Best TWAS P=6.39e-23 · Best GWAS P=1.81e-21 conditioned to 0.517
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Breast Mammary Tissue (Female) | GNA12 | 0.10 | -0.01 | enet | 16 | 0.00 | 4.5e-01 | -3.1 | 5.3 | 1.2e-07 | 0.18 | 0.06 | 0.06 | TRUE |
2 | GTEx | Colon Sigmoid | INTS1 | 0.39 | 0.25 | enet | 18 | 0.26 | 8.6e-10 | 4.8 | -5.6 | 1.9e-08 | 0.05 | 0.01 | 0.98 | FALSE |
3 | GTEx | Esophagus Mucosa | INTS1 | 0.34 | 0.27 | enet | 10 | 0.33 | 1.4e-22 | 4.9 | -5.1 | 3.0e-07 | 0.03 | 0.01 | 0.98 | FALSE |
4 | GTEx | Pancreas | INTS1 | 0.30 | 0.22 | enet | 8 | 0.20 | 6.6e-09 | 4.8 | -5.2 | 1.9e-07 | 0.03 | 0.01 | 0.98 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | TTYH3 | 0.22 | 0.00 | lasso | 5 | 0.00 | 6.4e-01 | 9.5 | 9.6 | 1.3e-21 | 0.81 | 0.01 | 0.85 | TRUE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | INTS1 | 0.36 | 0.25 | lasso | 7 | 0.27 | 5.4e-15 | 4.8 | -5.2 | 2.1e-07 | 0.04 | 0.01 | 0.98 | FALSE |
7 | GTEx | Small Intestine Terminal Ileum | GNA12 | 0.34 | 0.20 | lasso | 5 | 0.16 | 2.4e-04 | 3.4 | 5.7 | 1.4e-08 | 0.16 | 0.23 | 0.24 | TRUE |
8 | GTEx | Whole Blood | INTS1 | 0.19 | 0.07 | lasso | 9 | 0.10 | 2.1e-09 | 4.8 | -5.2 | 2.6e-07 | 0.04 | 0.01 | 0.98 | FALSE |
9 | YFS | Blood | CARD11 | 0.07 | 0.06 | lasso | 6 | 0.06 | 6.7e-18 | 9.4 | 9.9 | 6.4e-23 | 0.53 | 0.01 | 0.99 | TRUE |
10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | INTS1 | 0.28 | 0.21 | lasso | 5 | 0.20 | 1.8e-08 | 4.9 | -5.2 | 2.0e-07 | 0.04 | 0.01 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | INTS1 | 0.18 | 0.18 | enet | 8 | 0.18 | 1.3e-18 | 5.0 | -5.7 | 1.6e-08 | 0.04 | 0.01 | 0.99 | TRUE |