TWAS
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Traits
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Traits
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Crohns Disease (2017)
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chr11:75,457,950-77,069,746
Best TWAS P=1.11e-13 · Best GWAS P=4.69e-24 conditioned to 1.91e-10
75.4M
75.6M
75.8M
76M
76.2M
76.4M
76.6M
76.8M
77M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Adipose Visceral Omentum
LRRC32
0.21
0.00
enet
15
0.01
1.5e-01
9.9
7.4
1.1e-13
0.62
0.01
0.84
TRUE
1
CommonMind
Brain Pre-frontal Cortex
C11orf30
0.07
0.06
lasso
6
0.06
2.1e-07
6.4
-5.9
3.3e-09
-0.68
0.72
0.28
TRUE
3
YFS
Blood
LRRC32
0.02
0.00
bslmm
481
0.00
9.1e-02
6.5
-6.5
1.0e-10
-0.62
0.07
0.75
FALSE