TWAS hub - UBAC2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0860	0.0260	1.0e-05	0.062	0.033	0.033	0.034	0.039	5.0e-08	6.0e-05	6.8e-05	4.5e-05	1.5e-05
2	GTEx	Testis	0.2060	0.0780	4.1e-03	0.070	NA	0.065	NA	0.067	4.8e-04	NA	7.9e-04	NA	6.6e-04
3	GTEx	Thyroid	0.1030	0.0430	3.5e-03	-0.001	NA	-0.002	NA	-0.003	4.0e-01	NA	5.1e-01	NA	7.8e-01
4	YFS	Blood	0.0594	0.0152	4.1e-15	0.028	0.047	0.043	0.048	0.044	1.8e-09	3.9e-15	5.4e-14	2.1e-15	2.4e-14
5	TCGA	Breast Invasive Carcinoma	0.0486	0.0282	3.2e-04	0.001	0.016	0.013	NA	0.011	2.1e-01	2.8e-04	7.8e-04	NA	2.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5
Asthma	17.8	35.0	57.3	7.6	-4.8	-6.4	-7.3
Asthma (self-reported)	16.4	32.6	53.4	7.3	-4.6	-6.4	-6.9
Respiratory disease	14.3	31.9	51.4	7.2	-4.2	-6.5	-7.0
Blood Eosinophil Count	11.5	88.3	166.4	11.7	-9.4	-7.1	-12.9
Allergy	11.4	26.3	55.2	-5.7	4.4	4.9	7.4
Allergy or Eczema	7.7	20.2	48.0	4.3	-4.9	-3.2	-6.9
Wheeze or whistling in the chest in last year	7.7	13.7	31.8	5.2	-2.5	-5.6	-1.7
Hayfever, allergic rhinitis or eczema	6.3	13.6	31.9	3.6	-4.1	-2.5	-5.6
Ever depressed for a whole week	4.0	4.9	14.0	2.1	-3.7	-1.3	-2.2
Hypothyroidism (self reported)	3.8	8.7	22.9	-2.6	3.7	-0.5	4.8
Shortness of breath walking on level ground	3.8	4.5	11.2	3.3	-2.0	-2.4	-1.3
Medication: Ventolin 100micrograms inhaler	3.7	4.7	12.0	2.8	-0.9	-3.5	-1.7
Stomach or abdominal pain in last month	3.4	4.2	8.4	-2.9	2.7	2.1	0.8
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	9.9	-3.1	1.7	1.7	1.8
Ovarian Cancer	3.0	3.9	7.1	2.1	-2.3	-1.6	-2.7
Medication: Seretide 50 evohaler	3.0	3.4	11.4	1.7	-1.4	-3.4	-0.8
Supplements: Calcium	3.0	3.3	12.1	1.1	-1.8	-0.4	-3.5
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	11.5	-2.8	2.7	0.1	3.4
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	10.3	2.1	-2.1	-1.2	-3.2
Pain experienced in last month	2.6	4.4	8.7	2.9	-2.9	-1.8	-1.2
Medication: Co-codamol	2.3	2.6	5.0	2.2	-1.8	-2.2	-0.2
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	8.9	1.8	-0.3	-3.0	-0.1
Prostate Cancer	2.1	2.9	5.9	-2.0	2.2	2.4	0.1
Crohns Disease (2012)	2.1	3.4	8.9	-0.9	2.1	-1.7	3.0
Irritable Bowel Disease (IBD)	1.9	4.5	13.0	-1.5	2.7	-0.3	3.6
Medication: Levothyroxine sodium	1.9	3.2	6.9	-2.3	2.0	0.3	2.6
Medication for pain relief, constipation, heartburn	1.9	3.3	6.3	1.8	-2.5	-0.8	-2.5
Commuting to job workplace: Walk	1.9	2.1	5.7	-0.7	-0.5	2.4	-2.0
Tinnitus: Yes, now most or all of the time	1.9	2.3	5.4	-1.4	2.3	1.7	1.0
Chronic bronchitis/emphysema (mother)	1.8	2.0	4.5	1.8	-2.1	-1.2	-0.9
Chest pain or discomfort	1.7	2.5	7.4	2.1	-0.3	-2.7	-0.7
