TWAS hub - PSEN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0680	0.0290	4.5e-03	0.026	NA	0.023	NA	0.022	3.0e-03	NA	5.1e-03	NA	6.0e-03
2	GTEx	Adipose Visceral Omentum	0.1070	0.0470	8.4e-03	0.019	NA	0.003	NA	0.002	3.4e-02	NA	2.3e-01	NA	2.5e-01
3	GTEx	Artery Tibial	0.0817	0.0309	1.5e-03	0.070	NA	0.044	NA	0.055	3.7e-06	NA	2.3e-04	NA	4.1e-05
4	GTEx	Cells Transformed fibroblasts	0.0700	0.0310	7.5e-03	0.025	NA	-0.002	NA	0.016	5.0e-03	NA	5.3e-01	NA	2.1e-02
5	GTEx	Lung	0.1028	0.0379	1.1e-03	0.030	NA	0.018	NA	0.043	2.3e-03	NA	1.5e-02	NA	3.1e-04
6	GTEx	Muscle Skeletal	0.0832	0.0304	7.9e-04	0.005	NA	0.023	NA	0.017	1.0e-01	NA	2.3e-03	NA	8.1e-03
7	GTEx	Nerve Tibial	0.0979	0.0406	3.7e-03	0.043	NA	0.028	NA	0.039	4.8e-04	NA	4.2e-03	NA	9.3e-04
8	GTEx	Thyroid	0.0770	0.0290	1.6e-03	0.061	NA	0.044	NA	0.042	2.1e-05	NA	2.5e-04	NA	3.6e-04
9	GTEx	Whole Blood	0.1460	0.0410	5.5e-07	0.079	NA	0.137	NA	0.134	9.6e-08	NA	1.2e-12	NA	2.3e-12
10	METSIM	Adipose	0.0494	0.0164	4.4e-05	0.034	0.03	0.026	0.030	0.033	5.7e-06	2.2e-05	6.7e-05	2.4e-05	9.9e-06
11	NTR	Blood	0.0272	0.0106	2.2e-04	0.010	0.01	0.013	0.013	0.012	2.3e-04	1.9e-04	4.3e-05	3.6e-05	7.3e-05
12	TCGA	Prostate Adenocarcinoma	0.0678	0.0319	2.8e-05	0.035	0.05	0.039	NA	0.038	1.4e-04	5.2e-06	5.7e-05	NA	7.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Townsend deprivation index at recruitment	7.5	10.6	18.8	-3.6	-2.6	-4.3	-4.0	-3.5	-3.0	-4.2	-2.8	-1.5	-2.3	-3.0	-3.0
Blood Eosinophil Count	4.3	32.9	63.8	-6.1	-2.6	-5.3	-4.6	-4.8	-4.4	-5.3	-4.5	-7.0	-6.9	-8.0	-7.1
Hearing difficulty/problems: Yes	4.3	6.5	17.9	2.1	-0.1	2.0	1.9	1.8	1.8	1.7	1.7	3.8	3.4	4.2	3.2
Relative age voice broke	4.3	6.6	14.0	3.7	0.7	3.7	3.7	1.6	1.0	2.6	1.1	2.0	2.9	2.9	2.1
Number of children fathered	4.2	4.8	12.0	2.0	1.8	2.0	2.2	2.8	2.9	2.8	3.5	1.0	-0.0	-0.0	2.0
Osteoporosis (self-reported)	4.2	5.2	8.3	2.6	1.1	2.9	2.4	2.0	2.1	2.0	1.5	1.8	2.9	2.8	2.4
Number of operations (self-reported)	4.2	6.3	17.4	-2.1	-2.4	-2.5	-1.4	-2.9	-2.3	-2.7	-2.3	-1.4	-4.2	-2.9	-1.9
HbA1C	4.1	4.6	10.9	1.3	3.3	0.7	0.3	2.6	2.8	2.3	2.5	2.5	-0.2	1.6	2.7
Alzheimer’s Disease (in mother)	3.7	4.4	8.4	-2.9	-2.8	-2.6	-2.1	-1.9	-1.2	-2.4	-1.3	-2.7	-0.5	-1.6	-1.6
Relative age of first facial hair	3.7	7.5	16.0	3.3	1.1	4.0	3.6	2.3	1.7	2.8	1.5	1.7	3.1	3.4	2.5
Number of incorrect matches in round	3.3	5.5	7.1	-2.5	-2.0	-2.7	-2.6	-2.6	-2.2	-2.6	-2.6	-1.5	-2.6	-1.5	-2.0
Heart disease (siblings)	3.2	3.9	7.3	2.3	1.7	1.8	1.5	2.1	1.7	2.4	2.1	2.4	2.7	1.4	1.1
Type 2 Diabetes (T2D) (2012)	3.1	3.6	8.4	1.7	1.6	1.3	1.4	2.4	2.5	2.5	2.9	1.2	0.1	1.3	2.0
Prospective memory result	3.1	3.9	8.1	-1.8	-1.3	-2.4	-1.9	-2.9	-1.2	-2.8	-2.4	-0.0	-2.4	-1.3	-1.2
Alzheimer’s Disease (including proxy)	3.0	4.3	8.8	-2.6	-3.0	-2.6	-2.1	-2.1	-1.7	-2.4	-1.8	-1.6	-1.4	-1.0	-1.6
Loud music exposure frequency	2.9	3.2	9.3	-1.0	-2.0	-1.2	-1.1	-1.8	-3.0	-1.9	-2.7	-1.7	0.4	-0.6	-1.9
Forced vital capacity (FVC), Best measure	2.8	10.1	17.2	-4.0	-4.1	-3.5	-3.0	-3.2	-2.8	-4.0	-3.2	-2.8	-1.6	-2.8	-2.3
Chest pain or discomfort	2.8	4.1	6.0	1.9	2.4	1.5	1.5	2.4	1.6	2.4	2.3	2.3	1.3	2.4	1.7
Type 2 Diabetes (T2D) (2018)	2.6	4.9	5.9	-2.4	-2.0	-2.4	-1.6	-2.2	-2.2	-2.4	-1.8	-2.1	-2.3	-2.4	-2.4
Length of working week for main job	2.6	2.9	4.5	-1.8	-1.8	-2.1	-1.6	-1.7	-1.5	-1.7	-1.3	-1.4	-1.3	-2.0	-2.0
Supplements: Calcium	2.6	2.8	5.9	1.9	1.8	1.7	1.1	2.4	1.6	2.1	1.8	1.3	1.0	1.7	1.1
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	5.3	-2.2	-1.0	-2.3	-2.2	-1.8	-1.0	-1.9	-1.4	-0.5	-1.9	-1.5	-1.1
Taking other prescription medications	2.4	3.6	8.1	-2.1	-1.2	-2.5	-1.7	-1.9	-2.9	-1.9	-1.9	0.1	-2.2	0.1	-2.1
Handedness (chirality/laterality): Left-handed	2.4	2.9	5.7	-1.7	-2.3	-1.5	-1.4	-2.2	-1.8	-2.3	-2.4	-1.0	-0.8	-0.6	-1.0
Hair/balding pattern: Pattern 3	2.3	3.5	5.7	2.1	2.4	2.4	2.4	1.7	1.9	2.3	1.8	0.7	1.5	1.1	1.4
Asthma	2.3	4.5	8.6	-2.7	-0.7	-2.6	-2.9	-2.0	-1.8	-2.2	-1.9	-1.7	-1.8	-1.7	-2.5
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	8.6	-2.5	-2.9	-2.5	-2.0	-2.3	-2.0	-2.9	-2.4	-1.2	-1.2	-1.7	-1.6
Asthma (self-reported)	2.3	4.5	9.2	-2.8	-0.6	-2.7	-3.0	-2.0	-1.6	-2.2	-1.8	-1.6	-1.9	-1.7	-2.4
Breast cancer (self-reported)	2.2	2.6	8.3	-2.0	0.1	-1.9	-1.9	-1.7	-0.8	-1.6	-1.4	-0.9	-2.9	-1.5	-0.6
