[Hub]/) : Traits : Blood Eosinophil Count :

chr10:110,937,872-112,588,355

Best TWAS P=1.55e-15 · Best GWAS P=1.09e-14 conditioned to 0.12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum ADD3 0.06 0.03 enet 7 0.04 4.1e-03 -6.9 -7.0 2.0e-12 0.83 0.04 0.92 FALSE
2 GTEx Artery Aorta ADD3 0.12 0.10 lasso 3 0.11 9.4e-07 -7.7 -7.1 9.2e-13 0.98 0.01 0.99 FALSE
3 GTEx Brain Cerebellar Hemisphere ADD3 0.40 0.34 lasso 6 0.45 4.2e-13 -7.4 -8.0 1.5e-15 0.88 0.04 0.96 TRUE
4 GTEx Brain Cerebellum ADD3 0.36 0.31 lasso 11 0.33 1.4e-10 -7.4 -7.8 5.4e-15 0.84 0.05 0.95 FALSE
5 GTEx Breast Mammary Tissue ADD3 0.08 0.05 lasso 3 0.04 3.4e-03 -7.7 -7.7 1.1e-14 1.00 0.02 0.87 FALSE
6 GTEx Breast Mammary Tissue (Female) ADD3 0.07 0.02 lasso 1 0.09 1.3e-03 -7.4 -7.4 9.9e-14 0.77 0.04 0.47 FALSE
7 GTEx Colon Sigmoid ADD3 0.10 0.04 lasso 7 0.03 3.3e-02 -7.5 -7.5 8.8e-14 0.92 0.04 0.86 FALSE
8 GTEx Heart Left Ventricle ADD3 0.10 0.02 enet 17 0.03 1.2e-02 -6.9 -7.1 1.4e-12 0.76 0.03 0.97 FALSE
9 GTEx Lung ADD3 0.07 0.05 lasso 4 0.04 2.2e-04 -7.6 -7.1 1.2e-12 0.77 0.02 0.97 FALSE
10 GTEx Nerve Tibial ADD3 0.08 0.07 lasso 3 0.04 4.3e-04 -7.7 -7.7 1.5e-14 0.98 0.01 0.99 FALSE
11 GTEx Pituitary ADD3 0.27 0.05 enet 9 0.08 4.0e-03 -6.6 -7.5 5.4e-14 0.93 0.04 0.90 FALSE
12 GTEx Spleen XPNPEP1 0.25 0.04 lasso 5 0.05 2.4e-02 -6.6 -6.0 1.5e-09 0.72 0.05 0.35 FALSE
13 GTEx Spleen ADD3 0.36 0.27 lasso 5 0.28 7.2e-08 -7.7 -7.7 1.0e-14 0.91 0.02 0.98 FALSE
14 GTEx Thyroid ADD3 0.06 0.00 enet 4 0.01 1.2e-01 -7.7 -7.9 3.6e-15 0.96 0.01 0.92 FALSE
15 METSIM Adipose XPNPEP1 0.05 0.01 blup 321 0.03 3.4e-05 -7.6 -5.5 4.0e-08 0.65 0.03 0.94 FALSE
16 ROSMAP Brain Pre-frontal Cortex ADD3 0.04 0.03 lasso 4 0.02 2.1e-03 -6.8 -6.4 1.2e-10 0.79 0.08 0.90 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma ADD3 0.04 0.03 lasso 2 0.02 8.5e-04 -4.2 -5.3 1.0e-07 0.53 0.08 0.17 FALSE