Hub : Genes

UBAC2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0860 0.0260 1.0e-05 0.062 0.033 0.033 0.034 0.039 5.0e-08 6.0e-05 6.8e-05 4.5e-05 1.5e-05
2 GTEx Testis 0.2060 0.0780 4.1e-03 0.070 NA 0.065 NA 0.067 4.8e-04 NA 7.9e-04 NA 6.6e-04
3 GTEx Thyroid 0.1030 0.0430 3.5e-03 -0.001 NA -0.002 NA -0.003 4.0e-01 NA 5.1e-01 NA 7.8e-01
4 YFS Blood 0.0594 0.0152 4.1e-15 0.028 0.047 0.043 0.048 0.044 1.8e-09 3.9e-15 5.4e-14 2.1e-15 2.4e-14
5 TCGA Breast Invasive Carcinoma 0.0486 0.0282 3.2e-04 0.001 0.016 0.013 NA 0.011 2.1e-01 2.8e-04 7.8e-04 NA 2.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.0 0.1 0.3 -0.0 -0.6 0.0 -0.2 -0.1
Bipolar Disorder or Schizophrenia 0.1 0.2 0.5 -0.1 -0.3 0.0 0.7 -0.7
Depressed Affect (Nagel 2018) 0.1 0.3 1.2 -0.5 -0.1 0.0 -0.4 1.1
Depression (Nagel 2018) 1.4 2.1 3.5 -1.8 1.6 0.0 1.9 1.2
Intelligence (Savage-Jansen 2018) 0.8 2.4 5.0 -2.2 1.8 0.0 1.8 0.4
Neuroticism (Nagel 2018) 0.1 0.3 0.8 -0.7 -0.3 0.0 -0.3 0.9
Schizophrenia (2018) 0.2 0.4 1.2 -0.1 0.1 0.0 1.1 -0.8
Schizophrenia vs Biploar Disorder 0.1 0.2 0.9 -0.1 0.1 0.0 -0.0 0.9
Worry (Nagel 2018) 0.1 0.2 0.3 0.0 -0.6 0.0 -0.6 0.5
Alzheimer’s Disease (in mother) 0.2 0.3 1.2 0.1 0.0 0.0 0.4 1.1
Alzheimer’s Disease (in father) 0.6 0.7 2.2 0.3 0.9 0.0 -0.4 1.5
Alzheimer’s Disease (including proxy) 0.2 0.3 1.3 0.1 0.5 0.0 -0.2 1.1
Crohns Disease (2017) 1.4 3.1 6.3 -1.7 2.5 0.0 -0.6 2.4
Irritable Bowel Disease (IBD) 1.9 4.5 13.0 -1.5 2.7 0.0 -0.3 3.6
Ulcerative Colitis (UC) 1.3 2.4 8.5 -1.0 1.6 0.0 0.2 2.9
Major Depression (MDD) 1.4 1.6 4.1 -1.2 2.0 0.0 1.6 0.4
Reaction Time 0.9 1.7 5.2 -1.1 2.3 0.0 0.1 1.4
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.8 -1.7 0.7 0.0 0.1 0.4
Breast Cancer 0.4 1.0 2.5 0.0 -1.6 0.0 -0.6 -1.5
Ovarian Cancer 3.0 3.9 7.1 2.1 -2.3 0.0 -1.6 -2.7
Prostate Cancer 2.1 2.9 5.9 -2.0 2.2 0.0 2.4 0.1
Age at First Birth 0.3 0.4 1.5 0.5 -0.1 0.0 0.6 -1.2
Bipolar Disorder (2011) 1.6 1.5 5.9 -0.3 -0.8 0.0 1.0 -2.4
Body Mass Index (BMI) (2010) 1.2 1.6 3.9 -2.0 1.0 0.0 1.7 0.3
Coronary Artery Disease (CAD) 0.8 0.9 3.9 -0.5 -0.7 0.0 0.1 2.0
Crohns Disease (2012) 2.1 3.4 8.9 -0.9 2.1 0.0 -1.7 3.0
Mean Putamen Volume 1.1 1.2 3.3 -1.1 1.3 0.0 1.8 -0.2
Fasting Glucose 0.3 0.4 1.7 -0.3 0.3 0.0 -0.4 1.3
HbA1C 0.4 0.4 1.0 0.2 -0.9 0.0 0.6 -1.0
HDL Cholesterol 0.5 0.8 3.3 -0.4 0.2 0.0 0.5 1.8
LDL Cholesterol 1.2 2.0 4.7 -2.0 0.9 0.0 2.2 0.6
Lupus 0.3 0.4 1.3 0.9 -1.2 0.0 -0.1 0.1
Neuroticism (2016) 0.4 0.6 1.6 -0.9 1.3 0.0 0.2 0.8
Primary Biliary Cirrhosis 1.1 1.6 5.6 1.2 0.4 0.0 -0.9 2.4
Rheumatoid Arthritis 1.6 2.3 6.1 2.5 -1.0 0.0 -1.9 -0.7
Schizophrenia (2014) 0.2 0.5 1.5 -0.2 -0.5 0.0 0.7 -1.2
Triglycerides 0.3 0.4 2.0 0.1 -0.2 0.0 -0.1 -1.4
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.9 -0.3 -0.5 0.0 0.4 -0.9