Diastolic blood pressure, automated reading	2.2	6.7	17.6	2.1	2.2	1.9	1.0	2.3	3.5	2.3	3.0	2.8	2.2	2.2	4.2
Hand grip strength (right)	2.1	5.7	15.5	1.0	3.4	1.5	0.9	3.9	2.8	3.3	3.4	0.9	0.8	1.4	2.1
Diabetes (self-reported)	2.1	3.2	7.1	-1.7	-1.8	-1.7	-0.9	-1.8	-1.4	-1.8	-1.1	-1.5	-2.7	-2.7	-1.7
Supplements: Fish oil (including cod liver oil)	2.1	2.7	6.5	-2.5	-0.8	-2.3	-1.9	-0.7	-1.2	-1.8	-1.0	-1.4	-2.3	-1.3	-1.4
Irritability	2.1	3.5	7.9	-2.6	0.1	-2.1	-2.1	-1.3	-0.8	-1.8	-1.4	-2.8	-0.7	-2.1	-2.5
Major Depression (MDD)	2.0	2.4	8.9	-0.6	-1.9	-0.7	-0.3	-1.8	-3.0	-1.2	-2.3	-0.6	-0.2	0.2	-2.3
Lung FEV1/FVC ratio	2.0	10.3	17.9	4.2	2.9	4.2	3.3	3.0	2.4	3.6	2.5	2.2	3.6	3.3	2.5
Forced vital capacity (FVC)	2.0	7.7	14.3	-3.8	-3.1	-3.2	-2.8	-2.3	-1.9	-3.3	-2.3	-2.8	-2.4	-2.9	-1.9
Back pain experienced in last month	2.0	3.0	5.9	1.8	1.6	1.0	1.6	1.5	2.4	1.7	2.4	1.7	0.0	1.3	2.2
Ovarian Cancer	1.9	2.5	4.7	-1.7	-1.0	-1.1	-0.9	-1.9	-1.6	-1.7	-1.6	-2.1	-2.2	-1.4	-1.2
Medication: Atenolol	1.9	2.4	5.5	0.9	1.3	0.8	1.0	1.7	2.0	1.8	2.3	1.8	1.1	1.1	2.0
Illnesses of siblings	1.9	2.7	6.9	-1.3	-2.1	-1.2	-0.5	-1.3	-2.6	-1.3	-1.8	-1.7	-1.8	-1.0	-1.9
Glaucoma (self-reported)	1.9	2.3	6.2	-1.9	-1.7	-2.0	-1.3	-0.5	-2.4	-1.1	-0.9	-0.9	-0.5	0.2	-2.5
Angina (self-reported)	1.9	2.6	3.7	1.3	1.7	1.5	1.5	1.8	1.4	1.9	1.8	1.6	0.8	1.8	1.9
Angina	1.8	2.3	3.3	1.4	1.6	1.5	1.5	1.6	1.2	1.8	1.6	1.5	0.8	1.7	1.8
Medication: Ramipril	1.8	2.4	8.5	0.9	1.2	0.8	0.6	1.1	2.0	1.0	1.5	2.5	0.7	1.3	2.9
Qualifications: College or University degree	1.8	5.6	10.2	-2.5	-3.0	-1.5	-1.8	-2.1	-3.2	-2.7	-2.9	-2.9	0.5	-0.8	-2.7
Ulcerative Colitis	1.7	2.5	3.6	1.9	1.6	1.8	1.5	1.5	1.0	1.9	1.5	1.6	1.6	1.6	1.5
Systolic blood pressure, automated reading	1.7	4.8	10.8	0.6	3.0	0.3	0.1	1.4	3.3	1.6	2.8	2.4	-3.1	-0.3	3.2
Age started oral contraceptive pill	1.7	2.2	5.0	2.0	1.6	2.1	1.7	1.8	1.0	2.2	1.4	0.2	0.8	0.6	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	9.0	-2.3	-1.1	-1.9	-1.5	-1.5	-0.6	-2.0	-0.8	-2.9	-1.5	-3.0	-1.9
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.2	-1.6	-0.6	-1.7	-1.8	-1.4	-1.7	-1.6	-1.8	-0.9	0.7	0.5	-1.2
Average weekly champagne plus white wine intake	1.6	2.2	5.0	1.3	2.2	0.9	0.5	2.2	1.5	2.1	2.0	0.2	1.7	0.7	0.0
Verbal and Numeric Reasoning (VNR)	1.5	3.6	13.2	-1.3	-3.5	-0.4	-0.1	-0.9	-2.2	-1.3	-1.7	-3.6	0.9	-0.4	-2.1
Blood Platelet Count	1.5	17.1	40.7	5.2	6.4	4.9	4.2	3.1	2.7	4.7	2.6	4.2	2.6	3.9	3.5
Average weekly fortified wine intake	1.5	1.7	4.9	1.8	0.8	1.8	2.2	0.4	-0.9	1.1	-0.4	1.7	0.6	1.7	-0.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.0	1.1	1.5	1.4	1.3	1.3	1.7	1.5	1.6	1.2	0.2	0.9	1.4
Eye problems/disorders: Glaucoma	1.5	1.8	3.8	-1.9	-0.8	-2.0	-1.6	-0.3	-1.8	-0.8	-0.7	-0.9	-1.3	-0.3	-1.9
Medication: Blood pressure	1.5	2.8	6.2	1.2	1.4	0.9	0.7	1.3	2.2	1.3	1.9	2.5	2.2	1.1	2.3
Pain experienced in last month	1.5	2.5	7.1	-0.3	-2.3	0.0	-0.2	-1.5	-2.6	-1.2	-2.7	-1.5	0.1	-0.6	-2.1
Serious illness, injury or assault to yourself	1.4	1.7	3.8	-0.1	-1.0	0.1	0.7	-1.8	-1.3	-1.0	-1.6	-1.9	-0.9	-1.6	-1.8
Time employed in main current job	1.4	1.6	9.2	-0.1	3.0	-0.2	-0.9	0.8	1.0	1.0	0.6	1.6	0.1	1.1	1.5
Noisy workplace	1.4	1.7	3.8	-1.0	-0.1	-2.0	-1.6	-1.5	-1.2	-1.4	-1.1	2.0	-1.5	-0.2	-0.2
Impedance of arm (left)	1.4	6.3	23.9	0.2	-4.9	0.6	1.0	-1.8	-3.4	-1.7	-3.1	-2.0	3.7	0.7	-2.2
High blood pressure (siblings)	1.4	2.0	4.5	0.6	1.1	0.9	0.4	1.1	2.1	0.9	1.4	1.4	2.1	1.4	2.0
Diabetes diagnosed by doctor	1.4	2.3	5.5	-1.4	-1.6	-1.5	-0.9	-1.5	-1.1	-1.5	-0.8	-1.2	-2.3	-2.2	-1.2
Primary Biliary Cirrhosis	1.3	1.9	5.3	1.0	1.2	0.5	-0.3	1.1	1.8	1.0	1.2	2.2	0.9	1.3	2.3
Rheumatoid Arthritis	1.3	1.7	5.9	-1.2	-1.4	-1.2	-1.1	-0.5	-2.3	-0.2	-1.3	-1.1	-0.0	-0.3	-2.4
Pain all over the body in last month	1.3	1.4	3.1	1.2	1.8	1.3	1.0	1.2	1.2	1.5	1.6	0.4	-0.1	0.2	1.3
Impedance of arm (right)	1.3	6.1	21.3	1.3	-4.6	1.5	2.0	-1.1	-3.0	-0.9	-2.5	-0.7	4.5	2.1	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.2	1.0	0.9	0.3	-0.1	1.4	0.9	0.7	1.4	1.6	1.4	1.7	1.8
Birth weight of first child	1.3	2.3	4.6	-1.6	-1.8	-1.1	-0.5	-1.6	-0.6	-1.5	-1.2	-2.1	-2.2	-1.8	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.7	0.9	1.6	0.8	0.7	1.2	1.9	0.9	1.5	1.4	0.9	0.5	1.5
Comparative height size at age 10	1.3	7.4	16.0	-2.8	-2.0	-2.1	-1.5	-2.2	-2.3	-2.4	-2.4	-4.0	-3.4	-3.2	-3.4
