Best TWAS P=8.19e-38 · Best GWAS P=1e-34 conditioned to 3.33e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | UBAC2 | 0.09 | 0.06 | lasso | 3 | 0.04 | 1.5e-05 | -11.52 | 11.7 | 1.9e-31 | -0.59 | 0.69 | 0.31 | TRUE |
2 | GTEx | Brain Cortex | DOCK9-AS2 | 0.25 | 0.08 | lasso | 6 | 0.05 | 2.2e-02 | 1.23 | -5.2 | 1.8e-07 | 0.06 | 0.14 | 0.05 | FALSE |
3 | GTEx | Breast Mammary Tissue (Male) | DOCK9-AS2 | 0.21 | 0.00 | lasso | 5 | -0.01 | 5.2e-01 | -10.94 | -9.7 | 3.3e-22 | 0.51 | 0.06 | 0.06 | FALSE |
4 | GTEx | Pituitary | TM9SF2 | 0.30 | 0.01 | enet | 34 | 0.10 | 1.9e-03 | -3.28 | -5.5 | 5.0e-08 | 0.27 | 0.08 | 0.09 | FALSE |
5 | GTEx | Testis | UBAC2 | 0.21 | 0.07 | lasso | 4 | 0.07 | 6.6e-04 | -8.73 | -9.4 | 5.9e-21 | 0.28 | 0.20 | 0.35 | FALSE |
6 | NTR | Blood | TM9SF2 | 0.03 | 0.02 | enet | 20 | 0.02 | 2.0e-06 | -6.72 | 5.5 | 3.7e-08 | 0.07 | 0.80 | 0.01 | TRUE |
7 | YFS | Blood | UBAC2 | 0.06 | 0.03 | bslmm | 612 | 0.05 | 2.1e-15 | 3.07 | -7.1 | 1.3e-12 | 0.56 | 0.92 | 0.08 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TM9SF2 | 0.02 | 0.00 | blup | 93 | 0.01 | 4.6e-04 | -5.35 | -6.7 | 1.7e-11 | 0.20 | 0.03 | 0.29 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UBAC2 | 0.05 | 0.00 | blup | 118 | 0.02 | 2.8e-04 | -0.79 | -12.9 | 8.2e-38 | 0.49 | 0.13 | 0.27 | TRUE |
10 | The Cancer Genome Atlas | Colon Adenocarcinoma | TM9SF2 | 0.23 | 0.01 | blup | 93 | 0.08 | 3.7e-05 | -6.17 | -5.2 | 2.0e-07 | 0.13 | 0.03 | 0.05 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TM9SF2 | 0.04 | 0.03 | blup | 93 | 0.02 | 1.9e-03 | -5.35 | -5.2 | 1.6e-07 | 0.00 | 0.42 | 0.10 | FALSE |