Ulcerative Colitis 1.1 1.6 6.3 -0.0 1.1 0.0 -0.7 2.5
Blood Eosinophil Count 11.5 88.3 166.4 11.7 -9.4 0.0 -7.1 -12.9
Blood Platelet Count 0.1 0.7 1.0 1.0 -1.0 0.0 -0.9 -0.8
Blood Red Count 0.2 2.1 4.9 -1.6 0.6 0.0 1.6 2.2
Blood White Count 0.4 2.8 6.7 2.5 -1.0 0.0 -2.6 -0.5
Heel T-Score 0.4 3.2 10.0 -1.2 -1.6 0.0 -3.2 -1.3
BMI 0.2 0.9 3.2 0.8 -0.8 0.0 -0.0 1.8
Height 0.3 5.5 13.5 3.5 -1.1 0.0 -3.7 -0.4
Waist Hip Ratio (WHR) 0.6 2.8 10.0 1.7 -0.2 0.0 -3.2 -1.0
Systolic Blood Pressure 0.1 0.3 1.2 -0.1 -0.5 0.0 1.1 -0.5
Smoking Status 0.3 0.8 2.1 -1.1 0.0 0.0 1.4 0.7
Allergy or Eczema 7.7 20.2 48.0 4.3 -4.9 0.0 -3.2 -6.9
Cardiovascular Disease 0.1 0.2 0.8 0.1 -0.2 0.0 0.9 0.5
Hypothyroidism (self reported) 3.8 8.7 22.9 -2.6 3.7 0.0 -0.5 4.8
Respiratory disease 14.3 31.9 51.4 7.2 -4.2 0.0 -6.5 -7.0
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.2 1.1 -1.4 0.0 -1.5 -0.3
Lung FEV1/FVC ratio 0.6 3.1 10.9 -0.6 -1.3 0.0 3.3 1.6
Lung FVC 0.5 2.6 7.2 -2.1 0.5 0.0 2.7 -0.9
Neuroticism 0.3 0.7 2.8 -0.7 -0.1 0.0 0.2 1.7
Chronotype (morning person) 0.1 0.3 1.3 0.5 -0.3 0.0 -1.1 0.2
Hair Pigment 0.0 1.0 2.3 1.5 -1.2 0.0 -1.0 -0.5
Tanning 0.1 1.2 2.9 -1.3 -0.3 0.0 1.0 -1.7
Hand grip strength (left) 0.2 0.4 1.8 -0.3 -0.0 0.0 1.3 -0.6
Number of treatments/medications taken 0.3 0.6 1.2 -0.0 1.1 0.0 -1.1 0.8
Average weekly spirits intake 0.3 0.4 1.1 1.1 -0.0 0.0 -1.0 -0.3
Sensitivity / hurt feelings 0.3 0.5 1.3 0.4 -0.2 0.0 -1.0 -1.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.7 -0.8 0.4 0.0 0.7 0.5
Hearing difficulty/problems: Yes 0.1 0.2 0.3 0.1 0.4 0.0 -0.5 -0.6
Relative age of first facial hair 0.0 0.1 0.2 -0.0 0.4 0.0 0.5 0.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.3 -1.0 1.5 0.0 0.7 1.3
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.2 -0.1 1.0 0.0 0.1 1.5
Ever had hysterectomy (womb removed) 1.2 1.3 4.1 -1.2 2.0 0.0 0.6 0.7
Systolic blood pressure, automated reading 0.2 0.5 2.1 -0.4 -0.4 0.0 1.4 -0.1
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.2 1.4 0.2 0.0 -1.8 0.6
Angina 0.3 0.4 1.3 1.1 0.8 0.0 0.2 -0.5
Medication for hormone replacement therapy 0.3 0.4 0.9 0.1 0.8 0.0 -0.6 1.0
Vitamin and mineral supplements 1.2 1.7 5.8 0.7 0.4 0.0 -2.4 1.4
Supplements: Zinc 0.4 0.5 1.2 -0.6 0.9 0.0 1.1 -0.1
Medication: Co-codamol 2.3 2.6 5.0 2.2 -1.8 0.0 -2.2 -0.2
Medication: Metformin 0.7 0.9 2.8 0.9 -0.8 0.0 -1.7 -0.6
Diabetes (father) 0.9 1.1 2.6 -0.9 1.2 0.0 0.5 1.6
Diabetes (mother) 0.7 0.9 1.4 -1.2 1.0 0.0 1.1 -1.0
Severe depression (siblings) 0.4 0.5 1.3 -0.4 -0.3 0.0 0.9 -1.1
Pack years adult smoking proportion 0.4 0.6 1.1 1.1 -0.9 0.0 -1.0 0.5
Impedance of leg (right) 0.3 1.4 3.4 1.8 -1.0 0.0 -1.7 -0.3
Leg fat-free mass (left) 0.0 0.1 0.3 0.1 0.2 0.0 0.3 0.6
