Hub : Genes

CARD11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0549	0.0206	9.4e-04	0.008	0.030	0.010	0.027	0.012	1.6e-02	2.0e-05	1.1e-02	4.8e-05	5.5e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.0867	0.0371	1.4e-02	0.014	0.007	0.047	0.022	0.039	5.6e-03	3.9e-02	1.1e-06	6.8e-04	7.3e-06
3	YFS	Blood	0.0656	0.0145	1.8e-11	0.055	0.044	0.052	0.054	0.057	1.3e-17	3.1e-14	1.1e-16	2.9e-17	6.7e-18
4	TCGA	Brain Lower Grade Glioma	0.1202	0.0311	1.3e-06	0.000	0.067	0.023	NA	0.009	3.3e-01	4.1e-08	1.0e-03	NA	3.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.6	2.6	6.4	1.1	-2.5	0.3	-1.6
Bipolar Disorder or Schizophrenia	2.5	6.1	10.1	2.0	-3.1	-0.5	-3.2
Depressed Affect (Nagel 2018)	0.7	1.6	2.7	-0.5	1.6	-1.3	1.3
Depression (Nagel 2018)	0.4	0.6	1.3	1.1	-0.2	0.9	-0.3
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.0	0.7	-1.0	0.8	-1.0
Neuroticism (Nagel 2018)	1.1	2.5	4.5	0.1	2.1	-1.8	1.5
Schizophrenia (2018)	2.0	4.1	8.3	1.7	-2.1	-0.9	-2.9
Schizophrenia vs Biploar Disorder	1.1	1.4	3.7	1.0	-0.9	-0.2	-1.9
Worry (Nagel 2018)	1.3	2.8	5.3	0.5	2.0	-1.3	2.3
Alzheimer’s Disease (in mother)	1.0	1.1	2.9	-1.7	-0.7	0.1	-1.1
Alzheimer’s Disease (in father)	1.6	1.8	5.1	2.3	-0.9	0.7	-0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-0.1	-0.9	1.0	-1.3
Crohns Disease (2017)	0.9	1.9	5.5	0.8	0.8	2.4	-0.8
Irritable Bowel Disease (IBD)	0.9	2.2	3.6	1.7	0.3	1.5	-1.9
Ulcerative Colitis (UC)	1.2	2.2	6.8	1.4	-0.5	-0.2	-2.6
Major Depression (MDD)	0.7	0.9	2.3	-1.5	0.1	0.2	-1.0
Reaction Time	0.4	0.8	2.6	-0.7	-1.6	0.2	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.3	3.3	1.4	-0.1	1.8	-0.4
Breast Cancer	0.2	0.5	1.5	-0.4	1.2	0.1	-0.7
Ovarian Cancer	0.6	0.8	2.6	-1.6	0.5	-0.3	0.4
Prostate Cancer	1.3	1.8	4.5	-1.3	0.6	-0.8	2.1
Age at First Birth	1.0	1.5	5.5	2.3	-0.2	0.3	-0.5
Bipolar Disorder (2011)	0.3	0.3	1.2	0.1	0.0	-1.1	0.0
Body Mass Index (BMI) (2010)	2.2	3.0	8.2	2.9	-1.3	1.4	-0.4
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.0	-0.0	0.5	0.8
Crohns Disease (2012)	0.1	0.1	0.2	0.1	0.4	0.5	0.2
Mean Putamen Volume	0.8	0.9	3.3	0.3	-1.8	0.1	-0.5
Fasting Glucose	1.0	1.1	2.9	0.8	-1.7	0.5	-0.9
HbA1C	0.3	0.3	0.6	-0.4	-0.8	0.6	-0.2
HDL Cholesterol	0.6	1.0	3.0	-1.7	1.0	0.1	-0.4
LDL Cholesterol	1.4	2.2	6.5	1.1	-0.3	2.6	-1.0
Lupus	1.4	2.1	3.4	-1.9	0.2	-1.8	-1.4
Neuroticism (2016)	0.7	1.0	1.4	1.1	-0.0	-1.2	1.1
Primary Biliary Cirrhosis	0.3	0.4	0.9	0.3	-0.9	0.5	-0.8
Rheumatoid Arthritis	1.1	1.5	2.9	1.7	-1.3	0.2	-1.3
Schizophrenia (2014)	2.5	5.6	9.9	2.0	-2.7	-1.0	-3.1
Triglycerides	0.7	1.1	1.7	1.2	0.2	1.0	1.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.3	0.2	-1.1	-0.3	0.3
