Best TWAS P=1.03e-11 · Best GWAS P=1.05e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | RP11-981P6.1 | 0.33 | 0.29 | lasso | 3 | 0.19 | 2.2e-07 | 5.7 | 6.8 | 1.0e-11 | 0.08 | 0.65 | 0.34 | TRUE |
2 | GTEx | Artery Tibial | RP11-981P6.1 | 0.07 | 0.06 | lasso | 1 | 0.03 | 1.3e-03 | 5.6 | 5.6 | 1.9e-08 | 0.05 | 0.41 | 0.33 | FALSE |
3 | GTEx | Colon Sigmoid | RP11-981P6.1 | 0.19 | 0.12 | lasso | 4 | 0.11 | 9.7e-05 | 5.7 | 5.8 | 7.8e-09 | 0.05 | 0.24 | 0.31 | FALSE |
4 | GTEx | Colon Transverse | RP11-981P6.1 | 0.14 | 0.05 | enet | 26 | 0.05 | 1.9e-03 | 5.9 | 6.0 | 1.4e-09 | 0.09 | 0.30 | 0.28 | FALSE |
5 | GTEx | Esophagus Muscularis | RP11-981P6.1 | 0.18 | 0.10 | lasso | 3 | 0.06 | 2.9e-04 | 5.8 | 5.6 | 2.2e-08 | 0.06 | 0.58 | 0.36 | FALSE |
6 | GTEx | Nerve Tibial | POC1B | 0.30 | 0.18 | lasso | 6 | 0.22 | 1.0e-15 | -5.4 | -6.6 | 3.4e-11 | -0.05 | 0.93 | 0.07 | FALSE |
7 | GTEx | Spleen | RP11-981P6.1 | 0.28 | 0.18 | lasso | 13 | 0.14 | 2.1e-04 | 5.6 | 6.1 | 1.0e-09 | 0.06 | 0.29 | 0.34 | FALSE |
8 | GTEx | Thyroid | RP11-981P6.1 | 0.24 | 0.25 | lasso | 5 | 0.26 | 3.9e-20 | 5.8 | 6.1 | 1.2e-09 | 0.05 | 0.46 | 0.54 | FALSE |
9 | METSIM | Adipose | POC1B | 0.07 | 0.03 | bslmm | 381 | 0.03 | 5.2e-05 | 5.9 | -5.8 | 7.3e-09 | -0.06 | 0.58 | 0.38 | FALSE |
10 | YFS | Blood | DUSP6 | 0.08 | 0.07 | lasso | 4 | 0.07 | 2.6e-22 | 6.5 | 6.6 | 4.2e-11 | 0.99 | 0.00 | 1.00 | TRUE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GALNT4 | 0.05 | 0.05 | lasso | 2 | 0.04 | 8.7e-06 | -5.3 | -5.4 | 7.4e-08 | -0.03 | 0.10 | 0.88 | FALSE |