Best TWAS P=1.72e-17 · Best GWAS P=5.47e-29 conditioned to 3.93e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADO | 0.04 | 0.01 | blup | 465 | 0.02 | 1.8e-03 | 7.4 | 7.9 | 3.0e-15 | 0.55 | 0.02 | 0.82 | FALSE |
| 2 | GTEx | Muscle Skeletal | ADO | 0.15 | 0.16 | lasso | 8 | 0.16 | 1.1e-15 | 8.2 | 8.5 | 1.7e-17 | 0.61 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Muscle Skeletal | RP11-436D10.3 | 0.08 | 0.04 | enet | 13 | 0.06 | 3.2e-06 | -4.7 | 6.1 | 1.2e-09 | 0.50 | 0.90 | 0.05 | FALSE |
| 4 | GTEx | Testis | ADO | 0.21 | 0.23 | lasso | 7 | 0.22 | 6.6e-10 | 8.2 | -8.2 | 1.9e-16 | -0.60 | 0.88 | 0.12 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADO | 0.03 | 0.02 | blup | 53 | 0.03 | 1.8e-06 | 5.5 | 6.7 | 1.9e-11 | 0.51 | 0.33 | 0.67 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADO | 0.10 | 0.03 | enet | 6 | 0.06 | 4.6e-07 | 7.4 | 5.7 | 1.2e-08 | 0.52 | 0.02 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADO | 0.07 | 0.06 | blup | 53 | 0.05 | 2.5e-06 | 7.4 | 7.4 | 1.1e-13 | 0.54 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | EGR2 | 0.12 | 0.10 | blup | 56 | 0.10 | 1.4e-03 | 5.7 | 7.1 | 1.2e-12 | 0.38 | 0.03 | 0.13 | FALSE |