Trunk fat percentage 0.1 0.3 1.1 0.7 0.0 0.0 -0.2 1.1
Hand grip strength (right) 0.4 1.0 4.4 -0.6 0.0 0.0 2.1 -0.5
Townsend deprivation index at recruitment 0.2 0.3 0.9 -0.5 0.3 0.0 0.3 0.9
Current tobacco smoking 0.2 0.3 0.9 -0.3 0.5 0.0 -0.9 0.5
Average weekly fortified wine intake 1.2 1.4 5.2 -0.6 -0.2 0.0 2.3 -1.1
Maternal smoking around birth 0.8 1.2 5.1 0.0 -2.3 0.0 -0.5 -0.7
Fed-up feelings 0.1 0.1 0.4 -0.0 0.3 0.0 -0.4 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.9 -2.0 1.8 0.0 1.4 1.0
Relative age voice broke 0.1 0.2 0.8 -0.3 0.3 0.0 0.9 0.2
Taking other prescription medications 0.8 1.2 4.1 0.8 0.9 0.0 -2.0 0.7
Age when periods started (menarche) 1.3 3.1 7.0 2.7 -1.6 0.0 -0.9 -2.3
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 4.5 0.1 2.1 0.0 -0.8 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 9.9 0.4 -2.4 0.0 -3.1 -0.3
Tinnitus: Yes, but not now, but have in the past 2.3 2.4 8.9 1.8 -0.3 0.0 -3.0 -0.1
Qualifications: CSEs or equivalent 0.1 0.2 0.5 0.1 0.7 0.0 -0.6 0.2
Serious illness, injury or assault to yourself 0.4 0.5 1.7 1.3 0.6 0.0 0.1 -0.6
High blood pressure 0.0 0.1 0.1 0.4 -0.3 0.0 0.2 0.2
Hayfever, allergic rhinitis or eczema 6.3 13.6 31.9 3.6 -4.1 0.0 -2.5 -5.6
Multivitamins +/- minerals 1.1 1.4 3.9 -1.4 0.0 0.0 2.0 -0.9
Stomach or abdominal pain in last month 3.4 4.2 8.4 -2.9 2.7 0.0 2.1 0.8
Supplements: Glucosamine 0.2 0.3 1.2 0.4 -0.4 0.0 0.2 1.1
Diverticular disease/diverticulitis (self-reported) 3.2 3.8 9.9 -3.1 1.7 0.0 1.7 1.8
Medication: Atenolol 0.5 0.6 2.7 -0.1 1.6 0.0 0.5 0.0
Medication: Levothyroxine sodium 1.9 3.2 6.9 -2.3 2.0 0.0 0.3 2.6
Sitting height 0.1 0.7 2.1 -0.3 0.6 0.0 1.5 0.9
Chronic bronchitis/emphysema (father) 0.7 0.9 2.6 1.1 -0.5 0.0 -0.4 -1.6
High blood pressure (mother) 1.4 2.0 3.8 -2.0 1.9 0.0 1.7 0.0
Body mass index (BMI) 0.1 0.6 2.8 -0.4 0.2 0.0 0.4 1.7
Impedance of leg (left) 0.2 1.1 2.7 1.6 -0.7 0.0 -1.4 -0.7
Leg predicted mass (left) 0.0 0.1 0.3 0.0 0.2 0.0 0.3 0.6
Trunk fat mass 0.1 0.3 0.9 0.7 0.1 0.0 0.0 0.9
Waist circumference 0.2 0.6 1.2 1.1 -0.2 0.0 -1.1 0.7
Number of incorrect matches in round 0.4 0.6 1.8 -0.3 1.1 0.0 -1.4 0.0
Past tobacco smoking 0.1 0.2 0.8 0.2 0.9 0.0 -0.5 0.3
Alcohol usually taken with meals 0.7 1.2 4.9 0.6 -2.2 0.0 -0.2 -0.8
Nervous feelings 0.1 0.2 0.6 0.0 -0.7 0.0 -0.5 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.2 -0.8 0.2 0.0 1.1 -0.8
Hearing difficulty/problems with background noise 1.3 2.0 4.6 -1.8 2.1 0.0 1.4 0.7
Hair/balding pattern: Pattern 2 0.9 1.1 2.7 -1.7 -0.3 0.0 1.3 1.0
Had menopause 0.1 0.1 0.4 0.6 0.1 0.0 0.3 -0.3
Had other major operations 0.1 0.1 0.3 0.4 -0.6 0.0 0.4 0.0
Forced vital capacity (FVC) 0.4 1.5 3.8 -1.6 0.1 0.0 2.0 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.5 10.0 0.5 -2.5 0.0 -3.2 -1.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.8 -0.8 -1.3 0.0 0.8 -0.2
