Hub : Genes

DLST

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0930 0.0290 3.2e-09 0.106 0.083 0.102 0.092 0.109 8.4e-13 2.4e-10 2.2e-12 2.6e-11 4.0e-13
2 GTEx Cells Transformed fibroblasts 0.0810 0.0390 8.9e-03 -0.001 NA -0.001 NA 0.010 3.6e-01 NA 4.3e-01 NA 5.8e-02
3 GTEx Esophagus Muscularis 0.1170 0.0470 1.9e-03 0.033 NA 0.017 NA 0.023 4.4e-03 NA 3.1e-02 NA 1.4e-02
4 GTEx Muscle Skeletal 0.2782 0.0512 0.0e+00 0.264 NA 0.260 NA 0.259 6.8e-26 NA 2.1e-25 NA 2.4e-25
5 NTR Blood 0.0484 0.0121 6.7e-15 0.054 0.052 0.059 0.056 0.057 6.8e-17 3.2e-16 2.5e-18 2.1e-17 7.2e-18
6 TCGA Thyroid Carcinoma 0.0390 0.0250 5.2e-03 0.033 0.024 0.014 NA 0.025 3.1e-04 1.8e-03 1.5e-02 NA 1.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.2 0.6 0.1 0.2 0.3 0.7 -0.7 -0.5
Bipolar Disorder or Schizophrenia 0.3 0.7 1.2 1.1 -0.6 -0.3 -0.9 -1.0 0.7
Depressed Affect (Nagel 2018) 5.5 11.6 37.3 4.9 -1.4 -1.3 -6.1 1.2 1.9
Depression (Nagel 2018) 1.4 2.1 5.7 2.4 1.3 1.2 -1.5 -0.8 -0.9
Intelligence (Savage-Jansen 2018) 0.4 1.3 3.8 -2.0 -0.8 -0.0 1.5 -0.8 0.4
Neuroticism (Nagel 2018) 7.2 17.0 55.2 6.7 -0.6 -0.3 -7.4 -0.0 1.4
Schizophrenia (2018) 0.6 1.3 2.6 1.3 -1.0 -0.5 -1.6 -0.7 1.3
Schizophrenia vs Biploar Disorder 2.5 3.2 4.9 1.0 -1.9 -2.0 -2.2 1.4 2.0
Worry (Nagel 2018) 8.2 17.3 51.6 7.2 1.4 1.5 -6.8 -1.3 -0.6
Alzheimer’s Disease (in mother) 0.8 0.9 3.4 -1.0 -0.6 0.3 1.9 -0.8 0.2
Alzheimer’s Disease (in father) 0.5 0.5 1.0 -0.1 0.8 0.6 0.4 -0.9 -1.0
Alzheimer’s Disease (including proxy) 0.4 0.6 1.5 -1.2 -0.6 -0.7 0.9 0.6 0.3
Crohns Disease (2017) 1.0 2.1 2.9 1.6 1.7 1.6 -0.2 -1.6 -1.5
Irritable Bowel Disease (IBD) 2.7 6.5 10.7 1.7 3.2 2.8 1.0 -2.4 -3.3
Ulcerative Colitis (UC) 3.0 5.6 11.2 1.5 3.1 2.5 1.2 -1.8 -3.3
Major Depression (MDD) 4.8 5.8 12.8 3.6 1.9 2.0 -2.7 -2.0 -1.8
Reaction Time 6.3 11.9 18.3 -0.3 3.8 4.1 3.2 -3.4 -4.3
Verbal and Numeric Reasoning (VNR) 1.1 2.7 8.3 -2.9 -0.7 0.3 2.5 -0.9 0.3
Breast Cancer 0.0 0.1 0.2 0.3 -0.1 0.4 0.1 -0.4 -0.0
Ovarian Cancer 1.1 1.5 1.9 1.4 1.3 1.3 -0.4 -1.3 -1.3
Prostate Cancer 1.3 1.9 5.0 2.2 -0.6 0.2 -2.0 -0.8 1.1
Age at First Birth 5.2 7.5 13.2 -2.4 -3.1 -3.0 0.1 3.6 2.7
Bipolar Disorder (2011) 0.9 0.9 2.4 -0.8 -1.5 -0.9 -0.2 -0.1 1.2
Body Mass Index (BMI) (2010) 2.9 4.0 6.4 1.9 2.5 2.3 -0.2 -1.7 -2.4
Coronary Artery Disease (CAD) 2.5 3.0 8.3 2.8 -1.0 -0.3 -2.9 0.2 0.8
Crohns Disease (2012) 0.2 0.3 0.8 -0.2 -0.8 -0.6 -0.3 -0.0 0.9
Mean Putamen Volume 0.4 0.5 0.9 1.0 0.9 0.6 -0.6 -0.1 -0.5
Fasting Glucose 0.4 0.5 1.3 -0.6 0.3 0.5 1.1 -0.7 -0.6
HbA1C 0.2 0.2 0.4 -0.6 -0.3 0.6 0.5 -0.5 0.3
HDL Cholesterol 1.6 2.7 5.6 -2.4 -1.7 -1.5 1.6 0.9 1.3
LDL Cholesterol 1.0 1.7 4.7 -1.6 0.0 -0.9 1.3 2.2 0.1
Lupus 1.2 1.8 4.7 0.7 -1.0 -1.4 -1.3 2.2 0.9
Neuroticism (2016) 3.8 5.5 14.6 3.8 -0.9 0.1 -3.7 -1.3 1.4
Primary Biliary Cirrhosis 0.4 0.6 1.2 1.1 -0.4 -0.4 -1.1 0.8 0.7
Rheumatoid Arthritis 0.6 0.8 1.6 -0.9 -0.9 -1.3 0.3 0.9 0.7
Schizophrenia (2014) 2.5 5.4 12.6 2.6 -2.0 -1.4 -3.6 -0.4 2.7
Triglycerides 1.1 1.8 5.3 2.1 0.5 0.5 -2.3 0.5 -0.1
