TWAS
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Traits
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Traits
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Crohns Disease (2017)
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chr12:39,904,158-41,454,590
Best TWAS P=2.81e-11 · Best GWAS P=6.06e-21 conditioned to 3.56e-09
40M
40.2M
40.4M
40.6M
40.8M
41M
41.2M
41.4M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Stomach
LRRK2
0.14
0.00
lasso
3
0.03
1.8e-02
7.8
6.7
2.8e-11
0.71
0.54
0.44
TRUE
1
GTEx
Artery Coronary
LRRK2
0.33
-0.01
enet
48
0.12
1.0e-04
2.8
5.9
3.0e-09
0.56
0.03
0.94
TRUE
2
GTEx
Nerve Tibial
LRRK2
0.20
0.11
lasso
6
0.19
1.2e-13
2.3
5.9
3.3e-09
0.55
0.75
0.25
FALSE