Best TWAS P=2.73e-33 · Best GWAS P=1.21e-50 conditioned to 1.46e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | KDM8 | 0.13 | 0.05 | enet | 4 | 0.05 | 6.4e-05 | 9.2 | -8.8 | 1.2e-18 | -0.54 | 0.88 | 0.01 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CTD-3203P2.1 | 0.12 | 0.01 | lasso | 7 | 0.02 | 9.2e-03 | 7.7 | -9.2 | 3.5e-20 | -0.59 | 0.29 | 0.33 | TRUE |
| 3 | GTEx | Esophagus Mucosa | CTD-3203P2.1 | 0.11 | 0.01 | lasso | 3 | 0.00 | 4.6e-01 | -6.9 | -7.2 | 7.4e-13 | -0.36 | 0.10 | 0.06 | TRUE |
| 4 | GTEx | Nerve Tibial | CTD-3203P2.1 | 0.21 | 0.05 | lasso | 6 | 0.09 | 8.5e-07 | 10.4 | -10.1 | 7.7e-24 | -0.54 | 0.76 | 0.05 | FALSE |
| 5 | NTR | Blood | IL4R | 0.03 | 0.01 | enet | 10 | 0.01 | 8.1e-04 | 11.3 | -11.3 | 9.4e-30 | -0.72 | 0.56 | 0.24 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | NSMCE1 | 0.07 | 0.03 | bslmm | 510 | 0.02 | 3.1e-03 | 9.2 | 9.9 | 4.6e-23 | 0.47 | 0.69 | 0.13 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | CTD-3203P2.1 | 0.14 | 0.07 | enet | 24 | 0.07 | 2.3e-09 | 10.4 | -9.9 | 3.3e-23 | -0.55 | 1.00 | 0.00 | FALSE |
| 8 | YFS | Blood | IL21R | 0.05 | 0.02 | enet | 45 | 0.02 | 1.6e-07 | 4.7 | 5.6 | 1.9e-08 | -0.01 | 1.00 | 0.00 | TRUE |
| 9 | YFS | Blood | IL4R | 0.13 | 0.04 | enet | 35 | 0.10 | 2.0e-32 | 12.0 | -12.0 | 2.7e-33 | -0.50 | 1.00 | 0.00 | TRUE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL21R | 0.03 | 0.03 | lasso | 3 | 0.02 | 2.1e-05 | 6.5 | 5.4 | 5.2e-08 | 0.32 | 0.78 | 0.01 | TRUE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | JMJD5 | 0.04 | 0.04 | blup | 67 | 0.02 | 3.5e-03 | 10.4 | -10.3 | 7.6e-25 | -0.49 | 0.00 | 1.00 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | NSMCE1 | 0.09 | 0.06 | blup | 48 | 0.05 | 5.6e-04 | -4.6 | 5.9 | 3.3e-09 | 0.36 | 0.40 | 0.06 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JMJD5 | 0.06 | 0.01 | blup | 69 | 0.03 | 3.5e-04 | -8.6 | -7.3 | 2.0e-13 | -0.29 | 0.04 | 0.16 | TRUE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | JMJD5 | 0.05 | 0.01 | blup | 68 | 0.04 | 5.0e-05 | 7.7 | -6.3 | 3.4e-10 | -0.41 | 0.02 | 0.58 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | JMJD5 | 0.04 | 0.01 | blup | 69 | 0.02 | 8.6e-03 | 8.2 | -6.8 | 1.5e-11 | -0.48 | 0.08 | 0.36 | TRUE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | JMJD5 | 0.04 | 0.01 | enet | 9 | 0.02 | 7.1e-03 | 9.2 | -8.1 | 7.9e-16 | -0.51 | 0.24 | 0.55 | FALSE |