TWAS hub - JAK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0880	0.0270	2.6e-04	0.017	0.022	0.028	0.022	0.031	3.6e-03	9.0e-04	1.9e-04	9.5e-04	1.0e-04
2	GTEx	Esophagus Mucosa	0.1890	0.0610	1.7e-03	0.007	NA	0.019	NA	0.015	9.6e-02	NA	1.9e-02	NA	3.3e-02
3	GTEx	Nerve Tibial	0.1667	0.0684	7.2e-03	0.078	NA	0.066	NA	0.043	3.7e-06	NA	1.8e-05	NA	4.9e-04
4	YFS	Blood	0.0316	0.0103	1.9e-06	0.027	0.021	0.029	0.025	0.031	2.7e-09	1.3e-07	5.6e-10	1.2e-08	1.4e-10
5	TCGA	Lung Adenocarcinoma	0.0657	0.0447	6.6e-03	0.001	0.019	0.007	NA	0.001	2.7e-01	2.2e-03	4.9e-02	NA	2.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Platelet Count	18.8	218.3	524.4	-6.0	-13.7	-22.9	-18.0	-4.3
Irritable Bowel Disease (IBD)	11.5	27.3	60.8	2.8	4.7	1.8	7.8	6.5
Ulcerative Colitis (UC)	9.7	18.2	39.7	1.7	4.3	1.9	6.3	5.2
Crohns Disease (2017)	7.7	16.9	32.8	2.9	3.4	1.3	5.7	5.5
Ulcerative Colitis	6.3	9.2	24.4	1.2	3.0	1.0	4.9	3.2
Blood Eosinophil Count	5.7	43.6	163.8	2.0	3.7	-0.9	12.8	6.0
Crohns Disease (2012)	4.9	7.9	18.5	1.5	2.5	0.9	4.3	3.4
Blood Red Count	4.4	42.5	99.0	-9.9	-1.4	-8.5	4.7	4.2
Hayfever/allergic rhinitis (self-reported)	3.9	5.1	12.7	-0.2	2.1	-0.4	2.9	3.6
Allergy or Eczema	2.8	7.5	21.7	-0.0	0.7	-2.6	4.7	2.9
Hayfever, allergic rhinitis or eczema	2.8	6.0	15.2	-0.3	1.0	-2.0	3.9	3.2
Allergy	2.8	6.4	13.5	0.0	-0.7	2.3	-3.7	-3.6
Age at first live birth	2.6	4.6	15.3	-1.2	0.4	3.9	1.2	2.1
Type 2 Diabetes (T2D) (2012)	2.5	2.9	12.5	0.7	1.1	3.5	-0.1	0.5
Age at last live birth	2.5	3.6	10.5	-1.9	-0.1	3.2	-0.3	1.9
Commuting to job workplace: Car/motor vehicle	2.5	2.8	12.2	3.5	0.6	0.8	0.7	-0.7
Eye problems/disorders: Glaucoma	2.2	2.6	5.3	2.1	-1.7	0.7	-2.3	-0.4
Average weekly beer plus cider intake	2.2	3.2	11.5	-3.4	-0.8	-1.6	-0.7	-0.8
Relative age voice broke	2.0	3.1	13.0	-3.6	-0.4	0.8	0.9	0.8
Risk taking	2.0	3.0	10.3	-0.1	-0.1	0.5	-2.1	-3.2
Lupus	1.9	2.9	6.4	1.6	2.1	-0.2	2.5	0.9
Loud music exposure frequency	1.9	2.0	5.0	-1.4	0.6	-0.2	-2.2	-1.7
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	6.4	-0.6	-1.5	1.2	1.1	2.5
Supplements: Calcium	1.9	2.1	6.0	-0.2	-0.9	-1.9	0.3	-2.5
Asthma	1.8	3.5	7.7	0.8	-0.1	-2.3	2.8	2.1
Asthma (self-reported)	1.8	3.6	7.2	0.3	-0.3	-2.3	2.7	2.3
Pulse wave reflection index	1.7	2.1	5.0	0.5	0.3	-1.8	2.2	1.3
Illnesses of father: Heart disease	1.7	2.3	9.3	0.6	0.4	3.1	1.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	8.0	-1.2	-1.7	-2.8	-1.9	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	2.5	1.0	1.6	1.4	-1.0	-1.6
Eye problems/disorders: None of the above	1.6	1.9	2.5	-1.4	1.2	-1.6	1.6	1.1
Reaction Time	1.5	2.8	10.4	-0.5	-0.6	-0.5	1.6	3.2
Townsend deprivation index at recruitment	1.5	2.0	4.3	0.6	-1.5	1.1	-1.5	-2.1
Average weekly fortified wine intake	1.5	1.7	5.4	-0.7	1.6	2.3	-0.4	-0.0
Father’s age at death	1.5	2.0	3.7	1.9	-1.0	-1.0	-1.9	-0.8