Ulcerative Colitis	1.1	1.6	4.3	2.1	-0.0	0.7	-1.4
Blood Eosinophil Count	4.5	34.5	97.2	4.7	1.3	9.9	4.2
Blood Platelet Count	0.1	1.2	1.8	-1.3	-0.2	-1.2	1.1
Blood Red Count	0.4	3.9	10.8	0.4	-3.3	-0.7	-2.1
Blood White Count	0.4	2.6	8.2	-1.4	-0.1	-2.9	0.7
Heel T-Score	0.1	1.1	3.9	-2.0	-0.3	-0.0	-0.5
BMI	0.8	4.4	7.7	1.3	-2.1	-2.8	-1.9
Height	0.4	8.4	28.7	5.4	1.3	-1.7	-0.8
Waist Hip Ratio (WHR)	0.3	1.5	2.8	-1.1	-1.1	1.7	0.7
Systolic Blood Pressure	0.3	1.7	3.8	-1.9	1.0	-1.5	0.1
Smoking Status	2.6	6.2	21.8	-4.7	0.8	-0.2	-1.5
Allergy or Eczema	2.7	7.2	22.7	-0.4	2.4	-4.8	0.2
Cardiovascular Disease	0.2	0.6	1.2	-0.9	-0.7	-1.1	-0.1
Hypothyroidism (self reported)	0.8	1.9	6.1	2.5	0.5	-0.1	-1.1
Respiratory disease	3.8	8.5	15.0	-2.5	3.9	-3.1	1.8
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.7	-1.7	-1.1	0.5	-1.9
Lung FEV1/FVC ratio	0.4	1.8	3.7	-0.3	-1.8	-0.2	-1.9
Lung FVC	0.4	2.2	5.2	-1.6	2.3	0.3	1.0
Neuroticism	1.0	2.3	5.3	0.3	0.7	-2.3	1.8
Chronotype (morning person)	0.2	0.5	0.9	-0.8	-0.9	-0.8	0.2
Hair Pigment	0.1	1.8	4.7	0.8	1.4	2.2	-0.1
Tanning	0.1	1.8	3.4	-1.8	-0.2	1.5	1.3
Hand grip strength (left)	0.6	1.6	3.4	0.5	0.7	-1.8	-1.5
Number of treatments/medications taken	0.4	0.7	2.3	0.1	0.8	-1.5	0.0
Average weekly spirits intake	1.6	2.0	5.2	-2.3	1.6	-0.6	-0.4
Sensitivity / hurt feelings	0.3	0.5	1.6	0.5	0.2	-1.2	0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	1.1	-0.1	-0.1	-0.8
Hearing difficulty/problems: Yes	0.6	1.0	2.5	0.6	1.6	-0.5	0.8
Relative age of first facial hair	0.6	1.3	4.8	-0.6	0.0	2.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.7	1.9	-0.5	-0.2	0.9
Ever used hormone-replacement therapy (HRT)	2.3	2.9	6.5	1.5	1.6	-0.6	2.5
Ever had hysterectomy (womb removed)	0.4	0.5	1.7	0.3	-1.3	-0.3	0.1
Systolic blood pressure, automated reading	0.4	1.3	3.7	0.3	-0.1	-1.9	-1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.1	-0.0	0.1	0.6	1.4
Angina	0.4	0.5	1.0	0.4	1.0	-0.9	0.2
Medication for hormone replacement therapy	0.3	0.3	0.9	0.6	-0.9	0.3	0.0
Vitamin and mineral supplements	0.5	0.6	1.6	-0.7	0.5	1.3	-0.4
Supplements: Zinc	2.8	3.1	6.0	0.4	-2.2	-1.1	-2.5
Medication: Co-codamol	0.5	0.6	1.3	1.2	0.6	0.3	-0.7
Medication: Metformin	2.6	3.7	9.7	-0.8	-1.9	-0.9	-3.1
Diabetes (father)	2.4	3.0	6.2	-0.7	-2.5	1.7	-1.5
Diabetes (mother)	1.4	1.8	4.7	0.3	-1.3	-0.7	-2.2
Severe depression (siblings)	0.6	0.7	1.6	-0.4	-0.5	-1.2	0.9
Pack years adult smoking proportion	1.0	1.6	5.3	0.3	-0.9	0.3	2.3
Impedance of leg (right)	0.9	4.4	10.7	-1.6	1.2	1.7	3.3
Leg fat-free mass (left)	0.9	4.9	8.0	2.8	-0.7	-1.8	-2.8
Trunk fat percentage	0.6	2.3	3.2	1.8	-1.8	-1.5	-0.6
