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chr14:102,364,918-104,892,153

Best TWAS P=2.81e-17 · Best GWAS P=2e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EIF5	0.07	0.04	lasso	7	0.03	9.7e-05	-5.4	6.3	3.3e-10	-0.10	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	KLC1	0.06	0.02	lasso	2	0.00	2.2e-01	-5.2	5.3	1.2e-07	-0.08	0.16	0.05	FALSE
3	GTEx	Artery Aorta	KLC1	0.10	0.14	lasso	3	0.14	6.1e-08	-5.3	5.4	8.7e-08	-0.07	0.99	0.00	FALSE
4	GTEx	Artery Aorta	TRMT61A	0.14	0.07	lasso	5	0.12	6.4e-07	-5.8	-6.3	2.5e-10	0.07	0.82	0.01	TRUE
5	GTEx	Artery Tibial	ZFYVE21	0.11	0.09	lasso	1	0.08	8.0e-07	-5.3	5.3	1.4e-07	-0.06	0.98	0.00	FALSE
6	GTEx	Artery Tibial	KLC1	0.11	0.08	lasso	3	0.08	1.1e-06	-5.2	5.2	1.9e-07	-0.06	0.88	0.00	FALSE
7	GTEx	Brain Frontal Cortex BA9	APOPT1	0.17	0.07	lasso	3	0.08	4.6e-03	5.5	-6.2	6.2e-10	0.06	0.18	0.05	FALSE
8	GTEx	Breast Mammary Tissue	MARK3	0.12	0.11	lasso	2	0.08	3.9e-05	-5.7	-5.7	1.1e-08	0.06	0.63	0.02	FALSE
9	GTEx	Breast Mammary Tissue (Male)	MARK3	0.08	0.00	enet	9	-0.01	7.2e-01	-5.7	-5.4	6.9e-08	0.04	0.04	0.06	FALSE
10	GTEx	Cells Transformed fibroblasts	RP11-45P15.4	0.18	0.02	lasso	3	0.08	1.2e-06	-5.4	-5.7	1.5e-08	0.10	0.04	0.71	FALSE
11	GTEx	Esophagus Muscularis	ZFYVE21	0.11	0.06	lasso	5	0.05	5.7e-04	-4.8	5.3	9.9e-08	-0.08	0.61	0.02	FALSE
12	GTEx	Lung	MARK3	0.06	0.02	lasso	3	0.01	6.6e-02	-5.7	-5.5	4.4e-08	0.05	0.44	0.04	FALSE
13	GTEx	Lung	CKB	0.07	0.01	lasso	2	0.01	3.4e-02	-5.2	-6.0	1.7e-09	0.06	0.32	0.10	FALSE
14	GTEx	Muscle Skeletal	ZFYVE21	0.10	0.05	lasso	2	0.03	3.3e-04	-5.3	5.3	9.8e-08	-0.08	0.64	0.02	FALSE
15	GTEx	Muscle Skeletal	KLC1	0.11	0.07	lasso	7	0.08	3.3e-08	-5.3	5.4	5.2e-08	-0.08	1.00	0.00	FALSE
16	GTEx	Muscle Skeletal	APOPT1	0.14	0.21	enet	10	0.22	6.7e-21	-4.8	5.4	6.1e-08	-0.06	1.00	0.00	FALSE
17	GTEx	Pituitary	MARK3	0.21	0.27	enet	8	0.25	4.9e-07	-5.7	-5.9	3.7e-09	0.06	0.59	0.03	FALSE
18	GTEx	Prostate	MARK3	0.18	0.22	enet	11	0.20	8.0e-06	-5.7	-5.9	3.2e-09	0.06	0.49	0.03	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	MARK3	0.16	0.10	lasso	3	0.10	6.7e-06	-5.7	-5.3	1.5e-07	0.06	0.96	0.00	FALSE
20	GTEx	Skin Sun Exposed Lower leg	MARK3	0.10	0.09	enet	13	0.08	7.5e-07	-5.8	-6.1	9.3e-10	0.06	1.00	0.00	FALSE
21	GTEx	Skin Sun Exposed Lower leg	RP11-45P15.4	0.10	0.04	enet	18	0.07	1.5e-06	-5.4	-6.5	6.2e-11	0.10	0.05	0.92	TRUE
22	GTEx	Spleen	KLC1	0.15	0.05	lasso	3	0.03	6.4e-02	5.5	5.4	6.4e-08	-0.08	0.10	0.06	FALSE
23	GTEx	Stomach	MARK3	0.10	0.09	lasso	2	0.04	4.5e-03	-5.7	-5.6	2.0e-08	0.06	0.34	0.03	FALSE
