TWAS hub - DLST

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0930	0.0290	3.2e-09	0.106	0.083	0.102	0.092	0.109	8.4e-13	2.4e-10	2.2e-12	2.6e-11	4.0e-13
2	GTEx	Cells Transformed fibroblasts	0.0810	0.0390	8.9e-03	-0.001	NA	-0.001	NA	0.010	3.6e-01	NA	4.3e-01	NA	5.8e-02
3	GTEx	Esophagus Muscularis	0.1170	0.0470	1.9e-03	0.033	NA	0.017	NA	0.023	4.4e-03	NA	3.1e-02	NA	1.4e-02
4	GTEx	Muscle Skeletal	0.2782	0.0512	0.0e+00	0.264	NA	0.260	NA	0.259	6.8e-26	NA	2.1e-25	NA	2.4e-25
5	NTR	Blood	0.0484	0.0121	6.7e-15	0.054	0.052	0.059	0.056	0.057	6.8e-17	3.2e-16	2.5e-18	2.1e-17	7.2e-18
6	TCGA	Thyroid Carcinoma	0.0390	0.0250	5.2e-03	0.033	0.024	0.014	NA	0.025	3.1e-04	1.8e-03	1.5e-02	NA	1.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Worry (Nagel 2018)	8.2	17.3	51.6	7.2	1.4	1.5	-6.8	-1.3	-0.6
Neuroticism	8.1	19.6	58.9	7.6	0.4	1.0	-7.7	-0.7	0.4
Taking other prescription medications	7.5	11.5	37.8	6.2	1.7	1.4	-4.9	-0.3	-1.4
Number of treatments/medications taken	7.3	13.2	43.0	6.6	1.6	1.2	-5.4	-0.6	-1.4
Neuroticism (Nagel 2018)	7.2	17.0	55.2	6.7	-0.6	-0.3	-7.4	-0.0	1.4
Neuroticism score	7.2	15.0	46.0	6.6	0.1	0.5	-6.8	-0.1	0.6
Fed-up feelings	6.9	12.5	40.1	5.6	-0.6	-0.7	-6.3	1.1	1.1
Nervous feelings	6.5	12.1	36.0	6.0	2.0	1.9	-5.0	-1.3	-1.3
Reaction Time	6.3	11.9	18.3	-0.3	3.8	4.1	3.2	-3.4	-4.3
Worrier / anxious feelings	6.2	11.7	37.9	6.2	1.2	1.5	-5.1	-1.4	-0.6
Guilty feelings	6.0	9.0	26.6	5.0	-0.5	0.1	-5.2	-0.6	1.3
Mood swings	5.6	10.2	32.0	5.0	-0.9	-0.7	-5.7	0.7	1.4
Depressed Affect (Nagel 2018)	5.5	11.6	37.3	4.9	-1.4	-1.3	-6.1	1.2	1.9
Tense / ‘highly strung’	5.5	9.1	20.6	4.5	2.9	2.7	-3.0	-1.9	-2.4
Suffer from ‘nerves’	5.5	8.6	27.8	4.7	-0.1	-0.2	-5.3	0.7	0.9
Age at First Birth	5.2	7.5	13.2	-2.4	-3.1	-3.0	0.1	3.6	2.7
Illnesses of father: High blood pressure	5.2	6.4	10.1	3.0	3.2	2.7	-0.8	-1.9	-2.9
Chronic bronchitis/emphysema (mother)	5.0	5.9	8.6	0.9	-2.4	-2.9	-2.2	2.9	2.6
Major Depression (MDD)	4.8	5.8	12.8	3.6	1.9	2.0	-2.7	-2.0	-1.8
Chronic bronchitis/emphysema (father)	4.6	5.4	8.4	-1.4	-2.7	-2.8	-0.8	2.6	2.9
Chest pain or discomfort	4.4	6.4	11.5	2.2	3.4	2.9	0.1	-1.9	-3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	4.3	6.6	20.3	4.5	1.5	1.3	-3.6	-0.4	-1.4
Medication for cholesterol	4.2	6.4	16.4	-4.0	-2.6	-1.5	2.5	-0.9	2.4
Medication: Bendroflumethiazide	4.2	6.4	11.7	2.8	3.4	2.4	-1.2	-1.1	-3.2
Medication for pain relief, constipation, heartburn	4.1	6.9	22.9	-4.8	-0.7	-0.7	4.0	1.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.1	4.8	13.7	2.3	-1.0	-1.3	-3.7	2.2	1.5
Systolic Blood Pressure	4.0	20.2	31.8	5.6	4.8	5.1	-2.1	-4.2	-4.3
Neuroticism (2016)	3.8	5.5	14.6	3.8	-0.9	0.1	-3.7	-1.3	1.4
Trunk fat percentage	3.8	15.2	24.6	5.0	4.3	4.3	-1.3	-3.4	-4.1
Body fat percentage	3.8	15.1	29.9	5.5	4.1	4.1	-1.9	-3.0	-3.8
Arm fat percentage (right)	3.5	13.9	18.7	4.3	4.3	4.3	-0.8	-3.1	-4.1
Length of working week for main job	3.5	3.9	6.0	-0.9	-2.3	-2.4	-1.1	2.3	2.1
Ever unenthusiastic/disinterested for a whole week	3.4	4.1	14.2	3.8	0.6	0.7	-3.0	0.3	-0.7