Mean time to correctly identify matches	1.5	2.8	7.9	-0.8	-1.7	-1.0	1.4	2.8
Mean Putamen Volume	1.4	1.6	3.3	0.4	-0.7	1.7	-1.8	-0.9
Supplements: Zinc	1.4	1.5	3.3	0.2	-0.9	-1.6	1.0	-1.8
Qualifications: CSEs or equivalent	1.4	1.8	5.2	-1.8	0.4	0.6	2.3	-0.3
Glaucoma (self-reported)	1.4	1.7	7.8	2.8	0.1	0.7	-0.1	0.2
Medication: Seretide 50 evohaler	1.4	1.6	4.0	1.6	-0.8	0.9	-0.0	2.0
Osteoporosis (self-reported)	1.4	1.7	4.3	0.5	-1.9	-0.4	-2.1	-0.6
Blood White Count	1.3	9.7	17.1	-0.7	1.9	-3.9	4.1	3.5
High blood pressure (mother)	1.3	1.8	5.7	-0.0	-1.1	-2.4	-0.6	-1.2
Alcohol usually taken with meals	1.3	2.1	4.8	0.1	-0.1	2.2	1.8	1.5
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.7	-1.4	-0.3	-0.3	1.9	2.2
High blood pressure (siblings)	1.3	1.9	2.8	1.5	-1.0	1.2	-1.7	-1.3
Alzheimer’s Disease (in mother)	1.2	1.4	3.9	-2.0	-0.4	1.7	-0.6	-0.1
Prostate Cancer	1.2	1.7	5.6	0.5	1.2	2.4	0.7	-0.9
Serious illness, injury or assault to yourself	1.2	1.4	3.8	1.6	0.5	-0.6	-0.5	-1.9
Diabetes (self-reported)	1.2	1.8	6.1	0.9	-0.8	-1.0	-2.5	-0.9
Gout (self-reported)	1.2	1.7	3.9	-0.6	1.6	1.1	2.0	-0.4
Exposure to tobacco smoke outside home	1.2	1.6	3.1	-1.8	-1.5	-1.6	-0.0	0.2
Medication: Ibuprofen	1.2	1.4	5.8	-0.3	-0.1	2.4	-1.1	0.2
Suffer from ‘nerves’	1.2	1.8	3.4	-1.8	0.7	-1.8	-0.8	-1.2
Age started oral contraceptive pill	1.2	1.5	4.6	0.2	-1.5	-0.7	0.4	2.1
Unable to work because of sickness or disability	1.2	1.6	4.9	0.8	0.8	-0.4	2.2	1.2
Schizophrenia (2018)	1.1	2.2	5.8	0.4	-0.9	-1.3	-2.4	-1.6
Worry (Nagel 2018)	1.1	2.3	6.1	-2.0	0.6	-2.5	-0.8	-0.9
Type 2 Diabetes (T2D) (2018)	1.1	2.0	6.0	0.9	-0.1	-0.2	-2.5	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.8	-1.8	0.5	-2.0	-0.9	-0.5
Hearing difficulty/problems with background noise	1.1	1.7	4.1	-1.5	-0.9	-2.0	0.8	1.0
Medication: Lansoprazole	1.1	1.3	2.8	0.7	-1.2	-1.7	-0.5	-1.1
Prospective memory result	1.1	1.3	3.1	-0.4	1.2	-1.8	0.6	1.3
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.5	0.5	-0.9	-1.6	-0.8	-1.6
Medication: Blood pressure	1.1	1.9	5.6	1.4	-0.3	0.2	-1.3	-2.4
Friendships satisfaction	1.1	1.4	4.0	-0.0	-1.3	-1.0	-2.0	-0.2
Smoking status: Current	1.1	1.8	3.4	-1.9	0.5	-1.7	-1.0	-1.1
Wears glasses or contact lenses	1.1	1.2	2.7	1.6	-1.0	0.7	-0.6	1.3
Ever taken oral contraceptive pill	1.1	1.3	4.1	0.6	-0.7	-2.0	-1.1	-0.1
Respiratory disease	1.0	2.2	4.4	-0.1	-0.7	-2.1	1.6	1.9
Current tobacco smoking	1.0	1.6	2.6	-1.6	0.4	-1.6	-1.0	-1.2
Supplements: Glucosamine	1.0	1.4	2.2	-1.3	0.8	0.1	1.5	1.4
Chronic bronchitis/emphysema (father)	1.0	1.2	2.8	1.0	-0.3	-1.4	1.7	-0.4
Medication: Amlodipine	1.0	1.4	4.6	-0.4	0.5	-0.4	-1.4	-2.1
Number of full brothers	1.0	1.2	2.3	1.3	0.8	-1.0	1.5	0.6
Chest pain or discomfort	1.0	1.5	4.6	0.5	-2.1	-0.3	-0.0	1.6
Supplements: Vitamin C	1.0	1.1	3.1	0.6	1.1	1.0	1.8	-0.4
