Best TWAS P=2.1e-11 · Best GWAS P=1.04e-12 conditioned to 6.44e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TTC26 | 0.06 | 0.03 | lasso | 4 | 0.03 | 1.0e-04 | 5.2 | 5.7 | 1.4e-08 | 0.81 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ZC3HAV1 | 0.32 | 0.14 | enet | 16 | 0.20 | 6.4e-15 | 6.8 | 6.7 | 2.1e-11 | 0.67 | 0.01 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZC3HAV1 | 0.09 | 0.02 | blup | 76 | 0.05 | 1.1e-06 | 4.5 | 5.4 | 6.8e-08 | 0.57 | 0.10 | 0.54 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | PARP12 | 0.02 | 0.01 | blup | 68 | 0.01 | 2.4e-02 | -5.5 | 5.2 | 2.1e-07 | -0.06 | 0.01 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZC3HAV1 | 0.04 | 0.01 | blup | 76 | 0.02 | 2.4e-03 | 2.8 | 6.4 | 1.9e-10 | 0.49 | 0.03 | 0.22 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PARP12 | 0.06 | 0.04 | lasso | 2 | 0.04 | 1.3e-04 | -5.5 | -5.8 | 7.7e-09 | 0.05 | 0.01 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | PARP12 | 0.14 | 0.11 | enet | 10 | 0.12 | 9.4e-12 | -5.5 | 5.7 | 1.1e-08 | -0.06 | 0.00 | 0.99 | FALSE |