Hand grip strength (right)	0.5	1.5	4.1	-0.1	0.7	-1.2	-2.0
Townsend deprivation index at recruitment	1.6	2.2	6.7	-0.1	-1.4	2.6	-0.6
Current tobacco smoking	0.6	0.9	1.3	-1.1	-0.7	1.1	-0.9
Average weekly fortified wine intake	1.3	1.5	3.5	-1.4	-0.7	-1.9	-0.4
Maternal smoking around birth	1.7	2.5	7.7	-2.8	1.2	0.4	0.8
Fed-up feelings	1.2	2.2	5.1	-1.2	1.5	0.1	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.2	1.5	0.3	0.8	1.2
Relative age voice broke	0.9	1.4	3.7	0.2	1.3	1.9	-0.2
Taking other prescription medications	0.1	0.2	0.4	0.6	0.6	-0.2	-0.2
Age when periods started (menarche)	0.9	2.1	6.3	-1.1	-0.9	2.5	-0.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.6	0.9	-1.3	-1.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	-1.0	0.1	-0.1	0.3
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	4.3	0.5	-1.6	2.1	-1.1
Qualifications: CSEs or equivalent	3.2	4.2	9.7	-2.3	3.1	-0.3	1.3
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.7	-0.0	0.0	-0.5
High blood pressure	0.4	1.0	1.8	-0.8	-0.8	-1.1	-1.3
Hayfever, allergic rhinitis or eczema	3.3	7.2	25.0	-0.8	1.4	-5.0	-1.2
Multivitamins +/- minerals	0.5	0.6	1.4	1.2	-0.4	-0.9	0.0
Stomach or abdominal pain in last month	0.8	1.0	1.5	-1.2	-0.1	-1.1	-1.2
Supplements: Glucosamine	0.3	0.4	0.8	0.8	-0.3	-0.9	0.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.7	0.4	-1.1	-0.4	-1.9
Medication: Atenolol	1.1	1.4	3.1	-0.6	-0.8	-1.8	-1.2
Medication: Levothyroxine sodium	0.8	1.4	4.3	2.1	0.6	0.9	0.1
Sitting height	0.6	4.2	7.0	1.8	-1.2	-2.6	-2.3
Chronic bronchitis/emphysema (father)	2.8	3.2	7.7	-0.8	2.8	0.2	2.1
High blood pressure (mother)	1.2	1.6	4.1	-1.3	0.7	-0.5	-2.0
Body mass index (BMI)	0.7	2.9	6.4	1.5	-1.5	-2.5	-0.9
Impedance of leg (left)	0.6	3.0	6.6	-2.0	0.6	1.1	2.6
Leg predicted mass (left)	0.9	4.9	8.0	2.8	-0.7	-1.9	-2.8
Trunk fat mass	0.8	3.4	5.5	2.4	-1.5	-2.1	-1.2
Waist circumference	0.8	3.1	4.1	2.0	-2.0	-1.6	-1.2
Number of incorrect matches in round	0.1	0.2	0.5	0.1	-0.2	-0.3	-0.7
Past tobacco smoking	2.9	5.3	17.5	4.2	-0.3	0.1	1.9
Alcohol usually taken with meals	3.5	5.6	10.3	1.6	-3.1	-0.4	-3.2
Nervous feelings	0.8	1.5	3.2	1.4	0.8	-0.4	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	5.2	2.3	0.2	-0.1	0.2
Hearing difficulty/problems with background noise	1.6	2.5	6.6	-1.4	1.2	-2.6	0.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.0	-0.0	-0.8	-0.5
Had menopause	0.6	0.8	1.7	0.8	-1.3	-0.9	-0.1
Had other major operations	1.6	2.0	4.9	1.5	0.9	0.1	2.2
Forced vital capacity (FVC)	0.2	0.8	1.4	-0.3	1.1	1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.6	-0.7	-0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.4	0.5	1.2	0.0	0.3