Long-standing illness, disability or infirmity	1.0	1.6	3.9	-0.6	0.6	-1.4	1.2	2.0
Average weekly champagne plus white wine intake	1.0	1.4	3.7	1.1	0.8	0.8	1.9	0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.6	-0.2	1.6	-1.2	1.1	-1.2
Heart disease (siblings)	1.0	1.2	3.0	0.5	0.6	0.7	1.4	1.7
Depression (Nagel 2018)	0.9	1.3	3.0	-1.0	0.4	-1.5	-0.5	-1.7
Vitamin and mineral supplements	0.9	1.2	3.6	0.1	-0.5	1.4	-0.7	1.9
Age when periods started (menarche)	0.9	2.3	3.9	-2.0	1.1	1.4	1.8	1.0
Nervous feelings	0.9	1.6	4.3	-2.1	0.3	-1.5	-0.3	-1.1
Had menopause	0.9	1.1	2.5	-1.4	-0.9	-0.2	-1.6	-0.5
Mouth/teeth dental problems: Dentures	0.9	1.4	3.3	-0.6	-0.8	-1.5	-1.8	-0.8
Birth weight of first child	0.9	1.6	3.6	-0.1	-1.0	-0.6	1.9	1.7
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.6	0.9	-0.1	-1.2	1.6	1.1
Medication: Allopurinol	0.9	1.1	3.3	-0.4	1.4	0.5	1.8	0.3
Handedness (chirality/laterality): Left-handed	0.9	1.0	4.9	0.2	-0.4	-0.1	-2.2	-0.1
Ever had bowel cancer screening	0.9	1.1	4.7	2.2	0.1	0.0	0.6	0.6
Qualifications: nursing, teaching	0.9	1.4	2.5	-1.6	1.4	0.8	-1.1	-0.8
Myopia	0.9	1.2	2.9	0.8	-0.9	-0.8	1.1	1.7
Ovarian Cancer	0.8	1.1	2.1	0.5	-0.9	1.1	-1.5	-0.9
Smoking Status	0.8	1.9	6.2	-1.3	-0.4	-0.2	-2.5	-1.3
Hypothyroidism (self reported)	0.8	1.8	3.3	-0.4	-1.0	-1.7	-1.3	-1.8
Sensitivity / hurt feelings	0.8	1.3	2.2	-0.8	-1.3	-1.5	-1.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.9	-2.2	0.3	-0.6	-0.3	-0.2
Number of incorrect matches in round	0.8	1.4	5.8	-0.6	-0.8	0.2	2.4	0.2
Financial difficulties in last 2 years	0.8	1.1	2.5	-0.3	0.1	-1.6	-1.2	-1.1
Medication: Simvastatin	0.8	1.2	4.2	0.3	1.2	-0.4	-2.0	-0.1
Neuroticism score	0.8	1.7	2.9	-1.2	-0.3	-1.7	-1.7	-1.1
Noisy workplace	0.8	1.0	2.8	-0.6	-0.6	-1.7	-0.4	-1.2
Hair/balding pattern: Pattern 4	0.8	1.9	2.9	-1.2	-1.7	1.0	-1.5	-1.5
Wheeze or whistling in the chest in last year	0.8	1.5	4.6	0.4	0.7	-0.5	2.1	1.3
Number of children fathered	0.8	1.0	2.7	0.4	0.2	-0.3	1.6	1.3
Emphysema/chronic bronchitis	0.8	0.9	3.2	1.8	0.0	0.1	-0.9	-0.6
Medication for pain relief, constipation, heartburn	0.8	1.3	2.0	-1.4	1.4	-0.7	1.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-0.3	-1.2	-0.9	-1.3	-0.8
Leg pain on walking	0.8	1.0	2.7	-0.7	0.4	0.9	1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	5.8	-0.3	-1.2	-2.4	-0.5	0.6
Eye problems/disorders: Cataract	0.8	0.9	2.6	0.7	-0.9	0.5	1.6	0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.3	0.2	-0.8	-0.3	0.8	2.3
Miserableness	0.8	1.4	2.3	-0.9	-1.2	-1.5	-0.9	-1.2
Ever depressed for a whole week	0.8	1.0	3.4	0.6	-0.5	1.8	0.8	-0.3
Commuting to job workplace: Cycle	0.8	1.0	3.7	-1.9	-0.7	-0.2	0.8	0.3
Alcohol drinker status: Previous	0.8	0.9	3.3	0.4	0.4	0.9	0.5	-1.8
Alzheimer’s Disease (including proxy)	0.7	1.0	2.5	-1.6	-1.0	0.9	-0.2	-0.7
Age at First Birth	0.7	1.0	2.9	0.5	-0.4	1.7	0.4	1.3
