TWAS hub - JMJD5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0413	0.0186	0.0015	0.044	0.018	0.018	NA	0.010	9.5e-06	0.00350	0.0039	NA	0.024
2	TCGA	Brain Lower Grade Glioma	0.0575	0.0265	0.0011	0.010	0.028	0.008	NA	0.004	2.4e-02	0.00035	0.0330	NA	0.094
3	TCGA	Lung Squamous Cell Carcinoma	0.0517	0.0261	0.0013	0.005	0.036	0.025	NA	0.004	7.7e-02	0.00005	0.0007	NA	0.091
4	TCGA	Prostate Adenocarcinoma	0.0436	0.0213	0.0015	0.011	0.015	0.002	NA	0.005	2.3e-02	0.00860	0.1900	NA	0.088
5	TCGA	Thyroid Carcinoma	0.0430	0.0210	0.0014	0.010	0.017	0.017	NA	0.014	3.4e-02	0.00770	0.0071	NA	0.015

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Asthma (self-reported)	12.1	24.1	45.0	-6.7	-4.3	-4.1	-3.4	-5.4
Asthma	11.0	21.8	44.4	-6.7	-4.0	-3.8	-3.0	-5.0
Respiratory disease	10.0	22.2	50.3	-7.1	-3.9	-3.9	-2.9	-4.6
Blood Eosinophil Count	8.1	62.0	106.1	-10.3	-7.3	-6.3	-6.8	-8.1
Allergy	7.5	17.3	36.4	6.0	5.0	2.4	1.9	3.9
Ever had hysterectomy (womb removed)	5.8	6.6	9.4	2.7	1.6	2.5	2.7	3.1
Allergy or Eczema	5.2	13.7	28.7	-5.4	-4.6	-2.5	-2.0	-3.0
Hayfever, allergic rhinitis or eczema	5.1	11.1	22.1	-4.7	-4.2	-1.8	-1.9	-3.0
Mean Putamen Volume	4.8	5.5	11.6	1.6	3.4	2.1	2.0	2.2
Medication: Ventolin 100micrograms inhaler	4.6	5.9	11.7	-3.4	-2.5	-1.2	-1.6	-2.8
Migraine (self-reported)	4.5	5.6	11.4	2.2	0.6	2.1	2.7	3.4
Age at first live birth	3.6	6.4	8.0	-2.8	-1.6	-2.5	-2.7	-2.8
Mouth/teeth dental problems: Loose teeth	3.2	3.8	6.8	2.0	0.6	1.9	2.0	2.6
Supplements: Fish oil (including cod liver oil)	3.0	3.9	10.4	0.5	0.0	2.1	3.2	2.1
Medication: Seretide 50 evohaler	2.9	3.3	8.4	-2.9	-0.9	-1.8	-0.4	-2.0
Wheeze or whistling in the chest in last year	2.8	4.9	7.4	-2.2	-2.7	-1.3	-1.9	-2.7
Ever used hormone-replacement therapy (HRT)	2.5	3.2	4.7	1.8	1.9	0.6	2.2	2.0
Supplements: Zinc	2.5	2.7	6.3	2.0	0.7	2.5	0.7	1.5
Mineral and other dietary supplements	2.5	3.4	6.0	-1.1	0.2	-2.5	-2.4	-2.0
Myopia	2.4	3.5	5.7	-2.4	-2.1	-2.3	-0.9	-1.2
Severe depression (siblings)	2.3	2.6	5.8	1.1	1.5	2.4	1.5	1.2
Average weekly red wine intake	2.2	3.2	6.2	-1.1	-1.2	-2.5	-2.0	-1.8
Heart disease (siblings)	2.2	2.7	7.5	0.7	1.0	1.4	2.7	1.6
Alzheimer’s Disease (in mother)	2.1	2.5	5.2	-1.8	-1.7	-0.4	-0.9	-2.3
Number of live births	2.1	2.9	5.7	1.0	0.6	1.7	2.4	2.2
Age at last live birth	2.1	3.0	4.9	-2.2	-1.1	-1.6	-1.7	-1.9
Guilty feelings	2.1	3.2	5.3	1.2	1.7	1.7	2.0	2.3
Qualifications: College or University degree	2.0	6.3	12.6	-0.4	-2.0	-2.4	-2.9	-3.6
Diabetes (father)	1.9	2.3	3.7	1.9	1.5	1.2	1.6	1.2
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	4.4	1.3	0.7	1.2	2.1	1.8
Qualifications: A levels/AS levels or equivalent	1.9	4.2	5.6	-1.8	-2.4	-2.0	-2.3	-1.6
Family relationship satisfaction	1.9	2.3	4.2	1.9	1.2	0.6	1.5	2.0
Osteoarthritis (self-reported)	1.9	2.5	3.9	1.6	1.6	0.7	1.8	2.0
Coronary Artery Disease (CAD)	1.8	2.2	5.9	0.2	-0.6	-1.6	-2.4	-1.5
Alcohol usually taken with meals	1.8	2.9	6.6	-2.6	-1.7	-1.4	-1.8	-0.3
Had menopause	1.8	2.2	3.1	-0.4	1.8	1.7	1.6	1.5
Alcohol drinker status: Never	1.8	2.1	6.3	1.3	1.1	0.6	1.0	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	5.9	-1.2	-0.1	-1.4	-0.6	-2.4
