TWAS
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Traits
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Traits
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Crohns Disease (2017)
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chr9:116,849,447-118,389,134
Best TWAS P=4.26e-21 · Best GWAS P=1.75e-21 conditioned to 0.0461
116.8M
117M
117.2M
117.4M
117.6M
117.8M
118M
118.2M
118.4M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
METSIM
Adipose
TNFSF15
0.05
0.06
lasso
3
0.06
5.4e-09
-9.2
-9.4
4.3e-21
0.82
0.03
0.97
TRUE
2
NTR
Blood
TNFSF8
0.05
0.04
enet
4
0.04
2.3e-13
6.7
-5.7
1.3e-08
0.11
1.00
0.00
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
TNFSF15
0.02
0.01
blup
54
0.01
7.6e-03
-9.2
-9.2
3.6e-20
0.73
0.01
0.62
FALSE