.8
Osteoarthritis (self-reported)	1.8	2.4	5.9	0.4	2.4	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.1	0.5	1.8	1.6
Mouth/teeth dental problems	1.6	2.4	4.6	-2.1	-1.6	-0.2
Handedness (chirality/laterality): Left-handed	1.6	1.9	2.8	-1.7	-0.6	-1.6
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.8	2.6	1.1	1.2
Mineral and other dietary supplements	1.5	2.0	4.0	-2.0	-0.6	-1.3
LDL Cholesterol	1.4	2.2	4.3	1.0	2.1	1.1
Medication for hormone replacement therapy	1.4	1.5	2.5	1.6	-0.1	1.5
Fed-up feelings	1.4	2.6	6.1	1.1	2.5	0.7
Had menopause	1.4	1.8	3.5	1.9	1.1	0.7
Headache pain in last month	1.4	2.3	4.2	1.7	2.0	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	3.5	1.9	1.1	0.9
Commuting to job workplace: Walk	1.4	1.5	3.0	1.0	1.7	0.7
Ovarian Cancer	1.3	1.8	4.0	-1.0	0.5	-2.0
Qualifications: A levels/AS levels or equivalent	1.3	2.9	5.9	-1.6	-2.4	-0.5
Alcohol intake frequency.	1.3	3.1	8.6	0.3	2.9	0.7
Medication: Aspirin	1.3	1.7	4.8	2.2	-0.1	0.5
Ever taken oral contraceptive pill	1.3	1.5	2.4	0.9	1.1	1.6
Alcohol drinker status: Never	1.3	1.6	3.3	0.8	1.8	-0.9
Nervous feelings	1.2	2.3	4.5	2.1	1.2	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.6	1.2	1.6	0.6
Illnesses of mother	1.2	1.5	2.1	-0.8	-1.4	-1.3
Mean time to correctly identify matches	1.2	2.3	3.8	1.9	-0.7	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.1	-1.5	-1.1	1.1
Allergy or Eczema	1.1	2.9	5.7	2.4	0.6	1.6
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.3	1.8	0.9	0.5
Medication: Lansoprazole	1.1	1.2	3.0	-0.8	-0.2	-1.7
Medication: Blood pressure	1.1	2.1	3.4	1.8	1.3	-1.1
Irritability	1.1	1.9	2.7	1.6	1.6	0.8
Breast Cancer	1.0	2.4	3.0	1.7	1.7	-1.2
Blood White Count	1.0	7.5	16.8	-4.1	-2.1	-1.2
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.7	-0.9	-0.3	-1.6
Illnesses of siblings	1.0	1.4	3.8	0.0	-0.7	1.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.5	0.6	-2.1	0.1
Medication: Amlodipine	1.0	1.3	2.0	-0.5	-1.4	-1.3
Illnesses of father: None of the above (group 1)	1.0	1.3	2.2	-1.3	0.1	-1.5
Alzheimer’s Disease (in father)	0.9	0.9	1.8	-0.7	-1.3	0.8
HbA1C	0.9	1.0	2.2	-1.5	0.5	-0.8
Blood Eosinophil Count	0.9	6.7	16.1	1.5	1.3	4.0
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.7	1.1	1.3	1.0
Hair/balding pattern: Pattern 3	0.9	1.3	2.7	-1.6	-1.0	0.3
Happiness	0.9	1.0	2.4	1.6	0.2	0.8
Medication: Ibuprofen	0.9	1.1	2.5	0.7	-0.6	1.6
Medication: Aspirin	0.9	1.2	3.3	1.8	-0.5	0.2
Bipolar Disorder or Schizophrenia	0.8	1.9	3.3	-1.6	-1.8	0.2
Depression (Nagel 2018)	0.8	1.2	1.6	1.3	1.0	0.9
Schizophrenia (2018)	0.8	1.6	2.9	-1.7	-1.3	0.0
Mean Putamen Volume	0.8	0.9	1.2	1.1	1.0	0.7
Ever had hysterectomy (womb removed)	0.8	0.9	1.9	0.6	1.4	0.5
Trunk fat percentage	0.8	3.1	8.2	-2.9	-0.6	-0.9
Current tobacco smoking	0.8	1.4	3.7	-0.6	-0.0	-1.9
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.3	0.7	1.5	-0.0
Financial difficulties in last 2 years	0.8	1.1	1.3	-0.9	-1.0	1.1
Time employed in main current job	0.8	1.0	2.2	-0.7	-0.5	1.5
Breastfed as a baby	0.8	1.0	2.4	0.6	-1.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.5	0.9	1.6	0.5
