TWAS hub - CREM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.1530	0.064	0.00014	0.122	NA	0.151	NA	0.126	0.00009	NA	1.2e-05	NA	6.9e-05
2	GTEx	Cells Transformed fibroblasts	0.0560	0.029	0.00540	0.032	NA	0.033	NA	0.032	0.00180	NA	1.6e-03	NA	1.9e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.0347	0.016	0.00038	0.019	0.022	0.033	0.024	0.025	0.00160	0.00058	3.3e-05	0.00037	3.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Crohns Disease (2017)	23.0	50.6	58.6	-7.7	-7.3	-6.3
Crohns Disease (2012)	19.4	31.2	35.9	-6.0	-5.9	-4.8
Irritable Bowel Disease (IBD)	17.6	41.8	49.2	-6.9	-7.0	-5.4
Ulcerative Colitis	14.1	20.4	24.4	-4.7	-4.9	-3.9
Frequency of depressed mood in last 2 weeks	10.1	14.1	20.7	-3.4	-4.5	-3.2
Relative age of first facial hair	8.5	17.5	21.0	-4.1	-4.6	-3.8
Asthma	7.8	15.4	17.2	-3.9	-4.2	-3.7
Asthma (self-reported)	7.7	15.3	17.7	-3.9	-4.2	-3.6
Lupus	7.6	11.4	14.8	-3.2	-3.9	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	7.0	9.3	12.1	-2.8	-3.5	-2.8
Medication: Seretide 50 evohaler	6.8	7.8	12.5	-2.7	-3.5	-1.9
Frequency of tiredness / lethargy in last 2 weeks	6.7	10.9	14.8	-3.3	-3.8	-2.7
Loneliness, isolation	6.5	9.0	17.0	-2.7	-4.1	-1.7
Ulcerative Colitis (UC)	5.8	10.9	13.8	-3.5	-3.7	-2.6
Birth weight of first child	5.8	10.5	12.5	-3.3	-3.5	-2.8
Eye problems/disorders: Glaucoma	5.7	6.7	7.5	2.7	2.5	2.5
Medication: Ventolin 100micrograms inhaler	5.6	7.2	10.3	-2.9	-3.2	-1.7
Mother’s age at death	5.5	6.9	7.9	2.8	2.5	2.5
Fed-up feelings	5.3	9.7	18.3	-2.8	-4.3	-1.7
Medication: Atenolol	5.0	6.2	8.1	2.4	2.2	2.8
Headache pain in last month	5.0	8.6	11.1	-2.8	-3.3	-2.7
Frequency of tenseness / restlessness in last 2 weeks	4.9	7.7	10.8	-2.5	-3.3	-2.4
Neuroticism	4.5	10.8	20.5	-2.9	-4.5	-1.8
Hair Pigment	4.5	128.2	151.3	-12.3	-10.6	-11.0
Vascular/heart problems diagnosed by doctor	4.5	12.3	15.8	-3.2	-4.0	-3.3
Blood Eosinophil Count	4.3	33.4	41.3	-6.4	-5.7	-5.1
High blood pressure	4.2	11.7	14.4	3.1	3.8	3.3
Illnesses of mother	4.1	5.0	5.2	-2.3	-2.2	-2.3
Medication: Blood pressure	4.1	7.3	8.7	2.2	2.9	2.9
Relative age voice broke	4.0	6.2	10.5	-2.3	-3.2	-1.7
Medication: Blood pressure	4.0	7.6	8.7	2.8	2.5	2.9
Depression (Nagel 2018)	3.9	5.9	8.8	-2.2	-3.0	-2.0
Medication: Ibuprofen	3.9	4.7	7.9	-1.7	-2.8	-1.8
Medication: Metformin	3.8	5.3	5.8	-2.4	-2.3	-2.2
Overall health rating	3.8	8.1	10.5	-3.2	-3.1	-2.1
Neuroticism score	3.6	7.6	15.0	-2.3	-3.9	-1.6
Smoking Status	3.4	8.2	12.7	2.8	2.0	3.6
Had other major operations	3.4	4.1	6.5	1.8	1.6	2.5
Worrier / anxious feelings	3.4	6.5	14.2	-2.0	-3.8	-1.1
Medication for cholesterol, blood pressure or diabetes	3.3	5.4	7.9	-1.9	-2.8	-2.1
Systolic Blood Pressure	3.2	16.2	18.7	4.3	4.2	3.6
Hypertension (Self-reported)	3.2	8.8	12.2	2.6	3.5	2.7