Friendships satisfaction	1.3	1.6	7.4	0.1	-1.4	0.6	0.9	0.0	-0.8	-0.3	-0.7	0.2	2.7	2.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.2	-1.9	-1.3	-2.3	-1.6	-0.4	-0.7	-1.1	-0.4	-0.1	-1.5	-0.8	-0.6
Commuting to job workplace: Public transport	1.3	1.6	3.8	-1.5	-0.6	-0.9	-0.9	-0.7	-0.9	-1.0	-0.8	-1.8	-2.0	-1.6	-1.4
Bipolar Disorder (2018)	1.2	1.9	5.7	-1.2	-1.2	-0.8	-0.9	-1.2	-2.1	-1.2	-1.6	-1.5	0.4	-0.6	-2.4
Blood Red Count	1.2	12.1	44.9	2.0	6.7	-0.4	-1.2	3.3	4.3	3.3	4.3	4.7	-3.1	-0.5	2.0
Ever used hormone-replacement therapy (HRT)	1.2	1.6	3.3	1.7	1.1	1.4	1.4	1.2	0.7	1.8	1.3	1.2	1.0	1.0	0.5
Had menopause	1.2	1.5	3.9	1.9	1.4	1.7	1.4	0.3	0.3	1.2	0.2	2.0	0.7	0.9	0.7
Qualifications: None of the above	1.2	2.6	7.0	0.8	2.6	0.1	0.1	1.2	2.5	1.5	2.1	2.2	-1.2	-0.1	1.8
Lung cancer (father)	1.2	1.4	3.8	-1.0	0.2	-1.7	-1.5	-2.0	-0.9	-1.6	-1.4	0.9	-0.7	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	7.8	-2.3	-2.8	-2.1	-2.0	-2.0	-1.5	-2.5	-2.1	-1.9	-0.3	-1.7	-1.2
Medication: Seretide 50 evohaler	1.2	1.4	2.8	-0.7	-0.2	-1.1	-1.1	-1.3	-1.4	-1.5	-1.4	1.7	0.0	1.6	0.6
Number of full sisters	1.2	1.5	5.9	1.4	-1.3	1.6	2.0	-0.4	0.3	0.3	0.0	0.1	2.4	0.3	1.1
Lung FVC	1.1	5.8	12.4	-3.3	-1.7	-3.1	-2.7	-1.9	-0.9	-2.7	-1.3	-1.6	-3.5	-3.2	-1.0
Sensitivity / hurt feelings	1.1	1.9	4.8	1.5	1.4	1.4	0.7	1.4	0.8	1.8	1.0	0.7	2.2	1.8	-0.1
Impedance of leg (right)	1.1	5.3	22.5	2.4	-2.7	3.0	3.5	1.3	0.4	1.3	0.8	0.0	4.7	1.6	1.0
Age when periods started (menarche)	1.1	2.7	17.6	1.3	-1.4	1.7	1.5	1.2	0.8	0.9	0.5	0.3	4.2	1.5	1.1
Father’s age at death	1.1	1.4	4.9	-0.1	-1.3	0.6	0.2	0.2	-1.2	0.2	-0.9	-2.2	1.9	-0.0	-2.1
Medication: Paracetamol	1.1	1.8	6.1	0.3	1.3	-0.2	-0.3	0.8	2.0	0.7	1.7	2.5	0.3	0.9	2.1
Medication: Amlodipine	1.1	1.5	4.4	0.1	1.7	-0.4	-0.3	0.6	1.3	0.4	1.3	1.7	-1.8	0.4	2.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.7	0.9	1.2	0.7	0.4	0.9	1.0	1.1	0.6	1.4	0.1	1.9	1.8
Mineral and other dietary supplements	1.1	1.5	5.1	1.8	-0.2	1.6	1.5	0.1	0.5	0.9	0.4	1.2	2.3	1.3	0.8
Medication: Gliclazide	1.1	1.2	2.2	-1.4	-1.5	-1.2	-0.4	-0.7	-0.8	-1.2	-0.2	-1.4	-1.5	-0.7	-1.1
Myopia	1.1	1.5	3.9	1.6	-0.9	1.7	2.0	0.4	0.9	0.9	0.7	-1.9	1.2	-0.8	-0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.2	0.4	1.0	1.0	1.0	1.2	1.5	1.5	1.5	1.0	1.1	1.1	1.3
Depression (Nagel 2018)	1.0	1.5	3.5	1.3	1.1	1.6	1.7	1.6	0.8	1.9	1.1	0.5	0.6	1.1	-0.2
Intelligence (Savage-Jansen 2018)	1.0	2.9	9.3	-1.1	-2.5	-0.2	-0.2	-0.7	-2.1	-1.0	-1.3	-3.1	2.7	0.4	-1.6
Severe depression (siblings)	1.0	1.1	5.9	0.5	-1.3	0.5	0.9	-0.0	-1.3	-0.2	-0.4	0.5	2.4	1.3	-0.6
Qualifications: CSEs or equivalent	1.0	1.3	4.3	1.3	2.1	0.7	0.7	0.7	0.1	1.1	0.6	1.8	-0.9	1.0	1.3
Number of full brothers	1.0	1.3	5.9	-1.2	-0.6	-0.9	-1.0	-0.6	0.9	-0.3	-0.0	-2.1	-0.3	-2.4	-0.4
Migraine (self-reported)	1.0	1.2	2.8	-0.4	-0.8	-0.4	-0.3	-1.5	-1.0	-1.4	-1.4	0.8	1.5	1.7	0.7
Family relationship satisfaction	1.0	1.2	4.8	-0.3	-2.2	-0.1	0.3	-1.1	-1.6	-1.3	-1.5	-0.4	0.9	0.7	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.4	0.4	1.8	0.7	0.4	1.4	1.8	1.5	1.2	0.1	-0.1	-0.3	0.8
Smoking status: Current	1.0	1.5	4.1	-1.0	-2.0	-1.3	-0.7	-1.4	-0.8	-1.5	-1.0	-0.6	-1.1	-1.5	-1.0
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.3	-1.4	-0.7	-1.8	-1.2	-1.5	0.1	-1.5	-0.4	-0.1	-1.3	-1.0	0.2
Average weekly beer plus cider intake	1.0	1.5	3.2	-1.5	-0.8	-1.4	-1.1	-1.6	0.8	-1.8	-0.6	0.7	-1.1	-0.1	1.8
Ever depressed for a whole week	1.0	1.2	5.0	1.1	-0.3	0.9	0.8	0.1	-1.6	0.3	-0.7	1.1	1.6	2.2	0.1
Systolic Blood Pressure	0.9	4.7	10.5	1.2	2.5	1.4	1.1	2.1	2.9	2.2	3.1	2.3	-1.2	0.1	3.2
Hypothyroidism (self reported)	0.9	2.0	6.7	-1.5	-1.1	-1.0	-1.1	-0.4	-1.5	-0.6	-0.9	-2.0	0.6	-1.9	-2.6
Hand grip strength (left)	0.9	2.4	7.4	0.2	2.5	0.5	-0.2	2.7	1.5	1.9	2.2	0.7	0.4	1.2	1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.8	1.7	1.1	1.6	2.0	-0.1	-0.4	0.6	-0.4	1.6	0.2	1.0	0.2
Medication for hormone replacement therapy	0.9	1.0	2.6	0.8	0.8	1.1	1.6	1.0	1.2	0.9	1.6	0.3	1.0	0.1	0.3
Medication: Metformin	0.9	1.3	2.7	-1.1	-1.1	-1.2	-0.3	-1.1	-1.2	-1.0	-0.5	-1.0	-1.7	-1.6	-1.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.0	-1.0	0.1	-1.3	-0.9	-1.1	-1.3	-1.3	-0.8	-0.2	-1.4	-0.8	-0.9
Had other major operations	0.9	1.1	3.8	-1.0	-0.8	-1.5	-0.9	-1.0	-0.5	-1.0	-0.6	0.5	-2.0	-1.1	-0.6
Heart attack	0.9	1.1	2.1	0.5	0.9	1.1	1.0	1.1	1.2	1.4	1.2	0.8	1.2	1.0	1.0