Qualifications: None of the above	0.8	1.7	4.0	-1.4	-1.0	0.1	2.0
Financial difficulties in last 2 years	0.7	0.9	2.0	-1.2	0.4	0.3	1.4
Mouth/teeth dental problems	0.2	0.3	0.9	0.9	-0.2	0.1	0.5
Heart attack	0.6	0.8	2.2	-1.5	-0.6	0.3	-0.7
Allergy	3.7	8.4	23.0	1.2	-3.0	4.8	0.2
Pain all over the body in last month	0.8	0.8	2.9	-1.7	0.2	0.0	0.5
Diabetes (self-reported)	0.6	0.9	1.2	-0.9	-1.0	-0.7	-1.1
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	7.2	0.2	-1.0	-2.7	-1.9
Medication: Ramipril	1.1	1.4	4.2	-0.3	2.0	0.6	1.1
Medication: Simvastatin	1.0	1.4	3.8	-0.3	-1.3	-0.1	-2.0
Fluid intelligence score	0.0	0.0	0.1	0.3	-0.0	-0.1	0.0
Illnesses of siblings	0.8	1.2	2.1	-1.4	-0.1	0.7	-1.4
Neuroticism score	0.6	1.2	2.6	0.3	0.2	-1.5	1.6
Weight	1.0	5.1	7.7	2.6	-1.6	-2.8	-1.8
Impedance of arm (right)	0.4	1.7	6.3	-0.2	0.7	2.5	0.3
Arm fat percentage (right)	0.5	2.0	3.9	2.0	-1.2	-1.4	-0.8
Trunk fat-free mass	0.8	4.8	7.8	2.5	-0.4	-2.8	-2.3
Hip circumference	1.3	5.6	8.6	2.9	-2.3	-1.9	-2.2
Time employed in main current job	1.2	1.4	2.7	0.8	0.2	1.6	1.5
Alcohol intake versus 10 years previously	1.6	2.4	7.5	-2.7	0.2	-0.5	1.3
Father’s age at death	2.1	2.8	6.8	-0.0	-2.6	-0.3	-2.1
Worrier / anxious feelings	0.7	1.3	2.9	1.7	0.4	-0.8	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.5	1.9	-0.6	0.3	-1.4
Falls in the last year	0.7	1.0	2.1	-0.3	-0.9	1.4	-1.0
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	0.3	-0.4	0.1	-1.0
Number of live births	0.7	1.0	2.2	-1.5	0.0	-1.4	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.5	-0.3	0.9	1.2	-1.2
Pulse rate	0.4	0.7	1.5	-1.0	0.3	-0.5	1.2
Happiness	0.8	1.0	1.5	1.1	0.5	1.2	1.0
Noisy workplace	3.0	3.7	8.1	-1.7	2.8	-0.3	1.9
Qualifications: A levels/AS levels or equivalent	1.0	2.2	5.6	2.4	-0.1	-0.3	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	-0.1	-0.7	-0.3	-1.3
Mouth/teeth dental problems: Dentures	0.3	0.6	2.1	0.2	-0.1	1.5	0.4
Asthma	3.0	5.9	12.4	-1.1	3.5	-2.6	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.8	0.1	0.3	-0.3
Medication: Cholesterol lowering	0.3	0.5	1.0	-1.0	-0.8	-0.5	-0.2
Depression (self-reported)	0.4	0.5	1.0	0.7	-0.4	0.7	-1.0
Medication: Lansoprazole	0.5	0.6	1.2	-0.0	0.8	-0.7	1.1
Prospective memory result	0.1	0.2	0.4	-0.7	-0.2	-0.5	0.0
Lung cancer (father)	1.1	1.2	2.1	-1.0	0.7	-1.5	1.1
Illnesses of mother	1.0	1.2	2.2	1.4	-0.4	0.7	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.1	0.1	1.0	1.8	-1.4
Pulse wave Arterial Stiffness index	2.9	3.4	6.7	-0.2	-2.6	-1.2	-2.3
Impedance of arm (left)	0.4	2.0	7.5	-0.3	0.6	2.7	0.3