Neuroticism (Nagel 2018)	3.0	7.2	15.6	-2.0	-3.9	-1.4
Average weekly red wine intake	3.0	4.4	5.1	-2.3	-2.0	-2.0
Verbal and Numeric Reasoning (VNR)	2.9	7.0	8.5	2.9	2.3	2.7
Cardiovascular Disease	2.9	9.6	10.9	2.9	3.3	3.1
Nervous feelings	2.9	5.4	6.6	-1.9	-2.6	-2.5
Fluid intelligence score	2.9	6.0	8.1	2.8	1.7	2.7
Pulse wave reflection index	2.9	3.6	4.3	1.9	2.1	1.8
Number of operations (self-reported)	2.9	4.3	5.4	2.0	1.9	2.3
Number of full sisters	2.8	3.5	4.4	-1.6	-1.9	-2.1
Age when periods started (menarche)	2.7	6.4	8.2	-2.9	-2.8	-1.9
Father’s age at death	2.7	3.7	4.9	2.2	2.1	1.3
Birth weight	2.7	5.9	8.3	-2.5	-2.9	-1.7
Worry (Nagel 2018)	2.6	5.5	10.0	-1.9	-3.2	-1.7
Respiratory disease	2.6	5.7	9.6	-2.2	-3.1	-1.6
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	4.6	-2.2	-2.1	-1.2
Supplements: Glucosamine	2.6	3.4	6.2	1.8	0.8	2.5
Shortness of breath walking on level ground	2.6	3.0	4.5	-1.9	-2.1	-1.1
Mood swings	2.6	4.7	8.5	-1.7	-2.9	-1.6
Glaucoma (self-reported)	2.5	2.9	3.8	1.9	1.9	1.2
Medication: Omeprazole	2.5	3.0	3.9	1.8	2.0	1.3
Ever smoked	2.5	4.4	7.7	2.0	1.2	2.8
Alcohol drinker status: Previous	2.5	2.8	2.9	-1.7	-1.6	-1.7
Primary Biliary Cirrhosis	2.4	3.4	4.6	-2.1	-1.3	-2.0
Type 2 Diabetes (T2D) (2012)	2.4	2.7	3.6	-1.6	-1.4	-1.9
Current tobacco smoking	2.4	4.0	6.3	2.0	1.4	2.5
Number of incorrect matches in round	2.4	4.0	6.6	-2.1	-0.9	-2.6
Financial difficulties in last 2 years	2.4	3.3	3.5	-1.9	-1.8	-1.7
Smoking status: Current	2.3	3.7	6.3	1.8	1.2	2.5
Impedance of arm (right)	2.2	10.4	13.8	-3.1	-2.8	-3.7
Worry too long after embarrassment	2.2	3.7	7.3	-1.5	-2.7	-1.2
Medication: Atorvastatin	2.2	2.7	3.9	1.5	1.5	2.0
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	5.5	-1.0	-2.3	-1.2
Wheeze or whistling in the chest in last year	2.1	3.7	7.6	-1.7	-2.8	-0.9
Friendships satisfaction	2.1	2.6	3.1	-1.5	-1.8	-1.6
Systolic blood pressure, automated reading	2.0	5.8	6.8	2.6	2.4	2.2
High blood pressure (siblings)	2.0	2.9	3.4	1.8	1.5	1.8
Guilty feelings	2.0	3.0	6.2	-1.4	-2.5	-1.0
Bipolar Disorder (2011)	1.9	1.8	2.8	-1.7	-0.9	-1.4
Falls in the last year	1.9	2.6	3.9	1.6	2.0	1.1
Had major operations	1.9	2.2	3.5	1.4	1.9	1.2
Diabetes diagnosed by doctor	1.9	3.2	3.5	-1.9	-1.8	-1.7
Depressed Affect (Nagel 2018)	1.8	3.9	8.8	-1.5	-3.0	-0.7
Hand grip strength (left)	1.8	4.7	6.6	1.7	2.6	2.1
Impedance of leg (right)	1.8	8.8	12.0	-2.7	-2.6	-3.5
Family relationship satisfaction	1.8	2.2	3.5	-1.3	-1.9	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	2.3	1.5	1.5	1.4
Qualifications: A levels/AS levels or equivalent	1.7	3.7	5.3	1.7	1.6	2.3
Tense / ‘highly strung’	1.7	2.8	3.6	-1.3	-1.7	-1.9
Age at last live birth	1.7	2.4	4.9	-1.4	-0.7	-2.2
Vitamin and mineral supplements	1.6	2.2	3.1	1.0	1.8	1.5