Medication: Lansoprazole	3.4	3.9	12.6	3.5	0.9	0.5	-3.1	0.3	-0.3
Chronotype (morning person)	3.3	7.5	12.1	-2.2	-3.3	-3.5	-0.1	2.7	3.2
Happiness	3.3	4.0	14.0	1.8	-1.5	-1.2	-3.7	0.4	1.6
Leg fat percentage (right)	3.3	11.9	36.4	6.0	2.9	2.5	-3.7	-1.0	-2.3
Financial situation satisfaction	3.3	4.1	8.0	1.4	-2.4	-1.7	-2.8	0.2	2.4
Type 2 Diabetes (T2D) (2012)	3.2	3.7	7.1	-0.2	1.9	2.7	1.7	-2.2	-2.0
Qualifications: nursing, teaching	3.2	5.0	8.4	-2.8	-2.9	-2.1	1.0	0.4	2.8
Leg fat percentage (left)	3.2	11.4	35.9	6.0	2.7	2.4	-3.7	-1.1	-2.1
Irritability	3.2	5.4	16.9	4.1	1.1	1.3	-3.2	-1.3	-0.7
Medication: Omeprazole	3.1	3.8	7.7	2.2	-1.3	-1.7	-2.8	1.6	1.6
Heart disease (siblings)	3.1	3.8	4.9	2.1	2.1	2.0	0.4	-2.2	-2.2
Ulcerative Colitis (UC)	3.0	5.6	11.2	1.5	3.1	2.5	1.2	-1.8	-3.3
Lung FEV1/FVC ratio	3.0	15.3	47.2	-6.9	-1.1	-0.4	6.5	0.0	0.6
Age at first live birth	3.0	5.3	11.0	-3.3	-2.1	-2.1	1.7	2.3	1.9
Arm fat percentage (left)	3.0	12.1	17.1	4.1	3.9	4.0	-0.9	-3.1	-3.7
Body Mass Index (BMI) (2010)	2.9	4.0	6.4	1.9	2.5	2.3	-0.2	-1.7	-2.4
Systolic blood pressure, automated reading	2.9	8.6	16.6	4.1	2.9	3.1	-1.7	-2.5	-2.7
Back pain experienced in last month	2.9	4.2	8.9	2.5	-0.8	-1.6	-3.0	2.2	1.4
Mean time to correctly identify matches	2.8	5.4	9.4	-1.2	2.2	2.3	3.1	-1.9	-2.7
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	5.9	-1.0	-2.0	-2.3	-0.9	2.4	1.9
Smoking status: Previous	2.8	4.2	13.3	3.6	-0.3	0.0	-3.3	-0.4	0.5
Irritable Bowel Disease (IBD)	2.7	6.5	10.7	1.7	3.2	2.8	1.0	-2.4	-3.3
Past tobacco smoking	2.7	5.0	14.7	-3.8	0.4	0.3	3.8	-0.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	10.4	3.1	0.5	0.7	-3.2	-0.3	-0.3
Wheeze or whistling in the chest in last year	2.7	4.8	14.3	3.8	1.6	1.5	-2.9	-0.2	-1.1
Loneliness, isolation	2.7	3.7	11.6	2.9	-0.8	-0.7	-3.4	0.1	1.0
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	6.6	1.8	-1.5	-1.7	-2.6	1.4	1.7
Medication: Atenolol	2.6	3.2	9.3	3.0	1.4	0.8	-2.5	-0.3	-1.2
High blood pressure (mother)	2.6	3.6	7.0	1.4	2.6	2.5	0.3	-1.3	-2.3
Number of self-reported non-cancer illnesses	2.6	4.5	13.8	3.7	0.6	0.4	-3.5	0.0	-0.4
Ever smoked	2.6	4.5	13.7	2.7	-1.1	-1.3	-3.7	1.2	1.2
Schizophrenia vs Biploar Disorder	2.5	3.2	4.9	1.0	-1.9	-2.0	-2.2	1.4	2.0
Coronary Artery Disease (CAD)	2.5	3.0	8.3	2.8	-1.0	-0.3	-2.9	0.2	0.8
Schizophrenia (2014)	2.5	5.4	12.6	2.6	-2.0	-1.4	-3.6	-0.4	2.7
Medication: Allopurinol	2.5	3.4	5.2	-0.0	-2.2	-2.3	-1.1	2.1	2.0
Age at last live birth	2.5	3.6	6.6	-2.6	-2.1	-1.7	1.2	1.5	2.0
Medication: Blood pressure	2.5	4.7	14.2	3.8	1.8	1.1	-2.6	-0.2	-1.7
Gout (self-reported)	2.4	3.3	6.0	0.4	-1.9	-2.2	-1.2	2.4	1.9
Medication: Ventolin 100micrograms inhaler	2.4	3.1	4.5	0.1	-2.0	-1.6	-1.9	2.0	2.1
Medication: Gliclazide	2.4	2.7	4.0	1.4	1.8	1.7	0.1	-2.0	-2.0
Hearing difficulty/problems: Yes	2.3	3.4	6.1	1.8	2.5	1.8	0.5	-1.4	-2.4
Hearing difficulty/problems with background noise	2.3	3.6	6.5	2.6	2.0	1.7	-0.5	-1.9	-2.1
Pain type(s) experienced in last month: Hip pain	2.3	2.8	4.6	1.5	-1.1	-1.6	-2.0	2.1	1.5
Diastolic blood pressure, automated reading	2.3	7.1	14.1	3.8	2.8	2.9	-1.4	-2.2	-2.5
