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chr14:77,043,210-78,618,743

Best TWAS P=7.19e-12 · Best GWAS P=3.56e-10 conditioned to 0.978

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GSTZ1	0.18	0.17	lasso	4	0.17	5.9e-20	-5.8	-5.2	2.0e-07	-0.41	0.08	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SAMD15	0.11	0.11	lasso	3	0.12	7.6e-14	-5.8	5.5	3.0e-08	0.91	0.04	0.96	FALSE
3	GTEx	Adipose Subcutaneous	TMED8	0.17	0.10	lasso	9	0.12	3.5e-10	4.4	5.1	2.7e-07	0.68	0.85	0.15	FALSE
4	GTEx	Adipose Subcutaneous	VIPAS39	0.07	0.06	lasso	4	0.04	3.7e-04	-6.0	6.1	9.5e-10	0.94	0.04	0.96	FALSE
5	GTEx	Adipose Subcutaneous	NOXRED1	0.14	0.06	lasso	4	0.04	3.3e-04	6.2	-5.5	3.3e-08	-0.90	0.01	0.99	FALSE
6	GTEx	Adrenal Gland	GSTZ1	0.33	0.26	lasso	5	0.24	3.8e-09	-5.8	-5.7	1.2e-08	-0.52	0.07	0.93	FALSE
7	GTEx	Adrenal Gland	NOXRED1	0.24	0.15	lasso	5	0.09	3.7e-04	6.3	-6.4	1.2e-10	-0.95	0.01	0.98	FALSE
8	GTEx	Artery Aorta	TMED8	0.17	0.06	lasso	8	0.11	1.5e-06	3.9	5.4	7.8e-08	0.82	0.03	0.97	FALSE
9	GTEx	Artery Tibial	TMED8	0.12	0.02	enet	11	0.02	7.7e-03	3.9	6.2	7.4e-10	0.75	0.07	0.83	FALSE
10	GTEx	Artery Tibial	NOXRED1	0.08	0.06	lasso	7	0.04	5.0e-04	-6.0	-6.0	2.2e-09	-0.93	0.03	0.97	FALSE
11	GTEx	Brain Cortex	GSTZ1	0.29	0.18	lasso	5	0.14	1.4e-04	-5.7	-5.4	8.5e-08	-0.43	0.15	0.75	FALSE
12	GTEx	Brain Hypothalamus	GSTZ1	0.35	0.17	lasso	4	0.16	1.5e-04	-5.8	-5.1	2.8e-07	-0.51	0.07	0.42	FALSE
13	GTEx	Breast Mammary Tissue	TMED8	0.18	0.04	enet	16	0.06	4.3e-04	-5.6	6.1	1.1e-09	0.83	0.02	0.97	FALSE
14	GTEx	Breast Mammary Tissue	VIPAS39	0.08	0.02	enet	7	0.00	3.1e-01	-6.0	5.9	4.4e-09	0.95	0.03	0.93	FALSE
15	GTEx	Breast Mammary Tissue (Male)	TMED8	0.25	0.02	lasso	5	-0.01	6.1e-01	6.3	5.8	7.6e-09	0.93	0.03	0.68	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	NOXRED1	0.32	0.20	lasso	7	0.18	1.4e-06	-5.8	-6.0	1.9e-09	-0.95	0.04	0.96	FALSE
17	GTEx	Cells Transformed fibroblasts	GSTZ1	0.23	0.17	lasso	4	0.18	1.1e-13	-5.8	-5.8	7.8e-09	-0.54	0.08	0.92	FALSE
18	GTEx	Cells Transformed fibroblasts	NOXRED1	0.08	0.07	lasso	5	0.06	3.2e-05	-5.8	-6.0	1.5e-09	-0.95	0.04	0.95	FALSE
19	GTEx	Colon Transverse	GSTZ1	0.24	0.12	lasso	7	0.13	1.1e-06	-5.8	-5.8	7.4e-09	-0.53	0.14	0.86	FALSE
20	GTEx	Colon Transverse	NOXRED1	0.16	0.14	enet	19	0.17	1.2e-08	-5.8	-6.5	9.4e-11	-0.92	0.04	0.96	FALSE
21	GTEx	Esophagus Mucosa	TMED8	0.23	0.09	lasso	8	0.14	8.6e-10	6.3	5.9	2.9e-09	0.87	0.02	0.98	FALSE
22	GTEx	Esophagus Mucosa	NOXRED1	0.12	0.05	lasso	3	0.04	7.3e-04	-5.8	-6.1	1.1e-09	-0.94	0.03	0.96	FALSE
23	GTEx	Esophagus Muscularis	NOXRED1	0.10	0.07	lasso	4	0.06	8.8e-05	6.2	-6.2	5.3e-10	-0.95	0.02	0.97	FALSE