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.0	1.4	0.8	1.7
Allergy	1.6	3.7	6.2	1.8	2.5	1.3
Chest pain or discomfort	1.6	2.3	3.3	-1.5	-1.2	-1.8
Intelligence (Savage-Jansen 2018)	1.5	4.6	5.6	2.3	1.7	2.4
Severe depression (siblings)	1.5	1.7	2.1	1.5	1.4	0.9
Past tobacco smoking	1.5	2.8	5.5	-1.5	-0.8	-2.3
Ovarian Cancer	1.4	1.8	2.4	-1.5	-1.2	-1.3
Diabetes (self-reported)	1.4	2.2	3.3	-1.5	-1.8	-1.0
Medication: Cholesterol lowering	1.4	2.2	3.7	1.1	1.9	1.3
Heart disease (mother)	1.4	1.7	2.9	0.9	1.7	1.2
Alcohol intake frequency.	1.4	3.3	3.8	-1.9	-1.7	-1.8
Wears glasses or contact lenses	1.4	1.6	1.7	1.2	1.2	1.3
Diastolic blood pressure, automated reading	1.4	4.5	5.5	2.3	2.2	1.8
Sensitivity / hurt feelings	1.3	2.3	5.0	-0.9	-2.2	-1.0
Hayfever, allergic rhinitis or eczema	1.3	2.9	6.1	-1.2	-2.5	-1.0
High blood pressure (mother)	1.3	1.8	2.7	1.6	1.3	1.0
Impedance of arm (left)	1.3	5.8	8.1	-2.4	-1.9	-2.8
Number of full brothers	1.3	1.6	2.6	1.6	1.0	1.1
Commuting to job workplace: Car/motor vehicle	1.3	1.4	1.6	1.1	1.3	1.2
Commuting to job workplace: Walk	1.3	1.4	2.2	-1.2	-0.8	-1.5
Pain experienced in last month	1.3	2.2	4.2	1.5	2.0	0.5
Impedance of leg (left)	1.2	5.7	7.4	-2.1	-2.3	-2.7
Loud music exposure frequency	1.2	1.3	1.8	1.1	0.9	1.3
Qualifications: College or University degree	1.2	3.6	4.5	-2.1	-1.7	-1.9
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	-1.3	-1.6	-0.4
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.5	-1.6	-1.2	-0.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.2	0.7	1.8	0.7
Medication: Lisinopril	1.2	1.5	2.0	1.0	1.4	1.2
Illnesses of father: High blood pressure	1.2	1.5	1.7	1.1	1.3	1.3
Basal cell carcinoma (self-reported)	1.2	1.5	2.0	1.4	0.6	1.4
Major Depression (MDD)	1.1	1.4	2.8	-1.0	-0.7	-1.7
Allergy or Eczema	1.1	2.8	4.9	-1.3	-2.2	-1.3
Taking other prescription medications	1.1	1.7	2.9	-1.4	-1.7	-0.7
Qualifications: CSEs or equivalent	1.1	1.5	3.0	-0.6	-1.7	-1.0
Pulse wave peak to peak time	1.1	1.3	2.4	-0.9	-0.7	-1.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.7	0.9	1.6	0.5
Medication: Allopurinol	1.1	1.4	2.5	0.9	1.0	1.6
Osteoarthritis (self-reported)	1.1	1.4	1.6	1.3	1.3	1.0
Impedance of whole body	1.1	5.8	8.3	-2.2	-2.1	-2.9
Body Mass Index (BMI) (2010)	1.0	1.3	2.1	-1.4	-0.1	-1.4
Neuroticism (2016)	1.0	1.5	2.5	-0.9	-1.6	-1.0
Schizophrenia (2014)	1.0	2.1	3.6	-1.6	-0.2	-1.9
Angina	1.0	1.3	1.8	1.3	0.6	1.3
Number of live births	1.0	1.4	2.3	-0.8	-1.5	-1.1
Noisy workplace	1.0	1.2	1.6	1.0	1.3	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.9	1.1	1.4	0.5
Depression (self-reported)	1.0	1.2	1.5	-1.0	-1.2	-1.0
Pulse wave Arterial Stiffness index	1.0	1.1	2.1	0.9	0.7	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.7	-1.2	-2.2	-0.4
Medication: Aspirin	1.0	1.3	2.0	0.9	1.4	1.1
