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Depressed Affect (Nagel 2018)
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chr14:74,531,485-76,089,054
Best TWAS P=1.04e-09 · Best GWAS P=2.06e-10 conditioned to 0.066
74.6M
74.8M
75M
75.2M
75.4M
75.6M
75.8M
76M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Muscle Skeletal
DLST
0.28
0.26
enet
23
0.26
2.1e-25
-5.9
-6.1
1.0e-09
0.93
0.05
0.95
TRUE
3
GTEx
Skin Not Sun Exposed Suprapubic
RPS6KL1
0.08
0.08
enet
11
0.07
1.5e-04
4.4
5.5
4.6e-08
-0.72
0.31
0.65
FALSE
1
GTEx
Adipose Subcutaneous
YLPM1
0.10
0.03
lasso
6
0.02
7.9e-03
-5.5
5.4
7.4e-08
-0.77
0.08
0.47
FALSE