Type 2 Diabetes (T2D) (2012) 3.2 3.7 7.1 -0.2 1.9 2.7 1.7 -2.2 -2.0
Ulcerative Colitis 1.4 2.0 3.4 1.0 1.7 1.5 0.4 -1.4 -1.9
Blood Eosinophil Count 0.7 5.7 13.5 -3.7 -2.5 -1.8 1.8 1.2 2.5
Blood Platelet Count 1.4 16.7 50.3 -7.1 0.4 0.4 6.9 -0.2 -1.2
Blood Red Count 0.0 0.2 0.7 0.3 0.1 -0.4 -0.1 0.8 -0.0
Blood White Count 0.5 3.8 12.2 -3.1 0.0 0.1 3.5 -0.9 -0.4
Heel T-Score 1.0 8.3 19.5 2.9 -2.5 -2.1 -4.4 1.9 2.8
BMI 1.1 6.2 10.1 2.8 3.2 3.0 -0.5 -1.4 -2.8
Height 1.5 29.1 50.8 -7.1 -6.3 -5.7 2.4 3.6 5.8
Waist Hip Ratio (WHR) 1.8 8.1 13.0 3.6 3.3 3.1 -1.1 -2.3 -2.9
Systolic Blood Pressure 4.0 20.2 31.8 5.6 4.8 5.1 -2.1 -4.2 -4.3
Smoking Status 1.3 3.1 8.6 2.6 -0.9 -1.0 -2.9 0.6 1.1
Allergy or Eczema 1.1 2.8 10.0 -0.0 1.1 1.9 0.8 -3.2 -1.1
Cardiovascular Disease 1.2 3.8 8.7 2.9 2.0 1.7 -1.9 -0.6 -2.0
Hypothyroidism (self reported) 1.9 4.3 13.1 3.6 0.8 1.0 -3.4 -0.1 -0.3
Respiratory disease 1.2 2.6 6.6 2.6 1.1 1.4 -2.1 -1.0 -0.7
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.9 0.2 0.7 0.6 0.6 -0.9 -0.9
Lung FEV1/FVC ratio 3.0 15.3 47.2 -6.9 -1.1 -0.4 6.5 0.0 0.6
Lung FVC 1.9 9.7 18.3 3.2 4.1 3.2 -0.6 -1.3 -4.3
Neuroticism 8.1 19.6 58.9 7.6 0.4 1.0 -7.7 -0.7 0.4
Chronotype (morning person) 3.3 7.5 12.1 -2.2 -3.3 -3.5 -0.1 2.7 3.2
Hair Pigment 0.1 1.6 5.7 2.4 0.9 0.9 -1.3 -0.3 -0.8
Tanning 0.4 5.1 14.7 -3.8 -1.8 -1.7 2.1 1.5 1.8
Hand grip strength (left) 2.1 5.6 17.3 4.2 0.1 1.1 -3.3 -1.9 0.7
Number of treatments/medications taken 7.3 13.2 43.0 6.6 1.6 1.2 -5.4 -0.6 -1.4
Average weekly spirits intake 1.5 1.8 4.6 -1.4 0.5 0.6 2.1 -1.9 -0.5
Sensitivity / hurt feelings 1.5 2.6 7.0 2.1 -0.8 -1.0 -2.6 1.2 0.9
Frequency of depressed mood in last 2 weeks 1.7 2.4 7.7 2.8 0.2 0.4 -2.4 -0.8 -0.0
Hearing difficulty/problems: Yes 2.3 3.4 6.1 1.8 2.5 1.8 0.5 -1.4 -2.4
Relative age of first facial hair 0.3 0.6 1.4 -0.7 -0.5 -1.0 0.1 1.2 0.6
Other serious medical condition/disability diagnosed by doctor 1.8 2.4 7.4 2.7 0.7 0.2 -2.4 -0.1 -0.6
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.7 1.9 -0.3 -0.1 -1.9 0.4 0.3
Ever had hysterectomy (womb removed) 0.8 0.9 2.1 0.7 -0.8 -0.8 -1.4 0.6 1.2
Systolic blood pressure, automated reading 2.9 8.6 16.6 4.1 2.9 3.1 -1.7 -2.5 -2.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.8 1.3 0.2 0.5 -1.0 -1.2 -0.4
Angina 1.7 2.2 3.9 1.9 2.0 1.4 -0.7 -0.4 -1.7
Medication for hormone replacement therapy 1.2 1.4 3.1 1.8 1.0 1.0 -1.5 0.2 -0.9
Vitamin and mineral supplements 0.6 0.9 3.7 -0.5 -0.3 -1.1 -0.0 1.9 -0.0
Supplements: Zinc 0.6 0.6 1.0 0.5 0.9 1.0 0.4 -0.9 -0.8
Medication: Co-codamol 1.3 1.6 4.6 1.9 -0.4 -0.4 -2.1 0.6 0.6
Medication: Metformin 1.4 2.0 5.0 0.8 2.0 1.2 0.7 -0.7 -2.2
Diabetes (father) 0.5 0.7 1.3 1.1 1.0 0.5 -0.7 -0.2 -0.9
Diabetes (mother) 0.3 0.4 0.7 -0.5 -0.7 -0.6 -0.3 0.7 0.9
Severe depression (siblings) 1.3 1.5 4.8 2.2 0.6 0.7 -1.6 -0.7 -0.4
Pack years adult smoking proportion 1.5 2.2 3.3 -0.9 -1.8 -1.8 -0.4 1.8 1.7
Impedance of leg (right) 1.1 5.4 17.6 4.2 0.9 0.2 -3.7 0.5 -0.4