Arm fat mass (right)	0.8	3.3	5.4	2.1	-1.3	-2.3	-1.3
Trunk predicted mass	0.8	4.8	7.8	2.5	-0.3	-2.8	-2.3
Standing height	0.3	3.2	8.4	2.9	-0.3	-0.7	-2.0
Length of working week for main job	1.6	1.7	2.4	1.4	0.9	1.3	1.5
Exposure to tobacco smoke at home	0.9	1.0	2.7	1.1	-0.0	1.6	-0.1
Breastfed as a baby	0.9	1.1	3.0	0.6	-1.7	-0.1	-1.0
Tense / ‘highly strung’	0.5	0.9	2.3	0.0	-0.3	-1.5	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.2	-0.9	-0.5	-0.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	-0.5	-0.2	-0.6	-0.3
Birth weight of first child	0.8	1.5	2.4	1.3	1.5	-0.8	1.1
Peak expiratory flow (PEF)	0.6	1.3	2.0	-1.2	1.4	-1.2	-0.7
Pulse wave reflection index	2.6	3.2	5.8	-0.7	-1.9	-1.6	-2.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.3	-1.2	0.6	-1.5	0.5
Loud music exposure frequency	0.2	0.2	0.6	0.8	-0.3	0.3	-0.3
Qualifications: O levels/GCSEs or equivalent	3.2	5.0	13.2	1.4	-2.1	-0.7	-3.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.2	-1.8	0.7	-0.4	0.1
Blood clot in the leg (DVT)	0.4	0.5	1.4	-0.1	1.2	-0.8	0.3
Medication: Paracetamol	0.6	0.9	1.9	-0.9	1.4	-0.8	0.6
Headache pain in last month	0.3	0.5	1.6	-0.3	0.6	-0.1	1.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.4	1.6	1.0	1.3	1.4
Glaucoma (self-reported)	1.9	2.2	5.8	-2.4	1.5	-0.8	0.6
Gout (self-reported)	0.7	1.0	2.8	1.1	0.1	-1.7	-0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.5	2.1	0.3	0.5	-0.0
Medication: Amlodipine	0.3	0.4	0.5	0.5	-0.6	0.6	0.7
Medication: Ventolin 100micrograms inhaler	2.3	3.0	9.5	-1.3	3.1	-0.9	-0.0
Birth weight	0.9	1.9	5.9	0.1	-0.6	-1.2	-2.4
Chronic bronchitis/emphysema (mother)	1.4	1.7	3.2	-1.8	1.4	0.3	1.2
High blood pressure (siblings)	0.4	0.5	1.3	1.1	-0.2	-0.8	0.3
Forced vital capacity (FVC), Best measure	0.3	1.2	2.5	0.3	1.6	1.5	-0.2
Body fat percentage	0.5	2.0	3.7	1.4	-1.5	-1.9	-0.4
Leg fat percentage (right)	0.4	1.5	4.0	0.5	-1.2	-2.0	0.6
Arm fat-free mass (right)	0.7	3.8	7.7	2.0	-0.9	-2.8	-1.7
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.6	0.9	-0.1	0.6
Comparative body size at age 10	0.9	2.6	4.1	1.3	-2.0	0.6	-2.0
Number of full brothers	0.8	1.0	2.6	0.8	-1.6	-0.5	-0.8
Worry too long after embarrassment	0.7	1.1	3.3	1.8	-0.6	-0.7	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.7	6.8	0.2	-2.6	1.4	-1.3
Wheeze or whistling in the chest in last year	2.4	4.2	8.9	-1.1	3.0	-1.7	2.0
Number of children fathered	0.6	0.7	2.3	0.0	-0.7	0.0	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.1	-0.1	-1.1	-0.3	-0.0
Age at first live birth	1.0	1.8	3.7	1.9	-1.0	0.4	-1.6
Pulse wave peak to peak time	2.7	3.2	6.5	0.3	2.5	1.2	2.1
