Best TWAS P=2.19e-20 · Best GWAS P=1.73e-19 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LTBR | 0.16 | 0.07 | lasso | 5 | 0.07 | 8.7e-09 | 7.0 | 7.4 | 1.2e-13 | 0.13 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | LTBR | 0.35 | 0.28 | lasso | 2 | 0.26 | 9.9e-22 | 6.9 | 7.0 | 1.9e-12 | 0.07 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adrenal Gland | LTBR | 0.36 | 0.26 | enet | 12 | 0.27 | 3.3e-10 | 7.0 | 7.3 | 2.4e-13 | 0.09 | 0.98 | 0.00 | FALSE |
| 4 | GTEx | Artery Aorta | LTBR | 0.26 | 0.28 | lasso | 2 | 0.29 | 3.8e-16 | 6.9 | 6.9 | 5.3e-12 | 0.07 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Tibial | LTBR | 0.43 | 0.33 | lasso | 4 | 0.32 | 4.3e-26 | 6.9 | 7.0 | 2.2e-12 | 0.10 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | LTBR | 0.23 | 0.17 | lasso | 4 | 0.20 | 1.3e-14 | 6.9 | 6.8 | 1.1e-11 | 0.04 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Mucosa | LTBR | 0.36 | 0.23 | lasso | 6 | 0.22 | 8.8e-15 | 6.9 | 6.8 | 1.3e-11 | 0.06 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Esophagus Muscularis | LTBR | 0.22 | 0.19 | lasso | 2 | 0.19 | 7.6e-12 | 6.9 | 7.0 | 3.0e-12 | 0.07 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Lung | LTBR | 0.24 | 0.18 | enet | 7 | 0.19 | 1.1e-14 | 6.3 | 7.1 | 1.4e-12 | 0.05 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Muscle Skeletal | LTBR | 0.24 | 0.15 | lasso | 5 | 0.15 | 1.3e-14 | 6.9 | 6.7 | 2.5e-11 | 0.07 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Nerve Tibial | LTBR | 0.31 | 0.29 | lasso | 2 | 0.29 | 1.4e-20 | 6.9 | 6.9 | 4.0e-12 | 0.07 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Testis | LTBR | 0.57 | 0.46 | enet | 14 | 0.49 | 1.2e-24 | 6.9 | 6.8 | 1.0e-11 | 0.06 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Thyroid | LTBR | 0.25 | 0.20 | enet | 8 | 0.20 | 3.5e-15 | 6.9 | 7.2 | 7.7e-13 | 0.07 | 1.00 | 0.00 | FALSE |
| 14 | METSIM | Adipose | LTBR | 0.33 | 0.26 | bslmm | 454 | 0.26 | 6.1e-39 | 6.7 | 6.9 | 6.1e-12 | 0.05 | 1.00 | 0.00 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | GNB3 | 0.04 | 0.02 | lasso | 3 | 0.01 | 7.3e-03 | 6.9 | 7.0 | 2.0e-12 | 0.07 | 0.06 | 0.02 | FALSE |
| 16 | YFS | Blood | LTBR | 0.14 | 0.06 | enet | 28 | 0.10 | 8.0e-30 | 7.0 | 8.4 | 3.2e-17 | 0.54 | 1.00 | 0.00 | TRUE |
| 17 | YFS | Blood | TNFRSF1A | 0.06 | 0.05 | lasso | 3 | 0.05 | 5.5e-15 | 9.0 | 9.2 | 2.2e-20 | 0.97 | 0.00 | 1.00 | TRUE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LTBR | 0.07 | 0.06 | lasso | 3 | 0.06 | 7.4e-07 | 7.0 | 7.2 | 7.6e-13 | 0.06 | 1.00 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | LTBR | 0.08 | 0.07 | lasso | 1 | 0.06 | 4.1e-06 | 7.0 | 7.0 | 3.5e-12 | 0.06 | 0.88 | 0.00 | FALSE |