Qualifications: None of the above 0.3 0.6 2.0 -0.6 0.7 0.0 -0.4 1.4
Financial difficulties in last 2 years 0.4 0.5 1.4 -1.2 0.1 0.0 -0.6 1.0
Mouth/teeth dental problems 0.3 0.5 1.4 0.5 -1.2 0.0 -0.4 -0.7
Heart attack 1.6 2.0 5.1 2.3 -0.2 0.0 -2.2 0.4
Allergy 11.4 26.3 55.2 -5.7 4.4 0.0 4.9 7.4
Pain all over the body in last month 0.1 0.1 0.3 -0.2 -0.4 0.0 0.1 -0.5
Diabetes (self-reported) 0.1 0.2 0.9 0.0 -0.5 0.0 -1.0 -0.1
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 3.9 1.3 -0.7 0.0 -0.3 -2.0
Medication: Ramipril 0.2 0.3 0.6 0.6 -0.6 0.0 -0.8 0.4
Medication: Simvastatin 1.0 1.4 4.0 2.0 -1.6 0.0 -0.8 -0.2
Fluid intelligence score 0.2 0.4 1.2 -1.1 0.6 0.0 -0.7 -0.1
Illnesses of siblings 0.5 0.8 2.7 0.9 -0.3 0.0 -0.4 -1.6
Neuroticism score 0.1 0.1 0.3 0.2 -0.6 0.0 -0.6 0.2
Weight 0.1 0.4 1.2 0.8 -0.2 0.0 -0.2 1.1
Impedance of arm (right) 0.6 2.6 7.2 2.3 -0.7 0.0 -2.7 -0.2
Arm fat percentage (right) 0.2 0.7 2.8 0.6 -0.0 0.0 -0.6 1.7
Trunk fat-free mass 0.0 0.1 0.6 -0.1 0.1 0.0 0.8 0.1
Hip circumference 0.1 0.2 1.0 0.2 -0.1 0.0 0.2 1.0
Time employed in main current job 0.4 0.5 1.7 -0.2 0.8 0.0 -0.2 1.3
Alcohol intake versus 10 years previously 0.8 1.2 2.7 -0.8 1.0 0.0 1.6 1.3
Father’s age at death 0.8 1.1 4.9 -0.3 2.2 0.0 0.4 -0.8
Worrier / anxious feelings 0.2 0.3 0.7 0.3 -0.8 0.0 0.1 -0.8
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.9 5.8 -1.4 2.4 0.0 0.8 0.9
Falls in the last year 0.4 0.6 1.5 0.8 -1.2 0.0 0.6 -0.6
Hair/balding pattern: Pattern 3 0.1 0.1 0.5 -0.1 -0.1 0.0 0.3 -0.7
Number of live births 0.1 0.1 0.3 -0.3 -0.4 0.0 0.4 -0.6
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 5.9 -1.7 -0.0 0.0 2.4 -0.5
Pulse rate 0.2 0.3 1.3 0.2 -1.1 0.0 0.1 0.3
Happiness 0.7 0.9 1.9 -1.4 0.4 0.0 1.3 0.7
Noisy workplace 0.2 0.3 0.8 0.4 0.5 0.0 -0.3 -0.9
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.2 -0.0 -0.0 0.0 0.1 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.6 1.2 0.0 0.0 -0.8 -1.6
Mouth/teeth dental problems: Dentures 1.1 1.8 4.3 -1.3 1.7 0.0 0.6 2.1
Asthma 17.8 35.0 57.3 7.6 -4.8 0.0 -6.4 -7.3
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.3 -1.5 1.0 0.0 1.0 0.7
Medication: Cholesterol lowering 0.1 0.1 0.3 0.5 0.0 0.0 -0.2 -0.6
Depression (self-reported) 1.1 1.3 4.3 1.5 -0.0 0.0 -2.1 0.1
Medication: Lansoprazole 0.7 0.8 1.6 -0.5 1.0 0.0 1.2 1.3
Prospective memory result 0.4 0.5 1.5 0.1 0.7 0.0 0.7 1.2
Lung cancer (father) 0.4 0.5 1.2 -0.2 1.1 0.0 0.0 1.0
Illnesses of mother 1.3 1.6 2.9 1.6 -1.7 0.0 -1.7 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 7.2 -1.9 0.4 0.0 2.7 -0.1
Pulse wave Arterial Stiffness index 1.3 1.5 4.8 -0.0 2.2 0.0 -0.4 1.6
Impedance of arm (left) 0.5 2.2 6.0 2.1 -0.5 0.0 -2.4 0.2