Fluid intelligence score	0.9	2.0	9.1	-0.8	-2.4	0.1	0.3	0.6	-1.5	-0.3	-0.2	-3.0	1.3	0.3	-1.8
Depression (self-reported)	0.9	1.0	2.9	-0.9	-1.1	-0.8	-0.8	-0.4	-1.7	-0.7	-0.9	-0.4	0.6	1.5	-1.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.1	0.7	0.1	1.6	0.7	1.8	1.5	1.3	1.0	-1.2	1.8	0.1	0.8
Birth weight	0.9	1.9	6.4	-0.7	-0.1	0.2	0.6	-0.8	-0.3	-0.2	-1.1	-2.5	-1.9	-2.5	-1.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.0	-1.7	-0.2	-1.2	-1.0	-0.7	-0.8	-1.1	-0.7	-0.2	-2.0	-1.2	-0.6
Leg fat-free mass (right)	0.9	4.7	19.3	-2.7	1.2	-2.9	-2.8	-1.0	-0.8	-1.3	-0.6	-1.0	-4.4	-2.0	-1.7
Medication for cholesterol	0.9	1.3	4.4	-0.5	-0.6	-0.5	-0.9	-1.2	-1.7	-0.8	-2.1	-1.3	-1.5	-0.4	-0.9
Leg predicted mass (right)	0.9	4.8	19.1	-2.8	1.3	-3.0	-2.9	-1.0	-0.8	-1.4	-0.6	-1.0	-4.4	-1.9	-1.6
Financial situation satisfaction	0.9	1.1	5.4	0.9	1.2	0.2	0.2	0.8	0.4	0.4	1.0	2.3	1.0	1.5	0.3
Pack years of smoking	0.9	1.3	4.0	0.4	1.1	0.3	0.3	0.9	1.7	0.9	1.3	1.7	-0.3	0.7	2.0
Irritable Bowel Disease (IBD)	0.8	1.9	4.4	1.7	1.2	2.1	1.6	1.1	1.0	1.9	0.9	0.7	1.7	1.0	1.0
Ulcerative Colitis (UC)	0.8	1.5	3.2	1.6	1.2	1.8	1.4	1.1	0.6	1.7	0.7	0.9	1.1	1.1	0.9
Supplements: Zinc	0.8	0.9	3.6	-0.3	1.9	0.1	-0.5	1.2	1.1	0.5	0.7	0.1	-0.2	0.8	1.6
Current tobacco smoking	0.8	1.3	5.0	-1.0	-2.2	-1.3	-0.7	-1.3	-0.5	-1.4	-0.8	-0.4	-1.0	-1.3	-0.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.5	0.3	0.9	0.1	-0.0	-0.1	0.9	-0.1	0.4	1.1	2.3	0.8	1.7
Impedance of leg (left)	0.8	4.0	14.8	2.1	-2.7	2.6	3.0	1.2	0.4	1.2	0.8	-0.3	3.9	1.2	1.0
Hearing difficulty/problems with background noise	0.8	1.3	5.5	-0.7	-1.0	-0.6	-0.8	-0.2	-0.4	-1.0	-0.3	1.7	1.7	2.3	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.1	-1.4	-0.6	-2.0	-1.8	-1.0	-0.6	-1.4	-0.5	-0.2	-0.1	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.6	-2.1	-1.8	-1.9	-1.8	-1.2	-1.2	-1.9	-1.4	-1.7	-0.9	-1.7	-1.2
Happiness	0.8	1.0	4.7	0.2	-0.8	0.2	0.4	0.5	0.2	-0.1	0.1	1.3	1.7	2.2	1.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	4.7	0.2	1.8	-0.3	-0.7	0.6	0.2	0.0	0.6	2.2	0.3	1.6	0.2
Comparative body size at age 10	0.8	2.3	6.4	-0.5	2.3	-1.2	-1.0	1.4	1.0	1.0	1.6	2.5	-1.1	2.1	1.4
Leg pain on walking	0.8	1.0	2.0	-0.8	-0.3	-0.8	-0.7	-1.4	-1.2	-1.1	-1.3	-1.0	-0.4	-1.1	-1.3
Osteoarthritis (self-reported)	0.8	1.0	2.8	-1.3	0.2	-1.6	-1.7	-0.5	0.0	-0.7	0.0	-0.7	-1.6	-1.1	-0.2
Ever smoked	0.8	1.4	2.9	-1.3	-0.8	-1.3	-1.1	-1.4	-1.4	-1.5	-1.7	-0.8	-0.6	-0.6	-0.9
Leg fat percentage (left)	0.8	2.7	6.3	0.7	2.5	0.1	0.4	1.3	1.9	1.5	2.5	2.1	-2.4	-0.0	1.5
Fractured/broken bones in last 5 years	0.8	1.0	3.0	0.4	-0.3	0.1	-0.2	-0.7	-0.9	-0.6	-1.6	1.3	1.6	1.7	0.2
Impedance of whole body	0.8	4.0	17.0	1.3	-3.8	1.8	2.3	-0.3	-1.5	-0.2	-1.2	-1.2	4.1	1.1	-0.6
Schizophrenia vs Biploar Disorder	0.7	0.9	3.3	0.7	1.7	0.2	0.5	-0.2	0.9	0.4	0.3	0.7	-1.8	-1.0	1.2
Age at First Birth	0.7	1.1	3.1	-0.0	-0.8	0.7	0.2	1.5	0.5	0.8	1.0	-1.8	1.5	-1.3	-0.8
Blood White Count	0.7	5.3	10.2	-2.6	-2.3	-2.9	-1.9	-2.4	-1.8	-2.6	-1.9	-1.1	-3.2	-2.5	-1.4
Heel T-Score	0.7	5.5	17.6	-1.4	-2.0	-1.4	-0.6	-2.3	-2.0	-1.9	-1.9	-3.0	-2.0	-4.2	-3.1
Respiratory disease	0.7	1.5	4.1	-1.4	0.5	-1.6	-2.0	-0.8	-1.0	-1.0	-0.7	-0.5	-1.3	-1.0	-1.8
Average weekly spirits intake	0.7	0.9	5.7	0.1	0.6	-0.7	-0.6	0.4	0.3	0.2	0.8	2.4	0.9	1.0	0.8
Leg fat-free mass (left)	0.7	3.6	15.1	-2.4	1.2	-2.6	-2.3	-0.9	-0.7	-1.2	-0.4	-0.7	-3.9	-1.6	-1.5
Multivitamins +/- minerals	0.7	0.9	3.5	-0.8	-1.9	-0.4	-0.5	-0.9	-1.1	-1.2	-1.3	-0.5	-0.7	0.2	0.1
Leg predicted mass (left)	0.7	3.5	14.7	-2.4	1.3	-2.6	-2.3	-0.9	-0.7	-1.1	-0.4	-0.7	-3.8	-1.6	-1.5
Mouth/teeth dental problems	0.7	1.0	4.0	0.5	-0.2	0.4	0.5	-0.9	-1.4	-0.1	-1.2	-2.0	-0.4	-1.3	-1.2
Pulse wave reflection index	0.7	0.9	2.7	-0.9	-0.5	-0.3	-0.3	-0.7	-0.7	-0.7	-1.0	-1.6	-1.2	-1.6	-0.7
Leg fat percentage (right)	0.7	2.6	6.0	1.0	2.4	0.5	0.9	1.3	1.8	1.6	2.4	2.1	-1.8	0.3	1.5
Arm fat-free mass (right)	0.7	3.7	17.6	-2.3	1.8	-2.3	-2.1	-0.4	0.3	-0.7	0.4	-0.9	-4.2	-2.4	-1.2
Wheeze or whistling in the chest in last year	0.7	1.2	2.5	0.7	1.5	1.0	0.9	1.4	1.0	1.2	1.3	1.1	0.5	1.6	0.6
Health satisfaction	0.7	0.9	2.6	0.9	0.9	0.5	0.4	0.8	0.2	0.5	0.9	1.6	1.4	1.4	0.5
Medication: Omeprazole	0.7	0.8	2.8	1.0	1.0	0.8	0.8	1.3	0.3	1.7	1.2	-0.1	0.0	-0.6	-0.1