Miserableness	1.0	1.7	3.9	-0.7	-2.0	-0.9
Bipolar Disorder or Schizophrenia	0.9	2.3	4.0	-1.6	-0.5	-2.0
Alzheimer’s Disease (including proxy)	0.9	1.3	2.0	-1.1	-1.4	-0.8
Coronary Artery Disease (CAD)	0.9	1.1	1.6	-1.3	-1.0	-0.7
Lung FEV1/FVC ratio	0.9	4.4	5.5	2.3	1.6	2.3
Medication for hormone replacement therapy	0.9	1.0	2.8	-0.3	-1.7	0.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	2.4	1.6	0.7	1.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.8	-0.6	-1.4	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.4	0.9	0.3	1.5
Pulse rate, automated reading	0.9	3.0	3.4	-1.6	-1.7	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.3	-0.8	-0.4	-1.8
Heart disease (siblings)	0.9	1.2	2.5	-1.0	-1.6	-0.1
Breast Cancer	0.8	1.9	2.6	1.6	0.9	1.6
Triglycerides	0.8	1.3	1.3	-1.1	-1.1	-1.1
Multivitamins +/- minerals	0.8	1.0	2.0	-0.3	-1.4	-0.9
Lung cancer (father)	0.8	0.9	1.7	-0.7	-0.8	-1.3
Number of children fathered	0.8	1.0	1.9	-0.9	0.4	-1.4
Angina (self-reported)	0.8	1.1	1.7	1.2	0.5	1.3
Arm predicted mass (right)	0.8	4.2	6.0	1.9	1.8	2.5
Long-standing illness, disability or infirmity	0.8	1.3	1.8	-1.3	-1.2	-0.7
Medication for cholesterol	0.8	1.3	2.6	-1.1	-0.3	-1.6
Ever depressed for a whole week	0.8	1.0	1.5	-1.0	-1.2	-0.6
Age at First Birth	0.7	1.0	1.4	-1.0	-0.8	-1.2
Mean Putamen Volume	0.7	0.8	2.3	-0.2	-0.2	-1.5
Blood Red Count	0.7	6.8	12.9	-2.6	-0.8	-3.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	1.8	-1.0	-1.1	-1.3
Lung FVC	0.7	3.4	7.1	-1.7	-0.3	-2.7
Tanning	0.7	8.6	10.1	3.2	3.0	2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.5	-0.6	-0.3	-2.1
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.4	-1.1	-0.3	-1.2
Peak expiratory flow (PEF)	0.7	1.7	1.9	1.2	1.4	1.3
Arm fat-free mass (right)	0.7	3.7	5.4	1.7	1.7	2.3
Comparative body size at age 10	0.7	2.1	3.1	1.8	1.2	1.3
Leg fat-free mass (right)	0.7	3.5	5.5	1.7	1.5	2.3
Leg predicted mass (right)	0.7	3.7	5.7	1.7	1.6	2.4
Hearing aid user	0.7	0.8	1.7	0.5	0.8	1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.5	0.6	1.6	-0.1
Bipolar Disorder (2018)	0.6	0.9	1.5	-1.1	-0.4	-1.2
Schizophrenia (2018)	0.6	1.3	2.5	-1.2	-0.3	-1.6
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	-1.2	-0.8	-0.7
Average weekly spirits intake	0.6	0.7	1.2	0.9	1.1	0.3
Supplements: Zinc	0.6	0.7	0.8	0.8	0.8	0.9
Diabetes (mother)	0.6	0.7	1.0	0.6	1.0	0.9
Hand grip strength (right)	0.6	1.6	2.4	0.8	1.4	1.5
Medication: Aspirin	0.6	0.8	1.4	0.7	1.2	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.1	-0.3	1.1	-0.9
Whole body fat-free mass	0.6	3.2	4.8	1.6	1.6	2.2
Qualifications: nursing, teaching	0.6	0.9	1.7	0.6	1.3	0.8
Ever taken oral contraceptive pill	0.6	0.7	1.1	0.8	0.6	1.1
Irritability	0.6	1.1	1.6	-0.3	-1.3	-1.2
HDL Cholesterol	0.5	0.9	1.1	1.0	1.0	0.8