Health satisfaction	0.4	0.6	1.0	-0.6	0.9	1.0	-0.3
Shortness of breath walking on level ground	0.6	0.7	2.0	-0.8	0.5	1.4	-0.1
Qualifications: College or University degree	1.5	4.6	13.2	3.6	1.1	0.7	-1.9
Eye problems/disorders: None of the above	1.3	1.5	4.9	0.5	-0.4	2.2	0.7
Mouth/teeth dental problems: Loose teeth	1.9	2.2	6.2	-0.9	-2.5	0.1	-1.3
Emphysema/chronic bronchitis	0.4	0.5	1.8	-0.0	-0.1	-1.3	0.2
Medication for pain relief, constipation, heartburn	0.4	0.6	1.0	0.8	-0.4	1.0	0.8
Neck or shoulder pain in last month	1.0	1.4	3.5	1.1	-0.2	-1.0	-1.9
Medication: Blood pressure	0.7	1.3	2.4	-1.6	-0.3	-1.0	-1.3
Angina (self-reported)	0.3	0.5	1.0	0.2	0.9	-1.0	0.1
Migraine (self-reported)	0.2	0.3	0.4	0.5	0.2	0.6	-0.7
Medication: Ibuprofen	0.9	1.0	1.9	-1.3	1.4	0.5	0.5
Medication: Allopurinol	0.9	1.3	4.4	0.5	-0.1	-2.1	-0.7
Medication: Omeprazole	1.0	1.2	1.9	1.4	-0.1	1.3	-1.0
Medication: Seretide 50 evohaler	2.9	3.4	6.7	-2.0	2.6	-1.5	0.7
Mean time to correctly identify matches	0.6	1.2	3.6	-0.7	-1.9	0.1	0.8
Heart disease (mother)	0.4	0.5	1.1	0.1	1.1	-0.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.9	-2.2	-1.0	-0.0	-1.4
Whole body fat mass	0.7	3.0	5.3	1.9	-1.3	-2.3	-1.1
Leg fat mass (right)	0.6	2.2	4.1	1.8	-1.2	-2.0	-0.3
Arm predicted mass (right)	0.8	4.0	8.5	2.0	-0.8	-2.9	-1.7
Pulse rate, automated reading	0.3	1.1	2.2	-1.5	-0.3	-1.3	0.5
Alcohol intake frequency.	0.6	1.4	2.8	1.7	-0.0	0.9	1.4
Comparative height size at age 10	0.6	3.1	10.4	3.2	-0.9	0.4	-0.9
Number of full sisters	0.8	0.9	1.5	-1.0	1.2	0.9	0.6
Suffer from ‘nerves’	2.2	3.4	4.8	2.2	2.1	1.4	1.5
Overall health rating	0.4	0.9	2.1	-1.5	1.2	-0.3	0.2
Chest pain or discomfort	0.7	1.0	3.0	-0.3	0.6	-0.9	1.7
Had major operations	0.4	0.4	0.8	0.8	0.0	0.9	0.6
Age at last live birth	0.0	0.1	0.1	0.3	0.3	0.1	-0.2
Family relationship satisfaction	0.3	0.3	0.5	0.7	0.5	0.7	-0.0
Leg pain on walking	1.0	1.3	2.1	1.1	1.4	0.7	1.2
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	8.4	-2.9	1.2	-1.1	0.4
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.9	-1.3	1.7	-1.4	0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	0.8	0.4	0.3	0.5
Medication: Aspirin	1.9	2.5	6.2	-1.2	-1.4	-0.7	-2.5
Supplements: Vitamin C	0.1	0.1	0.3	-0.3	0.5	0.1	0.0
Knee pain experienced in last month	0.4	0.7	1.7	-0.4	1.3	-0.4	0.9
Hypertension (Self-reported)	0.4	1.1	1.6	-0.4	-1.0	-1.3	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.6	1.6	-0.2	-0.5	0.0
Illnesses of father: Heart disease	1.1	1.6	4.0	-1.4	2.0	-0.4	0.5
Illnesses of siblings: Diabetes	0.7	0.8	1.7	1.3	-0.7	-0.0	1.0