Arm predicted mass (right)	0.7	3.7	16.6	-2.3	1.9	-2.4	-2.2	-0.3	0.5	-0.6	0.6	-0.8	-4.1	-2.2	-1.0
Had major operations	0.7	0.9	2.5	0.1	-1.0	0.3	0.9	-0.9	-1.1	-0.6	-0.7	-1.1	-1.6	-1.3	-0.7
Illnesses of father: Heart disease	0.7	1.0	2.9	0.5	0.3	1.0	0.9	1.4	0.7	1.0	1.1	0.5	1.7	1.3	1.0
Illnesses of siblings: Diabetes	0.7	0.9	2.4	0.1	-0.7	-0.5	-0.0	-1.6	-0.5	-1.3	-0.9	-0.3	-1.5	-1.5	-0.3
Long-standing illness, disability or infirmity	0.7	1.0	5.1	1.0	1.8	0.1	0.4	0.2	0.2	0.8	0.9	2.3	0.1	0.9	0.0
Eye problems/disorders: Cataract	0.7	0.8	2.1	0.8	1.4	0.9	1.2	0.8	-0.7	1.4	0.0	-0.1	0.2	0.1	-1.4
Miserableness	0.7	1.2	4.7	-1.0	0.4	-0.9	-0.9	-0.2	-2.2	-0.7	-1.3	-0.6	-0.1	0.2	-2.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.2	0.2	-0.8	0.4	0.5	0.9	0.2	0.4	0.7	1.3	0.8	1.8	1.3
Worry (Nagel 2018)	0.6	1.4	3.2	0.6	1.1	0.9	0.9	1.8	0.8	1.4	1.0	1.0	1.4	1.6	-0.1
Prostate Cancer	0.6	0.8	4.9	-0.1	0.2	-0.3	-0.1	0.4	2.2	0.3	1.1	-0.8	0.4	-1.4	0.7
BMI	0.6	3.7	14.4	-0.6	3.8	-2.0	-1.9	0.4	1.0	0.3	1.5	1.9	-3.7	-0.7	0.3
Height	0.6	11.4	22.8	-3.9	-4.3	-2.8	-1.8	-2.9	-3.6	-3.4	-3.5	-4.8	-0.7	-2.6	-4.2
Chronotype (morning person)	0.6	1.4	6.2	-0.9	1.4	-0.0	-0.0	0.7	-1.4	0.4	-0.3	-2.5	-0.6	-0.7	-2.1
Ever had hysterectomy (womb removed)	0.6	0.7	1.8	-1.0	-0.6	-1.4	-0.8	0.1	0.4	-0.5	0.8	-0.1	-1.4	-1.2	-0.0
Medication: Co-codamol	0.6	0.7	3.0	-0.7	0.2	-0.9	-0.7	0.4	0.8	0.1	1.2	0.1	-1.7	-0.1	1.2
Pack years adult smoking proportion	0.6	0.9	3.5	0.0	0.7	-0.2	-0.1	0.5	1.6	0.5	1.0	1.4	-0.4	0.3	1.9
Supplements: Glucosamine	0.6	0.8	4.0	-1.0	0.4	-0.8	-1.0	0.2	-0.1	-0.5	0.2	-0.9	-2.0	-1.3	-0.4
Body mass index (BMI)	0.6	2.6	11.9	-0.4	3.2	-1.2	-1.2	0.1	1.0	0.4	1.3	1.6	-3.4	-0.6	0.4
Past tobacco smoking	0.6	1.0	2.0	1.2	-0.3	1.2	1.4	1.3	0.8	1.0	1.4	0.4	1.1	0.4	0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.3	0.9	0.6	0.6	0.5	0.2	-0.6	0.5	0.2	1.1	1.5	1.5	0.1
Financial difficulties in last 2 years	0.6	0.7	1.5	1.0	1.2	0.1	0.1	0.8	0.9	0.8	1.2	-0.3	0.9	-1.0	-0.9
Allergy	0.6	1.4	5.4	1.1	-0.0	1.1	1.5	0.6	2.0	0.6	1.1	0.7	0.4	0.3	2.3
Worrier / anxious feelings	0.6	1.2	3.5	0.6	0.8	0.9	1.0	1.9	1.0	1.4	1.5	-0.1	1.4	0.5	-0.1
Medication: Lansoprazole	0.6	0.7	2.3	-1.2	-0.4	-1.1	-0.7	-0.7	-0.1	-0.6	-0.5	-0.9	-1.5	-0.5	-0.1
Pulse wave Arterial Stiffness index	0.6	0.7	2.8	-0.8	-0.3	-0.7	-0.5	-1.0	-0.6	-0.8	-1.0	-0.1	-1.7	-0.8	-0.3
Standing height	0.6	5.6	11.5	-2.8	-2.9	-2.0	-1.3	-1.7	-2.5	-2.2	-2.3	-3.4	-1.3	-1.9	-3.0
Tense / ‘highly strung’	0.6	1.0	6.6	-0.4	0.8	-0.3	-0.7	0.7	0.6	0.6	0.4	0.9	2.6	1.4	0.2
Blood clot in the leg (DVT)	0.6	0.8	1.6	-0.6	-1.0	-1.0	-1.2	-0.5	-0.7	-0.8	-0.6	-0.9	0.6	-1.3	-1.3
Headache pain in last month	0.6	1.0	2.3	-1.4	-0.3	-1.5	-1.5	-1.4	-0.6	-1.5	-0.8	0.3	-0.4	-0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	4.7	-1.1	0.5	-0.8	-1.1	-0.5	-1.4	-0.3	-1.0	-1.3	0.4	-1.5	-2.2
Exposure to tobacco smoke outside home	0.6	0.8	2.1	-0.3	-0.4	-1.2	-1.0	-0.6	-1.1	-0.9	-0.5	1.4	1.0	0.4	-0.7
Medication for pain relief, constipation, heartburn	0.6	1.0	4.2	-0.1	-0.9	0.4	0.2	-1.0	-0.6	-1.0	-1.6	-2.0	0.3	-0.9	-0.9
Medication: Aspirin	0.6	0.8	2.4	0.3	1.3	0.4	0.4	0.9	0.1	1.0	1.1	1.0	0.8	1.5	0.6
Whole body fat-free mass	0.6	3.2	15.6	-2.2	1.6	-2.3	-2.2	-0.4	-0.2	-0.6	0.1	-0.6	-4.0	-1.6	-1.2
Whole body water mass	0.6	3.5	16.5	-2.4	1.5	-2.5	-2.3	-0.6	-0.4	-0.9	-0.1	-0.6	-4.1	-1.6	-1.3
Wears glasses or contact lenses	0.6	0.7	4.7	0.4	2.2	0.4	0.4	0.6	0.1	1.2	0.7	0.4	-1.1	0.0	-0.2
Hearing aid user	0.6	0.7	2.2	-0.3	-1.3	0.0	0.4	-0.7	-1.5	-0.6	-1.0	0.9	-0.3	1.1	-0.1
Mother’s age at death	0.6	0.8	2.3	0.9	-0.6	1.4	1.2	0.2	-0.6	0.7	-0.3	-1.0	1.5	0.6	-0.3
Medication: Lisinopril	0.6	0.8	3.6	-0.4	-0.5	-0.7	-0.4	0.4	0.6	0.2	0.9	-0.9	-1.7	-1.9	-0.5
Illnesses of father: High blood pressure	0.6	0.7	4.0	-0.3	-0.4	0.2	0.5	0.2	0.5	0.2	0.5	-2.0	-0.4	-1.7	-0.5
Basal metabolic rate	0.6	3.2	16.3	-2.2	1.6	-2.4	-2.2	-0.5	-0.3	-0.7	0.1	-0.5	-4.0	-1.6	-1.2
Arm fat-free mass (left)	0.6	2.9	16.1	-1.8	2.3	-2.0	-1.8	0.1	0.6	-0.1	0.9	0.0	-4.0	-1.3	-0.4
Unable to work because of sickness or disability	0.6	0.8	2.5	-0.9	-0.3	-1.4	-1.6	-0.6	0.6	-0.6	0.1	0.8	-1.0	0.1	0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.8	-0.6	-0.9	-1.0	-1.1	-0.4	-0.8	-0.7	-0.6	-0.6	0.4	-1.3	-1.3
Arm predicted mass (left)	0.6	3.3	16.9	-1.9	2.6	-2.1	-1.9	0.3	0.7	-0.0	1.1	0.1	-4.1	-1.4	-0.4