Leg fat-free mass (left)	0.5	2.5	3.7	1.4	1.4	1.9
Stomach or abdominal pain in last month	0.5	0.7	1.5	-1.2	-0.7	-0.3
Leg predicted mass (left)	0.5	2.6	3.8	1.4	1.4	1.9
Had menopause	0.5	0.6	0.8	-0.9	-0.9	-0.5
Mouth/teeth dental problems	0.5	0.7	1.4	0.6	1.2	0.7
Pain all over the body in last month	0.5	0.6	0.6	-0.7	-0.8	-0.8
Trunk fat-free mass	0.5	2.7	4.0	1.3	1.5	2.0
Trunk predicted mass	0.5	2.8	4.1	1.4	1.6	2.0
Supplements: Vitamin C	0.5	0.6	0.8	-0.9	-0.5	-0.8
Illnesses of father: Heart disease	0.5	0.7	1.8	-0.5	-0.3	-1.3
Illnesses of siblings: Diabetes	0.5	0.6	0.8	-0.8	-0.6	-0.9
Smoking status: Previous	0.5	0.7	1.4	0.7	0.4	1.2
Whole body water mass	0.5	3.0	4.5	1.5	1.5	2.1
Chronotype (morning person)	0.4	0.9	1.7	-0.3	1.3	-1.0
Medication: Co-codamol	0.4	0.5	1.1	-1.1	-0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.5	0.1	0.2	-1.6
Heart attack	0.4	0.5	1.4	0.3	1.2	-0.2
Happiness	0.4	0.5	0.8	-0.6	-0.9	0.5
Prospective memory result	0.4	0.5	1.6	0.2	1.3	0.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	-0.5	-1.1	-0.3
Medication: Amlodipine	0.4	0.6	1.2	0.6	-0.3	1.1
Health satisfaction	0.4	0.5	1.3	-0.2	-1.1	0.3
Suffer from ‘nerves’	0.4	0.7	1.7	-0.6	-1.3	-0.1
Leg pain on walking	0.4	0.5	0.9	0.6	0.5	1.0
Medication: Gliclazide	0.4	0.5	0.8	-0.6	-0.9	-0.5
Financial situation satisfaction	0.4	0.5	0.9	-0.2	-0.9	0.7
High cholesterol (Self-reported)	0.4	0.7	1.2	0.3	1.1	0.8
Basal metabolic rate	0.4	2.1	3.3	1.2	1.3	1.8
Risk taking	0.4	0.5	1.1	0.7	1.1	-0.0
Fractured/broken bones in last 5 years	0.4	0.5	1.1	-0.0	1.0	0.6
Arm predicted mass (left)	0.4	1.8	3.0	1.2	1.1	1.7
Prostate Cancer	0.3	0.4	1.1	0.3	-0.3	1.1
Waist Hip Ratio (WHR)	0.3	1.2	1.6	-0.9	-1.1	-1.2
Trunk fat percentage	0.3	1.0	1.8	-1.4	-0.5	-1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.3	0.8	0.5
Sitting height	0.3	1.8	2.4	1.6	0.7	1.6
Time employed in main current job	0.3	0.3	0.5	-0.6	0.2	-0.7
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	0.3	0.9	-0.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	-0.8	-1.3	0.1
Body fat percentage	0.3	1.2	2.0	-1.4	-0.6	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.5	0.5	-0.7	-0.5	-0.7
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.6	-0.3	-0.8
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.7	-0.8	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.4	-0.9	-0.5
Medication: Bendroflumethiazide	0.3	0.5	1.1	0.1	1.1	0.5
Medication: Paracetamol	0.3	0.4	0.7	-0.3	-0.8	-0.7
Alcohol drinker status: Never	0.3	0.3	0.8	-0.2	-0.9	-0.2
Arm fat-free mass (left)	0.3	1.5	2.3	1.1	1.0	1.5
Cholesterol lowering medication	0.3	0.4	0.9	0.4	0.3	1.0
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.1	-0.8	-0.2
Reaction Time	0.2	0.3	0.8	-0.3	0.2	-0.9