24	GTEx	Heart Atrial Appendage	GSTZ1	0.19	0.08	enet	17	0.06	1.5e-03	-4.8	-5.6	2.4e-08	-0.39	0.15	0.79	FALSE
25	GTEx	Lung	TMED8	0.16	0.16	enet	19	0.17	6.3e-13	-6.2	6.0	2.5e-09	0.96	0.01	0.99	FALSE
26	GTEx	Lung	VIPAS39	0.08	0.02	enet	15	0.02	1.6e-02	-5.8	6.1	1.4e-09	0.95	0.03	0.97	FALSE
27	GTEx	Nerve Tibial	VIPAS39	0.09	0.06	lasso	5	0.04	6.6e-04	5.8	5.9	3.4e-09	0.98	0.03	0.97	FALSE
28	GTEx	Nerve Tibial	NOXRED1	0.19	0.16	lasso	7	0.16	1.1e-11	-5.8	-5.8	5.2e-09	-0.95	0.03	0.97	FALSE
29	GTEx	Prostate	NOXRED1	0.26	0.03	enet	34	0.02	1.1e-01	-5.8	-5.4	7.3e-08	-0.88	0.03	0.87	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	GSTZ1	0.17	0.10	lasso	5	0.13	1.7e-07	-5.8	-5.5	4.6e-08	-0.45	0.09	0.89	FALSE
31	GTEx	Skin Sun Exposed Lower leg	VIPAS39	0.14	0.14	lasso	3	0.13	8.9e-11	-5.8	5.8	6.4e-09	0.95	0.02	0.98	FALSE
32	GTEx	Skin Sun Exposed Lower leg	NOXRED1	0.16	0.14	lasso	6	0.14	3.0e-11	-6.0	-6.6	4.0e-11	-0.91	0.03	0.97	FALSE
33	GTEx	Spleen	TMED8	0.30	0.07	lasso	6	0.15	1.1e-04	-6.0	5.6	1.6e-08	0.88	0.04	0.83	FALSE
34	GTEx	Stomach	GSTZ1	0.11	0.01	lasso	3	0.02	5.6e-02	-4.8	-5.2	2.2e-07	-0.48	0.15	0.72	FALSE
35	GTEx	Stomach	TMED8	0.14	0.07	lasso	6	0.13	1.0e-06	3.8	5.3	1.2e-07	0.65	0.42	0.38	FALSE
36	GTEx	Testis	POMT2	0.32	0.18	lasso	10	0.15	4.4e-07	-5.8	-5.8	5.3e-09	-0.48	0.16	0.83	FALSE
37	GTEx	Testis	VIPAS39	0.26	0.18	enet	13	0.15	3.4e-07	-5.8	6.0	2.6e-09	0.96	0.03	0.97	FALSE
38	GTEx	Thyroid	GSTZ1	0.20	0.17	enet	6	0.20	2.6e-15	-4.8	-5.3	1.1e-07	-0.45	0.16	0.84	FALSE
39	GTEx	Thyroid	NOXRED1	0.06	0.01	lasso	9	0.00	7.6e-01	-6.0	-6.3	2.4e-10	-0.78	0.04	0.83	FALSE
40	GTEx	Whole Blood	TMED8	0.14	0.09	enet	17	0.07	8.1e-07	6.3	5.8	7.6e-09	0.97	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C14orf148	0.04	0.06	enet	5	0.07	1.9e-06	5.8	-5.9	4.3e-09	-0.98	0.03	0.97	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	AHSA1	0.01	0.01	blup	56	0.01	2.9e-03	-6.0	-5.8	6.8e-09	-0.92	0.02	0.80	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf148	0.02	0.01	blup	53	0.02	1.1e-04	-6.0	-5.3	1.2e-07	-0.85	0.03	0.94	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf174	0.02	0.02	lasso	2	0.02	6.0e-05	5.9	5.9	4.9e-09	0.98	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	C14orf148	0.04	0.02	blup	53	0.03	5.2e-03	6.3	-6.1	1.2e-09	-0.96	0.02	0.83	FALSE