Smoking status: Previous	2.6	4.0	13.0	-3.6	1.1	-1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.6	0.4	0.4	0.7	-0.4
Whole body fat-free mass	0.9	5.3	7.2	2.7	-0.6	-2.6	-2.6
Leg fat-free mass (right)	1.0	5.5	9.9	2.7	-1.0	-2.0	-3.1
Arm fat percentage (left)	0.5	1.8	3.4	1.9	-1.1	-1.4	-0.7
Average weekly red wine intake	3.2	4.7	12.8	0.0	-2.4	0.2	-3.6
Handedness (chirality/laterality): Left-handed	1.0	1.3	2.5	-1.2	1.6	-0.9	-0.5
Mood swings	0.2	0.4	0.6	-0.7	0.6	-0.7	0.5
Loneliness, isolation	0.2	0.2	0.4	0.5	0.6	0.1	-0.5
Long-standing illness, disability or infirmity	0.4	0.6	1.2	0.1	0.9	-0.7	1.1
Ever had bowel cancer screening	1.2	1.4	3.3	-0.8	-0.6	-1.8	-1.2
Diabetes diagnosed by doctor	0.9	1.4	2.6	-1.0	-1.2	-0.8	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.7	-0.1	1.3	-0.6	0.7
Friendships satisfaction	2.3	2.9	5.3	-2.3	1.5	-0.3	2.0
Qualifications: nursing, teaching	2.0	3.2	9.4	3.1	0.6	-1.5	0.7
Commuting to job workplace: Walk	2.0	2.2	5.1	1.6	-2.3	0.7	-0.7
Eye problems/disorders: Cataract	0.5	0.5	1.1	0.6	-1.0	-0.8	-0.4
Mouth/teeth dental problems: Mouth ulcers	3.7	5.9	14.1	-0.3	0.0	-3.8	-3.1
Medication for cholesterol	0.7	1.1	3.1	-1.0	1.8	0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.9	0.6	-0.2	-0.6
Back pain experienced in last month	0.8	1.2	2.6	-1.6	-0.1	-0.9	-1.2
Mineral and other dietary supplements	0.8	1.0	2.3	-0.5	1.5	1.2	0.4
Breast cancer (self-reported)	1.1	1.3	4.2	0.7	-0.5	0.5	-2.1
Asthma (self-reported)	2.4	4.8	9.9	-1.1	3.1	-2.2	1.8
Osteoporosis (self-reported)	0.6	0.7	1.1	-0.6	-0.6	-1.0	-1.0
Osteoarthritis (self-reported)	1.6	2.1	4.3	-0.8	2.1	0.5	1.9
Medication: Aspirin	1.2	1.6	4.5	-1.1	-0.7	-0.5	-2.1
Medication: Gliclazide	2.1	2.4	3.7	-1.9	-0.8	-1.2	-1.9
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.1	-0.4	0.1	0.3
Smoking status: Current	0.6	0.9	1.8	-0.9	-0.7	0.8	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	4.1	-0.9	2.0	2.0	1.8
Whole body water mass	0.9	5.4	7.3	2.5	-0.8	-2.6	-2.7
Leg predicted mass (right)	1.0	5.3	9.5	2.6	-1.0	-2.0	-3.1
Arm fat mass (left)	0.8	3.2	5.2	2.2	-1.1	-2.3	-1.3
Number of self-reported non-cancer illnesses	0.5	0.9	1.5	1.1	0.7	-1.2	0.7
Average weekly champagne plus white wine intake	1.4	2.0	3.6	-1.9	0.5	-1.6	-1.3
Miserableness	0.7	1.2	2.4	-1.5	0.0	-1.6	-0.6
Guilty feelings	0.2	0.3	0.8	0.2	0.1	-0.4	-0.9
Wears glasses or contact lenses	0.4	0.5	1.3	0.1	-0.7	1.2	0.2
Ever taken oral contraceptive pill	3.0	3.3	9.9	-3.1	1.7	0.1	-0.7
Hearing aid user	0.6	0.7	1.1	-0.7	0.8	-0.7	1.1
Mother’s age at death	0.8	1.0	2.8	0.2	1.7	-0.9	-0.5
Financial situation satisfaction	2.1	2.6	4.5	-0.0	1.7	2.1	1.7