Bipolar Disorder (2011)	1.6	1.5	5.9	-0.3	-0.8	1.0	-2.4
Rheumatoid Arthritis	1.6	2.3	6.1	2.5	-1.0	-1.9	-0.7
Heart attack	1.6	2.0	5.1	2.3	-0.2	-2.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	11.4	-2.0	1.0	3.4	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.9	-2.0	1.8	1.4	1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	10.0	0.5	-2.5	-3.2	-1.0
Pulse wave peak to peak time	1.5	1.8	5.6	0.3	-2.4	0.3	-1.8
Medication for cholesterol	1.5	2.3	7.1	-1.9	0.5	2.7	-0.7
Hearing aid user	1.5	1.7	4.4	-1.0	2.1	-0.1	1.7
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.9	2.2	-0.4	-2.1	0.3
Depression (Nagel 2018)	1.4	2.1	3.5	-1.8	1.6	1.9	1.2
Crohns Disease (2017)	1.4	3.1	6.3	-1.7	2.5	-0.6	2.4
Major Depression (MDD)	1.4	1.6	4.1	-1.2	2.0	1.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	9.9	0.4	-2.4	-3.1	-0.3
High blood pressure (mother)	1.4	2.0	3.8	-2.0	1.9	1.7	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.4	1.8	-1.2	-1.9	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.5	-1.6	0.9	2.1	0.2
Irritability	1.4	2.4	5.0	2.2	-1.7	-1.6	-1.2
Ulcerative Colitis (UC)	1.3	2.4	8.5	-1.0	1.6	0.2	2.9
Age when periods started (menarche)	1.3	3.1	7.0	2.7	-1.6	-0.9	-2.3
Hearing difficulty/problems with background noise	1.3	2.0	4.6	-1.8	2.1	1.4	0.7
Illnesses of mother	1.3	1.6	2.9	1.6	-1.7	-1.7	0.3
Pulse wave Arterial Stiffness index	1.3	1.5	4.8	-0.0	2.2	-0.4	1.6
Medication: Paracetamol	1.3	2.0	4.8	-1.6	2.2	-0.3	1.6
Illnesses of father: High blood pressure	1.3	1.6	4.1	-2.0	1.1	1.7	0.1
Body Mass Index (BMI) (2010)	1.2	1.6	3.9	-2.0	1.0	1.7	0.3
LDL Cholesterol	1.2	2.0	4.7	-2.0	0.9	2.2	0.6
Ever had hysterectomy (womb removed)	1.2	1.3	4.1	-1.2	2.0	0.6	0.7
Vitamin and mineral supplements	1.2	1.7	5.8	0.7	0.4	-2.4	1.4
Average weekly fortified wine intake	1.2	1.4	5.2	-0.6	-0.2	2.3	-1.1
Medication: Paracetamol	1.2	1.9	4.1	-1.3	2.0	-0.8	1.8
Neck or shoulder pain in last month	1.2	1.7	3.3	-1.8	1.7	1.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.0	-1.5	1.1	1.7	1.0
Ever had bowel cancer screening	1.2	1.4	3.1	-0.5	1.8	1.7	0.8
Number of self-reported non-cancer illnesses	1.2	2.1	6.1	1.9	-0.2	-2.5	-0.9
Mean Putamen Volume	1.1	1.2	3.3	-1.1	1.3	1.8	-0.2
Primary Biliary Cirrhosis	1.1	1.6	5.6	1.2	0.4	-0.9	2.4
Ulcerative Colitis	1.1	1.6	6.3	-0.0	1.1	-0.7	2.5
Multivitamins +/- minerals	1.1	1.4	3.9	-1.4	0.0	2.0	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	5.8	-1.4	2.4	0.8	0.9
Mouth/teeth dental problems: Dentures	1.1	1.8	4.3	-1.3	1.7	0.6	2.1
Depression (self-reported)	1.1	1.3	4.3	1.5	-0.0	-2.1	0.1
Medication: Omeprazole	1.1	1.3	3.0	-1.6	1.7	0.9	-0.1