Neuroticism	0.7	1.7	2.7	-1.1	-0.6	-1.6	-1.5	-1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.3	-0.6	0.7	-0.9	-0.4	-1.8
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	1.3	-0.1	-0.4	1.5	-0.4
Ever had hysterectomy (womb removed)	0.7	0.8	3.0	-1.0	1.7	-0.1	-0.2	-0.3
Medication: Levothyroxine sodium	0.7	1.1	3.8	-1.2	-0.1	0.4	-0.3	-1.9
Falls in the last year	0.7	1.0	2.0	-0.2	0.7	1.4	0.8	1.3
Hair/balding pattern: Pattern 3	0.7	1.1	2.2	0.3	1.2	1.5	1.2	0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.6	7.0	-0.1	0.8	2.7	-0.1	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.3	0.4	-0.1	1.8	-0.9	-0.5
Illnesses of mother	0.7	0.8	3.8	-0.1	0.1	2.0	0.3	0.3
Exposure to tobacco smoke at home	0.7	0.7	1.4	-0.9	0.6	-1.0	-1.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.0	-0.2	-0.1	1.7	-0.4	1.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.7	-0.2	-0.7	-1.1	-1.0	-1.9
Medication: Omeprazole	0.7	0.9	2.2	0.8	-1.1	1.5	-0.2	0.4
Diabetes diagnosed by doctor	0.7	1.2	3.2	0.2	-0.8	-0.8	-1.8	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.2	-1.1	0.8	-0.5	-1.0	-0.7
Mineral and other dietary supplements	0.7	1.0	1.6	0.8	-0.9	1.3	-0.5	1.2
Medication: Gliclazide	0.7	0.8	1.7	-1.1	-0.5	0.9	-1.3	-0.0
Illnesses of father: None of the above (group 1)	0.7	0.9	2.2	-0.5	0.8	-1.5	-0.5	1.0
Financial situation satisfaction	0.7	0.9	2.6	0.5	0.8	-1.6	-0.1	-0.9
Commuting to job workplace: Public transport	0.7	0.9	2.3	-1.5	-0.9	0.4	-0.2	0.9
Medication: Paracetamol	0.7	1.1	3.2	0.6	0.8	1.1	-1.8	-0.1
Alcohol drinker status: Never	0.7	0.8	3.5	-0.7	0.1	-1.9	0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.1	-1.4	0.3	0.1	-1.3	-0.9
Coronary Artery Disease (CAD)	0.6	0.7	2.2	1.5	-0.8	-0.8	0.1	-0.3
HbA1C	0.6	0.7	2.6	0.1	-0.9	-0.1	-0.4	-1.6
Waist Hip Ratio (WHR)	0.6	2.9	8.3	-2.9	-0.6	-2.0	-1.2	0.6
Medication for hormone replacement therapy	0.6	0.6	1.3	0.2	-0.2	-1.1	-1.0	0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.0	-0.0	-0.3	-0.1	-0.6	1.7
Had other major operations	0.6	0.7	2.3	-0.6	-0.7	-0.2	-1.5	-0.6
Heart attack	0.6	0.8	1.7	-1.3	0.6	0.2	-1.2	-0.7
Worrier / anxious feelings	0.6	1.1	1.8	-1.3	1.1	-1.3	-0.6	0.7
Pulse rate	0.6	1.0	3.6	-0.5	0.3	0.9	-1.9	0.7
Breastfed as a baby	0.6	0.8	2.1	0.0	0.7	1.5	0.9	-0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	0.5	1.2	0.4	0.1	1.3
Illnesses of siblings: Diabetes	0.6	0.8	1.7	0.8	0.4	0.7	0.9	-1.3
Medication for cholesterol	0.6	0.9	3.3	0.5	-0.3	0.5	0.9	-1.8
Guilty feelings	0.6	0.8	2.2	0.2	-1.5	-1.1	-0.2	-0.9
Hearing aid user	0.6	0.7	1.9	0.4	1.1	-0.7	-1.4	0.0
Bipolar Disorder (2018)	0.5	0.8	2.1	-0.2	-0.9	-0.7	0.9	1.4
Bipolar Disorder or Schizophrenia	0.5	1.1	2.1	0.2	-1.3	-1.5	-1.3	-0.3
Neuroticism (Nagel 2018)	0.5	1.2	3.0	-1.7	-0.4	-1.6	-0.7	-0.2
