Best TWAS P=2.81e-11 · Best GWAS P=6.06e-21 conditioned to 3.56e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | LRRK2 | 0.33 | -0.01 | enet | 48 | 0.12 | 1.0e-04 | 2.8 | 5.9 | 3.0e-09 | 0.56 | 0.03 | 0.94 | TRUE |
| 2 | GTEx | Nerve Tibial | LRRK2 | 0.20 | 0.11 | lasso | 6 | 0.19 | 1.2e-13 | 2.3 | 5.9 | 3.3e-09 | 0.55 | 0.75 | 0.25 | FALSE |
| 3 | GTEx | Stomach | LRRK2 | 0.14 | 0.00 | lasso | 3 | 0.03 | 1.8e-02 | 7.8 | 6.7 | 2.8e-11 | 0.71 | 0.54 | 0.44 | TRUE |