Best TWAS P=8.6e-15 · Best GWAS P=6.34e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | CREM | 0.15 | 0.12 | enet | 11 | 0.15 | 1.3e-05 | 7.7 | -7.7 | 1.9e-14 | -0.98 | 0.05 | 0.94 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CREM | 0.06 | 0.03 | enet | 3 | 0.03 | 1.6e-03 | 5.2 | -7.3 | 2.8e-13 | -0.87 | 0.05 | 0.83 | FALSE |
| 3 | NTR | Blood | CUL2 | 0.04 | 0.09 | lasso | 13 | 0.09 | 4.4e-26 | 7.6 | -7.6 | 3.4e-14 | -0.99 | 0.04 | 0.96 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | CREM | 0.03 | 0.02 | enet | 26 | 0.03 | 3.3e-05 | 7.7 | -6.3 | 3.0e-10 | -0.88 | 0.04 | 0.95 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CUL2 | 0.02 | 0.02 | blup | 64 | 0.01 | 7.6e-02 | 7.7 | -7.8 | 8.6e-15 | -0.99 | 0.03 | 0.88 | TRUE |