Bipolar Disorder (2011)	0.5	0.5	2.1	0.4	-1.4	-0.3	0.1	-0.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.5	1.2	-0.9	1.0	-0.1	0.1
HDL Cholesterol	0.5	0.8	1.9	-0.7	1.0	0.0	1.4	0.6
Cardiovascular Disease	0.5	1.8	6.1	-1.0	0.5	0.6	-2.5	-1.2
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-1.2	0.1	-0.9	-0.5	-1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.8	1.7	-0.3	-0.5	-0.2	0.4
Angina	0.5	0.6	1.4	-0.5	-1.2	-0.3	-1.1	-0.3
Trunk fat percentage	0.5	2.0	4.8	-1.3	-0.2	-2.2	-0.1	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.8	0.8	0.1	0.2	-1.3	-1.9
Stomach or abdominal pain in last month	0.5	0.6	1.3	0.3	0.0	-0.7	-1.2	-1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	0.8	1.0	0.9	0.3	0.2
Qualifications: None of the above	0.5	1.0	4.0	0.9	0.1	-2.0	0.4	-0.3
Illnesses of siblings	0.5	0.7	1.6	-1.2	0.3	-1.1	-0.2	0.6
Number of live births	0.5	0.7	1.7	-1.0	1.0	-0.1	0.3	-1.3
Medication: Cholesterol lowering	0.5	0.7	1.9	0.3	1.4	0.6	-0.6	-1.0
Lung cancer (father)	0.5	0.6	1.8	1.3	-0.2	-0.7	0.8	-0.1
Medication: Paracetamol	0.5	0.9	2.8	0.7	0.3	0.9	-1.7	-0.4
Leg fat percentage (right)	0.5	1.8	3.9	-2.0	0.5	-1.6	-1.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.3	0.3	-0.1	0.6	1.5	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.1	0.4	0.6	-0.1	-0.1	1.5
Overall health rating	0.5	1.0	3.1	0.3	0.5	-1.8	-1.2	0.1
Family relationship satisfaction	0.5	0.6	1.6	-0.2	-0.8	-0.7	-1.3	0.1
Smoking status: Previous	0.5	0.7	3.2	0.4	-0.0	1.8	-0.4	-0.4
Mood swings	0.5	1.0	2.9	-1.7	-0.3	1.1	-0.6	-0.7
Loneliness, isolation	0.5	0.7	1.1	-0.9	-1.1	-0.5	-0.9	0.8
Commuting to job workplace: Walk	0.5	0.5	1.3	-1.1	1.1	-0.1	-0.2	0.0
Leg fat percentage (left)	0.5	1.7	3.0	-1.7	0.5	-1.6	-1.3	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	0.1	0.6	-0.2	-1.3	0.9
Fractured/broken bones in last 5 years	0.5	0.7	1.8	0.0	1.1	-0.2	1.3	0.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.8	0.7	-0.4	1.3	0.2	0.9
Depressed Affect (Nagel 2018)	0.4	0.8	2.4	-1.6	-0.5	-0.3	-1.1	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.7	-1.4	-1.2	-0.3	-0.8	-1.6
Alzheimer’s Disease (in father)	0.4	0.4	1.1	0.2	-1.1	-0.2	-0.4	-0.8
Major Depression (MDD)	0.4	0.5	2.3	0.2	1.5	-0.3	0.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.0	-0.7	-0.7	0.4	-1.3	-1.4
LDL Cholesterol	0.4	0.7	1.5	-0.2	-0.8	1.0	-1.2	0.0
Neuroticism (2016)	0.4	0.5	2.0	-0.3	-0.7	-1.4	-0.1	-0.1
Heel T-Score	0.4	3.3	6.8	-2.0	1.4	0.9	-1.7	-2.6
Lung FEV1/FVC ratio	0.4	2.2	4.9	-0.2	-1.7	0.2	-1.8	-2.2
Lung FVC	0.4	2.3	4.1	1.4	-0.7	-1.1	-1.9	-2.0
Chronotype (morning person)	0.4	0.9	2.7	-1.6	0.9	-0.8	0.3	0.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.2	0.7	-0.6	0.5	-1.1	-0.0
Medication: Co-codamol	0.4	0.5	0.8	-0.4	-0.7	0.5	-0.8	-0.9
Diabetes (father)	0.4	0.4	2.1	0.2	-0.1	0.2	-1.4	0.1
Fed-up feelings	0.4	0.8	1.7	-0.5	-0.8	-0.7	-1.3	-0.9