Mother’s age at death	1.1	1.4	6.3	-0.1	0.2	0.8	-2.5
Cholesterol lowering medication	1.1	1.6	3.6	1.9	-1.8	-1.1	0.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.2	1.4	0.2	-1.8	0.6
Medication: Simvastatin	1.0	1.4	4.0	2.0	-1.6	-0.8	-0.2
Health satisfaction	1.0	1.4	2.7	-1.6	1.7	1.0	0.8
Pulse rate, automated reading	1.0	3.1	11.7	1.5	-3.4	-1.1	-0.7
Reaction Time	0.9	1.7	5.2	-1.1	2.3	0.1	1.4
Diabetes (father)	0.9	1.1	2.6	-0.9	1.2	0.5	1.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	4.5	0.1	2.1	-0.8	0.6
Hair/balding pattern: Pattern 2	0.9	1.1	2.7	-1.7	-0.3	1.3	1.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.9	1.3	-0.7	-0.3	-2.0
Osteoporosis (self-reported)	0.9	1.1	4.1	0.4	0.8	0.5	-2.0
Illnesses of father: None of the above (group 1)	0.9	1.1	2.8	0.7	-1.2	-0.9	-1.7
Myopia	0.9	1.3	2.9	1.1	-1.4	-1.7	0.6
Basal cell carcinoma (self-reported)	0.9	1.0	3.5	0.2	1.2	-0.0	1.9
Intelligence (Savage-Jansen 2018)	0.8	2.4	5.0	-2.2	1.8	1.8	0.4
Coronary Artery Disease (CAD)	0.8	0.9	3.9	-0.5	-0.7	0.1	2.0
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.3	-1.0	1.5	0.7	1.3
Maternal smoking around birth	0.8	1.2	5.1	0.0	-2.3	-0.5	-0.7
Taking other prescription medications	0.8	1.2	4.1	0.8	0.9	-2.0	0.7
Alcohol intake versus 10 years previously	0.8	1.2	2.7	-0.8	1.0	1.6	1.3
Father’s age at death	0.8	1.1	4.9	-0.3	2.2	0.4	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.6	1.2	0.0	-0.8	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.3	-1.5	1.0	1.0	0.7
Migraine (self-reported)	0.8	1.0	1.8	-1.2	1.3	1.3	-0.2
Medication: Ibuprofen	0.8	1.0	2.2	-1.5	0.6	1.2	1.0
Mean time to correctly identify matches	0.8	1.6	4.8	-1.1	2.2	0.7	1.2
Medication: Aspirin	0.8	1.0	2.5	1.1	-0.2	-1.2	1.6
Illnesses of father: Heart disease	0.8	1.1	4.9	0.8	0.1	0.3	2.2
Medication: Aspirin	0.8	1.1	2.1	1.3	-0.6	-1.1	1.5
Average weekly beer plus cider intake	0.8	1.2	2.4	-1.3	-0.3	1.5	1.3
Ever had prostate specific antigen (PSA) test	0.8	1.0	4.5	-0.4	0.4	2.1	-0.2
Medication: Metformin	0.7	0.9	2.8	0.9	-0.8	-1.7	-0.6
Diabetes (mother)	0.7	0.9	1.4	-1.2	1.0	1.1	-1.0
Chronic bronchitis/emphysema (father)	0.7	0.9	2.6	1.1	-0.5	-0.4	-1.6
Alcohol usually taken with meals	0.7	1.2	4.9	0.6	-2.2	-0.2	-0.8
Happiness	0.7	0.9	1.9	-1.4	0.4	1.3	0.7
Medication: Lansoprazole	0.7	0.8	1.6	-0.5	1.0	1.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	7.2	-1.9	0.4	2.7	-0.1
Tense / ‘highly strung’	0.7	1.1	4.2	1.1	0.0	-2.0	-0.4
Number of children fathered	0.7	0.8	2.3	-0.3	1.5	-0.7	1.1
Emphysema/chronic bronchitis	0.7	0.8	2.8	1.0	0.4	-1.7	-0.0
Overall health rating	0.7	1.5	5.5	-1.4	2.3	0.2	0.1
Leg pain on walking	0.7	0.9	3.2	-0.5	1.8	-0.3	0.9