Migraine (self-reported)	0.8	1.0	1.6	1.0	0.6	-1.3
Medication: Seretide 50 evohaler	0.8	1.0	2.7	-0.2	0.3	-1.7
Mood swings	0.8	1.4	3.2	0.3	1.8	-0.9
Unable to work because of sickness or disability	0.8	1.1	2.7	0.5	1.6	0.6
Commuting to job workplace: Cycle	0.8	1.0	2.3	-0.7	-1.5	0.4
Myopia	0.8	1.1	1.6	-1.2	-1.3	0.5
Reaction Time	0.7	1.3	2.4	1.6	-0.9	0.7
Respiratory disease	0.7	1.5	2.5	-1.3	-0.4	-1.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	1.3	0.9	0.5
Falls in the last year	0.7	0.9	1.3	0.4	1.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.8	0.9	0.0	1.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.6	0.0	0.1	-1.6
Number of children fathered	0.7	0.8	2.0	-0.5	-1.4	0.2
Age at last live birth	0.7	1.0	1.7	-0.9	-0.7	-1.3
Family relationship satisfaction	0.7	0.8	2.0	-0.6	-1.4	0.4
Illnesses of father: Heart disease	0.7	1.0	2.5	1.6	0.2	0.7
Eye problems/disorders: Cataract	0.7	0.9	1.3	0.8	0.8	1.1
Smoking status: Current	0.7	1.1	3.0	-0.2	0.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.1	-1.1	-1.8	-0.3
Wears glasses or contact lenses	0.7	0.8	1.2	-1.1	-1.1	0.2
Supplements: Calcium	0.7	0.8	1.6	1.3	0.9	0.1
Major Depression (MDD)	0.6	0.8	1.3	0.4	-1.0	1.1
Age at First Birth	0.6	0.9	1.5	1.2	-0.9	-0.6
HDL Cholesterol	0.6	0.9	2.4	-1.6	-0.1	-0.6
Waist Hip Ratio (WHR)	0.6	2.9	5.2	1.4	2.3	1.2
Diabetes (mother)	0.6	0.7	1.8	-0.6	0.2	-1.3
Relative age voice broke	0.6	0.9	2.1	-0.8	-0.0	-1.4
Allergy	0.6	1.4	3.7	-1.9	-0.6	-0.1
Pain all over the body in last month	0.6	0.6	0.6	0.8	0.8	0.8
Arm fat percentage (right)	0.6	2.3	5.3	-2.3	-0.3	-1.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.6	1.3	0.3	-0.7
Body fat percentage	0.6	2.2	6.0	-2.5	-0.2	-0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	-0.5	-0.7	-1.1
Knee pain experienced in last month	0.6	1.0	1.9	0.8	1.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	1.6	1.3	1.1	0.9
Arm fat percentage (left)	0.6	2.5	6.4	-2.5	-0.7	-0.9
Qualifications: nursing, teaching	0.6	0.9	1.4	-1.0	-0.6	1.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.6	1.6	0.5	0.5
Commuting to job workplace: Public transport	0.6	0.7	1.1	1.1	0.5	0.9
Illnesses of father: High blood pressure	0.6	0.7	1.0	1.0	0.7	0.7
Pain experienced in last month	0.6	0.9	2.8	0.0	-0.3	-1.7
Body Mass Index (BMI) (2010)	0.5	0.7	1.8	-0.3	0.5	1.3
Schizophrenia (2014)	0.5	1.1	2.0	-1.4	-1.1	0.1
Cardiovascular Disease	0.5	1.6	3.5	1.9	1.1	-0.1
Severe depression (siblings)	0.5	0.6	1.7	-0.1	1.3	-0.3
Hand grip strength (right)	0.5	1.4	2.2	1.0	1.0	1.5
Average weekly fortified wine intake	0.5	0.6	1.4	-0.2	-1.2	-0.6
Maternal smoking around birth	0.5	0.7	1.7	0.5	0.5	-1.3
Number of incorrect matches in round	0.5	0.8	1.3	0.6	-0.8	-1.1
Alcohol usually taken with meals	0.5	0.8	2.2	0.3	0.5	-1.5
Hearing difficulty/problems with background noise	0.5	0.8	1.9	-0.4	-1.4	0.7
Father’s age at death	0.5	0.7	1.7	0.1	-0.6	1.3
Blood clot in the leg (DVT)	0.5	0.7	1.3	-0.9	0.0	-1.1
Number of full brothers	0.5	0.7	1.0	1.0	-0.2	1.0
Overall health rating	0.5	1.0	2.0	0.9	1.4	-0.5