High blood pressure	0.4	1.0	3.5	0.4	0.4	0.4	-1.9	-1.0
Multivitamins +/- minerals	0.4	0.6	1.1	-0.9	-0.1	-1.1	-0.0	-1.0
Trunk fat mass	0.4	1.8	3.6	-1.3	-0.2	-1.8	-0.5	1.9
Waist circumference	0.4	1.4	3.1	-1.8	-0.6	-1.1	-1.4	0.6
Hair/balding pattern: Pattern 2	0.4	0.6	1.0	1.0	0.6	-0.6	-0.3	1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.6	-0.9	1.0	0.6	0.3
Impedance of arm (right)	0.4	2.1	5.5	-1.6	-1.3	-0.4	2.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	-0.9	-0.7	-1.3	-0.3	0.4
Happiness	0.4	0.5	1.2	0.8	-0.1	-0.6	-0.5	-1.1
Depression (self-reported)	0.4	0.4	1.1	0.3	-0.6	-1.0	0.3	-0.7
Impedance of arm (left)	0.4	1.8	4.0	-1.8	-0.6	-0.9	2.0	0.7
Length of working week for main job	0.4	0.4	1.2	-0.4	-0.3	-0.4	-1.1	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	-0.6	0.9	-1.3	-0.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.5	-0.1	-0.3	0.4	1.2	1.0
Birth weight	0.4	1.0	3.6	-1.9	-0.9	0.4	-0.4	0.3
Body fat percentage	0.4	1.6	3.5	-1.5	-0.1	-1.9	-0.5	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	0.1	0.1	-1.0	-0.1	-1.2
Pulse wave peak to peak time	0.4	0.4	1.5	-0.1	-0.6	0.3	-0.4	-1.2
Health satisfaction	0.4	0.5	0.9	0.7	0.0	-0.9	-0.9	-0.7
Qualifications: College or University degree	0.4	1.3	3.0	-0.9	0.8	1.7	1.4	0.6
Neck or shoulder pain in last month	0.4	0.5	1.4	-0.8	0.2	-1.2	0.8	-0.2
Angina (self-reported)	0.4	0.6	1.6	-0.6	-1.3	-0.4	-0.8	-0.1
Whole body fat mass	0.4	1.5	2.8	-1.3	0.1	-1.6	-0.7	1.7
Leg fat mass (right)	0.4	1.6	2.8	-1.7	0.4	-1.4	-0.9	1.6
Alcohol intake frequency.	0.4	0.9	2.8	-1.7	0.6	-1.2	-0.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.9	0.7	-1.4	0.1	0.2	-0.5
Back pain experienced in last month	0.4	0.5	1.1	0.5	1.0	-1.0	0.3	0.5
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.6	0.6	0.7	1.0	-0.6
Mother’s age at death	0.4	0.5	1.1	1.0	-0.3	0.7	0.3	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	-0.4	0.4	0.7	1.0	0.9
High cholesterol (Self-reported)	0.4	0.7	3.0	-0.7	1.7	-0.1	0.0	-0.4
Number of operations (self-reported)	0.4	0.6	1.0	-0.7	-1.0	-0.8	-0.8	-0.5
Irritability	0.4	0.6	2.1	-0.7	0.5	0.1	0.1	1.5
Basal cell carcinoma (self-reported)	0.4	0.5	0.8	-0.9	-0.2	0.9	-0.1	0.9
Leg fat mass (left)	0.4	1.7	3.1	-1.5	0.5	-1.4	-1.0	1.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	-0.3	-0.0	0.7	-1.0	-0.4
Fasting Glucose	0.3	0.3	1.4	-0.3	-1.2	-0.5	0.1	-0.1
Primary Biliary Cirrhosis	0.3	0.5	2.3	-0.2	0.1	-0.3	-0.1	-1.5
Rheumatoid Arthritis	0.3	0.4	0.8	0.9	0.9	-0.4	0.7	-0.2
Triglycerides	0.3	0.4	1.1	1.1	0.5	-0.3	-0.6	0.5
Average weekly spirits intake	0.3	0.4	1.1	0.4	0.4	-0.1	-0.6	-1.1
Relative age of first facial hair	0.3	0.7	3.2	-1.8	-0.4	0.1	-0.2	0.1
Medication: Metformin	0.3	0.4	1.6	-0.6	-0.0	-0.2	-0.2	1.3
