[Hub]/) : Traits : Blood Eosinophil Count :

chr15:84,151,637-86,990,983

Best TWAS P=1.67e-10 · Best GWAS P=8.89e-15 conditioned to 2e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex UBE2Q2P1 0.08 0.04 blup 382 0.05 2.3e-06 3.8 -5.6 2.6e-08 0.12 0.94 0.01 FALSE
2 CommonMind Brain Pre-frontal Cortex ZSCAN2 0.03 0.02 enet 5 0.02 9.7e-04 -6.3 5.7 1.0e-08 -0.08 0.01 0.99 FALSE
3 GTEx Adipose Subcutaneous WDR73 0.19 0.13 enet 13 0.16 3.5e-13 -6.3 6.0 1.5e-09 -0.01 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous RP11-182J1.16 0.23 0.03 enet 32 0.10 9.1e-09 -6.3 5.7 1.5e-08 -0.01 0.01 0.99 FALSE
5 GTEx Adipose Visceral Omentum CSPG4P11 0.14 0.07 enet 15 0.09 2.9e-05 -4.2 5.3 1.2e-07 -0.07 0.02 0.98 FALSE
6 GTEx Artery Aorta WDR73 0.16 0.12 lasso 5 0.12 2.9e-07 -6.3 6.2 5.4e-10 -0.07 0.01 0.99 FALSE
7 GTEx Artery Tibial WDR73 0.18 0.17 lasso 3 0.17 4.2e-13 -6.3 6.1 8.2e-10 -0.07 0.01 0.99 FALSE
8 GTEx Artery Tibial RP11-182J1.16 0.11 0.09 enet 14 0.08 4.1e-07 -4.2 5.4 8.3e-08 -0.06 0.06 0.93 FALSE
9 GTEx Brain Cortex WDR73 0.25 0.17 lasso 11 0.16 3.4e-05 -6.3 6.2 4.7e-10 -0.04 0.01 0.97 FALSE
10 GTEx Brain Hippocampus AC103965.1 0.26 0.12 lasso 11 0.20 2.1e-05 -6.3 5.7 9.4e-09 -0.11 0.03 0.92 FALSE
11 GTEx Brain Hypothalamus WDR73 0.24 0.04 lasso 8 0.00 4.0e-01 -6.3 5.3 9.9e-08 -0.01 0.02 0.79 FALSE
12 GTEx Breast Mammary Tissue WDR73 0.12 0.12 lasso 3 0.10 1.0e-05 -6.3 6.3 3.0e-10 -0.07 0.00 0.99 FALSE
13 GTEx Breast Mammary Tissue CSPG4P11 0.08 0.08 lasso 2 0.05 1.3e-03 -6.4 6.0 1.6e-09 -0.07 0.01 0.97 FALSE
14 GTEx Breast Mammary Tissue (Male) WDR73 0.02 0.00 enet 3 -0.01 5.9e-01 -6.3 6.3 3.2e-10 -0.03 0.02 0.40 FALSE
15 GTEx Breast Mammary Tissue (Female) CSPG4P11 0.17 0.15 enet 7 0.10 5.1e-04 -6.3 6.3 3.5e-10 -0.07 0.01 0.97 FALSE
16 GTEx Cells Transformed fibroblasts WDR73 0.26 0.20 lasso 8 0.18 1.4e-13 -6.3 5.3 9.0e-08 -0.04 0.01 0.99 FALSE
17 GTEx Colon Sigmoid WDR73 0.19 0.28 lasso 4 0.21 4.7e-08 -6.3 6.3 3.3e-10 -0.07 0.01 0.99 FALSE
18 GTEx Colon Transverse WDR73 0.18 0.15 enet 13 0.14 4.7e-07 -6.3 5.7 9.7e-09 -0.04 0.01 0.99 FALSE
19 GTEx Esophagus Gastroesophageal Junction WDR73 0.16 0.00 enet 8 0.05 5.8e-03 -6.3 5.2 2.2e-07 0.00 0.01 0.92 FALSE