Migraine (self-reported)	2.2	2.7	8.8	2.6	-0.3	-0.4	-3.0	-0.2	0.7
Medication: Aspirin	2.2	2.9	8.4	2.9	1.3	0.6	-2.2	-0.0	-1.4
Hand grip strength (left)	2.1	5.6	17.3	4.2	0.1	1.1	-3.3	-1.9	0.7
Average weekly fortified wine intake	2.1	2.5	4.9	1.4	2.2	1.5	-0.2	-0.8	-2.2
Age when periods started (menarche)	2.1	5.0	7.7	-0.6	-2.3	-2.5	-1.7	2.8	2.7
Father’s age at death	2.1	2.8	9.2	-3.0	-0.4	-0.8	2.3	1.3	-0.0
Average weekly red wine intake	2.1	3.1	9.2	-3.0	-0.1	-0.1	3.0	0.1	-0.3
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.7	-2.2	-1.4	-2.0	1.1	1.3	1.0
Medication: Levothyroxine sodium	2.0	3.4	9.9	3.1	1.5	1.3	-2.3	-0.1	-1.0
Health satisfaction	2.0	2.6	7.9	2.8	0.6	0.6	-2.4	-0.9	-0.7
Shortness of breath walking on level ground	2.0	2.4	4.1	2.0	1.8	1.3	-0.9	-1.2	-1.7
Angina (self-reported)	2.0	2.6	4.9	1.7	2.2	1.8	-0.2	-0.8	-2.0
Hypothyroidism (self reported)	1.9	4.3	13.1	3.6	0.8	1.0	-3.4	-0.1	-0.3
Lung FVC	1.9	9.7	18.3	3.2	4.1	3.2	-0.6	-1.3	-4.3
Trunk fat-free mass	1.9	10.9	20.7	-4.5	-3.4	-3.2	1.6	3.2	3.2
Trunk predicted mass	1.9	11.1	20.6	-4.5	-3.4	-3.2	1.6	3.2	3.3
Medication: Seretide 50 evohaler	1.9	2.2	3.8	-0.7	-1.6	-1.9	-0.7	1.7	1.7
Long-standing illness, disability or infirmity	1.9	2.8	9.4	3.1	0.9	0.4	-2.5	0.1	-0.7
Wears glasses or contact lenses	1.9	2.2	4.0	-0.2	-1.5	-1.7	-1.5	2.0	1.3
Waist Hip Ratio (WHR)	1.8	8.1	13.0	3.6	3.3	3.1	-1.1	-2.3	-2.9
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	7.4	2.7	0.7	0.2	-2.4	-0.1	-0.6
Medication: Paracetamol	1.8	3.0	9.6	3.1	0.3	0.6	-2.4	-1.3	-0.2
Headache pain in last month	1.8	3.0	10.3	3.2	0.5	0.3	-2.7	-0.2	-0.3
Glaucoma (self-reported)	1.8	2.1	3.8	1.9	1.3	1.3	-0.1	-1.9	-1.3
Birth weight	1.8	3.8	6.0	-0.9	-2.1	-2.4	-0.9	2.4	2.3
Number of full sisters	1.8	2.2	4.2	0.0	-1.8	-1.8	-1.5	0.8	2.0
Supplements: Calcium	1.8	2.0	6.0	2.5	1.0	0.9	-1.6	-0.8	-1.0
Frequency of depressed mood in last 2 weeks	1.7	2.4	7.7	2.8	0.2	0.4	-2.4	-0.8	-0.0
Angina	1.7	2.2	3.9	1.9	2.0	1.4	-0.7	-0.4	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.9	2.2	1.6	1.4	-1.1	-1.1	-1.2
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	10.1	3.1	0.4	0.4	-3.2	0.5	-0.0
Family relationship satisfaction	1.7	2.1	4.5	2.0	1.2	1.1	-2.1	-0.5	-1.0
Eye problems/disorders: Cataract	1.7	2.0	4.3	-2.1	-1.4	-0.9	1.8	0.3	1.2
HDL Cholesterol	1.6	2.7	5.6	-2.4	-1.7	-1.5	1.6	0.9	1.3
Trunk fat mass	1.6	6.9	11.0	3.3	2.9	3.0	-0.7	-2.3	-2.7
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	6.6	2.6	0.9	1.3	-1.9	-1.5	-0.7
Impedance of arm (right)	1.6	7.4	11.0	2.1	3.2	3.0	0.7	-3.0	-3.3
Qualifications: A levels/AS levels or equivalent	1.6	3.5	9.6	-2.7	-0.1	0.7	3.1	-1.8	-0.4
Overall health rating	1.6	3.5	11.7	3.4	0.9	0.7	-2.6	-0.6	-1.0
Pain experienced in last month	1.6	2.6	8.5	-2.9	-0.6	0.2	2.5	-0.5	0.1
Pack years of smoking	1.6	2.4	3.7	-1.1	-1.9	-1.9	-0.1	1.7	1.7
Height	1.5	29.1	50.8	-7.1	-6.3	-5.7	2.4	3.6	5.8
Average weekly spirits intake	1.5	1.8	4.6	-1.4	0.5	0.6	2.1	-1.9	-0.5
Sensitivity / hurt feelings	1.5	2.6	7.0	2.1	-0.8	-1.0	-2.6	1.2	0.9