Leg fat-free mass (left) 0.6 3.1 9.8 -3.1 -0.5 0.2 2.8 -0.4 0.2
Trunk fat percentage 3.8 15.2 24.6 5.0 4.3 4.3 -1.3 -3.4 -4.1
Hand grip strength (right) 0.6 1.7 4.1 2.0 -0.3 0.5 -1.9 -1.3 0.8
Townsend deprivation index at recruitment 1.1 1.5 5.2 1.6 -0.5 -0.6 -2.3 0.2 0.5
Current tobacco smoking 0.4 0.7 1.8 0.8 -0.3 -0.7 -1.4 1.1 0.4
Average weekly fortified wine intake 2.1 2.5 4.9 1.4 2.2 1.5 -0.2 -0.8 -2.2
Maternal smoking around birth 0.6 0.9 2.2 1.5 -0.5 -0.4 -1.4 0.2 0.9
Fed-up feelings 6.9 12.5 40.1 5.6 -0.6 -0.7 -6.3 1.1 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 4.9 2.2 1.6 1.4 -1.1 -1.1 -1.2
Relative age voice broke 0.1 0.1 0.2 0.1 -0.4 0.0 -0.4 -0.1 0.4
Taking other prescription medications 7.5 11.5 37.8 6.2 1.7 1.4 -4.9 -0.3 -1.4
Age when periods started (menarche) 2.1 5.0 7.7 -0.6 -2.3 -2.5 -1.7 2.8 2.7
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 1.8 1.1 -0.6 0.1 -1.3 -0.6 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 4.8 1.9 -1.3 -0.7 -2.2 0.8 1.5
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.2 0.3 1.4 1.2 0.8 -1.5 -1.2
Qualifications: CSEs or equivalent 0.4 0.5 1.1 1.1 0.7 0.5 -0.7 -0.4 -0.7
Serious illness, injury or assault to yourself 0.5 0.7 1.0 0.8 0.8 0.7 -0.7 -0.9 -1.0
High blood pressure 1.1 3.2 6.8 2.6 1.9 1.5 -1.7 -1.0 -1.8
Hayfever, allergic rhinitis or eczema 1.1 2.4 5.7 -0.1 1.4 1.9 1.1 -2.4 -1.4
Multivitamins +/- minerals 0.7 0.9 2.3 1.3 0.4 1.0 -0.5 -1.5 -0.3
Stomach or abdominal pain in last month 1.2 1.5 4.3 1.6 -1.0 -0.4 -2.1 -0.4 1.0
Supplements: Glucosamine 0.7 0.9 1.9 -0.6 1.0 1.4 0.7 -0.8 -0.9
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 4.7 -2.2 -1.4 -2.0 1.1 1.3 1.0
Medication: Atenolol 2.6 3.2 9.3 3.0 1.4 0.8 -2.5 -0.3 -1.2
Medication: Levothyroxine sodium 2.0 3.4 9.9 3.1 1.5 1.3 -2.3 -0.1 -1.0
Sitting height 0.2 1.3 4.8 -2.2 -0.8 -0.0 1.2 -0.6 0.8
Chronic bronchitis/emphysema (father) 4.6 5.4 8.4 -1.4 -2.7 -2.8 -0.8 2.6 2.9
High blood pressure (mother) 2.6 3.6 7.0 1.4 2.6 2.5 0.3 -1.3 -2.3
Body mass index (BMI) 0.9 3.8 8.4 2.9 2.1 2.1 -1.2 -1.0 -1.8
Impedance of leg (left) 1.2 5.7 18.8 4.3 0.7 0.0 -3.9 0.3 -0.2
Leg predicted mass (left) 0.6 3.2 10.1 -3.2 -0.6 0.1 2.9 -0.3 0.3
Trunk fat mass 1.6 6.9 11.0 3.3 2.9 3.0 -0.7 -2.3 -2.7
Waist circumference 1.0 3.7 5.9 2.2 2.4 2.3 -0.3 -1.0 -2.3
Number of incorrect matches in round 0.6 1.0 3.1 1.7 0.9 0.7 -0.9 -0.1 -0.9
Past tobacco smoking 2.7 5.0 14.7 -3.8 0.4 0.3 3.8 -0.1 -0.7
Alcohol usually taken with meals 1.1 1.7 4.8 -1.1 1.0 1.0 2.2 -1.0 -1.1
Nervous feelings 6.5 12.1 36.0 6.0 2.0 1.9 -5.0 -1.3 -1.3
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 6.6 2.6 0.9 1.3 -1.9 -1.5 -0.7
Hearing difficulty/problems with background noise 2.3 3.6 6.5 2.6 2.0 1.7 -0.5 -1.9 -2.1
Hair/balding pattern: Pattern 2 1.0 1.2 3.0 1.1 -0.0 -0.7 -1.6 1.7 0.3
Had menopause 0.6 0.8 1.2 0.6 -1.0 -1.1 -1.1 0.8 0.6
Had other major operations 1.3 1.6 4.5 1.2 -0.8 -1.2 -2.1 0.8 0.9
Forced vital capacity (FVC) 0.4 1.6 2.9 -0.9 1.3 1.2 1.7 -0.1 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 5.5 1.9 -1.0 -0.6 -2.3 0.2 1.2