Taking other prescription medications	0.3	0.5	1.5	0.4	-0.1	-0.3	1.2	0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.1	0.7	-0.4	-0.2	-1.0	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.7	1.3	0.4	0.3	0.1	-1.2
Mouth/teeth dental problems	0.3	0.4	0.7	0.4	0.8	0.4	0.8	-0.6
Time employed in main current job	0.3	0.3	0.9	-0.1	1.0	0.5	-0.4	0.4
Alcohol intake versus 10 years previously	0.3	0.5	1.5	0.6	-1.2	-0.3	0.4	0.6
Pulse wave Arterial Stiffness index	0.3	0.4	1.3	0.2	0.5	-0.1	0.6	1.1
Tense / ‘highly strung’	0.3	0.5	0.9	-0.9	0.7	-0.9	0.0	-0.4
Comparative body size at age 10	0.3	0.8	1.5	0.8	0.9	1.2	-1.0	-0.2
Shortness of breath walking on level ground	0.3	0.4	0.9	0.5	-1.0	-0.2	-0.0	-0.8
Migraine (self-reported)	0.3	0.4	1.2	-0.2	1.1	0.7	-0.6	-0.3
Pulse rate, automated reading	0.3	1.0	2.9	-1.1	-0.1	-0.7	-1.7	0.6
Comparative height size at age 10	0.3	1.8	3.6	-1.9	0.1	0.6	1.3	1.8
Number of full sisters	0.3	0.4	1.9	-0.3	0.1	1.4	0.2	0.3
Had major operations	0.3	0.4	0.6	-0.7	0.7	0.5	-0.5	0.7
Knee pain experienced in last month	0.3	0.4	1.7	-0.1	0.2	0.1	1.3	0.5
Hypertension (Self-reported)	0.3	0.9	2.2	-0.0	0.7	0.7	-1.5	-1.1
Arm fat percentage (left)	0.3	1.1	2.6	-1.0	0.2	-1.6	-0.1	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.7	-0.1	0.4	-0.3	0.4	-1.3
Arm fat mass (left)	0.3	1.1	2.4	-0.9	0.4	-1.3	-0.5	1.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	1.0	0.1	-0.3	-0.4	-0.6
Medication: Bendroflumethiazide	0.3	0.5	1.1	-0.4	0.7	1.1	-0.8	0.3
Medication: Lisinopril	0.3	0.4	1.4	-0.7	-0.2	1.2	-0.2	-0.6
Medication: Atorvastatin	0.3	0.4	1.4	-0.1	-0.1	0.4	0.5	-1.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.0	0.1	-0.4	-0.7	1.7	0.7
Pain experienced in last month	0.3	0.6	2.6	0.5	0.1	1.6	0.3	0.1
Breast Cancer	0.2	0.5	1.1	0.9	0.7	-0.3	1.0	0.3
Schizophrenia (2014)	0.2	0.5	2.0	-0.4	0.1	0.1	-1.4	-0.4
Hand grip strength (left)	0.2	0.5	1.9	0.7	0.5	1.4	-0.1	0.4
Number of treatments/medications taken	0.2	0.4	0.9	0.6	0.8	0.1	-1.0	-0.2
Diabetes (mother)	0.2	0.3	0.7	0.8	0.6	0.1	0.0	0.6
Severe depression (siblings)	0.2	0.2	0.4	-0.2	0.4	-0.0	0.7	-0.6
Leg fat-free mass (left)	0.2	1.0	4.5	-0.4	0.4	-0.3	-0.1	2.1
Hand grip strength (right)	0.2	0.5	1.4	0.7	0.2	1.2	0.2	0.7
Maternal smoking around birth	0.2	0.3	0.7	-0.4	-0.2	0.7	-0.8	-0.1
Medication: Atenolol	0.2	0.2	0.6	0.2	0.4	0.4	-0.2	-0.8
Sitting height	0.2	1.2	3.3	1.1	-1.1	-0.1	-0.5	1.8
Body mass index (BMI)	0.2	0.7	1.4	-0.5	0.5	-1.1	-1.2	0.7
Leg predicted mass (left)	0.2	1.0	4.6	-0.3	0.4	-0.3	0.0	2.1
Past tobacco smoking	0.2	0.3	1.0	0.2	-0.1	-1.0	0.7	0.2
Pain all over the body in last month	0.2	0.2	0.5	-0.7	0.3	0.1	0.2	-0.5
Fluid intelligence score	0.2	0.4	0.9	-0.4	-1.0	-0.2	-0.7	-0.7
Weight	0.2	1.1	2.9	-1.2	0.1	-0.8	-0.9	1.7
Arm fat percentage (right)	0.2	0.8	2.0	-0.9	-0.0	-1.4	0.1	1.1
Hip circumference	0.2	0.8	1.4	-1.1	-0.8	-0.4	-0.6	1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.4	-0.4	-1.0	1.2	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.0	-0.1	-0.9	-0.1	-1.4	-1.0