Diastolic blood pressure, automated reading	0.7	2.2	8.0	-1.5	-0.1	2.8	0.8
Commuting to job workplace: Cycle	0.7	0.9	2.8	-0.9	1.7	0.9	0.2
Alzheimer’s Disease (in father)	0.6	0.7	2.2	0.3	0.9	-0.4	1.5
Waist Hip Ratio (WHR)	0.6	2.8	10.0	1.7	-0.2	-3.2	-1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	1.1	-1.4	-1.5	-0.3
Lung FEV1/FVC ratio	0.6	3.1	10.9	-0.6	-1.3	3.3	1.6
Impedance of arm (right)	0.6	2.6	7.2	2.3	-0.7	-2.7	-0.2
Exposure to tobacco smoke at home	0.6	0.6	1.6	-0.5	1.0	0.5	1.3
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.5	0.3	-1.1	-1.6	-0.1
Loud music exposure frequency	0.6	0.6	1.5	0.8	-1.2	0.2	-1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.3	-0.2	1.1	0.5	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.5	-0.3	0.7	-0.4	1.9
Eye problems/disorders: None of the above	0.6	0.6	1.8	-1.0	0.7	1.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.5	-1.0	0.1	1.1	1.2
Illnesses of siblings: Diabetes	0.6	0.7	2.1	-1.0	0.6	0.2	1.5
Long-standing illness, disability or infirmity	0.6	1.0	3.1	-0.4	0.6	-1.1	1.8
Friendships satisfaction	0.6	0.8	2.0	-1.4	-0.4	1.3	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.5	-1.2	0.7	1.1	0.6
Wears glasses or contact lenses	0.6	0.7	2.1	-0.2	0.9	0.7	1.4
Age started oral contraceptive pill	0.6	0.7	1.3	1.1	-0.9	-0.2	-1.1
Unable to work because of sickness or disability	0.6	0.8	2.2	-0.5	1.5	-0.4	1.1
Pack years of smoking	0.6	0.8	1.8	1.3	-1.1	-0.9	0.6
HDL Cholesterol	0.5	0.8	3.3	-0.4	0.2	0.5	1.8
Lung FVC	0.5	2.6	7.2	-2.1	0.5	2.7	-0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.2	-0.1	1.0	0.1	1.5
Medication: Atenolol	0.5	0.6	2.7	-0.1	1.6	0.5	0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	-0.8	-1.3	0.8	-0.2
Illnesses of siblings	0.5	0.8	2.7	0.9	-0.3	-0.4	-1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	5.9	-1.7	-0.0	2.4	-0.5
Impedance of arm (left)	0.5	2.2	6.0	2.1	-0.5	-2.4	0.2
Hair/balding pattern: Pattern 4	0.5	1.2	2.9	-1.6	0.5	1.7	-0.0
Birth weight of first child	0.5	0.9	3.1	0.7	0.9	0.1	-1.7
Peak expiratory flow (PEF)	0.5	1.2	4.8	0.8	-2.2	-0.1	-0.7
Age at first live birth	0.5	0.9	3.8	0.2	0.3	0.8	-1.9
Heart disease (mother)	0.5	0.6	2.0	0.9	0.3	0.3	-1.4
Mineral and other dietary supplements	0.5	0.7	2.1	0.7	0.3	-1.4	0.8
Breast cancer (self-reported)	0.5	0.6	1.9	1.0	-0.2	-0.3	1.4
Medication: Gliclazide	0.5	0.6	2.1	0.1	-0.1	-1.4	0.9
Breast Cancer	0.4	1.0	2.5	0.0	-1.6	-0.6	-1.5
HbA1C	0.4	0.4	1.0	0.2	-0.9	0.6	-1.0
Neuroticism (2016)	0.4	0.6	1.6	-0.9	1.3	0.2	0.8
Blood White Count	0.4	2.8	6.7	2.5	-1.0	-2.6	-0.5
Heel T-Score	0.4	3.2	10.0	-1.2	-1.6	-3.2	-1.3
