Best TWAS P=4.33e-14 · Best GWAS P=6.42e-15 conditioned to 0.0424
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CARS | 0.06 | 0.06 | enet | 14 | 0.06 | 7.0e-06 | -5.9 | 5.8 | 6.5e-09 | 0.35 | 0.46 | 0.07 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | PHLDA2 | 0.09 | 0.06 | lasso | 4 | 0.05 | 1.2e-04 | -6.5 | -6.7 | 1.7e-11 | -0.40 | 0.35 | 0.53 | FALSE |
| 3 | GTEx | Esophagus Muscularis | C11orf21 | 0.18 | 0.10 | enet | 10 | 0.10 | 1.3e-06 | -6.5 | -5.3 | 1.2e-07 | -0.02 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Heart Left Ventricle | C11orf21 | 0.18 | 0.02 | lasso | 4 | 0.04 | 2.6e-03 | -6.5 | -5.5 | 3.6e-08 | -0.02 | 0.00 | 0.99 | TRUE |
| 5 | GTEx | Muscle Skeletal | NAP1L4 | 0.09 | 0.00 | lasso | 3 | 0.00 | 6.2e-01 | -6.7 | -7.5 | 4.3e-14 | -0.50 | 0.03 | 0.72 | TRUE |
| 6 | NTR | Blood | CARS | 0.05 | 0.03 | bslmm | 463 | 0.04 | 6.4e-13 | 4.0 | 6.3 | 2.2e-10 | 0.51 | 1.00 | 0.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PHLDA2 | 0.16 | 0.12 | lasso | 4 | 0.13 | 7.8e-17 | -6.0 | -6.1 | 1.2e-09 | -0.27 | 1.00 | 0.00 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | NAP1L4 | 0.07 | 0.01 | enet | 13 | 0.02 | 4.7e-04 | 7.8 | -5.6 | 2.0e-08 | -0.81 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC22A18AS | 0.02 | 0.00 | blup | 60 | 0.01 | 5.1e-04 | 7.6 | 7.0 | 2.0e-12 | 0.72 | 0.00 | 0.91 | TRUE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC22A18AS | 0.12 | 0.01 | blup | 60 | 0.08 | 2.7e-05 | -6.0 | 7.3 | 2.7e-13 | 0.58 | 0.05 | 0.32 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC22A18AS | 0.09 | 0.03 | blup | 60 | 0.06 | 2.3e-07 | 5.2 | 7.0 | 1.8e-12 | 0.57 | 0.87 | 0.07 | FALSE |
| 12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC22A18AS | 0.10 | 0.05 | enet | 8 | 0.04 | 7.9e-04 | 5.2 | 5.5 | 4.0e-08 | 0.41 | 0.24 | 0.06 | FALSE |
| 13 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SLC22A18AS | 0.16 | 0.04 | blup | 60 | 0.03 | 2.6e-02 | -5.5 | -5.3 | 9.9e-08 | -0.30 | 0.02 | 0.06 | FALSE |
| 14 | The Cancer Genome Atlas | Stomach Adenocarcinoma | NAP1L4 | 0.09 | 0.01 | blup | 80 | 0.03 | 2.5e-03 | 7.6 | -6.6 | 3.5e-11 | -0.74 | 0.01 | 0.80 | FALSE |