Arm fat mass (right)	0.2	0.8	2.4	-0.8	0.4	-1.0	-0.2	1.6
Standing height	0.2	1.7	5.0	-1.6	-0.5	0.7	0.6	2.2
Peak expiratory flow (PEF)	0.2	0.5	1.1	0.6	-0.8	0.2	0.5	1.0
Headache pain in last month	0.2	0.3	0.8	-0.0	-0.3	0.1	-0.8	0.9
Arm fat-free mass (right)	0.2	0.9	2.4	-0.3	0.7	0.0	-1.2	1.5
Worry too long after embarrassment	0.2	0.4	1.3	0.2	-0.1	-0.8	-1.1	-0.0
Arm predicted mass (right)	0.2	0.9	2.9	-0.4	0.7	-0.0	-1.1	1.7
Leg fat-free mass (right)	0.2	1.1	5.1	-0.2	0.4	-0.1	0.0	2.3
Average weekly red wine intake	0.2	0.3	0.7	0.4	-0.5	-0.4	-0.4	-0.8
Breast cancer (self-reported)	0.2	0.2	0.3	-0.5	-0.4	-0.1	0.5	0.6
Medication: Aspirin	0.2	0.3	0.4	0.6	-0.6	-0.5	-0.5	-0.4
Leg predicted mass (right)	0.2	1.1	5.3	-0.1	0.4	-0.1	0.0	2.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.1	-0.2	-1.0	-0.7	-0.2	-0.4
Illnesses of father: High blood pressure	0.2	0.2	0.6	-0.5	-0.0	0.8	-0.3	-0.3
Ever smoked	0.2	0.4	0.7	-0.5	0.9	0.3	-0.8	0.2
Diastolic blood pressure, automated reading	0.2	0.6	1.2	-0.9	-0.5	0.6	-0.5	1.1
Cholesterol lowering medication	0.2	0.3	0.7	0.6	0.8	0.0	-0.5	0.3
Impedance of whole body	0.2	1.1	2.6	-1.6	-0.4	-0.5	1.5	0.5
Arm predicted mass (left)	0.2	0.8	3.0	0.0	0.5	0.4	-0.8	1.7
BMI	0.1	0.6	2.5	0.0	0.2	0.8	-1.6	-0.3
Height	0.1	1.0	2.9	0.6	-0.1	0.7	1.2	1.7
Systolic Blood Pressure	0.1	0.7	1.2	-0.8	-0.7	0.9	-0.6	-1.1
Tanning	0.1	0.9	1.8	-1.2	-1.3	-0.5	-0.9	0.4
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.7	-0.3	0.9	-0.2	0.3
Impedance of leg (right)	0.1	0.7	2.5	-1.6	-0.2	-0.6	0.2	-0.7
Impedance of leg (left)	0.1	0.4	1.8	-1.4	0.0	-0.3	0.1	-0.2
Forced vital capacity (FVC)	0.1	0.4	1.0	-1.0	-0.2	0.9	-0.3	0.4
Medication: Ramipril	0.1	0.2	0.4	0.1	0.5	0.2	-0.6	-0.3
Trunk fat-free mass	0.1	0.6	1.2	-0.2	0.6	0.8	-1.0	1.1
Trunk predicted mass	0.1	0.7	1.4	-0.2	0.6	0.8	-0.8	1.2
Blood clot in the leg (DVT)	0.1	0.1	0.1	0.1	-0.0	0.3	0.4	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	-0.1	-0.6	-0.8	-0.8	0.0
Heart disease (mother)	0.1	0.1	0.3	0.6	-0.0	-0.5	0.1	0.2
Medication: Aspirin	0.1	0.1	0.5	0.7	-0.5	-0.2	-0.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.1	-0.0	0.6	-0.5	-0.1
Whole body fat-free mass	0.1	0.7	2.7	-0.2	0.6	0.4	-0.6	1.7
Whole body water mass	0.1	0.8	2.9	-0.2	0.5	0.4	-0.6	1.7
Medication: Blood pressure	0.1	0.2	0.6	-0.8	0.4	-0.0	-0.6	-0.1
Basal metabolic rate	0.1	0.8	3.3	-0.4	0.5	-0.0	-0.5	1.8
Arm fat-free mass (left)	0.1	0.7	2.2	-0.1	0.6	0.5	-0.8	1.5
Hair Pigment	0.0	0.7	2.2	1.5	-0.3	0.3	1.1	-0.2
Pack years adult smoking proportion	0.0	0.1	0.2	-0.3	0.4	0.3	-0.1	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.1	0.2	0.3	0.0	0.1
Pack years of smoking	0.0	0.1	0.1	-0.4	0.3	0.1	-0.1	0.0

Hub : Genes

JAK2

Models

Trait associations