20 GTEx Esophagus Mucosa RP11-182J1.16 0.20 0.05 lasso 5 0.10 1.8e-07 -4.4 5.2 1.8e-07 0.00 0.48 0.48 FALSE
21 GTEx Esophagus Muscularis RP11-182J1.16 0.12 0.10 lasso 8 0.11 4.5e-07 -4.2 5.6 2.4e-08 -0.06 0.02 0.98 FALSE
22 GTEx Heart Atrial Appendage AC103965.1 0.24 0.12 enet 24 0.14 7.2e-07 -5.2 6.4 1.7e-10 -0.05 0.08 0.92 TRUE
23 GTEx Heart Atrial Appendage RP11-182J1.16 0.24 0.20 lasso 8 0.13 2.6e-06 -6.3 6.0 2.0e-09 -0.05 0.01 0.99 FALSE
24 GTEx Heart Atrial Appendage CSPG4P11 0.12 0.08 lasso 5 0.10 4.3e-05 -4.2 5.4 7.4e-08 -0.05 0.05 0.94 FALSE
25 GTEx Heart Left Ventricle WDR73 0.11 0.07 lasso 5 0.06 2.4e-04 -6.3 6.0 1.6e-09 -0.05 0.01 0.97 FALSE
26 GTEx Heart Left Ventricle AC103965.1 0.16 0.13 enet 14 0.12 7.0e-07 -4.4 5.4 8.5e-08 -0.05 0.08 0.92 FALSE
27 GTEx Lung WDR73 0.12 0.08 lasso 8 0.08 1.3e-06 -6.3 5.2 2.4e-07 -0.05 0.01 0.99 FALSE
28 GTEx Muscle Skeletal WDR73 0.08 0.05 enet 11 0.07 1.5e-07 -6.3 6.3 2.4e-10 -0.08 0.00 1.00 FALSE
29 GTEx Muscle Skeletal RP11-182J1.16 0.10 0.03 enet 15 0.05 5.4e-06 -6.3 5.1 3.1e-07 0.00 0.01 0.98 FALSE
30 GTEx Muscle Skeletal RP11-182J1.14 0.10 0.05 lasso 5 0.04 4.4e-05 -4.4 -5.2 2.3e-07 0.08 0.92 0.04 FALSE
31 GTEx Muscle Skeletal CSPG4P11 0.14 0.07 lasso 5 0.08 1.4e-08 -6.3 5.7 1.5e-08 -0.03 0.01 0.99 FALSE
32 GTEx Nerve Tibial WDR73 0.34 0.29 lasso 7 0.29 1.7e-20 -6.3 5.9 2.9e-09 -0.07 0.01 0.99 FALSE
33 GTEx Ovary WDR73 0.36 0.23 lasso 7 0.30 5.4e-08 -6.3 5.5 3.4e-08 -0.02 0.01 0.98 FALSE
34 GTEx Ovary RP11-182J1.16 0.20 0.08 enet 14 0.15 1.4e-04 -5.2 5.5 3.4e-08 -0.04 0.02 0.94 FALSE
35 GTEx Ovary CSPG4P11 0.21 0.17 lasso 4 0.18 3.1e-05 -5.2 5.6 1.9e-08 -0.07 0.03 0.93 FALSE
36 GTEx Pituitary WDR73 0.19 0.07 lasso 8 0.07 7.9e-03 -6.3 6.1 1.0e-09 -0.06 0.01 0.94 FALSE
37 GTEx Prostate WDR73 0.29 0.25 enet 17 0.21 5.4e-06 -6.3 5.2 2.2e-07 -0.03 0.01 0.97 FALSE
38 GTEx Skin Not Sun Exposed Suprapubic AC103965.1 0.23 0.15 lasso 8 0.19 1.9e-10 -4.2 5.7 1.2e-08 -0.03 0.04 0.96 FALSE
39 GTEx Skin Not Sun Exposed Suprapubic RP11-182J1.16 0.10 0.01 enet 13 0.04 3.1e-03 -6.3 5.8 6.3e-09 -0.06 0.03 0.93 FALSE