Pack years adult smoking proportion	1.5	2.2	3.3	-0.9	-1.8	-1.8	-0.4	1.8	1.7
Alcohol intake frequency.	1.5	3.4	5.3	1.5	1.9	2.3	-0.0	-2.3	-2.0
Commuting to job workplace: Walk	1.5	1.6	4.4	0.9	1.1	1.5	0.2	-2.1	-0.8
Medication: Aspirin	1.5	2.0	5.6	2.4	1.3	0.5	-1.5	-0.0	-1.5
Depression (Nagel 2018)	1.4	2.1	5.7	2.4	1.3	1.2	-1.5	-0.8	-0.9
Ulcerative Colitis	1.4	2.0	3.4	1.0	1.7	1.5	0.4	-1.4	-1.9
Blood Platelet Count	1.4	16.7	50.3	-7.1	0.4	0.4	6.9	-0.2	-1.2
Medication: Metformin	1.4	2.0	5.0	0.8	2.0	1.2	0.7	-0.7	-2.2
Medication: Simvastatin	1.4	2.0	6.7	2.2	-0.2	-0.6	-2.6	0.5	0.2
Depression (self-reported)	1.4	1.7	6.6	1.8	-0.0	-0.1	-2.6	0.2	0.3
Comparative body size at age 10	1.4	4.0	5.6	-0.7	2.0	2.4	2.3	-2.2	-2.0
Whole body fat mass	1.4	5.9	11.3	3.4	2.6	2.7	-1.0	-1.9	-2.3
Hypertension (Self-reported)	1.4	4.0	8.7	2.9	2.1	1.5	-1.8	-0.9	-2.1
Friendships satisfaction	1.4	1.7	4.7	1.5	-1.1	-0.6	-2.2	-0.8	1.0
Commuting to job workplace: Public transport	1.4	1.7	3.1	-1.8	-1.5	-1.3	0.9	-0.0	1.5
Medication: Paracetamol	1.4	2.1	7.8	2.8	0.2	0.3	-2.0	-0.9	-0.3
Prostate Cancer	1.3	1.9	5.0	2.2	-0.6	0.2	-2.0	-0.8	1.1
Smoking Status	1.3	3.1	8.6	2.6	-0.9	-1.0	-2.9	0.6	1.1
Medication: Co-codamol	1.3	1.6	4.6	1.9	-0.4	-0.4	-2.1	0.6	0.6
Severe depression (siblings)	1.3	1.5	4.8	2.2	0.6	0.7	-1.6	-0.7	-0.4
Had other major operations	1.3	1.6	4.5	1.2	-0.8	-1.2	-2.1	0.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.7	1.9	1.0	1.1	-1.1	-1.6	-0.7
Lung cancer (father)	1.3	1.5	2.5	-0.5	-1.6	-1.3	-0.7	1.4	1.5
Standing height	1.3	12.7	32.9	-5.7	-3.3	-3.0	3.3	2.2	2.8
Comparative height size at age 10	1.3	7.3	23.3	-4.8	-1.0	-0.4	4.3	-0.5	0.6
Miserableness	1.3	2.3	6.8	2.3	-0.8	-0.1	-2.6	0.0	1.0
Ever depressed for a whole week	1.3	1.7	5.2	1.8	-0.7	-0.2	-2.3	0.2	0.9
Lupus	1.2	1.8	4.7	0.7	-1.0	-1.4	-1.3	2.2	0.9
Cardiovascular Disease	1.2	3.8	8.7	2.9	2.0	1.7	-1.9	-0.6	-2.0
Respiratory disease	1.2	2.6	6.6	2.6	1.1	1.4	-2.1	-1.0	-0.7
Medication for hormone replacement therapy	1.2	1.4	3.1	1.8	1.0	1.0	-1.5	0.2	-0.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.2	0.3	1.4	1.2	0.8	-1.5	-1.2
Stomach or abdominal pain in last month	1.2	1.5	4.3	1.6	-1.0	-0.4	-2.1	-0.4	1.0
Impedance of leg (left)	1.2	5.7	18.8	4.3	0.7	0.0	-3.9	0.3	-0.2
Mouth/teeth dental problems	1.2	1.8	5.7	-2.2	-0.3	-0.3	2.4	0.1	0.2
Illnesses of siblings	1.2	1.7	3.8	-1.9	-1.4	-1.3	0.6	0.6	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	6.7	2.6	-0.3	-0.1	-2.2	-0.2	0.5
Impedance of arm (left)	1.2	5.4	9.1	1.5	2.5	2.6	0.9	-3.0	-2.7
Arm fat-free mass (right)	1.2	6.4	9.2	-3.0	-2.9	-2.5	0.7	2.5	2.8
Exposure to tobacco smoke outside home	1.2	1.6	5.2	2.3	0.7	0.5	-1.5	-0.9	-0.7
Emphysema/chronic bronchitis	1.2	1.3	2.5	-1.2	-1.6	-1.3	0.1	0.8	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	3.1	0.6	1.5	1.3	0.7	-1.0	-1.8
Leg fat mass (right)	1.2	4.5	12.0	3.5	2.0	2.0	-1.7	-1.0	-1.7
Supplements: Vitamin C	1.2	1.4	3.5	-1.9	-0.9	-0.1	1.5	-0.9	1.1
Whole body water mass	1.2	6.6	15.5	-3.9	-2.5	-2.1	1.9	2.0	2.3