24	GTEx	Stomach	TRMT61A	0.12	0.11	lasso	5	0.08	1.2e-04	-5.7	-5.7	1.0e-08	0.06	0.55	0.02	FALSE
25	GTEx	Testis	ZFYVE21	0.11	0.14	lasso	2	0.11	1.4e-05	-5.3	5.3	1.0e-07	-0.07	0.61	0.02	FALSE
26	GTEx	Thyroid	MARK3	0.38	0.48	lasso	4	0.48	2.8e-41	-5.7	-5.7	1.1e-08	0.06	1.00	0.00	FALSE
27	NTR	Blood	BAG5	0.02	0.00	lasso	5	0.01	6.3e-03	-4.8	5.1	2.7e-07	-0.04	0.47	0.01	FALSE
28	YFS	Blood	EIF5	0.11	0.09	enet	29	0.10	1.5e-29	-5.4	-6.2	5.5e-10	0.11	1.00	0.00	FALSE
29	YFS	Blood	RCOR1	0.04	0.02	enet	17	0.02	3.9e-06	-7.5	-6.3	2.7e-10	0.71	0.14	0.85	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf153	0.05	0.02	lasso	4	0.02	8.0e-05	-4.8	-5.1	2.7e-07	0.05	0.03	0.96	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RCOR1	0.22	0.06	lasso	2	0.06	4.0e-04	-8.2	8.5	2.8e-17	-1.00	0.00	0.99	TRUE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	C14orf153	0.07	0.05	lasso	4	0.04	1.5e-03	-5.4	-5.1	3.1e-07	0.04	0.02	0.73	FALSE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf153	0.14	0.01	blup	40	0.03	3.5e-02	-4.8	-5.7	9.2e-09	0.04	0.01	0.51	FALSE
34	The Cancer Genome Atlas	Glioblastoma Multiforme	MARK3	0.12	0.05	blup	64	0.07	3.3e-03	-5.7	-6.1	7.9e-10	0.06	0.02	0.50	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	3.3	-5.7	1.1e-08	0.07	0.06	0.44	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	-4.8	-5.9	3.1e-09	0.08	0.04	0.84	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C14orf153	0.05	0.05	blup	40	0.04	8.6e-06	-5.3	-5.3	1.2e-07	0.03	0.02	0.97	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CKB	0.03	0.00	blup	34	0.02	1.4e-03	3.2	-5.3	1.1e-07	0.04	0.02	0.57	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BAG5	0.08	0.09	lasso	2	0.08	3.7e-04	-5.7	-5.7	1.1e-08	0.06	0.00	0.96	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf153	0.11	0.11	lasso	3	0.10	1.1e-04	-5.4	-5.5	3.5e-08	0.05	0.02	0.91	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf153	0.09	0.08	blup	38	0.09	6.2e-10	-5.4	-6.2	7.5e-10	0.06	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKB	0.07	0.09	blup	32	0.10	1.1e-10	5.5	-5.6	2.5e-08	0.07	0.05	0.95	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61A	0.03	0.01	blup	32	0.01	1.4e-02	-5.8	-5.3	1.2e-07	0.05	0.01	0.61	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	C14orf153	0.20	0.05	lasso	2	0.04	8.8e-04	5.5	-6.2	6.9e-10	0.05	0.01	0.86	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	ANKRD9	0.07	0.04	enet	7	0.04	1.2e-04	-4.3	5.2	2.0e-07	-0.19	0.05	0.03	TRUE
46	The Cancer Genome Atlas	Thyroid Carcinoma	MARK3	0.10	0.03	blup	61	0.03	4.0e-04	-1.9	-5.7	1.0e-08	0.09	0.02	0.54	FALSE