Best TWAS P=7.42e-11 · Best GWAS P=3.53e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | 6.1 | -6.2 | 7.5e-10 | -0.92 | 0.05 | 0.94 | FALSE |
2 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | -4.1 | -5.2 | 2.1e-07 | -0.63 | 0.08 | 0.63 | FALSE |
3 | GTEx | Artery Tibial | PSMB7 | 0.07 | 0.04 | enet | 7 | 0.03 | 4.1e-03 | 6.1 | -6.2 | 7.1e-10 | -0.88 | 0.02 | 0.96 | FALSE |
4 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | 6.6 | -6.5 | 7.4e-11 | -0.99 | 0.01 | 0.97 | TRUE |
5 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | 6.2 | -6.0 | 1.9e-09 | -0.92 | 0.03 | 0.97 | FALSE |
6 | GTEx | Thyroid | PSMB7 | 0.06 | 0.04 | lasso | 2 | 0.06 | 4.1e-05 | 5.2 | -6.1 | 9.0e-10 | -0.90 | 0.02 | 0.96 | FALSE |
7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NEK6 | 0.14 | 0.02 | blup | 87 | 0.05 | 2.8e-03 | -3.3 | 5.6 | 1.9e-08 | 0.73 | 0.02 | 0.53 | FALSE |
8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB7 | 0.03 | 0.04 | lasso | 4 | 0.04 | 1.2e-04 | 5.9 | -5.8 | 7.1e-09 | -0.88 | 0.08 | 0.84 | FALSE |
9 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB7 | 0.06 | 0.06 | lasso | 4 | 0.04 | 3.7e-05 | 5.3 | -5.3 | 1.4e-07 | -0.85 | 0.62 | 0.38 | FALSE |