TWAS
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Traits
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Traits
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Crohns Disease (2017)
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chr10:34,607,015-36,198,981
Best TWAS P=8.6e-15 · Best GWAS P=6.34e-15 conditioned to 1
34.6M
34.8M
35M
35.2M
35.4M
35.6M
35.8M
36M
36.2M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
CUL2
0.02
0.02
blup
64
0.01
7.6e-02
7.7
-7.8
8.6e-15
-0.99
0.03
0.88
TRUE
1
GTEx
Cells EBV-transformed lymphocytes
CREM
0.15
0.12
enet
11
0.15
1.3e-05
7.7
-7.7
1.9e-14
-0.98
0.05
0.94
FALSE
3
NTR
Blood
CUL2
0.04
0.09
lasso
13
0.09
4.4e-26
7.6
-7.6
3.4e-14
-0.99
0.04
0.96
FALSE
2
GTEx
Cells Transformed fibroblasts
CREM
0.06
0.03
enet
3
0.03
1.6e-03
5.2
-7.3
2.8e-13
-0.87
0.05
0.83
FALSE
4
ROSMAP
Brain Pre-frontal Cortex
CREM
0.03
0.02
enet
26
0.03
3.3e-05
7.7
-6.3
3.0e-10
-0.88
0.04
0.95
FALSE