LDL Cholesterol	0.2	0.3	0.6	-0.4	-0.4	0.8
Heel T-Score	0.2	1.6	3.7	0.8	0.8	-1.9
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.2	-0.6	0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.3	-0.7	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	-0.5	-0.4	-0.5
Diabetes (father)	0.2	0.2	0.4	0.4	0.0	0.6
Average weekly fortified wine intake	0.2	0.3	0.6	0.3	-0.4	0.8
Maternal smoking around birth	0.2	0.2	0.4	-0.6	-0.4	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.3	-0.5	-0.5
Medication: Levothyroxine sodium	0.2	0.4	0.5	0.7	0.6	0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.4	-0.5	-0.2
Body mass index (BMI)	0.2	0.7	0.9	0.4	0.9	1.0
Forced vital capacity (FVC)	0.2	0.7	1.3	-0.8	-0.1	-1.1
Medication: Ramipril	0.2	0.2	0.3	0.5	0.3	0.6
Illnesses of siblings	0.2	0.2	0.5	-0.4	0.0	-0.7
Arm fat percentage (right)	0.2	0.8	1.6	-1.3	-0.3	-0.8
Hip circumference	0.2	0.7	1.2	0.6	0.7	1.1
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	-0.2	-0.7	0.7
Medication: Lansoprazole	0.2	0.2	0.6	-0.8	-0.2	0.1
Breastfed as a baby	0.2	0.3	0.7	-0.8	-0.4	-0.3
Gout (self-reported)	0.2	0.3	0.8	0.4	-0.1	0.9
Forced vital capacity (FVC), Best measure	0.2	0.9	1.7	-0.9	-0.3	-1.3
Leg fat percentage (right)	0.2	0.8	1.5	-1.2	-0.5	-0.9
Exposure to tobacco smoke outside home	0.2	0.2	0.7	0.0	-0.8	0.1
Age at first live birth	0.2	0.3	0.9	-0.3	0.1	-0.9
Mean time to correctly identify matches	0.2	0.3	0.5	-0.5	0.4	-0.7
Knee pain experienced in last month	0.2	0.3	0.6	-0.3	-0.8	0.5
Ever had bowel cancer screening	0.2	0.2	0.3	-0.6	-0.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.3	0.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	-0.4	-0.7	0.3
Breast cancer (self-reported)	0.2	0.3	0.5	-0.5	-0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	-0.0	1.0	-0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.3	-0.7	-0.1
Commuting to job workplace: Cycle	0.2	0.2	0.3	-0.6	-0.5	0.0
Fasting Glucose	0.1	0.1	0.2	0.2	0.4	0.2
HbA1C	0.1	0.1	0.3	0.2	-0.1	0.5
Blood Platelet Count	0.1	1.3	3.6	-0.4	-1.9	0.2
Blood White Count	0.1	0.6	0.9	-1.0	-0.8	-0.5
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.4	-0.8	-0.5
Number of treatments/medications taken	0.1	0.1	0.2	-0.2	-0.5	0.2
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.4	0.2	0.5
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.1	-0.4	0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.2	-0.3	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.3	-0.3	0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.3	-0.0	0.5
Medication: Simvastatin	0.1	0.2	0.2	-0.5	0.5	-0.1
Weight	0.1	0.6	1.0	0.4	0.8	1.0
Pulse rate	0.1	0.1	0.4	0.2	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	0.3	0.6	-0.3
Length of working week for main job	0.1	0.1	0.2	0.1	-0.0	0.5