40 GTEx Skin Not Sun Exposed Suprapubic CSPG4P11 0.29 0.07 enet 29 0.13 9.6e-08 -4.2 5.9 3.5e-09 -0.02 0.05 0.95 FALSE
41 GTEx Skin Sun Exposed Lower leg ZSCAN2 0.08 0.02 enet 13 0.03 1.4e-03 3.8 -5.2 2.0e-07 0.01 0.08 0.81 FALSE
42 GTEx Skin Sun Exposed Lower leg WDR73 0.08 0.04 lasso 8 0.05 3.4e-05 -6.3 5.3 9.2e-08 -0.04 0.01 0.99 FALSE
43 GTEx Skin Sun Exposed Lower leg RP11-182J1.16 0.09 0.04 enet 18 0.04 1.4e-04 -4.2 5.4 6.2e-08 -0.03 0.02 0.97 FALSE
44 GTEx Skin Sun Exposed Lower leg CSPG4P11 0.18 0.07 lasso 11 0.19 9.1e-16 -6.3 6.2 6.3e-10 -0.03 0.01 0.99 FALSE
45 GTEx Testis GOLGA6L4 0.49 0.21 enet 31 0.39 3.1e-18 -6.3 5.3 1.1e-07 0.03 0.00 1.00 FALSE
46 GTEx Testis RN7SL417P 0.09 0.08 lasso 3 0.08 3.1e-04 -4.2 -5.7 1.5e-08 0.06 0.01 0.96 FALSE
47 GTEx Testis RP11-158M2.3 0.20 0.22 lasso 5 0.20 2.1e-09 -5.8 5.4 6.2e-08 -0.64 0.89 0.11 TRUE
48 GTEx Thyroid ZSCAN2 0.06 0.03 lasso 2 0.03 2.9e-03 -5.0 -5.3 9.5e-08 0.10 0.15 0.51 FALSE
49 GTEx Thyroid WDR73 0.28 0.26 lasso 8 0.28 1.1e-21 -6.3 6.3 2.9e-10 -0.06 0.00 1.00 FALSE
50 The Cancer Genome Atlas Breast Invasive Carcinoma WDR73 0.07 0.02 enet 10 0.05 4.5e-11 -2.4 6.1 1.3e-09 -0.13 0.01 0.99 FALSE
51 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WDR73 0.09 0.07 lasso 5 0.07 9.8e-09 -6.3 5.6 1.8e-08 -0.06 0.00 1.00 FALSE
52 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma WDR73 0.10 0.05 blup 40 0.07 7.0e-05 -6.3 5.4 8.2e-08 -0.07 0.01 0.98 FALSE
53 The Cancer Genome Atlas Brain Lower Grade Glioma AKAP13 0.06 0.00 blup 265 0.04 2.6e-05 -7.0 5.3 1.5e-07 -0.61 0.05 0.90 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma WDR73 0.20 0.20 lasso 7 0.26 1.8e-29 -6.3 5.2 1.6e-07 -0.04 0.01 0.99 FALSE
55 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ZSCAN2 0.05 0.01 blup 46 0.02 2.7e-02 -5.0 -5.9 3.5e-09 0.09 0.01 0.70 FALSE
56 The Cancer Genome Atlas Lung Adenocarcinoma WDR73 0.05 0.03 lasso 4 0.04 1.6e-05 -6.3 6.1 1.3e-09 -0.06 0.00 1.00 FALSE
57 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma WDR73 0.16 0.17 blup 40 0.19 4.3e-08 -6.3 6.2 5.0e-10 -0.08 0.01 0.99 FALSE
58 The Cancer Genome Atlas Prostate Adenocarcinoma WDR73 0.13 0.12 blup 40 0.14 4.7e-14 -6.3 5.8 6.0e-09 -0.11 0.00 1.00 FALSE