Ever unenthusiastic/disinterested for a whole week 3.4 4.1 14.2 3.8 0.6 0.7 -3.0 0.3 -0.7
Qualifications: None of the above 0.9 2.0 4.5 2.1 0.8 -0.4 -1.7 1.8 -0.6
Financial difficulties in last 2 years 0.9 1.2 2.7 -0.7 -1.6 -1.1 -0.2 0.4 1.5
Mouth/teeth dental problems 1.2 1.8 5.7 -2.2 -0.3 -0.3 2.4 0.1 0.2
Heart attack 0.4 0.5 1.2 1.0 -0.5 -0.7 -1.1 0.4 0.3
Allergy 0.7 1.6 4.1 -0.7 -1.1 -1.8 -0.1 2.0 1.0
Pain all over the body in last month 0.1 0.1 0.1 0.3 0.2 -0.0 0.3 0.2 -0.3
Diabetes (self-reported) 0.4 0.7 1.4 0.9 0.8 0.5 0.1 -0.9 -1.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.5 0.3 1.2 0.9 0.6 -0.1 -1.1
Medication: Ramipril 1.0 1.3 2.8 1.7 1.0 0.9 -0.5 -1.2 -1.3
Medication: Simvastatin 1.4 2.0 6.7 2.2 -0.2 -0.6 -2.6 0.5 0.2
Fluid intelligence score 0.7 1.5 3.9 -2.0 -0.5 0.7 1.6 -1.3 0.3
Illnesses of siblings 1.2 1.7 3.8 -1.9 -1.4 -1.3 0.6 0.6 1.2
Neuroticism score 7.2 15.0 46.0 6.6 0.1 0.5 -6.8 -0.1 0.6
Weight 0.1 0.4 0.9 0.2 0.8 1.0 0.5 -0.3 -0.8
Impedance of arm (right) 1.6 7.4 11.0 2.1 3.2 3.0 0.7 -3.0 -3.3
Arm fat percentage (right) 3.5 13.9 18.7 4.3 4.3 4.3 -0.8 -3.1 -4.1
Trunk fat-free mass 1.9 10.9 20.7 -4.5 -3.4 -3.2 1.6 3.2 3.2
Hip circumference 0.2 0.7 1.3 -0.2 1.0 0.7 1.1 0.1 -1.1
Time employed in main current job 0.1 0.2 0.4 0.1 0.3 0.6 0.1 -0.5 -0.4
Alcohol intake versus 10 years previously 0.1 0.1 0.3 -0.1 0.1 -0.4 0.5 0.5 -0.1
Father’s age at death 2.1 2.8 9.2 -3.0 -0.4 -0.8 2.3 1.3 -0.0
Worrier / anxious feelings 6.2 11.7 37.9 6.2 1.2 1.5 -5.1 -1.4 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 6.7 2.6 -0.3 -0.1 -2.2 -0.2 0.5
Falls in the last year 0.0 0.1 0.2 0.1 -0.3 -0.4 -0.0 -0.0 0.3
Hair/balding pattern: Pattern 3 0.6 1.0 2.6 -0.7 -1.6 -0.8 0.0 -0.3 1.4
Number of live births 0.0 0.0 0.1 -0.1 0.1 -0.0 0.4 -0.0 -0.4
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 8.4 -1.9 1.4 1.4 2.9 -0.4 -1.6
Pulse rate 1.1 1.9 3.7 -1.4 -1.9 -1.4 0.3 0.1 1.9
Happiness 3.3 4.0 14.0 1.8 -1.5 -1.2 -3.7 0.4 1.6
Noisy workplace 0.5 0.7 1.8 1.1 -0.2 -0.5 -1.3 0.8 0.3
Qualifications: A levels/AS levels or equivalent 1.6 3.5 9.6 -2.7 -0.1 0.7 3.1 -1.8 -0.4
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.2 -0.4 1.4 1.5 0.7 -0.7 -1.2
Mouth/teeth dental problems: Dentures 0.2 0.3 1.2 0.7 0.0 -0.1 -1.1 0.3 -0.1
Asthma 1.1 2.1 5.6 2.4 1.0 0.9 -2.2 0.1 -0.6
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 3.7 1.9 1.0 1.1 -1.1 -1.6 -0.7
Medication: Cholesterol lowering 0.6 1.0 1.9 1.0 1.0 0.8 -0.7 -0.8 -1.4
Depression (self-reported) 1.4 1.7 6.6 1.8 -0.0 -0.1 -2.6 0.2 0.3
Medication: Lansoprazole 3.4 3.9 12.6 3.5 0.9 0.5 -3.1 0.3 -0.3
Prospective memory result 0.5 0.6 1.4 -0.7 -0.4 -1.1 0.2 1.2 0.4
Lung cancer (father) 1.3 1.5 2.5 -0.5 -1.6 -1.3 -0.7 1.4 1.5
Illnesses of mother 0.4 0.5 2.4 -1.5 -0.2 -0.1 0.9 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 5.7 -1.7 1.2 1.0 2.4 0.2 -1.4
Pulse wave Arterial Stiffness index 0.3 0.4 1.5 -0.9 0.2 0.3 1.2 -0.2 -0.2