Depressed Affect (Nagel 2018)	0.5	1.1	3.2	0.4	1.8	0.6	0.6	1.6	-0.3	1.3	0.5	1.0	-0.4	1.7	-0.9
Bipolar Disorder (2011)	0.5	0.5	2.4	0.1	-0.1	0.5	-0.1	-0.4	-0.4	-0.2	-0.5	-1.2	0.8	-0.8	-1.6
Body Mass Index (BMI) (2010)	0.5	0.7	2.3	-0.1	1.5	-0.8	-1.0	0.5	0.3	0.8	0.3	1.1	-1.3	-0.3	-0.3
Maternal smoking around birth	0.5	0.7	1.7	-0.8	-0.9	-0.3	0.0	0.6	0.9	-0.0	1.3	0.9	-1.1	0.8	1.3
Fed-up feelings	0.5	0.8	3.6	-0.7	1.9	-0.7	-0.8	0.5	1.2	0.3	0.9	0.4	-1.4	0.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	6.8	-0.9	-0.1	-0.1	-0.0	-0.5	1.0	-0.6	0.4	-2.6	-0.3	-2.0	-0.5
Weight	0.5	2.7	14.8	-1.6	1.7	-2.1	-1.8	-0.7	-0.3	-0.7	0.1	-0.0	-3.9	-1.4	-1.0
Alcohol intake versus 10 years previously	0.5	0.8	3.4	0.5	1.1	-0.5	-0.4	0.4	0.8	0.7	1.0	0.2	-1.8	-1.4	0.0
Breastfed as a baby	0.5	0.6	2.2	0.5	-1.5	0.8	1.4	-0.3	-0.6	-0.0	-0.6	-0.4	0.8	0.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.9	-0.2	-0.8	0.1	-0.0	-0.3	-1.2	-0.4	-1.0	0.5	1.7	1.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.8	0.7	0.9	0.7	0.4	0.9	0.3	1.0	0.7	-0.8	1.4	0.0	-0.3
Eye problems/disorders: None of the above	0.5	0.5	2.5	0.3	-1.6	0.5	0.3	-0.6	0.8	-0.8	-0.3	-0.1	0.6	-0.1	1.2
Emphysema/chronic bronchitis	0.5	0.5	1.6	0.8	1.2	-0.0	-0.5	0.0	1.3	-0.0	0.7	1.2	0.4	0.3	0.6
Medication: Allopurinol	0.5	0.6	1.8	-0.2	-1.1	-0.7	-0.4	-1.3	0.2	-1.2	-0.5	-0.7	-0.8	-1.2	0.0
Mean time to correctly identify matches	0.5	0.9	4.3	1.0	-0.8	1.3	2.1	0.7	-0.1	0.5	0.6	0.1	0.6	1.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	2.2	1.5	0.8	1.2	1.0	0.1	0.3	0.7	-0.1	0.7	0.4	-0.2	-0.1
Knee pain experienced in last month	0.5	0.8	4.2	-0.8	1.2	-1.3	-1.1	0.0	-0.3	0.1	0.3	-0.2	-2.0	-0.7	-0.6
Average weekly red wine intake	0.5	0.7	2.3	-1.1	-0.0	-0.8	-1.5	0.2	-0.2	-0.6	0.0	-0.4	1.5	0.9	0.3
Qualifications: nursing, teaching	0.5	0.8	2.5	-0.7	-1.6	-0.3	-0.4	-0.1	-1.5	-0.6	-1.0	-0.8	0.8	0.4	-0.9
Number of self-reported non-cancer illnesses	0.5	0.8	1.6	-1.0	-0.9	-1.1	-0.1	-1.0	-1.3	-1.0	-0.6	0.3	-1.2	-0.7	-0.8
Medication: Paracetamol	0.5	0.7	3.6	0.3	1.2	0.1	0.0	0.5	0.9	0.5	0.8	1.9	0.2	0.8	1.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.1	0.6	0.6	0.6	0.6	1.3	0.1	1.4	1.3	-0.6	-0.1	-0.7	-0.4
Leg fat mass (left)	0.5	1.8	10.2	-0.5	2.2	-0.9	-0.6	0.3	1.0	0.5	1.5	0.8	-3.2	-1.0	0.3
Bipolar Disorder or Schizophrenia	0.4	0.9	3.2	0.4	0.0	0.8	0.6	-0.8	-1.8	-0.0	-1.7	-1.0	-0.3	-0.1	-1.5
Schizophrenia (2018)	0.4	0.9	2.9	1.4	1.0	1.7	1.5	-0.1	-0.6	1.0	-0.8	-0.1	-0.7	0.3	0.0
Coronary Artery Disease (CAD)	0.4	0.5	1.7	0.3	0.3	0.2	-0.3	0.5	1.1	0.3	0.7	0.9	0.9	0.8	1.3
LDL Cholesterol	0.4	0.6	3.0	0.3	-1.7	0.3	0.3	-0.0	-0.8	-0.4	-0.7	0.2	1.3	0.7	-0.1
Schizophrenia (2014)	0.4	1.0	3.1	1.3	1.0	1.7	1.8	-0.0	-0.1	1.1	-0.3	-0.4	-0.9	-0.5	-0.1
Smoking Status	0.4	0.9	1.9	-0.9	-0.9	-1.3	-1.4	-1.4	-0.3	-1.0	-1.3	0.4	-0.7	-0.5	0.4
Vitamin and mineral supplements	0.4	0.6	1.1	1.0	0.9	0.4	0.7	0.5	0.8	0.9	1.1	1.1	0.4	0.2	0.3
Diabetes (father)	0.4	0.5	1.8	-0.2	0.2	-0.1	-0.1	-0.7	0.5	-0.6	0.1	-1.3	-0.9	-1.3	-0.4
Medication: Levothyroxine sodium	0.4	0.6	2.9	0.6	1.7	0.8	0.0	0.7	-0.1	1.3	-0.0	0.0	1.1	-0.1	-0.5
High blood pressure (mother)	0.4	0.6	1.4	0.9	1.2	0.9	1.1	0.5	0.2	0.9	0.9	-0.1	0.8	0.1	-0.4
Alcohol usually taken with meals	0.4	0.6	2.9	0.7	1.7	1.0	0.2	0.7	-0.6	1.0	-0.0	-0.9	0.7	-0.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.8	0.3	1.0	0.6	0.4	0.2	1.3	0.4	0.6	0.3	1.7	0.9	0.7
Trunk fat-free mass	0.4	2.2	11.0	-1.8	1.5	-1.9	-1.8	-0.1	0.1	-0.3	0.3	-0.3	-3.3	-1.2	-0.8
Pulse rate	0.4	0.7	4.7	1.0	0.4	0.4	0.6	0.4	0.6	0.3	0.7	2.2	0.6	0.8	0.2
Arm fat mass (right)	0.4	1.7	10.2	-0.9	1.4	-1.7	-1.3	-0.9	-0.3	-0.6	0.1	0.9	-3.2	-0.6	-0.6
Trunk predicted mass	0.4	2.3	11.2	-2.0	1.4	-2.0	-1.9	-0.2	0.0	-0.4	0.2	-0.4	-3.3	-1.3	-1.0
Exposure to tobacco smoke at home	0.4	0.5	1.5	0.3	1.2	-0.3	-0.2	0.6	1.0	0.4	1.0	0.9	-0.3	-0.4	0.6
Worry too long after embarrassment	0.4	0.7	3.5	0.8	0.1	0.4	0.2	1.0	-0.2	1.0	0.6	-0.4	1.9	0.5	-1.1
Age at first live birth	0.4	0.6	2.0	0.9	-0.5	1.4	1.3	0.1	0.3	0.4	-0.1	-1.3	0.7	-0.1	0.6
Neck or shoulder pain in last month	0.4	0.5	3.6	0.3	0.2	-0.1	-0.1	-0.2	1.9	-0.0	0.9	0.7	0.7	-0.1	0.9
Medication: Blood pressure	0.4	0.7	2.9	-0.9	0.3	-0.6	-0.1	-0.5	0.4	-0.2	0.2	-0.8	-1.7	-1.7	-0.1
Heart disease (mother)	0.4	0.5	1.8	0.4	-0.9	0.5	0.5	-0.6	-0.0	-0.3	-0.4	0.7	0.6	0.9	1.4
