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chr14:54,715,845-56,575,157

Best TWAS P=1.31e-22 · Best GWAS P=3.61e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ATG14	0.03	0.02	blup	438	0.02	7.6e-04	9.9	9.5	1.7e-21	0.92	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FBXO34	0.05	0.10	lasso	4	0.09	2.5e-11	9.8	-9.8	1.5e-22	-0.97	0.02	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LGALS3	0.03	0.03	blup	421	0.02	1.2e-03	9.1	-8.0	1.1e-15	-0.87	0.06	0.92	FALSE
4	CommonMind	Brain Pre-frontal Cortex	MAPK1IP1L	0.05	0.00	blup	446	0.01	2.2e-02	3.2	5.9	3.2e-09	0.62	0.06	0.57	FALSE
5	CommonMind	Brain Pre-frontal Cortex	WDHD1	0.06	0.09	enet	24	0.09	5.7e-11	8.3	-8.1	4.5e-16	-0.75	0.87	0.13	FALSE
6	GTEx	Adipose Subcutaneous	ATG14	0.08	0.01	enet	30	0.06	2.1e-05	9.7	-8.0	9.3e-16	-0.80	0.04	0.96	FALSE
7	GTEx	Adrenal Gland	LGALS3	0.19	0.17	lasso	2	0.12	3.0e-05	9.0	-9.1	7.5e-20	-0.93	0.22	0.72	FALSE
8	GTEx	Adrenal Gland	WDHD1	0.18	0.12	lasso	2	0.09	3.9e-04	6.5	-6.4	1.1e-10	-0.69	0.20	0.14	FALSE
9	GTEx	Artery Aorta	LGALS3	0.12	0.03	enet	7	0.03	7.0e-03	9.6	-9.3	1.0e-20	-0.92	0.04	0.94	FALSE
10	GTEx	Artery Tibial	ATG14	0.05	0.06	enet	16	0.04	5.3e-04	9.7	-9.6	8.3e-22	-0.88	0.04	0.92	FALSE
11	GTEx	Cells Transformed fibroblasts	ATG14	0.10	0.01	lasso	8	0.02	7.3e-03	9.3	-9.4	7.2e-21	-0.92	0.06	0.94	FALSE
12	GTEx	Cells Transformed fibroblasts	MAPK1IP1L	0.05	0.05	lasso	1	0.02	8.7e-03	9.8	9.8	1.8e-22	0.98	0.04	0.91	FALSE
13	GTEx	Esophagus Mucosa	ATG14	0.13	0.13	lasso	9	0.17	1.2e-11	9.6	-9.3	1.7e-20	-0.95	0.04	0.96	FALSE
14	GTEx	Esophagus Mucosa	WDHD1	0.10	0.01	enet	16	0.03	3.4e-03	9.1	8.2	1.7e-16	0.78	0.06	0.74	FALSE
15	GTEx	Muscle Skeletal	ATG14	0.08	0.03	enet	27	0.03	6.5e-04	9.8	-7.1	1.5e-12	-0.75	0.03	0.96	FALSE
16	GTEx	Nerve Tibial	ATG14	0.06	0.02	lasso	6	0.00	4.7e-01	4.2	-5.6	1.7e-08	-0.66	0.06	0.64	FALSE
17	GTEx	Nerve Tibial	MAPK1IP1L	0.08	0.00	lasso	4	0.02	2.1e-02	9.0	8.5	2.6e-17	0.81	0.06	0.70	FALSE
18	GTEx	Pituitary	LGALS3	0.40	0.34	enet	20	0.43	3.5e-12	7.1	-8.3	7.1e-17	-0.89	0.24	0.76	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	ATG14	0.13	0.08	lasso	7	0.07	1.8e-04	9.7	-9.8	1.6e-22	-0.97	0.05	0.92	FALSE
20	GTEx	Skin Sun Exposed Lower leg	ATG14	0.10	0.10	lasso	3	0.15	1.0e-12	9.7	-8.6	5.2e-18	-0.89	0.03	0.97	FALSE
21	GTEx	Skin Sun Exposed Lower leg	FBXO34	0.05	0.00	enet	5	0.00	6.3e-01	9.7	-9.4	4.1e-21	-0.95	0.06	0.55	FALSE
22	GTEx	Testis	ATG14	0.12	0.16	lasso	4	0.15	3.4e-07	9.8	-9.7	4.9e-22	-0.97	0.03	0.97	FALSE
23	GTEx	Thyroid	FBXO34	0.12	0.09	lasso	6	0.10	4.3e-08	9.0	-8.2	2.6e-16	-0.89	0.75	0.25	FALSE
24	METSIM	Adipose	ATG14	0.05	0.06	lasso	3	0.07	4.5e-10	4.9	6.2	5.2e-10	0.66	0.75	0.25	FALSE
25	METSIM	Adipose	MAPK1IP1L	0.03	0.00	bslmm	436	0.01	4.2e-02	6.7	7.4	1.8e-13	0.68	0.32	0.34	FALSE
26	YFS	Blood	FBXO34	0.04	0.05	lasso	10	0.05	2.2e-15	6.7	8.3	9.0e-17	0.91	0.08	0.92	FALSE
27	YFS	Blood	LGALS3	0.02	0.04	enet	9	0.04	6.9e-13	9.0	-9.1	7.7e-20	-0.93	0.08	0.92	FALSE
28	The Cancer Genome Atlas	Esophageal Carcinoma	KIAA0831	0.10	0.05	blup	66	0.04	1.9e-02	9.7	-9.2	3.1e-20	-0.94	0.01	0.83	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	KIAA0831	0.25	0.01	blup	62	0.12	2.3e-04	3.8	-7.4	1.3e-13	-0.64	0.02	0.44	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA0831	0.03	0.03	blup	63	0.02	1.2e-03	9.5	-8.9	8.2e-19	-0.91	0.02	0.91	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA0831	0.02	0.04	lasso	1	0.04	2.2e-05	9.8	-9.8	1.3e-22	-0.96	0.01	0.95	TRUE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	FBXO34	0.02	0.02	blup	95	0.02	2.4e-03	9.8	9.4	3.8e-21	0.94	0.02	0.92	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA0831	0.03	0.02	enet	19	0.02	6.7e-04	9.7	-8.1	7.6e-16	-0.75	0.01	0.82	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA0831	0.03	0.04	lasso	1	0.03	2.1e-04	7.1	-7.1	1.6e-12	-0.82	0.06	0.78	FALSE