Impedance of arm (left) 1.2 5.4 9.1 1.5 2.5 2.6 0.9 -3.0 -2.7
Arm fat mass (right) 1.0 4.2 7.0 2.7 2.3 2.4 -0.6 -1.4 -2.1
Trunk predicted mass 1.9 11.1 20.6 -4.5 -3.4 -3.2 1.6 3.2 3.3
Standing height 1.3 12.7 32.9 -5.7 -3.3 -3.0 3.3 2.2 2.8
Length of working week for main job 3.5 3.9 6.0 -0.9 -2.3 -2.4 -1.1 2.3 2.1
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.5 0.3 0.3 -0.0 0.1 -0.3
Breastfed as a baby 1.1 1.4 4.1 -1.4 0.1 0.4 2.0 -1.3 -0.4
Tense / ‘highly strung’ 5.5 9.1 20.6 4.5 2.9 2.7 -3.0 -1.9 -2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 4.3 6.6 20.3 4.5 1.5 1.3 -3.6 -0.4 -1.4
Hair/balding pattern: Pattern 4 0.4 0.9 3.2 -1.8 -0.5 -0.4 1.2 0.1 0.4
Birth weight of first child 0.4 0.8 1.8 -1.3 0.6 -0.4 1.3 0.4 -0.8
Peak expiratory flow (PEF) 0.1 0.3 0.7 -0.6 0.5 0.3 0.7 0.9 -0.4
Pulse wave reflection index 0.6 0.7 2.0 -1.1 -0.2 -0.7 0.7 1.4 -0.0
Ever highly irritable/argumentative for 2 days 1.1 1.3 4.2 1.8 0.4 0.2 -2.1 0.3 -0.3
Loud music exposure frequency 0.3 0.3 1.6 0.1 -0.1 0.3 0.3 -1.3 0.2
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 4.0 -1.1 0.5 1.2 1.2 -2.0 -0.5
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.5 1.6 1.0 0.7 -1.0 -0.0 -0.6
Blood clot in the leg (DVT) 0.7 0.9 2.2 -0.1 -1.5 -0.9 -0.4 0.0 1.4
Medication: Paracetamol 1.8 3.0 9.6 3.1 0.3 0.6 -2.4 -1.3 -0.2
Headache pain in last month 1.8 3.0 10.3 3.2 0.5 0.3 -2.7 -0.2 -0.3
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 3.0 -1.7 -0.9 -0.4 1.6 0.2 1.2
Glaucoma (self-reported) 1.8 2.1 3.8 1.9 1.3 1.3 -0.1 -1.9 -1.3
Gout (self-reported) 2.4 3.3 6.0 0.4 -1.9 -2.2 -1.2 2.4 1.9
Hypothyroidism/myxoedema (self-reported) 1.7 3.4 10.1 3.1 0.4 0.4 -3.2 0.5 -0.0
Medication: Amlodipine 0.6 0.9 2.2 1.1 0.3 -0.5 -1.1 1.5 -0.6
Medication: Ventolin 100micrograms inhaler 2.4 3.1 4.5 0.1 -2.0 -1.6 -1.9 2.0 2.1
Birth weight 1.8 3.8 6.0 -0.9 -2.1 -2.4 -0.9 2.4 2.3
Chronic bronchitis/emphysema (mother) 5.0 5.9 8.6 0.9 -2.4 -2.9 -2.2 2.9 2.6
High blood pressure (siblings) 0.3 0.4 0.7 0.5 -0.6 -0.4 -0.7 0.8 0.8
Forced vital capacity (FVC), Best measure 0.3 1.2 2.1 -0.7 1.3 0.9 1.4 0.3 -1.4
Body fat percentage 3.8 15.1 29.9 5.5 4.1 4.1 -1.9 -3.0 -3.8
Leg fat percentage (right) 3.3 11.9 36.4 6.0 2.9 2.5 -3.7 -1.0 -2.3
Arm fat-free mass (right) 1.2 6.4 9.2 -3.0 -2.9 -2.5 0.7 2.5 2.8
Exposure to tobacco smoke outside home 1.2 1.6 5.2 2.3 0.7 0.5 -1.5 -0.9 -0.7
Comparative body size at age 10 1.4 4.0 5.6 -0.7 2.0 2.4 2.3 -2.2 -2.0
Number of full brothers 0.2 0.3 0.8 0.3 -0.4 -0.3 -0.9 0.3 0.6
Worry too long after embarrassment 1.1 1.9 3.7 0.8 -1.6 -0.9 -1.9 0.5 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.5 10.4 3.1 0.5 0.7 -3.2 -0.3 -0.3
Wheeze or whistling in the chest in last year 2.7 4.8 14.3 3.8 1.6 1.5 -2.9 -0.2 -1.1
Number of children fathered 0.7 0.8 1.4 1.2 0.8 0.9 0.3 -1.1 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 3.3 1.6 -0.0 -0.4 -1.8 0.6 0.2
Age at first live birth 3.0 5.3 11.0 -3.3 -2.1 -2.1 1.7 2.3 1.9
