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chr7:134,081,554-136,074,356

Best TWAS P=1.88e-14 · Best GWAS P=1.1e-11 conditioned to 0.0066

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C7orf73	0.19	0.19	lasso	8	0.22	1.3e-26	5.7	-6.5	9.1e-11	-0.49	0.48	0.52	FALSE
2	GTEx	Adipose Subcutaneous	RP11-134L10.1	0.06	0.02	enet	14	0.01	3.0e-02	4.8	5.4	8.3e-08	0.14	0.24	0.07	TRUE
3	GTEx	Adipose Visceral Omentum	C7orf73	0.18	0.11	lasso	4	0.09	2.8e-05	5.7	-5.6	2.6e-08	-0.20	0.61	0.36	FALSE
4	GTEx	Adrenal Gland	C7orf73	0.24	0.23	lasso	1	0.21	3.8e-08	5.4	-5.4	5.9e-08	-0.38	0.66	0.18	FALSE
5	GTEx	Artery Tibial	C7orf73	0.18	0.18	lasso	5	0.18	2.5e-14	5.7	-5.5	4.8e-08	-0.40	0.54	0.46	FALSE
6	GTEx	Breast Mammary Tissue (Female)	C7orf73	0.20	0.17	lasso	4	0.12	1.5e-04	5.4	-5.6	2.7e-08	-0.36	0.29	0.06	FALSE
7	GTEx	Cells Transformed fibroblasts	C7orf73	0.44	0.49	lasso	8	0.53	5.3e-46	5.7	-5.5	3.5e-08	-0.34	0.51	0.49	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	C7orf73	0.25	0.19	lasso	3	0.14	8.6e-06	5.7	-5.8	7.1e-09	-0.41	0.36	0.36	FALSE
9	GTEx	Esophagus Mucosa	C7orf49	0.37	0.20	lasso	6	0.32	3.2e-22	4.7	5.3	9.4e-08	-0.01	1.00	0.00	FALSE
10	GTEx	Esophagus Muscularis	C7orf73	0.22	0.31	lasso	2	0.29	8.8e-18	5.4	-5.3	9.5e-08	-0.38	0.83	0.17	FALSE
11	GTEx	Testis	C7orf73	0.38	0.27	lasso	4	0.30	1.1e-13	5.7	-5.4	5.7e-08	-0.37	0.62	0.38	FALSE
12	GTEx	Uterus	C7orf73	0.35	0.23	lasso	5	0.21	4.8e-05	5.7	-5.9	3.2e-09	-0.28	0.07	0.15	FALSE
13	GTEx	Vagina	C7orf73	0.27	0.19	lasso	3	0.17	9.3e-05	5.7	-5.7	1.6e-08	-0.32	0.23	0.13	FALSE
14	GTEx	Whole Blood	C7orf73	0.08	0.01	lasso	3	0.01	1.8e-02	5.7	-5.2	2.5e-07	-0.33	0.14	0.08	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	PL-5283	0.33	0.24	enet	14	0.24	1.5e-48	5.7	-5.2	2.0e-07	-0.43	0.49	0.51	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC13A4	0.14	0.05	lasso	5	0.07	1.5e-13	5.7	6.3	3.7e-10	0.35	0.14	0.86	FALSE
17	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PL-5283	0.26	0.22	lasso	6	0.20	2.5e-10	5.7	-5.3	1.0e-07	-0.36	0.49	0.51	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	PL-5283	0.52	0.40	lasso	4	0.42	6.8e-26	5.7	-6.0	2.1e-09	-0.39	0.49	0.51	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC13A4	0.46	0.24	lasso	3	0.24	2.4e-14	5.7	6.0	2.7e-09	0.37	0.14	0.86	FALSE
20	The Cancer Genome Atlas	Esophageal Carcinoma	PL-5283	0.39	0.23	lasso	3	0.20	5.0e-07	5.7	-5.2	1.7e-07	-0.30	0.38	0.37	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC13A4	0.35	0.08	blup	56	0.20	1.8e-22	5.7	5.6	2.7e-08	0.22	0.17	0.83	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PL-5283	0.22	0.14	lasso	4	0.12	2.0e-07	5.7	-5.2	2.3e-07	-0.33	0.49	0.50	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	PL-5283	0.35	0.28	lasso	5	0.28	1.2e-31	5.7	-5.2	2.5e-07	-0.34	0.49	0.51	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC13A4	0.19	0.06	enet	15	0.09	3.8e-10	5.7	7.7	1.9e-14	0.48	0.14	0.85	TRUE
25	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PL-5283	0.34	0.18	lasso	2	0.15	1.2e-07	5.7	-5.7	1.4e-08	-0.40	0.48	0.51	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC13A4	0.20	0.11	enet	12	0.15	2.9e-17	5.7	6.0	1.9e-09	0.31	0.15	0.85	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PL-5283	0.22	0.16	lasso	3	0.15	5.6e-17	5.7	-5.3	1.4e-07	-0.36	0.49	0.51	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC13A4	0.14	0.01	enet	9	0.07	2.3e-08	1.3	6.0	2.1e-09	0.30	0.04	0.70	FALSE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C7orf49	0.06	0.00	blup	61	0.04	6.9e-03	3.4	5.1	3.0e-07	-0.02	0.01	0.24	FALSE
30	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PL-5283	0.50	0.34	enet	12	0.37	3.1e-16	5.7	-5.8	5.9e-09	-0.24	0.49	0.51	FALSE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SLC13A4	0.33	0.16	lasso	3	0.16	5.5e-07	5.7	6.0	2.0e-09	0.38	0.11	0.68	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	PL-5283	0.40	0.31	enet	7	0.33	3.8e-35	5.7	-6.0	2.3e-09	-0.35	0.49	0.51	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC13A4	0.45	0.17	lasso	6	0.23	3.6e-24	5.7	7.2	4.0e-13	0.43	0.14	0.86	FALSE
34	The Cancer Genome Atlas	Rectum Adenocarcinoma	SLC13A4	0.55	0.21	lasso	3	0.17	7.1e-05	5.7	5.8	6.0e-09	0.41	0.04	0.30	FALSE
35	The Cancer Genome Atlas	Soft Tissue Sarcoma	NUP205	0.07	0.05	lasso	4	0.04	2.7e-03	5.9	-5.6	2.6e-08	-0.45	0.02	0.09	FALSE
36	The Cancer Genome Atlas	Soft Tissue Sarcoma	PL-5283	0.20	0.12	lasso	2	0.11	5.1e-07	5.7	-5.2	1.6e-07	-0.30	0.46	0.48	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	PL-5283	0.28	0.20	lasso	5	0.19	1.5e-13	5.7	-5.4	5.9e-08	-0.35	0.49	0.51	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC13A4	0.31	0.17	lasso	5	0.24	3.4e-17	5.7	5.8	9.1e-09	0.28	0.14	0.86	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	PL-5283	0.59	0.38	lasso	6	0.42	1.5e-44	5.7	-5.3	1.3e-07	-0.27	0.49	0.51	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	SLC13A4	0.44	0.18	blup	56	0.24	2.0e-23	5.7	6.5	1.0e-10	0.37	0.14	0.86	FALSE