Arm fat mass (right) 0.1 0.4 2.0 0.4 -0.1 0.0 -0.3 1.4
Trunk predicted mass 0.0 0.1 0.6 -0.2 0.1 0.0 0.8 0.1
Standing height 0.1 1.4 4.7 2.2 -0.5 0.0 -1.1 -0.8
Length of working week for main job 0.2 0.2 0.4 -0.3 -0.5 0.0 -0.5 0.7
Exposure to tobacco smoke at home 0.6 0.6 1.6 -0.5 1.0 0.0 0.5 1.3
Breastfed as a baby 0.1 0.1 0.4 0.3 0.2 0.0 0.6 -0.4
Tense / ‘highly strung’ 0.7 1.1 4.2 1.1 0.0 0.0 -2.0 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 0.6 -0.1 0.0 -0.7 0.5
Hair/balding pattern: Pattern 4 0.5 1.2 2.9 -1.6 0.5 0.0 1.7 -0.0
Birth weight of first child 0.5 0.9 3.1 0.7 0.9 0.0 0.1 -1.7
Peak expiratory flow (PEF) 0.5 1.2 4.8 0.8 -2.2 0.0 -0.1 -0.7
Pulse wave reflection index 0.4 0.5 1.5 1.2 0.7 0.0 -0.3 0.9
Ever highly irritable/argumentative for 2 days 0.6 0.8 2.5 0.3 -1.1 0.0 -1.6 -0.1
Loud music exposure frequency 0.6 0.6 1.5 0.8 -1.2 0.0 0.2 -1.0
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 -0.3 -0.1 0.0 0.1 -0.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.3 -0.2 1.1 0.0 0.5 1.5
Blood clot in the leg (DVT) 0.4 0.5 2.4 0.4 0.0 0.0 -0.4 -1.6
Medication: Paracetamol 1.2 1.9 4.1 -1.3 2.0 0.0 -0.8 1.8
Headache pain in last month 0.1 0.2 0.6 -0.7 0.5 0.0 -0.5 -0.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.6 -0.0 -0.5 0.0 -0.2 -0.8
Glaucoma (self-reported) 0.1 0.2 0.5 -0.1 -0.7 0.0 0.2 -0.6
Gout (self-reported) 0.4 0.6 1.7 0.1 1.0 0.0 0.5 1.3
Hypothyroidism/myxoedema (self-reported) 2.7 5.3 11.5 -2.8 2.7 0.0 0.1 3.4
Medication: Amlodipine 0.1 0.1 0.3 0.4 -0.0 0.0 -0.3 0.5
Medication: Ventolin 100micrograms inhaler 3.7 4.7 12.0 2.8 -0.9 0.0 -3.5 -1.7
Birth weight 0.2 0.5 1.6 -0.9 0.4 0.0 1.3 -0.3
Chronic bronchitis/emphysema (mother) 1.8 2.0 4.5 1.8 -2.1 0.0 -1.2 -0.9
High blood pressure (siblings) 0.2 0.4 1.2 -1.1 0.3 0.0 0.6 0.2
Forced vital capacity (FVC), Best measure 0.4 1.4 4.0 -1.6 0.4 0.0 2.0 -0.5
Body fat percentage 0.1 0.5 2.0 0.5 0.1 0.0 -0.0 1.4
Leg fat percentage (right) 0.2 0.5 1.7 0.9 -0.4 0.0 -0.1 1.3
Arm fat-free mass (right) 0.0 0.2 0.8 0.0 0.2 0.0 0.9 0.2
Exposure to tobacco smoke outside home 0.3 0.4 1.3 -0.0 -1.1 0.0 -0.2 -0.6
Comparative body size at age 10 0.0 0.1 0.2 -0.3 0.1 0.0 -0.2 -0.4
Number of full brothers 0.4 0.6 1.3 -0.3 -1.1 0.0 -0.2 -1.2
Worry too long after embarrassment 0.1 0.2 0.5 -0.7 0.4 0.0 0.4 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.5 -0.3 0.7 0.0 -0.4 1.9
Wheeze or whistling in the chest in last year 7.7 13.7 31.8 5.2 -2.5 0.0 -5.6 -1.7
Number of children fathered 0.7 0.8 2.3 -0.3 1.5 0.0 -0.7 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.0 1.0 -0.1 0.0 -0.1 -0.2
Age at first live birth 0.5 0.9 3.8 0.2 0.3 0.0 0.8 -1.9
Pulse wave peak to peak time 1.5 1.8 5.6 0.3 -2.4 0.0 0.3 -1.8