Supplements: Zinc	0.4	0.5	1.2	-0.6	0.9	1.1	-0.1
Severe depression (siblings)	0.4	0.5	1.3	-0.4	-0.3	0.9	-1.1
Pack years adult smoking proportion	0.4	0.6	1.1	1.1	-0.9	-1.0	0.5
Hand grip strength (right)	0.4	1.0	4.4	-0.6	0.0	2.1	-0.5
Serious illness, injury or assault to yourself	0.4	0.5	1.7	1.3	0.6	0.1	-0.6
Number of incorrect matches in round	0.4	0.6	1.8	-0.3	1.1	-1.4	0.0
Forced vital capacity (FVC)	0.4	1.5	3.8	-1.6	0.1	2.0	-1.1
Financial difficulties in last 2 years	0.4	0.5	1.4	-1.2	0.1	-0.6	1.0
Time employed in main current job	0.4	0.5	1.7	-0.2	0.8	-0.2	1.3
Falls in the last year	0.4	0.6	1.5	0.8	-1.2	0.6	-0.6
Prospective memory result	0.4	0.5	1.5	0.1	0.7	0.7	1.2
Lung cancer (father)	0.4	0.5	1.2	-0.2	1.1	0.0	1.0
Pulse wave reflection index	0.4	0.5	1.5	1.2	0.7	-0.3	0.9
Blood clot in the leg (DVT)	0.4	0.5	2.4	0.4	0.0	-0.4	-1.6
Gout (self-reported)	0.4	0.6	1.7	0.1	1.0	0.5	1.3
Forced vital capacity (FVC), Best measure	0.4	1.4	4.0	-1.6	0.4	2.0	-0.5
Number of full brothers	0.4	0.6	1.3	-0.3	-1.1	-0.2	-1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.5	1.2	-0.1	-0.2	1.1
Supplements: Vitamin C	0.4	0.4	1.0	-0.8	1.0	0.4	0.6
Knee pain experienced in last month	0.4	0.7	2.2	-0.3	1.1	0.3	1.5
Average weekly red wine intake	0.4	0.6	1.5	-1.1	-0.5	1.2	-0.4
Qualifications: nursing, teaching	0.4	0.6	1.4	-0.8	1.2	0.9	0.4
Average weekly champagne plus white wine intake	0.4	0.5	1.2	-1.1	-1.0	0.6	-0.2
Financial situation satisfaction	0.4	0.5	2.0	-1.4	0.7	-0.2	0.2
Medication: Blood pressure	0.4	0.7	2.3	1.0	-0.2	-1.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	-0.8	1.1	0.7	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.1	0.6	0.1	-0.3	-1.4
Impedance of whole body	0.4	2.0	4.5	2.1	-0.8	-2.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.8	-1.7	0.7	0.1	0.4
Age at First Birth	0.3	0.4	1.5	0.5	-0.1	0.6	-1.2
Fasting Glucose	0.3	0.4	1.7	-0.3	0.3	-0.4	1.3
Lupus	0.3	0.4	1.3	0.9	-1.2	-0.1	0.1
Triglycerides	0.3	0.4	2.0	0.1	-0.2	-0.1	-1.4
Height	0.3	5.5	13.5	3.5	-1.1	-3.7	-0.4
Smoking Status	0.3	0.8	2.1	-1.1	0.0	1.4	0.7
Neuroticism	0.3	0.7	2.8	-0.7	-0.1	0.2	1.7
Number of treatments/medications taken	0.3	0.6	1.2	-0.0	1.1	-1.1	0.8
Average weekly spirits intake	0.3	0.4	1.1	1.1	-0.0	-1.0	-0.3
Sensitivity / hurt feelings	0.3	0.5	1.3	0.4	-0.2	-1.0	-1.1
Angina	0.3	0.4	1.3	1.1	0.8	0.2	-0.5
Medication for hormone replacement therapy	0.3	0.4	0.9	0.1	0.8	-0.6	1.0
Impedance of leg (right)	0.3	1.4	3.4	1.8	-1.0	-1.7	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.8	0.2	1.1	-0.8
Qualifications: None of the above	0.3	0.6	2.0	-0.6	0.7	-0.4	1.4
