TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Crohns Disease (2017)
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chr9:4,287,179-5,824,205
Best TWAS P=3.68e-14 · Best GWAS P=1.58e-16 conditioned to 0.00102
4.2M
4.4M
4.6M
4.8M
5M
5.2M
5.4M
5.6M
5.8M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
IGHEP2
0.08
0.07
enet
12
0.08
3.7e-10
7.4
-7.6
3.7e-14
-0.91
1.00
0.00
TRUE
2
YFS
Blood
JAK2
0.03
0.03
lasso
4
0.03
1.4e-10
-4.1
5.7
1.0e-08
0.71
0.99
0.01
FALSE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
JAK2
0.07
0.00
blup
83
0.02
2.2e-03
7.4
5.5
3.8e-08
0.70
0.03
0.08
FALSE