Health satisfaction 1.0 1.4 2.7 -1.6 1.7 0.0 1.0 0.8
Shortness of breath walking on level ground 3.8 4.5 11.2 3.3 -2.0 0.0 -2.4 -1.3
Qualifications: College or University degree 0.1 0.2 0.5 0.1 -0.1 0.0 -0.5 -0.7
Eye problems/disorders: None of the above 0.6 0.6 1.8 -1.0 0.7 0.0 1.3 -0.1
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.5 1.2 -0.1 0.0 -0.2 1.1
Emphysema/chronic bronchitis 0.7 0.8 2.8 1.0 0.4 0.0 -1.7 -0.0
Medication for pain relief, constipation, heartburn 1.9 3.3 6.3 1.8 -2.5 0.0 -0.8 -2.5
Neck or shoulder pain in last month 1.2 1.7 3.3 -1.8 1.7 0.0 1.2 0.9
Medication: Blood pressure 0.1 0.2 0.7 0.1 0.8 0.0 0.2 0.6
Angina (self-reported) 0.3 0.4 1.6 0.7 1.3 0.0 0.3 -0.1
Migraine (self-reported) 0.8 1.0 1.8 -1.2 1.3 0.0 1.3 -0.2
Medication: Ibuprofen 0.8 1.0 2.2 -1.5 0.6 0.0 1.2 1.0
Medication: Allopurinol 0.2 0.3 0.9 1.0 -0.4 0.0 -0.2 0.4
Medication: Omeprazole 1.1 1.3 3.0 -1.6 1.7 0.0 0.9 -0.1
Medication: Seretide 50 evohaler 3.0 3.4 11.4 1.7 -1.4 0.0 -3.4 -0.8
Mean time to correctly identify matches 0.8 1.6 4.8 -1.1 2.2 0.0 0.7 1.2
Heart disease (mother) 0.5 0.6 2.0 0.9 0.3 0.0 0.3 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 3.4 1.8 -1.2 0.0 -1.9 -0.5
Whole body fat mass 0.1 0.3 1.5 0.5 0.1 0.0 0.1 1.2
Leg fat mass (right) 0.1 0.4 1.1 0.9 -0.4 0.0 -0.2 1.1
Arm predicted mass (right) 0.0 0.2 1.1 -0.2 0.2 0.0 1.1 0.1
Pulse rate, automated reading 1.0 3.1 11.7 1.5 -3.4 0.0 -1.1 -0.7
Alcohol intake frequency. 0.1 0.2 0.7 0.4 0.2 0.0 0.6 -0.8
Comparative height size at age 10 0.1 0.6 1.7 -0.0 0.9 0.0 -0.4 1.3
Number of full sisters 0.3 0.4 1.4 1.2 0.3 0.0 -0.3 -0.5
Suffer from ‘nerves’ 0.1 0.2 0.7 -0.8 -0.5 0.0 0.1 0.1
Overall health rating 0.7 1.5 5.5 -1.4 2.3 0.0 0.2 0.1
Chest pain or discomfort 1.7 2.5 7.4 2.1 -0.3 0.0 -2.7 -0.7
Had major operations 0.3 0.4 0.9 0.7 -0.3 0.0 -1.0 0.5
Age at last live birth 0.3 0.4 1.6 0.2 0.3 0.0 0.7 -1.3
Family relationship satisfaction 0.1 0.1 0.2 0.2 -0.3 0.0 0.5 0.2
Leg pain on walking 0.7 0.9 3.2 -0.5 1.8 0.0 -0.3 0.9
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 3.0 -1.5 1.1 0.0 1.7 1.0
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.5 -0.2 0.3 0.0 0.1 0.7
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.5 -1.0 0.1 0.0 1.1 1.2
Medication: Aspirin 0.8 1.0 2.5 1.1 -0.2 0.0 -1.2 1.6
Supplements: Vitamin C 0.4 0.4 1.0 -0.8 1.0 0.0 0.4 0.6
Knee pain experienced in last month 0.4 0.7 2.2 -0.3 1.1 0.0 0.3 1.5
Hypertension (Self-reported) 0.0 0.1 0.2 0.3 -0.4 0.0 0.1 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 4.5 -1.6 0.9 0.0 2.1 0.2
Illnesses of father: Heart disease 0.8 1.1 4.9 0.8 0.1 0.0 0.3 2.2
Illnesses of siblings: Diabetes 0.6 0.7 2.1 -1.0 0.6 0.0 0.2 1.5
Smoking status: Previous 0.3 0.4 1.3 0.3 -0.9 0.0 1.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.8 0.3 -0.5 0.0 -0.9 -0.1