Pulse wave peak to peak time 0.4 0.4 1.4 0.7 -0.4 -0.5 -1.2 0.4 0.4
Health satisfaction 2.0 2.6 7.9 2.8 0.6 0.6 -2.4 -0.9 -0.7
Shortness of breath walking on level ground 2.0 2.4 4.1 2.0 1.8 1.3 -0.9 -1.2 -1.7
Qualifications: College or University degree 0.8 2.5 7.7 -2.8 -1.5 -0.7 1.7 -0.4 1.4
Eye problems/disorders: None of the above 0.8 1.0 3.3 0.7 -0.4 -0.7 -1.8 0.7 0.9
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.0 0.0 -0.9 -1.3 -0.9 1.4 1.0
Emphysema/chronic bronchitis 1.2 1.3 2.5 -1.2 -1.6 -1.3 0.1 0.8 1.2
Medication for pain relief, constipation, heartburn 4.1 6.9 22.9 -4.8 -0.7 -0.7 4.0 1.2 0.6
Neck or shoulder pain in last month 0.9 1.3 3.3 1.8 1.1 0.1 -1.5 0.8 -0.8
Medication: Blood pressure 0.9 1.6 4.5 2.0 0.5 -0.4 -2.1 0.7 -0.4
Angina (self-reported) 2.0 2.6 4.9 1.7 2.2 1.8 -0.2 -0.8 -2.0
Migraine (self-reported) 2.2 2.7 8.8 2.6 -0.3 -0.4 -3.0 -0.2 0.7
Medication: Ibuprofen 0.8 1.0 2.1 1.4 0.7 0.9 -0.6 -1.5 -0.6
Medication: Allopurinol 2.5 3.4 5.2 -0.0 -2.2 -2.3 -1.1 2.1 2.0
Medication: Omeprazole 3.1 3.8 7.7 2.2 -1.3 -1.7 -2.8 1.6 1.6
Medication: Seretide 50 evohaler 1.9 2.2 3.8 -0.7 -1.6 -1.9 -0.7 1.7 1.7
Mean time to correctly identify matches 2.8 5.4 9.4 -1.2 2.2 2.3 3.1 -1.9 -2.7
Heart disease (mother) 0.7 0.9 2.7 1.6 -0.2 -0.3 -1.5 0.4 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 3.1 0.6 1.5 1.3 0.7 -1.0 -1.8
Whole body fat mass 1.4 5.9 11.3 3.4 2.6 2.7 -1.0 -1.9 -2.3
Leg fat mass (right) 1.2 4.5 12.0 3.5 2.0 2.0 -1.7 -1.0 -1.7
Arm predicted mass (right) 1.1 5.7 8.0 -2.8 -2.7 -2.4 0.5 2.4 2.6
Pulse rate, automated reading 0.6 1.9 4.0 2.0 0.4 1.5 -1.2 -1.9 -0.1
Alcohol intake frequency. 1.5 3.4 5.3 1.5 1.9 2.3 -0.0 -2.3 -2.0
Comparative height size at age 10 1.3 7.3 23.3 -4.8 -1.0 -0.4 4.3 -0.5 0.6
Number of full sisters 1.8 2.2 4.2 0.0 -1.8 -1.8 -1.5 0.8 2.0
Suffer from ‘nerves’ 5.5 8.6 27.8 4.7 -0.1 -0.2 -5.3 0.7 0.9
Overall health rating 1.6 3.5 11.7 3.4 0.9 0.7 -2.6 -0.6 -1.0
Chest pain or discomfort 4.4 6.4 11.5 2.2 3.4 2.9 0.1 -1.9 -3.2
Had major operations 0.0 0.0 0.1 0.0 -0.2 0.1 -0.3 -0.3 0.1
Age at last live birth 2.5 3.6 6.6 -2.6 -2.1 -1.7 1.2 1.5 2.0
Family relationship satisfaction 1.7 2.1 4.5 2.0 1.2 1.1 -2.1 -0.5 -1.0
Leg pain on walking 0.6 0.7 2.3 1.5 0.3 0.7 -0.5 -1.1 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.3 1.7 -0.2 0.2 -1.8 -0.9 0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.7 -0.4 0.6 0.3 0.6 0.5 -0.9
Illness, injury, bereavement, stress in last 2 years 2.8 3.4 5.9 -1.0 -2.0 -2.3 -0.9 2.4 1.9
Medication: Aspirin 2.2 2.9 8.4 2.9 1.3 0.6 -2.2 -0.0 -1.4
Supplements: Vitamin C 1.2 1.4 3.5 -1.9 -0.9 -0.1 1.5 -0.9 1.1
Knee pain experienced in last month 0.9 1.4 3.6 1.9 1.3 0.3 -1.2 0.9 -1.0
Hypertension (Self-reported) 1.4 4.0 8.7 2.9 2.1 1.5 -1.8 -0.9 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.1 4.8 13.7 2.3 -1.0 -1.3 -3.7 2.2 1.5
Illnesses of father: Heart disease 0.4 0.5 1.0 0.9 1.0 0.6 -0.1 0.1 -1.0
Illnesses of siblings: Diabetes 0.4 0.5 1.0 1.0 0.5 0.1 -0.9 0.9 -0.3
