Best TWAS P=2.33e-08 · Best GWAS P=2.44e-08 conditioned to 0.0174
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAM10 | 0.06 | 0.02 | lasso | 3 | 0.02 | 1.3e-02 | 5.0 | 5.3 | 1.4e-07 | 0.66 | 0.05 | 0.94 | FALSE |
| 2 | GTEx | Esophagus Mucosa | ADAM10 | 0.17 | 0.06 | lasso | 11 | 0.10 | 3.2e-07 | 5.3 | 5.6 | 2.3e-08 | 0.69 | 0.07 | 0.92 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ADAM10 | 0.09 | 0.05 | lasso | 7 | 0.02 | 5.3e-03 | 4.9 | 5.2 | 2.2e-07 | 0.57 | 0.08 | 0.91 | FALSE |
| 4 | YFS | Blood | FAM63B | 0.04 | 0.04 | lasso | 4 | 0.04 | 3.6e-14 | 4.2 | 5.4 | 6.0e-08 | 0.70 | 0.72 | 0.25 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HSP90AB4P | 0.02 | 0.01 | blup | 31 | 0.01 | 2.5e-02 | 5.2 | -5.4 | 6.6e-08 | -0.69 | 0.01 | 0.70 | FALSE |