Whole body fat-free mass 0.0 0.1 0.5 -0.1 0.2 0.0 0.7 0.1
Leg fat-free mass (right) 0.0 0.1 0.3 -0.2 0.3 0.0 0.6 0.3
Arm fat percentage (left) 0.2 0.9 3.9 0.6 0.1 0.0 -0.4 2.0
Average weekly red wine intake 0.4 0.6 1.5 -1.1 -0.5 0.0 1.2 -0.4
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.4 -0.4 0.7 0.0 0.2 0.3
Mood swings 0.1 0.2 0.6 -0.8 0.3 0.0 0.4 0.6
Loneliness, isolation 0.1 0.1 0.5 0.2 -0.2 0.0 -0.7 -0.1
Long-standing illness, disability or infirmity 0.6 1.0 3.1 -0.4 0.6 0.0 -1.1 1.8
Ever had bowel cancer screening 1.2 1.4 3.1 -0.5 1.8 0.0 1.7 0.8
Diabetes diagnosed by doctor 0.3 0.5 1.3 0.5 -0.6 0.0 -1.1 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 0.3 0.2 0.0 0.6 -1.0
Friendships satisfaction 0.6 0.8 2.0 -1.4 -0.4 0.0 1.3 -0.3
Qualifications: nursing, teaching 0.4 0.6 1.4 -0.8 1.2 0.0 0.9 0.4
Commuting to job workplace: Walk 1.9 2.1 5.7 -0.7 -0.5 0.0 2.4 -2.0
Eye problems/disorders: Cataract 0.2 0.2 0.9 0.2 -0.2 0.0 -0.9 0.5
Mouth/teeth dental problems: Mouth ulcers 2.6 4.1 10.3 2.1 -2.1 0.0 -1.2 -3.2
Medication for cholesterol 1.5 2.3 7.1 -1.9 0.5 0.0 2.7 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.5 -1.2 0.7 0.0 1.1 0.6
Back pain experienced in last month 0.1 0.2 0.6 -0.2 0.7 0.0 0.3 -0.3
Mineral and other dietary supplements 0.5 0.7 2.1 0.7 0.3 0.0 -1.4 0.8
Breast cancer (self-reported) 0.5 0.6 1.9 1.0 -0.2 0.0 -0.3 1.4
Asthma (self-reported) 16.4 32.6 53.4 7.3 -4.6 0.0 -6.4 -6.9
Osteoporosis (self-reported) 0.9 1.1 4.1 0.4 0.8 0.0 0.5 -2.0
Osteoarthritis (self-reported) 0.2 0.3 0.9 0.5 -0.5 0.0 -0.9 0.1
Medication: Aspirin 0.8 1.1 2.1 1.3 -0.6 0.0 -1.1 1.5
Medication: Gliclazide 0.5 0.6 2.1 0.1 -0.1 0.0 -1.4 0.9
Illnesses of father: None of the above (group 1) 0.9 1.1 2.8 0.7 -1.2 0.0 -0.9 -1.7
Smoking status: Current 0.1 0.2 0.8 -0.3 0.2 0.0 -0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 11.4 -2.0 1.0 0.0 3.4 -0.1
Whole body water mass 0.0 0.1 0.4 0.0 0.1 0.0 0.6 0.1
Leg predicted mass (right) 0.0 0.1 0.3 -0.2 0.3 0.0 0.6 0.3
Arm fat mass (left) 0.1 0.5 2.1 0.6 -0.2 0.0 -0.2 1.5
Number of self-reported non-cancer illnesses 1.2 2.1 6.1 1.9 -0.2 0.0 -2.5 -0.9
Average weekly champagne plus white wine intake 0.4 0.5 1.2 -1.1 -1.0 0.0 0.6 -0.2
Miserableness 0.3 0.5 1.1 -1.1 -0.5 0.0 1.0 0.0
Guilty feelings 0.2 0.2 0.8 -0.2 0.4 0.0 0.4 0.9
Wears glasses or contact lenses 0.6 0.7 2.1 -0.2 0.9 0.0 0.7 1.4
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.4 -0.0 0.0 0.2 0.4
Hearing aid user 1.5 1.7 4.4 -1.0 2.1 0.0 -0.1 1.7
Mother’s age at death 1.1 1.4 6.3 -0.1 0.2 0.0 0.8 -2.5
Financial situation satisfaction 0.4 0.5 2.0 -1.4 0.7 0.0 -0.2 0.2
Tinnitus: Yes, now most or all of the time 1.9 2.3 5.4 -1.4 2.3 0.0 1.7 1.0
