Best TWAS P=5.46e-22 · Best GWAS P=9.99e-48 conditioned to 5.37e-40
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | PRIMA1 | 0.22 | 0.10 | enet | 20 | 0.07 | 2.4e-04 | -3.0 | -5.8 | 5.2e-09 | -0.12 | 0.24 | 0.11 | TRUE |
| 2 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | -9.6 | 9.6 | 5.5e-22 | 0.03 | 0.27 | 0.38 | TRUE |
| 3 | GTEx | Esophagus Muscularis | RIN3 | 0.17 | 0.05 | lasso | 6 | 0.06 | 1.6e-04 | -6.7 | 7.7 | 1.4e-14 | 0.06 | 0.11 | 0.58 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | RIN3 | 0.05 | 0.00 | blup | 163 | 0.01 | 6.0e-02 | 10.4 | 6.6 | 5.7e-11 | 0.08 | 0.00 | 0.82 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RIN3 | 0.07 | 0.01 | enet | 9 | 0.04 | 8.7e-06 | 10.4 | 7.0 | 2.5e-12 | 0.05 | 0.01 | 0.93 | TRUE |