Eye problems/disorders: Glaucoma	1.2	1.4	2.2	1.5	1.1	1.2	-0.1	-1.4	-1.3
Number of operations (self-reported)	1.2	1.8	6.1	1.9	-0.2	-0.7	-2.5	0.8	0.3
Verbal and Numeric Reasoning (VNR)	1.1	2.7	8.3	-2.9	-0.7	0.3	2.5	-0.9	0.3
Ovarian Cancer	1.1	1.5	1.9	1.4	1.3	1.3	-0.4	-1.3	-1.3
Triglycerides	1.1	1.8	5.3	2.1	0.5	0.5	-2.3	0.5	-0.1
BMI	1.1	6.2	10.1	2.8	3.2	3.0	-0.5	-1.4	-2.8
Allergy or Eczema	1.1	2.8	10.0	-0.0	1.1	1.9	0.8	-3.2	-1.1
Impedance of leg (right)	1.1	5.4	17.6	4.2	0.9	0.2	-3.7	0.5	-0.4
Townsend deprivation index at recruitment	1.1	1.5	5.2	1.6	-0.5	-0.6	-2.3	0.2	0.5
High blood pressure	1.1	3.2	6.8	2.6	1.9	1.5	-1.7	-1.0	-1.8
Hayfever, allergic rhinitis or eczema	1.1	2.4	5.7	-0.1	1.4	1.9	1.1	-2.4	-1.4
Alcohol usually taken with meals	1.1	1.7	4.8	-1.1	1.0	1.0	2.2	-1.0	-1.1
Pulse rate	1.1	1.9	3.7	-1.4	-1.9	-1.4	0.3	0.1	1.9
Asthma	1.1	2.1	5.6	2.4	1.0	0.9	-2.2	0.1	-0.6
Breastfed as a baby	1.1	1.4	4.1	-1.4	0.1	0.4	2.0	-1.3	-0.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.2	1.8	0.4	0.2	-2.1	0.3	-0.3
Worry too long after embarrassment	1.1	1.9	3.7	0.8	-1.6	-0.9	-1.9	0.5	1.9
Arm predicted mass (right)	1.1	5.7	8.0	-2.8	-2.7	-2.4	0.5	2.4	2.6
Whole body fat-free mass	1.1	6.5	15.8	-4.0	-2.4	-2.0	2.0	1.9	2.2
Diabetes diagnosed by doctor	1.1	1.8	3.2	1.2	1.3	1.4	0.3	-1.8	-1.6
Asthma (self-reported)	1.1	2.1	5.8	2.4	0.9	0.9	-2.3	0.0	-0.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.5	-2.1	-0.8	-0.5	1.4	-0.4	0.4
Crohns Disease (2017)	1.0	2.1	2.9	1.6	1.7	1.6	-0.2	-1.6	-1.5
LDL Cholesterol	1.0	1.7	4.7	-1.6	0.0	-0.9	1.3	2.2	0.1
Heel T-Score	1.0	8.3	19.5	2.9	-2.5	-2.1	-4.4	1.9	2.8
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.7	1.9	-0.3	-0.1	-1.9	0.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.8	1.9	-1.3	-0.7	-2.2	0.8	1.5
Waist circumference	1.0	3.7	5.9	2.2	2.4	2.3	-0.3	-1.0	-2.3
Hair/balding pattern: Pattern 2	1.0	1.2	3.0	1.1	-0.0	-0.7	-1.6	1.7	0.3
Medication: Ramipril	1.0	1.3	2.8	1.7	1.0	0.9	-0.5	-1.2	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.2	-0.4	1.4	1.5	0.7	-0.7	-1.2
Arm fat mass (right)	1.0	4.2	7.0	2.7	2.3	2.4	-0.6	-1.4	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.3	1.7	-0.2	0.2	-1.8	-0.9	0.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.6	-0.4	0.7	1.0	1.5	-1.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.9	-0.3	-1.0	-1.4	-0.8	1.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.4	-0.3	2.0	1.5	1.2	-0.3	-2.1
Vascular/heart problems diagnosed by doctor	1.0	2.6	5.1	-2.3	-1.9	-1.3	1.3	0.4	1.9
Cholesterol lowering medication	1.0	1.5	3.2	1.6	-0.4	-0.8	-1.8	1.4	0.4
Basal cell carcinoma (self-reported)	1.0	1.2	4.4	-1.1	0.3	0.8	2.1	-0.9	-0.3
Impedance of whole body	1.0	4.9	11.7	3.4	2.1	1.9	-1.5	-1.9	-2.0
Leg fat mass (left)	1.0	3.7	10.6	3.3	1.7	1.7	-1.7	-1.0	-1.4
Bipolar Disorder (2011)	0.9	0.9	2.4	-0.8	-1.5	-0.9	-0.2	-0.1	1.2
Body mass index (BMI)	0.9	3.8	8.4	2.9	2.1	2.1	-1.2	-1.0	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.5	1.9	-1.0	-0.6	-2.3	0.2	1.2
Qualifications: None of the above	0.9	2.0	4.5	2.1	0.8	-0.4	-1.7	1.8	-0.6