Commuting to job workplace: Public transport 0.1 0.2 0.5 0.4 -0.2 0.0 -0.7 -0.4
Eye problems/disorders: Glaucoma 0.2 0.2 0.8 0.2 -0.9 0.0 0.5 -0.1
Medication: Blood pressure 0.4 0.7 2.3 1.0 -0.2 0.0 -1.5 0.3
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 0.4 0.1 0.0 -0.6 -0.1
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.1 -0.1 -0.2 0.0 0.4 -0.1
High cholesterol (Self-reported) 0.1 0.2 0.5 0.7 -0.4 0.0 0.4 0.3
Medication: Bendroflumethiazide 0.2 0.3 1.0 0.2 0.5 0.0 0.2 1.0
Medication: Paracetamol 1.3 2.0 4.8 -1.6 2.2 0.0 -0.3 1.6
Medication: Lisinopril 0.3 0.4 1.6 0.3 -0.2 0.0 -1.3 0.3
Medication: Atorvastatin 0.0 0.0 0.2 0.4 -0.1 0.0 0.1 -0.1
Illnesses of father: High blood pressure 1.3 1.6 4.1 -2.0 1.1 0.0 1.7 0.1
Alcohol drinker status: Never 0.2 0.3 0.7 0.8 0.3 0.0 -0.3 -0.7
Ever smoked 0.0 0.1 0.1 -0.3 -0.2 0.0 -0.1 0.4
Basal metabolic rate 0.0 0.1 0.2 0.2 -0.0 0.0 0.4 0.4
Leg fat percentage (left) 0.1 0.3 0.7 0.8 -0.4 0.0 0.0 0.8
Arm fat-free mass (left) 0.0 0.1 0.3 0.1 -0.3 0.0 0.5 0.0
Number of operations (self-reported) 0.1 0.2 0.3 -0.0 -0.5 0.0 -0.5 0.5
Average weekly beer plus cider intake 0.8 1.2 2.4 -1.3 -0.3 0.0 1.5 1.3
Irritability 1.4 2.4 5.0 2.2 -1.7 0.0 -1.6 -1.2
Risk taking 0.3 0.5 1.6 0.7 -1.2 0.0 0.3 -0.6
Ever had prostate specific antigen (PSA) test 0.8 1.0 4.5 -0.4 0.4 0.0 2.1 -0.2
Fractured/broken bones in last 5 years 0.1 0.1 0.3 -0.2 -0.6 0.0 -0.0 0.6
Age started oral contraceptive pill 0.6 0.7 1.3 1.1 -0.9 0.0 -0.2 -1.1
Diastolic blood pressure, automated reading 0.7 2.2 8.0 -1.5 -0.1 0.0 2.8 0.8
Ever depressed for a whole week 4.0 4.9 14.0 2.1 -3.7 0.0 -1.3 -2.2
Unable to work because of sickness or disability 0.6 0.8 2.2 -0.5 1.5 0.0 -0.4 1.1
Commuting to job workplace: Cycle 0.7 0.9 2.8 -0.9 1.7 0.0 0.9 0.2
Myopia 0.9 1.3 2.9 1.1 -1.4 0.0 -1.7 0.6
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.2 -0.5 0.1 0.0 -0.1 -0.2
Cholesterol lowering medication 1.1 1.6 3.6 1.9 -1.8 0.0 -1.1 0.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.1 -0.8 1.1 0.0 0.7 -0.3
Pain experienced in last month 2.6 4.4 8.7 2.9 -2.9 0.0 -1.8 -1.2
Supplements: Calcium 3.0 3.3 12.1 1.1 -1.8 0.0 -0.4 -3.5
Basal cell carcinoma (self-reported) 0.9 1.0 3.5 0.2 1.2 0.0 -0.0 1.9
Heart attack/myocardial infarction (self-reported) 1.5 1.9 4.9 2.2 -0.4 0.0 -2.1 0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.1 0.6 0.1 0.0 -0.3 -1.4
Heart disease (siblings) 0.2 0.3 1.2 -0.2 -0.2 0.0 -0.4 1.1
Alcohol drinker status: Previous 0.2 0.2 1.1 -0.0 -0.1 0.0 1.1 -0.2
Pack years of smoking 0.6 0.8 1.8 1.3 -1.1 0.0 -0.9 0.6
Impedance of whole body 0.4 2.0 4.5 2.1 -0.8 0.0 -2.1 -0.7
Leg fat mass (left) 0.1 0.3 1.0 1.0 -0.3 0.0 -0.2 0.7
Arm predicted mass (left) 0.0 0.2 0.8 -0.2 -0.0 0.0 0.9 0.1