Tinnitus: Yes, now most or all of the time	1.8	2.0	4.9	0.0	2.2	-1.7	0.7
Commuting to job workplace: Public transport	1.3	1.6	2.5	0.5	1.6	1.3	-1.4
Eye problems/disorders: Glaucoma	0.7	0.8	2.0	-1.4	0.7	-0.8	-0.5
Medication: Blood pressure	0.8	1.5	4.0	0.7	-2.0	-0.9	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	-0.8	0.1	0.3	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.1	-0.4	-0.5	0.2
High cholesterol (Self-reported)	0.2	0.3	1.1	-0.6	-1.0	-0.1	0.0
Medication: Bendroflumethiazide	0.4	0.6	0.9	0.6	-0.7	-0.9	-0.7
Medication: Paracetamol	0.8	1.2	3.4	-0.9	1.8	-0.5	0.7
Medication: Lisinopril	1.1	1.4	2.5	-0.2	-1.2	-1.3	-1.6
Medication: Atorvastatin	0.3	0.4	0.8	-0.5	-0.5	0.4	0.9
Illnesses of father: High blood pressure	1.1	1.4	4.5	-0.4	-0.5	-0.8	-2.1
Alcohol drinker status: Never	1.2	1.4	3.8	1.0	-1.9	0.9	-0.4
Ever smoked	3.3	5.9	18.7	-4.3	0.1	0.6	-2.1
Basal metabolic rate	0.9	5.0	7.1	2.7	-0.8	-2.6	-2.4
Leg fat percentage (left)	0.6	2.3	5.8	0.7	-1.7	-2.4	0.1
Arm fat-free mass (left)	1.0	5.0	9.4	2.2	-1.1	-3.1	-2.1
Number of operations (self-reported)	1.8	2.7	5.9	1.8	-0.5	1.3	2.4
Average weekly beer plus cider intake	2.1	3.0	5.7	1.1	1.6	1.6	2.4
Irritability	0.8	1.3	3.1	-1.1	0.8	-1.8	0.5
Risk taking	1.4	2.1	5.3	-1.2	-0.7	-0.9	-2.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	-0.6	-1.3	-1.1	0.3
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.5	0.1	0.2	0.6
Age started oral contraceptive pill	1.0	1.3	3.5	1.9	-0.9	0.8	0.5
Diastolic blood pressure, automated reading	1.0	3.0	5.1	-1.3	-0.4	-2.2	-2.3
Ever depressed for a whole week	0.8	1.0	2.3	0.2	1.5	1.2	0.1
Unable to work because of sickness or disability	0.6	0.8	2.4	-0.7	-1.6	0.6	0.2
Commuting to job workplace: Cycle	1.2	1.5	3.9	-0.2	1.4	-2.0	-0.3
Myopia	1.0	1.4	2.3	-1.4	1.5	-1.1	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.4	0.6	0.8	0.9	1.2
Cholesterol lowering medication	0.3	0.4	1.4	-0.0	-1.2	0.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.2	-0.5	0.9	-1.0
Pain experienced in last month	0.6	1.0	1.9	0.8	-0.5	1.1	1.4
Supplements: Calcium	0.3	0.3	0.9	-0.1	-0.9	-0.5	-0.2
Basal cell carcinoma (self-reported)	0.9	1.0	3.0	-1.7	-1.0	0.1	-0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	-1.5	-0.5	0.4	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	-0.2	1.1	-0.8	0.4
Heart disease (siblings)	0.2	0.3	0.8	-0.6	0.0	-0.9	0.3
Alcohol drinker status: Previous	1.1	1.3	3.7	0.4	1.1	1.9	0.2
Pack years of smoking	1.1	1.6	5.0	0.3	-1.1	0.2	2.2
Impedance of whole body	0.4	2.2	4.7	-1.3	0.6	2.2	1.4
Leg fat mass (left)	0.8	3.0	5.9	1.9	-1.5	-2.4	-0.7
Arm predicted mass (left)	1.0	4.9	9.0	2.3	-1.2	-3.0	-1.9