Mouth/teeth dental problems	0.3	0.5	1.4	0.5	-1.2	-0.4	-0.7
Exposure to tobacco smoke outside home	0.3	0.4	1.3	-0.0	-1.1	-0.2	-0.6
Angina (self-reported)	0.3	0.4	1.6	0.7	1.3	0.3	-0.1
Number of full sisters	0.3	0.4	1.4	1.2	0.3	-0.3	-0.5
Had major operations	0.3	0.4	0.9	0.7	-0.3	-1.0	0.5
Age at last live birth	0.3	0.4	1.6	0.2	0.3	0.7	-1.3
Smoking status: Previous	0.3	0.4	1.3	0.3	-0.9	1.1	-0.1
Diabetes diagnosed by doctor	0.3	0.5	1.3	0.5	-0.6	-1.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.3	0.2	0.6	-1.0
Miserableness	0.3	0.5	1.1	-1.1	-0.5	1.0	0.0
Medication: Lisinopril	0.3	0.4	1.6	0.3	-0.2	-1.3	0.3
Risk taking	0.3	0.5	1.6	0.7	-1.2	0.3	-0.6
Schizophrenia (2018)	0.2	0.4	1.2	-0.1	0.1	1.1	-0.8
Alzheimer’s Disease (in mother)	0.2	0.3	1.2	0.1	0.0	0.4	1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	1.3	0.1	0.5	-0.2	1.1
Schizophrenia (2014)	0.2	0.5	1.5	-0.2	-0.5	0.7	-1.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.9	-0.3	-0.5	0.4	-0.9
Blood Red Count	0.2	2.1	4.9	-1.6	0.6	1.6	2.2
BMI	0.2	0.9	3.2	0.8	-0.8	-0.0	1.8
Hand grip strength (left)	0.2	0.4	1.8	-0.3	-0.0	1.3	-0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.8	0.4	0.7	0.5
Systolic blood pressure, automated reading	0.2	0.5	2.1	-0.4	-0.4	1.4	-0.1
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.5	0.3	0.3	0.9
Current tobacco smoking	0.2	0.3	0.9	-0.3	0.5	-0.9	0.5
Supplements: Glucosamine	0.2	0.3	1.2	0.4	-0.4	0.2	1.1
Impedance of leg (left)	0.2	1.1	2.7	1.6	-0.7	-1.4	-0.7
Waist circumference	0.2	0.6	1.2	1.1	-0.2	-1.1	0.7
Medication: Ramipril	0.2	0.3	0.6	0.6	-0.6	-0.8	0.4
Fluid intelligence score	0.2	0.4	1.2	-1.1	0.6	-0.7	-0.1
Arm fat percentage (right)	0.2	0.7	2.8	0.6	-0.0	-0.6	1.7
Worrier / anxious feelings	0.2	0.3	0.7	0.3	-0.8	0.1	-0.8
Pulse rate	0.2	0.3	1.3	0.2	-1.1	0.1	0.3
Noisy workplace	0.2	0.3	0.8	0.4	0.5	-0.3	-0.9
Length of working week for main job	0.2	0.2	0.4	-0.3	-0.5	-0.5	0.7
Birth weight	0.2	0.5	1.6	-0.9	0.4	1.3	-0.3
High blood pressure (siblings)	0.2	0.4	1.2	-1.1	0.3	0.6	0.2
Leg fat percentage (right)	0.2	0.5	1.7	0.9	-0.4	-0.1	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	1.0	-0.1	-0.1	-0.2
Medication: Allopurinol	0.2	0.3	0.9	1.0	-0.4	-0.2	0.4
Arm fat percentage (left)	0.2	0.9	3.9	0.6	0.1	-0.4	2.0
Eye problems/disorders: Cataract	0.2	0.2	0.9	0.2	-0.2	-0.9	0.5
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.5	-0.5	-0.9	0.1
Guilty feelings	0.2	0.2	0.8	-0.2	0.4	0.4	0.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.8	0.2	-0.9	0.5	-0.1
Medication: Bendroflumethiazide	0.2	0.3	1.0	0.2	0.5	0.2	1.0
Alcohol drinker status: Never	0.2	0.3	0.7	0.8	0.3	-0.3	-0.7