Smoking status: Previous 2.8 4.2 13.3 3.6 -0.3 0.0 -3.3 -0.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.5 -1.6 -0.8 -0.7 0.8 0.1 0.9
Whole body fat-free mass 1.1 6.5 15.8 -4.0 -2.4 -2.0 2.0 1.9 2.2
Leg fat-free mass (right) 0.8 4.2 13.9 -3.7 -0.9 -0.2 3.2 -0.2 0.6
Arm fat percentage (left) 3.0 12.1 17.1 4.1 3.9 4.0 -0.9 -3.1 -3.7
Average weekly red wine intake 2.1 3.1 9.2 -3.0 -0.1 -0.1 3.0 0.1 -0.3
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.6 -0.4 0.7 1.0 1.5 -1.6 -0.8
Mood swings 5.6 10.2 32.0 5.0 -0.9 -0.7 -5.7 0.7 1.4
Loneliness, isolation 2.7 3.7 11.6 2.9 -0.8 -0.7 -3.4 0.1 1.0
Long-standing illness, disability or infirmity 1.9 2.8 9.4 3.1 0.9 0.4 -2.5 0.1 -0.7
Ever had bowel cancer screening 0.7 0.8 1.8 1.2 -0.8 -0.5 -1.3 -0.0 0.8
Diabetes diagnosed by doctor 1.1 1.8 3.2 1.2 1.3 1.4 0.3 -1.8 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.2 0.4 0.5 0.7 -0.1 -1.1 -0.6
Friendships satisfaction 1.4 1.7 4.7 1.5 -1.1 -0.6 -2.2 -0.8 1.0
Qualifications: nursing, teaching 3.2 5.0 8.4 -2.8 -2.9 -2.1 1.0 0.4 2.8
Commuting to job workplace: Walk 1.5 1.6 4.4 0.9 1.1 1.5 0.2 -2.1 -0.8
Eye problems/disorders: Cataract 1.7 2.0 4.3 -2.1 -1.4 -0.9 1.8 0.3 1.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.7 -1.3 -0.2 0.1 1.3 -0.8 -0.2
Medication for cholesterol 4.2 6.4 16.4 -4.0 -2.6 -1.5 2.5 -0.9 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.9 -0.3 -1.0 -1.4 -0.8 1.7 0.9
Back pain experienced in last month 2.9 4.2 8.9 2.5 -0.8 -1.6 -3.0 2.2 1.4
Mineral and other dietary supplements 0.2 0.2 0.8 -0.0 -0.5 -0.5 -0.2 0.9 0.3
Breast cancer (self-reported) 0.4 0.5 1.1 0.7 0.6 -0.3 -0.7 1.1 -0.6
Asthma (self-reported) 1.1 2.1 5.8 2.4 0.9 0.9 -2.3 0.0 -0.4
Osteoporosis (self-reported) 0.2 0.2 0.6 0.7 -0.4 -0.3 -0.8 -0.2 0.2
Osteoarthritis (self-reported) 0.5 0.6 2.3 0.8 0.3 -0.3 -0.7 1.5 -0.3
Medication: Aspirin 1.5 2.0 5.6 2.4 1.3 0.5 -1.5 -0.0 -1.5
Medication: Gliclazide 2.4 2.7 4.0 1.4 1.8 1.7 0.1 -2.0 -2.0
Illnesses of father: None of the above (group 1) 0.7 0.9 1.5 -1.1 -1.1 -1.2 0.2 0.7 1.0
Smoking status: Current 0.3 0.5 1.4 0.9 -0.0 -0.3 -1.2 0.7 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 4.4 -0.3 2.0 1.5 1.2 -0.3 -2.1
Whole body water mass 1.2 6.6 15.5 -3.9 -2.5 -2.1 1.9 2.0 2.3
Leg predicted mass (right) 0.8 4.2 13.9 -3.7 -0.9 -0.2 3.2 -0.2 0.6
Arm fat mass (left) 0.9 3.9 5.7 2.4 2.2 2.4 -0.4 -1.5 -2.1
Number of self-reported non-cancer illnesses 2.6 4.5 13.8 3.7 0.6 0.4 -3.5 0.0 -0.4
Average weekly champagne plus white wine intake 0.7 0.9 1.9 -0.8 -1.0 -1.0 -0.2 1.4 1.0
Miserableness 1.3 2.3 6.8 2.3 -0.8 -0.1 -2.6 0.0 1.0
Guilty feelings 6.0 9.0 26.6 5.0 -0.5 0.1 -5.2 -0.6 1.3
Wears glasses or contact lenses 1.9 2.2 4.0 -0.2 -1.5 -1.7 -1.5 2.0 1.3
Ever taken oral contraceptive pill 0.9 1.0 3.5 1.2 -0.2 -0.3 -1.9 1.0 0.5
Hearing aid user 0.7 0.8 2.0 -0.2 0.9 0.8 1.4 -0.4 -1.0
Mother’s age at death 0.3 0.4 1.4 -1.2 -0.4 -0.2 0.7 0.0 0.5
Financial situation satisfaction 3.3 4.1 8.0 1.4 -2.4 -1.7 -2.8 0.2 2.4
