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chr9:133,755,528-137,631,198

Best TWAS P=2.61e-30 · Best GWAS P=2.78e-33 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BRD3	0.18	0.16	lasso	5	0.16	3.6e-19	-6.78	7.5	7.9e-14	0.01	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	BRD3	0.24	0.06	enet	51	0.09	1.7e-07	-10.15	7.8	7.4e-15	-0.02	0.00	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	BRD3	0.21	0.01	lasso	5	0.00	1.8e-01	-9.76	9.7	4.7e-22	0.03	0.03	0.71	FALSE
4	GTEx	Artery Aorta	BRD3	0.34	0.03	lasso	9	0.09	7.9e-06	-8.91	9.3	1.1e-20	0.01	0.03	0.94	FALSE
5	GTEx	Artery Tibial	CACFD1	0.10	0.03	lasso	4	0.03	1.7e-03	4.22	-6.4	1.2e-10	-0.03	0.19	0.04	FALSE
6	GTEx	Artery Tibial	BRD3	0.17	0.03	enet	14	0.09	1.5e-07	5.38	9.8	1.1e-22	0.00	0.11	0.88	FALSE
7	GTEx	Cells Transformed fibroblasts	BRD3	0.29	0.23	lasso	4	0.27	3.7e-20	-8.91	9.9	3.1e-23	0.02	0.31	0.69	FALSE
8	GTEx	Esophagus Mucosa	CACFD1	0.23	0.17	enet	21	0.19	8.1e-13	4.22	5.2	2.5e-07	0.05	1.00	0.00	TRUE
9	GTEx	Esophagus Mucosa	BRD3	0.19	0.06	lasso	5	0.11	1.5e-07	-6.77	10.4	2.8e-25	0.00	0.01	0.98	FALSE
10	GTEx	Esophagus Muscularis	BRD3	0.18	0.03	enet	14	0.09	5.8e-06	-10.15	10.7	1.7e-26	0.00	0.01	0.99	FALSE
11	GTEx	Liver	REXO4	0.37	0.11	lasso	4	0.10	9.1e-04	4.56	5.1	3.1e-07	0.03	0.18	0.05	TRUE
12	GTEx	Muscle Skeletal	RAPGEF1	0.10	0.06	enet	11	0.07	3.1e-07	-4.87	5.3	1.2e-07	-0.05	0.00	0.98	TRUE
13	GTEx	Nerve Tibial	BRD3	0.23	0.10	lasso	5	0.16	2.7e-11	-9.89	10.9	1.0e-27	0.00	0.02	0.98	FALSE
14	GTEx	Prostate	GTF3C4	0.28	0.10	lasso	5	0.09	3.7e-03	-4.64	-5.7	1.5e-08	0.07	0.05	0.24	TRUE
15	GTEx	Skin Not Sun Exposed Suprapubic	BRD3	0.31	0.08	enet	46	0.13	1.0e-07	-6.78	6.4	1.4e-10	-0.01	0.06	0.93	FALSE
16	GTEx	Skin Sun Exposed Lower leg	BRD3	0.18	0.12	lasso	7	0.11	1.2e-09	-6.78	8.9	3.8e-19	0.02	0.65	0.35	FALSE
17	GTEx	Skin Sun Exposed Lower leg	LINC00094	0.14	0.01	enet	40	0.03	1.7e-03	3.80	6.5	1.1e-10	0.07	0.34	0.45	FALSE
18	GTEx	Testis	BRD3	0.20	0.18	lasso	3	0.18	3.2e-08	-10.00	10.0	1.0e-23	-0.01	0.01	0.99	FALSE
19	GTEx	Thyroid	BRD3	0.18	0.07	enet	34	0.06	1.7e-05	-6.78	6.0	1.5e-09	0.04	0.09	0.84	FALSE
20	METSIM	Adipose	BRD3	0.25	0.13	bslmm	590	0.20	1.7e-29	-7.51	9.4	3.5e-21	-0.03	0.12	0.88	FALSE
21	METSIM	Adipose	GBGT1	0.04	0.00	blup	570	0.01	4.8e-02	-0.14	5.5	2.9e-08	-0.08	0.15	0.03	TRUE
22	NTR	Blood	BRD3	0.04	0.04	bslmm	555	0.04	5.7e-12	-9.98	9.2	3.7e-20	-0.03	0.01	0.99	FALSE
23	YFS	Blood	BRD3	0.10	0.09	lasso	4	0.10	1.5e-31	-7.51	9.3	1.3e-20	-0.02	0.05	0.95	FALSE
24	YFS	Blood	GFI1B	0.02	0.03	enet	20	0.02	1.6e-08	7.75	-7.2	4.1e-13	-0.07	1.00	0.00	TRUE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABO	0.08	0.01	blup	43	0.07	7.9e-07	-8.91	-5.7	1.3e-08	-0.03	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	ABO	0.07	0.08	lasso	3	0.08	5.0e-16	-8.91	-8.9	6.9e-19	-0.02	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	BRD3	0.07	0.11	lasso	3	0.12	4.2e-23	-10.10	10.7	6.0e-27	-0.01	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ABO	0.11	0.05	blup	43	0.12	1.2e-06	2.90	-6.1	1.1e-09	-0.04	0.03	0.96	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	ABO	0.27	0.31	blup	43	0.33	2.1e-19	-8.88	-8.4	3.2e-17	-0.05	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	BRD3	0.15	0.11	lasso	4	0.12	3.7e-07	-9.76	10.3	6.2e-25	0.02	0.12	0.86	FALSE