Financial difficulties in last 2 years	0.9	1.2	2.7	-0.7	-1.6	-1.1	-0.2	0.4	1.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	8.4	-1.9	1.4	1.4	2.9	-0.4	-1.6
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	4.0	-1.1	0.5	1.2	1.2	-2.0	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.3	1.6	-0.0	-0.4	-1.8	0.6	0.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.0	0.0	-0.9	-1.3	-0.9	1.4	1.0
Neck or shoulder pain in last month	0.9	1.3	3.3	1.8	1.1	0.1	-1.5	0.8	-0.8
Medication: Blood pressure	0.9	1.6	4.5	2.0	0.5	-0.4	-2.1	0.7	-0.4
Knee pain experienced in last month	0.9	1.4	3.6	1.9	1.3	0.3	-1.2	0.9	-1.0
Arm fat mass (left)	0.9	3.9	5.7	2.4	2.2	2.4	-0.4	-1.5	-2.1
Ever taken oral contraceptive pill	0.9	1.0	3.5	1.2	-0.2	-0.3	-1.9	1.0	0.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.1	0.5	1.4	1.1	0.9	-0.7	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.8	-0.4	-1.7	-1.1	-0.2	0.2	1.7
Alzheimer’s Disease (in mother)	0.8	0.9	3.4	-1.0	-0.6	0.3	1.9	-0.8	0.2
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	0.7	-0.8	-0.8	-1.4	0.6	1.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.0	-1.7	-0.9	-0.4	1.6	0.2	1.2
Qualifications: College or University degree	0.8	2.5	7.7	-2.8	-1.5	-0.7	1.7	-0.4	1.4
Eye problems/disorders: None of the above	0.8	1.0	3.3	0.7	-0.4	-0.7	-1.8	0.7	0.9
Medication: Ibuprofen	0.8	1.0	2.1	1.4	0.7	0.9	-0.6	-1.5	-0.6
Leg fat-free mass (right)	0.8	4.2	13.9	-3.7	-0.9	-0.2	3.2	-0.2	0.6
Leg predicted mass (right)	0.8	4.2	13.9	-3.7	-0.9	-0.2	3.2	-0.2	0.6
High cholesterol (Self-reported)	0.8	1.5	3.2	1.1	-0.9	-1.2	-1.8	1.4	0.4
Arm fat-free mass (left)	0.8	4.1	5.8	-2.4	-2.1	-2.0	0.5	2.3	2.1
Arm predicted mass (left)	0.8	4.1	5.6	-2.2	-2.2	-2.0	0.3	2.4	2.2
Blood Eosinophil Count	0.7	5.7	13.5	-3.7	-2.5	-1.8	1.8	1.2	2.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.8	1.3	0.2	0.5	-1.0	-1.2	-0.4
Multivitamins +/- minerals	0.7	0.9	2.3	1.3	0.4	1.0	-0.5	-1.5	-0.3
Supplements: Glucosamine	0.7	0.9	1.9	-0.6	1.0	1.4	0.7	-0.8	-0.9
Allergy	0.7	1.6	4.1	-0.7	-1.1	-1.8	-0.1	2.0	1.0
Fluid intelligence score	0.7	1.5	3.9	-2.0	-0.5	0.7	1.6	-1.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	5.7	-1.7	1.2	1.0	2.4	0.2	-1.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.5	1.6	1.0	0.7	-1.0	-0.0	-0.6
Blood clot in the leg (DVT)	0.7	0.9	2.2	-0.1	-1.5	-0.9	-0.4	0.0	1.4
Number of children fathered	0.7	0.8	1.4	1.2	0.8	0.9	0.3	-1.1	-0.8
Heart disease (mother)	0.7	0.9	2.7	1.6	-0.2	-0.3	-1.5	0.4	0.5
Ever had bowel cancer screening	0.7	0.8	1.8	1.2	-0.8	-0.5	-1.3	-0.0	0.8
Illnesses of father: None of the above (group 1)	0.7	0.9	1.5	-1.1	-1.1	-1.2	0.2	0.7	1.0
Average weekly champagne plus white wine intake	0.7	0.9	1.9	-0.8	-1.0	-1.0	-0.2	1.4	1.0
Hearing aid user	0.7	0.8	2.0	-0.2	0.9	0.8	1.4	-0.4	-1.0
Risk taking	0.7	1.0	2.0	-1.4	-0.9	-1.1	0.4	1.1	0.9
Alcohol drinker status: Previous	0.7	0.7	2.5	1.6	-0.3	-0.2	-1.3	-0.4	-0.0
Schizophrenia (2018)	0.6	1.3	2.6	1.3	-1.0	-0.5	-1.6	-0.7	1.3
Rheumatoid Arthritis	0.6	0.8	1.6	-0.9	-0.9	-1.3	0.3	0.9	0.7