Heart disease (siblings)	0.2	0.3	1.2	-0.2	-0.2	-0.4	1.1
Alcohol drinker status: Previous	0.2	0.2	1.1	-0.0	-0.1	1.1	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.1	-0.3	0.7	-0.7
Depressed Affect (Nagel 2018)	0.1	0.3	1.2	-0.5	-0.1	-0.4	1.1
Neuroticism (Nagel 2018)	0.1	0.3	0.8	-0.7	-0.3	-0.3	0.9
Schizophrenia vs Biploar Disorder	0.1	0.2	0.9	-0.1	0.1	-0.0	0.9
Worry (Nagel 2018)	0.1	0.2	0.3	0.0	-0.6	-0.6	0.5
Blood Platelet Count	0.1	0.7	1.0	1.0	-1.0	-0.9	-0.8
Systolic Blood Pressure	0.1	0.3	1.2	-0.1	-0.5	1.1	-0.5
Cardiovascular Disease	0.1	0.2	0.8	0.1	-0.2	0.9	0.5
Chronotype (morning person)	0.1	0.3	1.3	0.5	-0.3	-1.1	0.2
Tanning	0.1	1.2	2.9	-1.3	-0.3	1.0	-1.7
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.1	0.4	-0.5	-0.6
Trunk fat percentage	0.1	0.3	1.1	0.7	0.0	-0.2	1.1
Fed-up feelings	0.1	0.1	0.4	-0.0	0.3	-0.4	0.6
Relative age voice broke	0.1	0.2	0.8	-0.3	0.3	0.9	0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.5	0.1	0.7	-0.6	0.2
Sitting height	0.1	0.7	2.1	-0.3	0.6	1.5	0.9
Body mass index (BMI)	0.1	0.6	2.8	-0.4	0.2	0.4	1.7
Trunk fat mass	0.1	0.3	0.9	0.7	0.1	0.0	0.9
Past tobacco smoking	0.1	0.2	0.8	0.2	0.9	-0.5	0.3
Nervous feelings	0.1	0.2	0.6	0.0	-0.7	-0.5	-0.3
Had menopause	0.1	0.1	0.4	0.6	0.1	0.3	-0.3
Had other major operations	0.1	0.1	0.3	0.4	-0.6	0.4	0.0
Pain all over the body in last month	0.1	0.1	0.3	-0.2	-0.4	0.1	-0.5
Diabetes (self-reported)	0.1	0.2	0.9	0.0	-0.5	-1.0	-0.1
Neuroticism score	0.1	0.1	0.3	0.2	-0.6	-0.6	0.2
Weight	0.1	0.4	1.2	0.8	-0.2	-0.2	1.1
Hip circumference	0.1	0.2	1.0	0.2	-0.1	0.2	1.0
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	-0.1	-0.1	0.3	-0.7
Number of live births	0.1	0.1	0.3	-0.3	-0.4	0.4	-0.6
Medication: Cholesterol lowering	0.1	0.1	0.3	0.5	0.0	-0.2	-0.6
Arm fat mass (right)	0.1	0.4	2.0	0.4	-0.1	-0.3	1.4
Standing height	0.1	1.4	4.7	2.2	-0.5	-1.1	-0.8
Breastfed as a baby	0.1	0.1	0.4	0.3	0.2	0.6	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.6	-0.1	-0.7	0.5
Headache pain in last month	0.1	0.2	0.6	-0.7	0.5	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.0	-0.5	-0.2	-0.8
Glaucoma (self-reported)	0.1	0.2	0.5	-0.1	-0.7	0.2	-0.6
Medication: Amlodipine	0.1	0.1	0.3	0.4	-0.0	-0.3	0.5
Body fat percentage	0.1	0.5	2.0	0.5	0.1	-0.0	1.4
Worry too long after embarrassment	0.1	0.2	0.5	-0.7	0.4	0.4	-0.6
Qualifications: College or University degree	0.1	0.2	0.5	0.1	-0.1	-0.5	-0.7
Medication: Blood pressure	0.1	0.2	0.7	0.1	0.8	0.2	0.6
Whole body fat mass	0.1	0.3	1.5	0.5	0.1	0.1	1.2
Leg fat mass (right)	0.1	0.4	1.1	0.9	-0.4	-0.2	1.1
Alcohol intake frequency.	0.1	0.2	0.7	0.4	0.2	0.6	-0.8