Average weekly red wine intake	0.5	0.7	1.2	1.0	0.2	-1.1
Back pain experienced in last month	0.5	0.8	1.8	-1.3	-0.8	0.0
Breast cancer (self-reported)	0.5	0.6	1.5	-0.2	1.2	-0.6
Osteoporosis (self-reported)	0.5	0.6	0.7	0.8	0.8	0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	-1.1	-0.5	0.7
Ever smoked	0.5	0.9	1.6	0.8	1.3	0.5
Average weekly beer plus cider intake	0.5	0.7	1.8	-0.4	-0.2	1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.8	-0.5	0.1	-1.3
Alcohol drinker status: Previous	0.5	0.5	0.6	-0.7	-0.8	-0.7
Bipolar Disorder (2018)	0.4	0.6	1.6	-0.4	-1.3	0.3
Hearing difficulty/problems: Yes	0.4	0.7	1.8	-0.4	-0.0	1.4
Townsend deprivation index at recruitment	0.4	0.5	1.3	0.5	-0.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.2	-1.1	-1.0	0.6
Multivitamins +/- minerals	0.4	0.5	1.3	-0.1	-1.1	-0.5
Medication: Atenolol	0.4	0.5	0.8	0.3	0.9	0.8
Trunk fat mass	0.4	1.5	4.0	-2.0	-0.1	-0.7
Past tobacco smoking	0.4	0.8	1.6	-0.9	-1.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.1	-1.1	-0.9	0.9
Medication: Simvastatin	0.4	0.6	0.8	0.8	-0.6	0.9
Prospective memory result	0.4	0.5	0.8	0.6	0.7	0.9
High blood pressure (siblings)	0.4	0.6	1.3	0.1	1.2	-0.7
Wheeze or whistling in the chest in last year	0.4	0.7	1.6	-1.3	0.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.1	-0.1	0.5	-1.0
Emphysema/chronic bronchitis	0.4	0.4	0.6	-0.7	-0.3	-0.8
Chest pain or discomfort	0.4	0.6	1.1	-0.8	-0.2	1.1
Supplements: Vitamin C	0.4	0.5	1.4	0.2	1.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.3	0.2	-1.1	0.2
Arm fat mass (left)	0.4	1.4	3.0	-1.7	-0.1	-1.1
Mother’s age at death	0.4	0.5	0.9	-0.3	-0.7	-1.0
Ever depressed for a whole week	0.4	0.5	0.8	0.5	0.7	0.9
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.4	-1.5	-0.8	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	-0.1	0.3	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.8	-0.6	0.4
Bipolar Disorder (2011)	0.3	0.3	0.7	-0.5	-0.2	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	0.8	0.6	-0.2
Smoking Status	0.3	0.6	1.5	-0.0	0.6	-1.2
Lung FVC	0.3	1.5	2.3	0.3	-1.5	1.4
Average weekly spirits intake	0.3	0.4	1.1	-0.0	1.0	0.2
Relative age of first facial hair	0.3	0.6	1.1	-0.7	-0.3	-1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.5	1.1	0.5	1.1	0.0
Medication: Co-codamol	0.3	0.3	0.5	-0.6	0.2	0.7
Age when periods started (menarche)	0.3	0.7	1.4	1.2	0.8	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	0.8	0.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.1	1.1	0.0	-0.1
High blood pressure	0.3	0.9	2.0	1.4	0.9	-0.3
Sitting height	0.3	2.3	3.8	1.2	1.9	1.3
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-0.2	0.4	1.0
High blood pressure (mother)	0.3	0.4	0.6	-0.4	0.8	0.8
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	0.8	0.5	-0.0
Fluid intelligence score	0.3	0.7	1.1	-1.0	-0.9	-0.2
Trunk fat-free mass	0.3	1.9	3.1	1.8	1.6	0.3
Hip circumference	0.3	1.4	2.3	-1.3	0.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.2	-0.1	-0.2	-1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	0.9	0.8	0.1
Arm fat mass (right)	0.3	1.4	2.4	-1.5	0.3	-1.3
