Best TWAS P=9.53e-54 · Best GWAS P=1.58e-35 conditioned to 0.115
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IFITM2 | 0.07 | 0.01 | enet | 12 | 0.04 | 2.1e-05 | 8.52 | -10.8 | 5.6e-27 | -0.40 | 0.24 | 0.14 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | IFITM2 | 0.16 | 0.14 | lasso | 5 | 0.16 | 1.1e-12 | 12.44 | -13.8 | 3.5e-43 | -0.95 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Aorta | RP11-326C3.7 | 0.16 | 0.20 | enet | 23 | 0.18 | 3.9e-10 | 9.61 | 9.6 | 7.1e-22 | 0.21 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | IFITM2 | 0.10 | 0.08 | enet | 42 | 0.05 | 8.5e-05 | 12.44 | -14.4 | 9.9e-47 | -0.65 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Brain Cerebellum | ATHL1 | 0.46 | 0.14 | enet | 17 | 0.30 | 1.5e-09 | -3.74 | -5.1 | 2.9e-07 | -0.12 | 0.45 | 0.05 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | IFITM2 | 0.24 | 0.04 | enet | 36 | 0.18 | 1.0e-13 | -2.87 | -8.3 | 8.8e-17 | -0.48 | 0.00 | 0.99 | FALSE |
| 7 | GTEx | Esophagus Mucosa | IFITM2 | 0.23 | 0.03 | enet | 28 | 0.13 | 2.9e-09 | 12.44 | -14.6 | 4.7e-48 | -0.59 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Esophagus Muscularis | IFITM2 | 0.11 | 0.01 | enet | 29 | 0.04 | 1.4e-03 | 8.19 | -12.4 | 2.0e-35 | -0.61 | 0.00 | 0.95 | TRUE |
| 9 | GTEx | Esophagus Muscularis | RP11-326C3.7 | 0.24 | 0.19 | lasso | 5 | 0.18 | 2.1e-11 | 9.61 | 9.7 | 4.8e-22 | 0.36 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | IFITM2 | 0.33 | 0.05 | lasso | 7 | 0.04 | 7.8e-03 | 12.44 | -12.6 | 1.3e-36 | -0.90 | 0.00 | 0.89 | FALSE |
| 11 | GTEx | Heart Left Ventricle | PTDSS2 | 0.18 | 0.02 | enet | 42 | 0.04 | 2.4e-03 | -0.35 | 7.4 | 1.4e-13 | 0.32 | 0.27 | 0.27 | FALSE |
| 12 | GTEx | Lung | RP11-326C3.7 | 0.22 | 0.05 | enet | 22 | 0.11 | 1.2e-08 | 9.61 | 7.1 | 1.0e-12 | 0.17 | 0.94 | 0.01 | FALSE |
| 13 | GTEx | Nerve Tibial | IFITM2 | 0.20 | 0.07 | lasso | 4 | 0.10 | 8.5e-08 | 12.44 | -13.4 | 1.2e-40 | -0.92 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Nerve Tibial | RP11-326C3.12 | 0.25 | 0.15 | enet | 30 | 0.18 | 9.7e-13 | 7.48 | -8.6 | 1.1e-17 | -0.27 | 0.99 | 0.01 | FALSE |
| 15 | GTEx | Skin Not Sun Exposed Suprapubic | B4GALNT4 | 0.21 | 0.00 | lasso | 6 | 0.00 | 4.5e-01 | 2.99 | 6.0 | 1.6e-09 | 0.29 | 0.05 | 0.04 | FALSE |
| 16 | GTEx | Thyroid | IFITM2 | 0.16 | 0.09 | lasso | 3 | 0.07 | 4.0e-06 | 12.44 | -13.4 | 5.7e-41 | -0.96 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Whole Blood | IFITM3 | 0.09 | 0.02 | enet | 12 | 0.07 | 5.2e-07 | 12.44 | 6.2 | 7.1e-10 | 0.68 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Whole Blood | IFITM2 | 0.17 | 0.08 | lasso | 8 | 0.09 | 6.2e-09 | 12.44 | -10.5 | 7.4e-26 | -0.82 | 0.00 | 1.00 | FALSE |
| 19 | METSIM | Adipose | RP11-326C3.12 | 0.08 | 0.03 | enet | 21 | 0.05 | 1.3e-08 | 7.48 | -7.0 | 2.2e-12 | -0.21 | 0.99 | 0.00 | FALSE |
| 20 | METSIM | Adipose | RP11-326C3.15 | 0.19 | 0.12 | lasso | 9 | 0.15 | 8.6e-22 | 7.48 | -10.6 | 3.0e-26 | 0.03 | 1.00 | 0.00 | FALSE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | ATHL1 | 0.29 | 0.10 | enet | 21 | 0.14 | 5.0e-18 | 4.19 | -10.0 | 1.4e-23 | -0.45 | 1.00 | 0.00 | FALSE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | IFITM2 | 0.17 | 0.08 | bslmm | 312 | 0.12 | 1.0e-14 | -1.60 | -10.4 | 2.8e-25 | -0.17 | 1.00 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IFITM2 | 0.08 | 0.03 | lasso | 3 | 0.04 | 1.4e-08 | 7.48 | -12.3 | 8.8e-35 | -0.19 | 0.97 | 0.01 | FALSE |
| 24 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IFITM2 | 0.08 | 0.00 | blup | 54 | 0.02 | 6.6e-03 | -11.13 | -15.4 | 9.5e-54 | -0.24 | 0.04 | 0.04 | TRUE |
| 25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IFITM3 | 0.04 | 0.02 | blup | 57 | 0.02 | 4.7e-03 | -1.93 | 8.2 | 3.7e-16 | 0.50 | 0.01 | 0.59 | FALSE |
| 26 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATHL1 | 0.08 | 0.00 | blup | 80 | 0.04 | 6.0e-05 | 9.80 | -5.5 | 2.9e-08 | -0.24 | 0.05 | 0.07 | FALSE |
| 27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IFITM2 | 0.15 | 0.02 | enet | 11 | 0.04 | 2.5e-05 | 9.61 | -12.1 | 7.2e-34 | -0.38 | 0.17 | 0.45 | FALSE |
| 28 | The Cancer Genome Atlas | Thyroid Carcinoma | IFITM3 | 0.08 | 0.01 | enet | 16 | 0.03 | 3.8e-04 | 2.68 | 9.1 | 6.5e-20 | 0.54 | 0.01 | 0.78 | FALSE |