[Hub]/) : Traits : Blood Eosinophil Count :

chr14:72,695,406-74,410,663

Best TWAS P=1.39e-15 · Best GWAS P=1.17e-10 conditioned to 0.831

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PSEN1 0.07 0.03 enet 7 0.02 5.1e-03 5.0 -6.1 1.1e-09 -0.48 0.10 0.53 FALSE
2 GTEx Artery Aorta RBM25 0.11 -0.01 enet 10 0.00 1.9e-01 3.6 6.1 1.0e-09 0.55 0.07 0.38 FALSE
3 GTEx Artery Tibial PSEN1 0.08 0.07 lasso 6 0.05 4.1e-05 5.0 -5.3 1.4e-07 -0.51 0.13 0.83 FALSE
4 GTEx Brain Cerebellar Hemisphere DCAF4 0.41 0.34 enet 19 0.36 4.0e-10 4.8 6.4 1.6e-10 0.69 0.02 0.97 FALSE
5 GTEx Brain Cerebellum DCAF4 0.38 0.17 lasso 6 0.34 7.5e-11 4.8 6.2 5.4e-10 0.70 0.05 0.95 FALSE
6 GTEx Cells EBV-transformed lymphocytes RP11-109N23.6 0.22 0.12 lasso 8 0.16 5.1e-06 -3.2 -5.1 2.7e-07 -0.31 0.13 0.76 FALSE
7 GTEx Nerve Tibial PSEN1 0.10 0.04 lasso 5 0.04 9.3e-04 4.7 -5.3 1.5e-07 -0.41 0.34 0.20 FALSE
8 GTEx Whole Blood PSEN1 0.15 0.08 enet 15 0.14 1.2e-12 5.3 -7.0 2.4e-12 -0.25 0.19 0.80 FALSE
9 GTEx Whole Blood RP4-647C14.2 0.07 0.05 lasso 3 0.06 7.0e-06 4.8 -6.1 1.1e-09 -0.39 0.24 0.18 FALSE
10 METSIM Adipose PSEN1 0.05 0.03 lasso 3 0.03 9.9e-06 6.4 -6.9 3.7e-12 -0.91 0.00 1.00 FALSE
11 NTR Blood PSEN1 0.03 0.01 bslmm 423 0.01 3.6e-05 5.3 -8.0 1.4e-15 -0.45 0.45 0.49 TRUE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma DCAF4 0.04 0.00 blup 83 0.01 5.8e-02 -2.1 5.8 6.0e-09 0.46 0.03 0.16 TRUE
13 The Cancer Genome Atlas Esophageal Carcinoma DCAF4 0.12 0.03 enet 14 0.05 9.5e-03 4.8 5.8 6.6e-09 0.50 0.04 0.45 FALSE
14 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DCAF4 0.04 0.02 blup 83 0.03 1.2e-04 6.0 5.5 4.7e-08 0.81 0.02 0.96 FALSE
15 The Cancer Genome Atlas Prostate Adenocarcinoma PSEN1 0.07 0.03 blup 58 0.05 5.2e-06 5.3 -7.1 1.2e-12 -0.28 0.01 0.97 FALSE
16 The Cancer Genome Atlas Stomach Adenocarcinoma DCAF4 0.07 0.02 blup 84 0.04 8.9e-04 6.4 6.6 4.2e-11 0.79 0.01 0.93 FALSE