Whole body fat mass	0.4	1.6	11.6	-0.8	1.5	-1.4	-1.0	-0.3	0.1	-0.1	0.7	0.5	-3.4	-1.0	-0.5
Leg fat mass (right)	0.4	1.4	7.7	-0.3	2.0	-0.8	-0.3	0.3	0.9	0.5	1.4	0.9	-2.8	-0.8	0.3
Alcohol intake frequency.	0.4	1.0	3.1	1.2	1.8	0.5	0.1	0.5	0.3	1.4	0.6	-0.1	-1.1	-1.7	-0.2
Smoking status: Previous	0.4	0.5	1.5	-0.7	1.1	-0.6	-1.0	-0.9	-0.1	-0.3	-0.9	-0.2	-1.2	-0.0	0.1
Arm fat mass (left)	0.4	1.6	9.4	-0.9	1.6	-1.6	-1.2	-0.7	-0.2	-0.4	0.2	0.6	-3.1	-0.8	-0.7
Medication: Bendroflumethiazide	0.4	0.6	1.9	-0.5	1.4	-0.5	-0.5	0.1	1.2	0.3	0.7	0.6	1.1	-0.5	0.7
Medication: Atorvastatin	0.4	0.5	2.6	-1.1	-0.4	-0.7	-0.3	-0.3	-0.7	-0.6	-0.3	0.6	-1.6	-0.2	-0.5
Risk taking	0.4	0.6	2.5	-0.8	-0.3	-0.5	-0.9	-0.2	0.5	-0.6	0.2	-1.5	1.6	-0.4	-0.7
Commuting to job workplace: Cycle	0.4	0.4	3.3	0.3	-0.0	0.6	0.4	0.2	-0.7	0.5	-0.2	-0.2	1.8	0.5	-0.1
Basal cell carcinoma (self-reported)	0.4	0.5	2.9	-0.4	0.3	0.1	0.3	-0.3	1.7	-0.0	0.6	-0.2	-0.8	-0.9	0.5
Neuroticism (Nagel 2018)	0.3	0.7	2.5	0.1	1.2	0.5	0.4	1.3	-0.2	0.9	0.2	0.4	0.7	1.6	-0.9
Alzheimer’s Disease (in father)	0.3	0.3	1.4	-0.5	-0.9	-0.7	-0.4	0.0	-0.0	-0.1	0.3	0.0	-1.2	0.2	0.1
Mean Putamen Volume	0.3	0.3	1.8	0.3	0.4	0.1	0.1	-0.0	0.6	0.2	0.3	-1.0	-0.2	-1.3	-0.4
Lupus	0.3	0.5	1.3	-0.8	-1.0	-0.5	-0.5	-0.5	0.6	-0.5	-0.1	-0.1	-1.1	-1.0	0.3
Neuroticism (2016)	0.3	0.5	1.9	-0.6	1.4	-0.7	-1.4	-0.1	-0.2	-0.0	-0.3	0.5	-0.4	0.3	-0.5
Triglycerides	0.3	0.5	1.7	0.4	0.2	0.0	0.0	1.0	1.0	0.8	1.3	0.7	-0.1	0.1	0.7
Neuroticism	0.3	0.7	2.6	-0.7	1.6	-0.5	-0.6	0.9	-0.3	0.7	0.3	0.3	-0.1	0.5	-1.6
Number of treatments/medications taken	0.3	0.6	2.0	-0.5	-0.6	-0.9	0.3	-0.4	-1.4	-0.4	-0.3	0.8	-1.4	0.1	-0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	0.2	-0.3	-0.4	-0.3	-0.4	-1.0	-0.3	-0.4	0.5	-0.8	-0.6	-1.0
High blood pressure	0.3	0.7	3.3	-1.1	0.4	-0.5	-0.4	-0.0	1.0	-0.1	0.9	-0.3	-1.1	-1.8	0.7
Sitting height	0.3	2.2	5.8	-2.2	-1.5	-2.4	-2.1	-1.2	-1.4	-2.1	-1.0	0.2	-0.9	0.2	-0.4
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	-0.9	1.2	-0.7	-0.7	0.2	-0.4	-0.3	0.0	0.4	0.1	-0.3	-0.5
Trunk fat mass	0.3	1.2	8.3	-0.8	0.9	-1.3	-0.7	-0.5	-0.3	-0.3	0.4	0.2	-2.9	-0.8	-0.8
Waist circumference	0.3	1.0	5.7	-0.6	1.5	-1.0	-0.7	-0.6	0.7	-0.4	0.5	0.7	-2.4	-0.8	0.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	0.1	-0.9	-0.2	-0.1	-1.1	-0.6	-1.0	-1.1	-0.1	-0.4	-0.5	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.2	-0.2	-0.0	0.8	0.0	1.0	-0.1	0.4	0.0	-1.4	1.8	0.4	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	1.5	-1.2	0.5	-0.9	-1.1	0.2	1.2	-0.2	0.2	0.2	-0.3	-0.1	0.9
Peak expiratory flow (PEF)	0.3	0.7	2.4	-1.0	0.0	-1.0	-0.9	-0.7	-0.1	-1.0	-0.5	-0.6	-0.7	-1.6	-0.3
Gout (self-reported)	0.3	0.4	2.7	0.5	-1.6	0.2	0.4	-0.8	0.1	-0.7	-0.3	0.0	0.8	0.1	0.5
Pulse rate, automated reading	0.3	0.9	3.7	0.9	0.5	0.5	0.5	0.4	0.6	0.2	0.8	1.9	0.1	1.5	1.4
Suffer from ‘nerves’	0.3	0.4	3.1	-0.4	0.1	0.1	-0.3	0.4	0.1	-0.2	-0.4	0.4	1.0	1.8	0.1
Overall health rating	0.3	0.6	1.8	-0.9	0.9	-1.4	-1.0	-0.7	0.1	-0.2	-0.0	1.0	-1.2	-0.1	0.5
Age at last live birth	0.3	0.4	1.3	0.8	-0.8	1.1	0.9	0.2	0.2	0.3	-0.3	-0.2	0.8	0.2	0.6
Supplements: Vitamin C	0.3	0.4	2.7	-0.1	1.6	0.3	-0.3	1.0	0.3	0.7	0.4	-0.2	-0.3	0.3	0.3
Arm fat percentage (left)	0.3	1.1	6.5	-0.5	0.7	-1.3	-0.9	-1.1	-0.6	-0.7	-0.2	0.7	-2.5	-0.5	-0.7
Loneliness, isolation	0.3	0.4	2.0	-0.1	-0.1	0.2	0.3	-0.5	-0.7	-0.2	-1.1	0.5	0.4	1.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.4	-0.0	1.2	0.0	0.1	0.6	0.4	0.4	0.9	0.1	1.0	0.4	0.3
Commuting to job workplace: Walk	0.3	0.4	1.2	-0.1	0.0	-0.3	-1.0	0.7	0.8	0.0	0.6	0.0	1.1	-0.6	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.8	0.6	-1.3	0.3	0.6	0.3	0.2	0.1	0.6	0.9	0.6	1.0	0.4
Medication: Aspirin	0.3	0.4	1.8	0.2	0.6	0.4	0.4	0.4	-0.1	0.6	0.7	0.7	0.9	1.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.2	-1.3	0.1	-1.2	-1.5	-0.4	0.5	-0.5	-0.4	-0.5	-0.3	-1.0	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	0.5	-0.7	0.6	0.9	-0.6	0.5	-0.6	0.1	0.2	1.1	-0.3	0.4
Reaction Time	0.2	0.3	1.4	0.3	-0.7	0.7	1.2	0.3	-0.4	0.1	0.2	-0.4	0.4	0.8	0.0
Crohns Disease (2012)	0.2	0.4	1.8	-0.4	1.0	-0.3	-0.8	-0.2	0.9	0.2	0.2	0.3	1.4	-0.0	-0.1
HDL Cholesterol	0.2	0.3	1.2	-0.3	0.1	-0.2	-0.2	-0.2	-0.6	0.1	0.2	-1.1	-0.6	0.1	-1.1
Waist Hip Ratio (WHR)	0.2	0.9	2.8	-0.8	-1.1	0.2	0.6	-0.9	1.6	-0.8	-0.2	-1.2	-0.0	-1.7	0.8