46	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf174	0.11	0.05	blup	43	0.04	1.7e-02	-6.2	6.9	7.2e-12	0.91	0.01	0.66	TRUE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C14orf148	0.03	0.04	lasso	3	0.03	3.1e-04	6.2	-5.4	5.1e-08	-0.90	0.02	0.97	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GSTZ1	0.04	0.05	lasso	3	0.04	2.0e-05	-5.4	-5.2	1.6e-07	-0.48	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AHSA1	0.02	0.04	blup	56	0.03	1.7e-04	-6.0	-5.4	8.5e-08	-0.92	0.02	0.97	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C14orf148	0.02	0.02	enet	5	0.01	1.1e-02	6.3	-6.3	2.8e-10	-0.99	0.01	0.86	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C14orf174	0.02	0.00	blup	43	0.02	4.4e-03	-5.8	5.5	3.6e-08	0.90	0.02	0.73	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C14orf174	0.05	0.04	lasso	2	0.06	3.7e-04	4.4	5.8	7.3e-09	0.80	0.01	0.85	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ISM2	0.11	0.09	blup	63	0.08	3.6e-05	3.6	-5.2	2.1e-07	-0.77	0.13	0.80	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf148	0.10	0.08	blup	53	0.10	2.6e-11	-6.2	-6.0	2.5e-09	-0.89	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf174	0.03	0.03	blup	43	0.03	2.3e-04	6.3	6.5	8.6e-11	0.95	0.01	0.98	FALSE
56	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C14orf148	0.11	0.02	blup	53	0.04	6.7e-03	5.8	-6.6	5.5e-11	-0.90	0.02	0.77	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf174	0.02	0.03	lasso	1	0.02	6.1e-04	-6.2	6.2	6.0e-10	0.98	0.01	0.97	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C14orf148	0.05	0.01	blup	53	0.02	2.2e-03	-5.8	-6.3	2.3e-10	-0.93	0.02	0.97	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C14orf174	0.07	0.03	blup	43	0.08	5.8e-06	5.9	6.1	1.2e-09	0.79	0.01	0.97	FALSE
60	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C14orf148	0.06	0.09	lasso	7	0.07	4.8e-04	-5.8	-5.9	3.5e-09	-0.96	0.02	0.95	FALSE
61	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf148	0.09	0.07	blup	53	0.07	1.3e-03	6.2	-6.2	6.3e-10	-0.96	0.02	0.90	FALSE
62	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GSTZ1	0.12	0.09	lasso	3	0.07	7.7e-04	-5.1	-5.1	2.7e-07	-0.48	0.02	0.82	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	AHSA1	0.02	0.02	enet	5	0.02	4.0e-03	-5.8	-5.8	6.7e-09	-0.96	0.02	0.88	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf148	0.05	0.05	blup	53	0.05	2.5e-06	-5.8	-6.4	1.5e-10	-0.96	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	GSTZ1	0.08	0.09	lasso	3	0.08	1.0e-08	-5.8	-5.6	2.2e-08	-0.48	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	AHSA1	0.03	0.03	enet	7	0.03	9.9e-04	6.2	-5.8	5.1e-09	-0.94	0.02	0.96	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	C14orf148	0.03	0.01	enet	8	0.01	5.0e-02	6.2	-5.5	4.5e-08	-0.84	0.02	0.88	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	C14orf174	0.11	0.14	enet	11	0.14	6.2e-14	-5.8	5.6	2.1e-08	0.96	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	TMED8	0.03	0.04	blup	72	0.03	3.3e-04	-5.4	6.3	4.0e-10	0.63	0.08	0.44	FALSE