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.1 0.5 1.4 1.1 0.9 -0.7 -1.3
Commuting to job workplace: Public transport 1.4 1.7 3.1 -1.8 -1.5 -1.3 0.9 -0.0 1.5
Eye problems/disorders: Glaucoma 1.2 1.4 2.2 1.5 1.1 1.2 -0.1 -1.4 -1.3
Medication: Blood pressure 2.5 4.7 14.2 3.8 1.8 1.1 -2.6 -0.2 -1.7
Pain type(s) experienced in last month: Hip pain 2.3 2.8 4.6 1.5 -1.1 -1.6 -2.0 2.1 1.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.3 -1.2 -0.2 -0.5 1.0 0.5 0.0
High cholesterol (Self-reported) 0.8 1.5 3.2 1.1 -0.9 -1.2 -1.8 1.4 0.4
Medication: Bendroflumethiazide 4.2 6.4 11.7 2.8 3.4 2.4 -1.2 -1.1 -3.2
Medication: Paracetamol 1.4 2.1 7.8 2.8 0.2 0.3 -2.0 -0.9 -0.3
Medication: Lisinopril 0.3 0.4 0.7 0.8 0.6 -0.1 -0.5 0.7 -0.8
Medication: Atorvastatin 0.4 0.6 1.5 0.5 0.9 0.4 -0.1 0.7 -1.2
Illnesses of father: High blood pressure 5.2 6.4 10.1 3.0 3.2 2.7 -0.8 -1.9 -2.9
Alcohol drinker status: Never 0.3 0.4 0.9 0.5 0.3 1.0 -0.2 -0.7 -0.5
Ever smoked 2.6 4.5 13.7 2.7 -1.1 -1.3 -3.7 1.2 1.2
Basal metabolic rate 0.6 3.1 8.6 -2.9 -1.5 -1.2 1.7 1.2 1.4
Leg fat percentage (left) 3.2 11.4 35.9 6.0 2.7 2.4 -3.7 -1.1 -2.1
Arm fat-free mass (left) 0.8 4.1 5.8 -2.4 -2.1 -2.0 0.5 2.3 2.1
Number of operations (self-reported) 1.2 1.8 6.1 1.9 -0.2 -0.7 -2.5 0.8 0.3
Average weekly beer plus cider intake 0.3 0.4 1.0 0.9 0.6 0.5 -1.0 -0.3 -0.3
Irritability 3.2 5.4 16.9 4.1 1.1 1.3 -3.2 -1.3 -0.7
Risk taking 0.7 1.0 2.0 -1.4 -0.9 -1.1 0.4 1.1 0.9
Ever had prostate specific antigen (PSA) test 1.1 1.3 4.5 -2.1 -0.8 -0.5 1.4 -0.4 0.4
Fractured/broken bones in last 5 years 0.4 0.6 1.1 0.2 0.8 0.8 0.3 -0.9 -1.1
Age started oral contraceptive pill 0.1 0.2 0.3 -0.4 -0.5 -0.5 -0.1 0.3 0.3
Diastolic blood pressure, automated reading 2.3 7.1 14.1 3.8 2.8 2.9 -1.4 -2.2 -2.5
Ever depressed for a whole week 1.3 1.7 5.2 1.8 -0.7 -0.2 -2.3 0.2 0.9
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.0 -0.4 -0.3 -0.5 -0.3 0.2
Commuting to job workplace: Cycle 0.5 0.6 1.6 -1.3 0.0 -0.4 1.1 0.7 -0.1
Myopia 0.4 0.5 1.8 0.3 0.0 -0.4 -1.0 1.3 0.3
Vascular/heart problems diagnosed by doctor 1.0 2.6 5.1 -2.3 -1.9 -1.3 1.3 0.4 1.9
Cholesterol lowering medication 1.0 1.5 3.2 1.6 -0.4 -0.8 -1.8 1.4 0.4
Medication: Omeprazole (e.g. Zanprol) 2.7 3.3 6.6 1.8 -1.5 -1.7 -2.6 1.4 1.7
Pain experienced in last month 1.6 2.6 8.5 -2.9 -0.6 0.2 2.5 -0.5 0.1
Supplements: Calcium 1.8 2.0 6.0 2.5 1.0 0.9 -1.6 -0.8 -1.0
Basal cell carcinoma (self-reported) 1.0 1.2 4.4 -1.1 0.3 0.8 2.1 -0.9 -0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.7 0.8 -0.5 -0.6 -0.8 0.3 0.3
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.8 -0.4 -1.7 -1.1 -0.2 0.2 1.7
Heart disease (siblings) 3.1 3.8 4.9 2.1 2.1 2.0 0.4 -2.2 -2.2
Alcohol drinker status: Previous 0.7 0.7 2.5 1.6 -0.3 -0.2 -1.3 -0.4 -0.0
Pack years of smoking 1.6 2.4 3.7 -1.1 -1.9 -1.9 -0.1 1.7 1.7
Impedance of whole body 1.0 4.9 11.7 3.4 2.1 1.9 -1.5 -1.9 -2.0
Leg fat mass (left) 1.0 3.7 10.6 3.3 1.7 1.7 -1.7 -1.0 -1.4
Arm predicted mass (left) 0.8 4.1 5.6 -2.2 -2.2 -2.0 0.3 2.4 2.2