31	The Cancer Genome Atlas	Esophageal Carcinoma	ABO	0.27	0.13	lasso	2	0.11	1.8e-04	-8.88	-8.8	2.0e-18	-0.02	0.00	0.99	FALSE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	ABO	0.18	0.01	blup	42	0.07	3.0e-03	-8.88	-7.5	6.1e-14	-0.05	0.00	0.76	TRUE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ABO	0.11	0.08	blup	43	0.12	2.5e-13	-8.88	-7.2	5.6e-13	-0.06	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BRD3	0.10	0.03	enet	11	0.06	9.2e-08	-9.81	8.3	1.0e-16	0.01	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SURF6	0.02	0.01	enet	7	0.01	1.6e-02	-3.39	-5.1	2.9e-07	-0.01	0.02	0.03	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABO	0.20	0.19	blup	43	0.33	3.0e-38	2.69	-5.7	1.6e-08	-0.01	0.68	0.32	TRUE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BRD3	0.09	0.10	lasso	4	0.08	9.5e-10	-10.00	10.8	3.9e-27	-0.01	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ABO	0.31	0.38	lasso	5	0.42	3.1e-26	-8.90	-8.5	2.2e-17	-0.03	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	ABO	0.26	0.23	enet	10	0.26	6.0e-29	-8.91	-9.2	4.9e-20	-0.03	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	BRD3	0.06	0.01	blup	59	0.03	1.6e-04	-9.81	11.4	2.6e-30	0.02	0.01	0.78	TRUE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	GFI1B	0.16	0.11	enet	7	0.11	2.4e-12	-4.57	-6.0	1.5e-09	0.05	1.00	0.00	TRUE
42	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABO	0.23	0.23	lasso	2	0.24	2.2e-11	-8.90	-8.9	4.0e-19	-0.04	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	ABO	0.21	0.25	lasso	5	0.25	2.1e-29	-8.91	-9.0	1.8e-19	-0.03	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	BRD3	0.04	0.01	enet	14	0.03	3.1e-04	-9.89	9.1	6.0e-20	-0.01	0.01	0.85	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	NCRNA00094	0.03	0.02	blup	52	0.02	2.1e-03	-7.51	-6.1	1.2e-09	0.00	0.03	0.17	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	SURF6	0.02	0.00	blup	22	0.01	1.7e-02	-3.42	-5.5	5.0e-08	0.01	0.05	0.07	TRUE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ABO	0.08	0.06	blup	43	0.09	1.7e-10	-8.91	-6.8	9.0e-12	-0.02	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NCRNA00094	0.03	0.03	enet	5	0.04	1.7e-05	-5.84	-9.0	2.7e-19	0.02	0.01	0.96	FALSE
49	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ABO	0.28	0.22	lasso	8	0.22	1.2e-14	-8.91	-9.2	2.8e-20	-0.02	0.00	1.00	TRUE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ABO	0.23	0.21	lasso	5	0.20	6.7e-09	-8.90	-8.1	7.9e-16	-0.05	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	BRD3	0.14	0.02	blup	60	0.09	2.0e-04	-8.83	10.6	2.3e-26	0.00	0.01	0.86	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ABO	0.23	0.23	lasso	3	0.23	2.0e-09	-8.88	-8.2	1.8e-16	-0.02	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BRD3	0.09	0.03	blup	60	0.01	1.1e-01	-10.04	10.9	8.1e-28	0.00	0.01	0.75	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABO	0.18	0.15	blup	43	0.21	3.4e-21	-8.90	-5.6	2.0e-08	-0.03	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	BRD3	0.09	0.07	lasso	3	0.07	1.3e-07	-8.91	9.5	1.6e-21	0.00	0.14	0.86	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCRNA00094	0.04	0.00	blup	52	0.02	5.2e-03	-5.84	-8.1	7.3e-16	0.01	0.02	0.77	FALSE
57	The Cancer Genome Atlas	Rectum Adenocarcinoma	ABO	0.48	0.23	enet	10	0.27	4.7e-07	-8.95	-8.7	2.9e-18	-0.06	0.00	0.98	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	BRD3	0.32	-0.01	blup	60	0.02	9.8e-02	-9.76	8.6	1.3e-17	0.02	0.01	0.48	FALSE
59	The Cancer Genome Atlas	Soft Tissue Sarcoma	ABO	0.32	0.18	enet	10	0.20	2.3e-12	-8.91	-7.1	1.0e-12	-0.04	0.00	1.00	TRUE
60	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ABO	0.38	0.11	blup	43	0.15	9.6e-05	-2.02	-6.6	4.3e-11	-0.05	0.01	0.90	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	ABO	0.20	0.10	blup	42	0.18	5.8e-13	-8.91	-8.2	2.6e-16	-0.06	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	BRD3	0.07	0.04	enet	12	0.04	4.3e-04	-10.00	10.3	1.1e-24	-0.01	0.01	0.94	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ABO	0.41	0.17	enet	12	0.25	3.0e-09	6.09	-7.4	1.0e-13	-0.01	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	ABO	0.44	0.57	enet	18	0.60	1.9e-73	-8.91	-8.2	2.6e-16	-0.03	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	BRD3	0.12	0.18	enet	8	0.21	8.4e-20	-10.10	10.9	1.2e-27	0.01	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ABO	0.23	0.07	blup	44	0.12	4.3e-04	-8.90	-6.5	9.6e-11	0.02	0.00	0.78	FALSE