Vitamin and mineral supplements	0.6	0.9	3.7	-0.5	-0.3	-1.1	-0.0	1.9	-0.0
Supplements: Zinc	0.6	0.6	1.0	0.5	0.9	1.0	0.4	-0.9	-0.8
Leg fat-free mass (left)	0.6	3.1	9.8	-3.1	-0.5	0.2	2.8	-0.4	0.2
Hand grip strength (right)	0.6	1.7	4.1	2.0	-0.3	0.5	-1.9	-1.3	0.8
Maternal smoking around birth	0.6	0.9	2.2	1.5	-0.5	-0.4	-1.4	0.2	0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.8	1.1	-0.6	0.1	-1.3	-0.6	0.4
Leg predicted mass (left)	0.6	3.2	10.1	-3.2	-0.6	0.1	2.9	-0.3	0.3
Number of incorrect matches in round	0.6	1.0	3.1	1.7	0.9	0.7	-0.9	-0.1	-0.9
Had menopause	0.6	0.8	1.2	0.6	-1.0	-1.1	-1.1	0.8	0.6
Hair/balding pattern: Pattern 3	0.6	1.0	2.6	-0.7	-1.6	-0.8	0.0	-0.3	1.4
Medication: Cholesterol lowering	0.6	1.0	1.9	1.0	1.0	0.8	-0.7	-0.8	-1.4
Pulse wave reflection index	0.6	0.7	2.0	-1.1	-0.2	-0.7	0.7	1.4	-0.0
Medication: Amlodipine	0.6	0.9	2.2	1.1	0.3	-0.5	-1.1	1.5	-0.6
Pulse rate, automated reading	0.6	1.9	4.0	2.0	0.4	1.5	-1.2	-1.9	-0.1
Leg pain on walking	0.6	0.7	2.3	1.5	0.3	0.7	-0.5	-1.1	-0.2
Basal metabolic rate	0.6	3.1	8.6	-2.9	-1.5	-1.2	1.7	1.2	1.4
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-0.1	0.8	0.6	0.4	-0.9	-1.0
Blood White Count	0.5	3.8	12.2	-3.1	0.0	0.1	3.5	-0.9	-0.4
Diabetes (father)	0.5	0.7	1.3	1.1	1.0	0.5	-0.7	-0.2	-0.9
Serious illness, injury or assault to yourself	0.5	0.7	1.0	0.8	0.8	0.7	-0.7	-0.9	-1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.5	0.3	1.2	0.9	0.6	-0.1	-1.1
Noisy workplace	0.5	0.7	1.8	1.1	-0.2	-0.5	-1.3	0.8	0.3
Prospective memory result	0.5	0.6	1.4	-0.7	-0.4	-1.1	0.2	1.2	0.4
Osteoarthritis (self-reported)	0.5	0.6	2.3	0.8	0.3	-0.3	-0.7	1.5	-0.3
Commuting to job workplace: Cycle	0.5	0.6	1.6	-1.3	0.0	-0.4	1.1	0.7	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.8	-2.0	-0.8	-0.0	1.5	-0.8	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	-1.2	-0.6	-0.7	0.9	0.6	0.3
Mean Putamen Volume	0.4	0.5	0.9	1.0	0.9	0.6	-0.6	-0.1	-0.5
Fasting Glucose	0.4	0.5	1.3	-0.6	0.3	0.5	1.1	-0.7	-0.6
Primary Biliary Cirrhosis	0.4	0.6	1.2	1.1	-0.4	-0.4	-1.1	0.8	0.7
Tanning	0.4	5.1	14.7	-3.8	-1.8	-1.7	2.1	1.5	1.8
Current tobacco smoking	0.4	0.7	1.8	0.8	-0.3	-0.7	-1.4	1.1	0.4
Qualifications: CSEs or equivalent	0.4	0.5	1.1	1.1	0.7	0.5	-0.7	-0.4	-0.7
Forced vital capacity (FVC)	0.4	1.6	2.9	-0.9	1.3	1.2	1.7	-0.1	-1.5
Heart attack	0.4	0.5	1.2	1.0	-0.5	-0.7	-1.1	0.4	0.3
Diabetes (self-reported)	0.4	0.7	1.4	0.9	0.8	0.5	0.1	-0.9	-1.2
Illnesses of mother	0.4	0.5	2.4	-1.5	-0.2	-0.1	0.9	-0.2	-0.2
Hair/balding pattern: Pattern 4	0.4	0.9	3.2	-1.8	-0.5	-0.4	1.2	0.1	0.4
Birth weight of first child	0.4	0.8	1.8	-1.3	0.6	-0.4	1.3	0.4	-0.8
Pulse wave peak to peak time	0.4	0.4	1.4	0.7	-0.4	-0.5	-1.2	0.4	0.4
Illnesses of father: Heart disease	0.4	0.5	1.0	0.9	1.0	0.6	-0.1	0.1	-1.0
Illnesses of siblings: Diabetes	0.4	0.5	1.0	1.0	0.5	0.1	-0.9	0.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.5	-1.6	-0.8	-0.7	0.8	0.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	0.4	0.5	0.7	-0.1	-1.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.7	-1.3	-0.2	0.1	1.3	-0.8	-0.2