Trunk predicted mass	0.3	1.9	3.2	1.8	1.5	0.3
Glaucoma (self-reported)	0.3	0.3	0.5	-0.2	0.6	0.7
Age at first live birth	0.3	0.5	0.7	-0.8	-0.9	-0.2
Qualifications: College or University degree	0.3	0.9	2.5	-0.4	-1.6	-0.3
Eye problems/disorders: None of the above	0.3	0.4	0.6	-0.8	-0.2	-0.7
Medication: Omeprazole	0.3	0.3	0.7	0.2	0.5	-0.8
Whole body fat mass	0.3	1.3	3.1	-1.8	0.2	-0.8
Had major operations	0.3	0.3	0.5	0.7	0.2	0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.1	-0.2	-1.1
Ever had bowel cancer screening	0.3	0.4	0.8	0.5	-0.3	0.9
Guilty feelings	0.3	0.5	1.4	1.2	0.1	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	0.1	0.2	0.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.3	0.3	0.9
Medication: Lisinopril	0.3	0.4	0.6	0.8	-0.4	0.5
Leg fat percentage (left)	0.3	1.2	3.3	-1.8	0.2	-0.5
Risk taking	0.3	0.4	0.6	0.6	0.5	-0.8
Heart disease (siblings)	0.3	0.3	0.8	0.2	0.9	-0.2
BMI	0.2	1.1	2.9	-1.7	-0.3	-0.5
Systolic Blood Pressure	0.2	0.9	1.5	1.1	0.0	1.2
Lung FEV1/FVC ratio	0.2	0.8	2.2	0.0	1.5	-0.5
Chronotype (morning person)	0.2	0.4	1.0	-1.0	0.4	0.3
Systolic blood pressure, automated reading	0.2	0.7	1.6	0.1	-1.2	0.7
Angina	0.2	0.3	0.7	-0.4	-0.8	-0.1
Qualifications: CSEs or equivalent	0.2	0.3	0.4	0.5	0.6	-0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.7	-0.3	0.0
Body mass index (BMI)	0.2	0.9	1.7	-1.3	-0.1	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	-0.0	0.9	0.3
Had other major operations	0.2	0.2	0.3	0.5	0.5	-0.2
Forced vital capacity (FVC)	0.2	0.7	1.3	0.7	-0.6	1.1
Qualifications: None of the above	0.2	0.5	0.7	-0.5	0.7	-0.9
Medication: Ramipril	0.2	0.2	0.5	0.7	-0.0	-0.2
Medication: Cholesterol lowering	0.2	0.2	0.4	-0.1	-0.6	0.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.7	0.2	0.8	0.4
Standing height	0.2	2.2	3.1	1.6	1.8	0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.1	0.3	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.9	0.9	0.6	0.0
Leg fat percentage (right)	0.2	0.8	1.7	-1.3	0.8	-0.5
Arm fat-free mass (right)	0.2	0.9	1.4	1.1	1.2	0.3
Pulse wave peak to peak time	0.2	0.2	0.5	-0.2	-0.7	-0.2
Angina (self-reported)	0.2	0.3	0.7	-0.4	-0.8	-0.0
Medication: Allopurinol	0.2	0.3	0.6	0.8	0.2	0.3
Leg fat mass (right)	0.2	0.8	1.2	-1.1	0.9	-0.6
Arm predicted mass (right)	0.2	1.1	1.7	1.3	1.3	0.1
Comparative height size at age 10	0.2	1.3	2.8	1.7	0.8	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.3	-0.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	0.4	-0.4	-0.7
Hypertension (Self-reported)	0.2	0.7	1.4	1.2	0.7	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.5	0.0	0.6
Smoking status: Previous	0.2	0.3	0.9	0.4	0.9	-0.1
Whole body fat-free mass	0.2	1.0	1.7	1.1	1.3	0.2
Whole body water mass	0.2	1.0	1.7	1.2	1.3	0.2
Arm fat-free mass (left)	0.2	1.0	1.8	1.0	1.4	-0.1
Number of operations (self-reported)	0.2	0.3	0.9	0.1	-0.3	0.9
Diastolic blood pressure, automated reading	0.2	0.5	1.0	-0.4	-0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.3	-0.4	-0.7
Leg fat mass (left)	0.2	0.8	1.8	-1.3	0.6	-0.5