Exposure to tobacco smoke at home	0.1	0.2	0.3	-0.3	-0.5	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.1	-0.3	-0.3	0.0
Medication: Paracetamol	0.1	0.1	0.3	0.6	0.3	0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	-0.0	0.7	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.5	0.2	-0.3
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.2	-0.4	-0.4
Comparative height size at age 10	0.1	0.3	0.5	-0.6	-0.3	-0.7
Arm fat percentage (left)	0.1	0.4	1.0	-1.0	0.0	-0.4
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.6	-0.2	-0.2
Back pain experienced in last month	0.1	0.2	0.3	-0.4	-0.6	-0.1
Mineral and other dietary supplements	0.1	0.2	0.5	-0.3	0.7	0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	0.1	-0.2	0.6
Number of self-reported non-cancer illnesses	0.1	0.3	0.5	0.1	0.5	0.7
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.5	0.3	-0.5
Commuting to job workplace: Public transport	0.1	0.2	0.3	0.3	0.6	0.3
Leg fat percentage (left)	0.1	0.3	0.6	-0.8	-0.2	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.1	0.3	-0.3	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.3	-0.5	-0.2
Age started oral contraceptive pill	0.1	0.1	0.1	0.3	0.4	-0.2
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.6	-0.3	-0.2
Myopia	0.1	0.1	0.2	0.5	-0.4	0.1
Supplements: Calcium	0.1	0.1	0.1	-0.2	0.1	0.4
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.0	0.0	0.3
Rheumatoid Arthritis	0.0	0.0	0.1	0.1	0.3	-0.3
BMI	0.0	0.3	0.6	-0.5	0.8	0.0
Height	0.0	0.9	2.3	0.2	0.7	1.5
Pack years adult smoking proportion	0.0	0.0	0.0	0.2	-0.1	0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.1	0.3	0.1
Trunk fat mass	0.0	0.2	0.5	-0.7	0.2	-0.3
Waist circumference	0.0	0.1	0.1	-0.2	0.3	0.2
Alcohol usually taken with meals	0.0	0.0	0.1	-0.2	-0.1	-0.2
Qualifications: None of the above	0.0	0.0	0.0	-0.0	0.1	0.1
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.4	0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.4	0.2	0.6	-0.3
Arm fat mass (right)	0.0	0.1	0.2	-0.5	0.4	0.0
Standing height	0.0	0.0	0.1	-0.3	-0.1	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.2	-0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.1	-0.1	0.3
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	-0.1	0.2	-0.1
Migraine (self-reported)	0.0	0.0	0.1	-0.1	0.3	0.0
Whole body fat mass	0.0	0.2	0.4	-0.7	0.1	-0.3
Leg fat mass (right)	0.0	0.1	0.2	-0.4	0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	0.1	-0.4	0.2
Osteoporosis (self-reported)	0.0	0.1	0.1	-0.2	-0.0	0.4
Arm fat mass (left)	0.0	0.1	0.3	-0.3	0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.2	-0.0	-0.1	0.4
Pack years of smoking	0.0	0.0	0.0	0.1	-0.1	0.1
Leg fat mass (left)	0.0	0.1	0.1	-0.2	0.3	0.2

Hub : Genes

CREM

Models

Trait associations