Comparative height size at age 10	0.1	0.6	1.7	-0.0	0.9	-0.4	1.3
Suffer from ‘nerves’	0.1	0.2	0.7	-0.8	-0.5	0.1	0.1
Family relationship satisfaction	0.1	0.1	0.2	0.2	-0.3	0.5	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	-0.2	0.3	0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	0.3	-0.5	-0.9	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.4	0.7	0.2	0.3
Mood swings	0.1	0.2	0.6	-0.8	0.3	0.4	0.6
Loneliness, isolation	0.1	0.1	0.5	0.2	-0.2	-0.7	-0.1
Back pain experienced in last month	0.1	0.2	0.6	-0.2	0.7	0.3	-0.3
Smoking status: Current	0.1	0.2	0.8	-0.3	0.2	-0.9	-0.1
Arm fat mass (left)	0.1	0.5	2.1	0.6	-0.2	-0.2	1.5
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.4	-0.0	0.2	0.4
Commuting to job workplace: Public transport	0.1	0.2	0.5	0.4	-0.2	-0.7	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.4	0.1	-0.6	-0.1
High cholesterol (Self-reported)	0.1	0.2	0.5	0.7	-0.4	0.4	0.3
Leg fat percentage (left)	0.1	0.3	0.7	0.8	-0.4	0.0	0.8
Number of operations (self-reported)	0.1	0.2	0.3	-0.0	-0.5	-0.5	0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.2	-0.6	-0.0	0.6
Leg fat mass (left)	0.1	0.3	1.0	1.0	-0.3	-0.2	0.7
Bipolar Disorder (2018)	0.0	0.1	0.3	-0.0	-0.6	-0.2	-0.1
Hair Pigment	0.0	1.0	2.3	1.5	-1.2	-1.0	-0.5
Relative age of first facial hair	0.0	0.1	0.2	-0.0	0.4	0.5	0.2
Leg fat-free mass (left)	0.0	0.1	0.3	0.1	0.2	0.3	0.6
High blood pressure	0.0	0.1	0.1	0.4	-0.3	0.2	0.2
Leg predicted mass (left)	0.0	0.1	0.3	0.0	0.2	0.3	0.6
Trunk fat-free mass	0.0	0.1	0.6	-0.1	0.1	0.8	0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.2	-0.0	-0.0	0.1	-0.4
Trunk predicted mass	0.0	0.1	0.6	-0.2	0.1	0.8	0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.3
Arm fat-free mass (right)	0.0	0.2	0.8	0.0	0.2	0.9	0.2
Comparative body size at age 10	0.0	0.1	0.2	-0.3	0.1	-0.2	-0.4
Arm predicted mass (right)	0.0	0.2	1.1	-0.2	0.2	1.1	0.1
Hypertension (Self-reported)	0.0	0.1	0.2	0.3	-0.4	0.1	0.2
Whole body fat-free mass	0.0	0.1	0.5	-0.1	0.2	0.7	0.1
Leg fat-free mass (right)	0.0	0.1	0.3	-0.2	0.3	0.6	0.3
Whole body water mass	0.0	0.1	0.4	0.0	0.1	0.6	0.1
Leg predicted mass (right)	0.0	0.1	0.3	-0.2	0.3	0.6	0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	-0.1	-0.2	0.4	-0.1
Medication: Atorvastatin	0.0	0.0	0.2	0.4	-0.1	0.1	-0.1
Ever smoked	0.0	0.1	0.1	-0.3	-0.2	-0.1	0.4
Basal metabolic rate	0.0	0.1	0.2	0.2	-0.0	0.4	0.4
Arm fat-free mass (left)	0.0	0.1	0.3	0.1	-0.3	0.5	0.0
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.5	0.1	-0.1	-0.2
Arm predicted mass (left)	0.0	0.2	0.8	-0.2	-0.0	0.9	0.1

Hub : Genes

UBAC2

Models

Trait associations