Arm predicted mass (left)	0.2	0.9	1.6	1.1	1.3	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	-0.1	-0.6	-0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	-0.8	-0.3	-0.1
Coronary Artery Disease (CAD)	0.1	0.2	0.5	0.0	0.1	-0.7
Fasting Glucose	0.1	0.1	0.2	0.4	-0.0	-0.2
Blood Platelet Count	0.1	0.9	2.3	-0.2	0.5	1.5
Heel T-Score	0.1	1.0	2.1	-1.0	-1.5	0.0
Tanning	0.1	1.5	3.4	-1.8	-1.0	0.3
Hand grip strength (left)	0.1	0.2	0.5	-0.7	-0.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.2	-0.0	0.4
Vitamin and mineral supplements	0.1	0.1	0.2	-0.3	0.5	0.2
Supplements: Zinc	0.1	0.1	0.3	-0.6	0.2	-0.1
Diabetes (father)	0.1	0.2	0.3	0.4	0.3	0.5
Pack years adult smoking proportion	0.1	0.1	0.2	-0.3	0.1	-0.5
Leg fat-free mass (left)	0.1	0.5	1.4	0.3	1.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.4	0.5	0.0
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.1	0.1	-0.4
Leg predicted mass (left)	0.1	0.5	1.4	0.3	1.2	-0.1
Waist circumference	0.1	0.4	1.0	0.0	1.0	-0.2
Weight	0.1	0.3	0.6	-0.4	0.8	-0.4
Impedance of arm (right)	0.1	0.7	1.5	-1.2	-0.3	-0.6
Number of live births	0.1	0.1	0.2	-0.1	-0.5	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.9	0.5	-0.0	0.9
Asthma	0.1	0.2	0.4	0.3	0.1	-0.7
Depression (self-reported)	0.1	0.2	0.3	-0.1	0.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	0.7	-0.1	0.4
Impedance of arm (left)	0.1	0.7	1.6	-1.3	-0.6	-0.0
Hair/balding pattern: Pattern 4	0.1	0.3	0.4	0.7	-0.3	0.6
Birth weight of first child	0.1	0.1	0.4	-0.0	-0.2	0.6
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.4	0.0	-0.7
Loud music exposure frequency	0.1	0.2	0.4	0.2	0.6	0.2
Gout (self-reported)	0.1	0.1	0.3	0.1	-0.0	0.5
Birth weight	0.1	0.3	0.5	-0.4	-0.7	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	0.8	-0.3	0.4
Health satisfaction	0.1	0.1	0.3	0.6	-0.1	0.1
Shortness of breath walking on level ground	0.1	0.2	0.2	-0.4	0.4	-0.5
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.2	0.2	0.6
Pulse rate, automated reading	0.1	0.5	1.0	-0.0	1.0	-0.6
Leg pain on walking	0.1	0.1	0.2	-0.4	0.3	0.1
Friendships satisfaction	0.1	0.1	0.3	0.1	-0.5	0.4
Asthma (self-reported)	0.1	0.1	0.2	0.4	0.3	-0.3
High cholesterol (Self-reported)	0.1	0.2	0.3	0.5	0.5	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.2	0.1	-0.5
Basal metabolic rate	0.1	0.8	1.7	0.8	1.3	0.2
Impedance of whole body	0.1	0.3	0.6	-0.8	-0.4	0.1
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.3	-0.0	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.1	0.1	0.1	-0.4	-0.4
Height	0.0	0.8	1.5	0.9	1.2	-0.2
Hair Pigment	0.0	0.1	0.1	0.3	-0.3	0.3
Impedance of leg (right)	0.0	0.2	0.4	0.2	0.6	0.2
Impedance of leg (left)	0.0	0.2	0.4	-0.6	-0.2	0.3
Pulse rate	0.0	0.1	0.2	-0.0	0.2	-0.4
Noisy workplace	0.0	0.0	0.1	0.4	0.1	0.1
Pulse wave reflection index	0.0	0.1	0.1	-0.2	-0.4	0.1
Medication: Blood pressure	0.0	0.0	0.1	-0.3	-0.0	0.3
Leg fat-free mass (right)	0.0	0.2	0.6	0.1	0.8	0.2
Leg predicted mass (right)	0.0	0.2	0.5	0.0	0.7	0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.1	0.1	0.3	0.1
Pack years of smoking	0.0	0.0	0.0	-0.1	-0.1	-0.2

Hub : Genes

FGFR1OP

Models

Trait associations