Best TWAS P=5.42e-09 · Best GWAS P=3.77e-08 conditioned to 0.314
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PPM1A | 0.10 | 0.10 | lasso | 2 | 0.10 | 1.1e-08 | 5.3 | 5.3 | 1.3e-07 | 0.67 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Muscularis | C14orf39 | 0.10 | 0.02 | enet | 9 | 0.02 | 2.9e-02 | 5.5 | 5.8 | 5.4e-09 | 0.85 | 0.01 | 0.91 | TRUE |
| 3 | GTEx | Nerve Tibial | PPM1A | 0.18 | 0.12 | lasso | 2 | 0.10 | 7.4e-08 | 5.3 | 5.3 | 1.5e-07 | 0.57 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | PPM1A | 0.21 | 0.21 | lasso | 3 | 0.18 | 2.2e-10 | 5.3 | 5.3 | 1.3e-07 | 0.59 | 0.02 | 0.98 | FALSE |