Allergy or Eczema	0.2	0.6	1.6	0.9	0.6	0.9	0.9	1.1	-0.5	1.3	0.7	0.6	-0.2	0.7	-0.8
Cardiovascular Disease	0.2	0.6	2.0	-0.3	1.1	-0.1	-0.2	0.5	0.5	0.2	1.0	1.4	0.8	0.4	1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	0.4	-0.1	0.6	0.6	0.2	0.8	0.5	0.4	-0.2	1.1	0.5	-0.2
Diabetes (mother)	0.2	0.2	0.8	0.6	0.2	0.4	0.3	0.0	-0.9	-0.1	-0.2	0.3	0.8	0.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	0.6	0.2	0.6	0.7	0.4	-0.2	0.6	0.3	-0.3	0.5	0.1	-0.9
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.3	0.6	0.1	0.5	0.5	0.8	-1.0	0.9	0.2	0.2	0.9	0.8	-1.2
Stomach or abdominal pain in last month	0.2	0.2	0.9	-0.4	0.6	-0.6	-0.4	0.1	-0.3	-0.1	0.1	0.1	0.9	0.5	-0.7
Nervous feelings	0.2	0.5	1.4	-0.5	1.2	0.2	-0.1	1.2	0.9	0.9	0.6	-0.4	0.5	0.3	0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.9	0.2	0.6	0.3	0.0	-0.5	0.0	-0.0	-0.9	0.0	-0.8	0.0	0.0
Neuroticism score	0.2	0.4	1.7	-0.6	1.3	-0.5	-0.7	0.6	-0.0	0.4	0.1	-0.0	0.7	0.7	-1.0
Arm fat percentage (right)	0.2	0.8	5.3	-0.1	0.8	-1.0	-0.5	-0.8	-0.5	-0.4	0.0	1.2	-2.3	-0.0	-0.3
Hip circumference	0.2	0.9	3.5	-0.0	1.6	-0.9	-0.7	-0.2	-0.4	-0.1	0.3	1.6	-1.9	0.6	-0.3
Falls in the last year	0.2	0.3	2.0	-0.1	0.4	-0.7	-0.4	0.2	-1.0	0.0	-0.0	-0.2	-0.0	-0.0	-1.4
Number of live births	0.2	0.3	1.4	-0.2	0.6	-0.2	-0.1	0.5	1.2	0.3	0.9	0.8	0.4	-0.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.2	-0.1	-0.6	-0.6	-0.0	-0.2	-1.1	-0.3	-0.2	0.3	0.2	0.4	-0.8
Illnesses of mother	0.2	0.2	0.7	0.2	0.4	0.1	-0.0	0.9	0.4	0.7	0.7	-0.1	-0.0	-0.4	0.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	0.6	0.4	0.6	0.8	0.9	-0.2	0.9	0.9	-0.3	0.6	0.4	-0.5
Body fat percentage	0.2	0.7	5.3	0.1	1.1	-0.6	-0.1	0.0	0.2	0.3	0.9	1.0	-2.3	-0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	-0.2	0.1	-0.0	-0.3	-0.1	-0.7	-0.3	-0.7	0.3	0.1	1.1	-0.9
Pulse wave peak to peak time	0.2	0.3	1.8	0.3	-0.2	0.3	0.2	0.5	0.2	0.3	0.4	-0.4	1.4	0.5	-0.0
Medication: Ibuprofen	0.2	0.3	1.6	-0.1	-0.1	-0.4	0.2	-0.1	-1.3	-0.1	-0.4	0.3	0.2	0.4	-1.0
Hypertension (Self-reported)	0.2	0.5	1.9	-0.8	0.5	-0.4	-0.3	-0.1	0.9	-0.0	0.9	-0.1	-0.7	-1.4	1.0
Mood swings	0.2	0.3	1.2	-0.4	0.3	-0.3	-0.2	-0.2	-1.1	-0.4	-0.6	0.0	0.1	0.9	-0.9
Guilty feelings	0.2	0.3	0.5	-0.7	0.6	-0.6	-0.6	-0.4	-0.6	-0.6	-0.7	-0.5	-0.3	0.3	-0.5
High cholesterol (Self-reported)	0.2	0.3	1.0	0.3	0.0	0.3	0.6	1.0	-0.0	0.4	0.9	0.9	0.6	0.5	0.2
Alcohol drinker status: Never	0.2	0.2	0.7	0.3	0.3	0.2	-0.1	-0.1	-0.6	-0.2	-0.4	-0.5	0.4	-0.8	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.7	0.6	-0.9	0.3	0.3	-0.4	-1.3	-0.3	-1.2	-0.4	0.7	1.0	-1.0
Alcohol drinker status: Previous	0.2	0.3	1.2	-0.0	0.1	-0.3	0.2	-0.9	0.1	-0.2	-0.3	-0.3	-1.1	-1.0	-0.2
Crohns Disease (2017)	0.1	0.3	1.4	0.4	0.5	0.7	0.3	0.3	0.6	0.8	0.4	0.1	1.2	0.0	0.3
Breast Cancer	0.1	0.2	0.7	-0.4	0.8	-0.1	-0.4	0.3	0.4	0.3	0.3	-0.3	-0.3	0.5	0.2
Fasting Glucose	0.1	0.1	0.2	-0.2	0.0	-0.2	0.5	-0.1	-0.3	-0.2	-0.4	0.1	0.1	-0.5	-0.4
Hair Pigment	0.1	3.7	9.6	1.4	3.1	1.7	1.2	1.8	2.4	2.3	2.0	1.4	-0.5	1.4	2.5
Trunk fat percentage	0.1	0.5	4.3	-0.1	0.6	-0.8	-0.1	-0.3	-0.4	-0.0	0.4	0.5	-2.1	-0.3	-0.6
Medication: Simvastatin	0.1	0.1	0.5	-0.0	-0.2	-0.2	0.1	-0.3	-0.5	-0.2	-0.1	-0.0	0.7	-0.7	-0.4
Medication: Cholesterol lowering	0.1	0.2	1.0	-0.7	-0.6	-0.5	0.1	-0.0	-0.6	-0.2	0.2	0.2	-1.0	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	0.6	0.1	0.4	-0.3	0.6	0.3	0.4	0.0	0.1	0.9	0.6	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	-0.1	0.4	-0.4	-0.5	-0.2	0.0	-0.1	-0.1	-0.2	-0.7	-0.3	-0.6
Shortness of breath walking on level ground	0.1	0.2	0.7	-0.2	-0.1	-0.5	-0.5	-0.4	-0.3	-0.5	-0.4	-0.2	0.0	-0.1	-0.8
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.6	-0.3	-0.3	-0.1	0.6	0.4	0.3	-0.2	0.4	0.8	0.2	0.0	-0.3
Ever had bowel cancer screening	0.1	0.1	0.3	0.3	-0.2	0.3	0.5	0.3	0.0	0.5	0.2	-0.1	-0.3	0.5	-0.1
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	0.5	0.2	-0.2	-0.6	-0.7	0.1	-0.1	-0.6	0.5	-0.4	0.0	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.6	-0.2	-0.8	-0.2	-0.2	0.0	-0.1	-0.1	0.2	-0.7	0.2	0.2	-0.6
Cholesterol lowering medication	0.1	0.1	0.4	0.1	0.2	-0.0	-0.2	-0.2	0.5	-0.2	0.3	0.3	0.5	-0.6	0.1
Tanning	0.0	0.3	1.5	-0.6	-0.2	-0.1	-0.1	-0.3	-0.3	-0.1	-0.6	-1.0	1.2	-0.5	-0.6

Hub : Genes

PSEN1

Models

Trait associations