Breast cancer (self-reported)	0.4	0.5	1.1	0.7	0.6	-0.3	-0.7	1.1	-0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	-1.2	-0.2	-0.5	1.0	0.5	0.0
Medication: Atorvastatin	0.4	0.6	1.5	0.5	0.9	0.4	-0.1	0.7	-1.2
Fractured/broken bones in last 5 years	0.4	0.6	1.1	0.2	0.8	0.8	0.3	-0.9	-1.1
Myopia	0.4	0.5	1.8	0.3	0.0	-0.4	-1.0	1.3	0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.2	1.1	-0.6	-0.3	-0.9	-1.0	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	0.2	0.7	0.6	0.6	-0.9	-0.9
Relative age of first facial hair	0.3	0.6	1.4	-0.7	-0.5	-1.0	0.1	1.2	0.6
Diabetes (mother)	0.3	0.4	0.7	-0.5	-0.7	-0.6	-0.3	0.7	0.9
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	-0.9	0.2	0.3	1.2	-0.2	-0.2
Loud music exposure frequency	0.3	0.3	1.6	0.1	-0.1	0.3	0.3	-1.3	0.2
High blood pressure (siblings)	0.3	0.4	0.7	0.5	-0.6	-0.4	-0.7	0.8	0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	2.1	-0.7	1.3	0.9	1.4	0.3	-1.4
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	-0.4	0.6	0.3	0.6	0.5	-0.9
Smoking status: Current	0.3	0.5	1.4	0.9	-0.0	-0.3	-1.2	0.7	0.1
Mother’s age at death	0.3	0.4	1.4	-1.2	-0.4	-0.2	0.7	0.0	0.5
Medication: Lisinopril	0.3	0.4	0.7	0.8	0.6	-0.1	-0.5	0.7	-0.8
Alcohol drinker status: Never	0.3	0.4	0.9	0.5	0.3	1.0	-0.2	-0.7	-0.5
Average weekly beer plus cider intake	0.3	0.4	1.0	0.9	0.6	0.5	-1.0	-0.3	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.7	0.8	-0.5	-0.6	-0.8	0.3	0.3
Bipolar Disorder (2018)	0.2	0.2	0.6	0.1	0.2	0.3	0.7	-0.7	-0.5
Crohns Disease (2012)	0.2	0.3	0.8	-0.2	-0.8	-0.6	-0.3	-0.0	0.9
HbA1C	0.2	0.2	0.4	-0.6	-0.3	0.6	0.5	-0.5	0.3
Sitting height	0.2	1.3	4.8	-2.2	-0.8	-0.0	1.2	-0.6	0.8
Hip circumference	0.2	0.7	1.3	-0.2	1.0	0.7	1.1	0.1	-1.1
Mouth/teeth dental problems: Dentures	0.2	0.3	1.2	0.7	0.0	-0.1	-1.1	0.3	-0.1
Number of full brothers	0.2	0.3	0.8	0.3	-0.4	-0.3	-0.9	0.3	0.6
Mineral and other dietary supplements	0.2	0.2	0.8	-0.0	-0.5	-0.5	-0.2	0.9	0.3
Osteoporosis (self-reported)	0.2	0.2	0.6	0.7	-0.4	-0.3	-0.8	-0.2	0.2
Hair Pigment	0.1	1.6	5.7	2.4	0.9	0.9	-1.3	-0.3	-0.8
Relative age voice broke	0.1	0.1	0.2	0.1	-0.4	0.0	-0.4	-0.1	0.4
Pain all over the body in last month	0.1	0.1	0.1	0.3	0.2	-0.0	0.3	0.2	-0.3
Weight	0.1	0.4	0.9	0.2	0.8	1.0	0.5	-0.3	-0.8
Time employed in main current job	0.1	0.2	0.4	0.1	0.3	0.6	0.1	-0.5	-0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.1	0.1	-0.4	0.5	0.5	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.5	0.3	0.3	-0.0	0.1	-0.3
Peak expiratory flow (PEF)	0.1	0.3	0.7	-0.6	0.5	0.3	0.7	0.9	-0.4
Age started oral contraceptive pill	0.1	0.2	0.3	-0.4	-0.5	-0.5	-0.1	0.3	0.3
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.0	-0.4	-0.3	-0.5	-0.3	0.2
Breast Cancer	0.0	0.1	0.2	0.3	-0.1	0.4	0.1	-0.4	-0.0
Blood Red Count	0.0	0.2	0.7	0.3	0.1	-0.4	-0.1	0.8	-0.0
Falls in the last year	0.0	0.1	0.2	0.1	-0.3	-0.4	-0.0	-0.0	0.3
Number of live births	0.0	0.0	0.1	-0.1	0.1	-0.0	0.4	-0.0	-0.4
Had major operations	0.0	0.0	0.1	0.0	-0.2	0.1	-0.3	-0.3	0.1

Hub : Genes

DLST

Models

Trait associations