Illnesses of father: High blood pressure	1.6	2.0	3.0	1.0	1.7	1.0	1.4	1.7
Alcohol drinker status: Previous	1.6	1.9	5.1	-0.2	0.7	2.3	1.7	1.0
Alzheimer’s Disease (in father)	1.5	1.6	4.7	2.2	1.6	-0.0	-0.1	1.0
Age at First Birth	1.5	2.2	4.1	0.4	1.8	0.9	1.6	2.0
Medication: Lansoprazole	1.5	1.7	2.8	1.4	-0.5	1.6	1.7	0.9
Commuting to job workplace: Walk	1.5	1.6	2.3	0.3	-1.5	-1.2	-1.5	-1.4
Schizophrenia (2014)	1.4	3.1	6.7	-1.8	-1.2	-2.6	-1.4	-1.6
Maternal smoking around birth	1.4	2.0	5.7	1.3	-2.4	-0.0	-0.9	-1.3
Age when periods started (menarche)	1.4	3.4	6.0	-1.4	-2.0	-1.8	-2.5	-1.4
Multivitamins +/- minerals	1.4	1.7	7.0	0.6	0.1	2.6	0.7	1.0
Pain all over the body in last month	1.4	1.6	3.8	0.9	0.8	0.5	1.6	1.9
Pulse wave Arterial Stiffness index	1.4	1.7	2.9	0.5	-1.5	-1.7	-1.6	-0.7
Pulse wave peak to peak time	1.4	1.6	2.8	-0.3	1.4	1.7	1.7	0.6
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.8	-1.3	-1.0	-0.7	-1.7	-1.3
Medication: Metformin	1.3	1.8	6.9	2.6	0.8	-0.1	0.9	0.9
Townsend deprivation index at recruitment	1.3	1.9	4.6	2.1	0.1	1.2	1.6	0.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.5	-2.1	-1.2	-0.6	-1.1	-1.0
Fluid intelligence score	1.3	2.7	4.5	-0.9	-2.1	-1.1	-1.8	-2.0
Pulse rate	1.3	2.2	5.2	-0.6	-1.0	-1.9	-0.8	-2.3
Illnesses of father: None of the above (group 1)	1.3	1.6	3.2	-1.8	-0.1	-0.8	-1.8	-1.1
Schizophrenia vs Biploar Disorder	1.2	1.6	2.7	-1.2	-0.8	-1.6	-1.7	-1.0
Ovarian Cancer	1.2	1.6	3.0	0.1	1.5	1.7	0.8	1.4
Diabetes (mother)	1.2	1.5	2.9	1.3	1.7	0.5	0.9	1.2
Pack years adult smoking proportion	1.2	1.9	5.3	2.3	1.2	1.3	0.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.1	-0.9	0.2	-1.2	-1.2	-1.8
Length of working week for main job	1.2	1.3	2.9	0.2	0.1	1.7	0.8	1.7
Hair/balding pattern: Pattern 4	1.2	2.9	4.2	1.3	2.0	1.7	1.8	1.5
Peak expiratory flow (PEF)	1.2	2.9	4.8	-2.2	-1.5	-1.3	-1.7	-1.6
Alcohol intake frequency.	1.2	2.8	6.4	0.6	0.2	2.5	2.0	1.9
Medication for hormone replacement therapy	1.1	1.2	3.3	1.3	1.8	-0.3	0.7	0.7
Trunk fat percentage	1.1	4.5	13.5	-0.3	-3.7	-1.6	-2.0	-1.6
Mouth/teeth dental problems	1.1	1.6	2.8	-1.6	0.1	-1.0	-1.7	-1.3
Mouth/teeth dental problems: Dentures	1.1	1.8	2.7	1.5	0.6	1.6	1.7	1.0
Body fat percentage	1.1	4.4	12.1	-0.3	-3.5	-1.8	-2.0	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.6	-1.3	-0.1	1.9	1.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.3	1.5	1.3	0.6	0.3	1.5
Hearing aid user	1.1	1.3	2.1	1.4	1.3	0.7	1.4	0.2
Fasting Glucose	1.0	1.2	2.6	-0.7	-1.6	0.1	-0.3	-1.6
LDL Cholesterol	1.0	1.6	3.7	0.6	1.9	1.3	1.2	0.8
Smoking Status	1.0	2.5	4.9	2.2	1.2	0.8	1.3	2.0
Trunk fat mass	1.0	4.2	13.6	0.2	-3.7	-1.5	-1.6	-1.6
Illnesses of siblings	1.0	1.5	3.0	-1.1	-0.9	-1.3	-1.7	-0.8
Hair/balding pattern: Pattern 3	1.0	1.5	3.3	-1.1	-0.5	-0.7	-1.5	-1.8
Number of full brothers	1.0	1.2	2.6	0.6	1.2	1.0	1.6	0.9
Shortness of breath walking on level ground	1.0	1.2	3.1	1.2	-0.7	0.9	1.8	0.5
Medication: Ibuprofen	1.0	1.2	4.5	0.2	-2.1	-0.4	-0.3	-1.1
Illnesses of siblings: Diabetes	1.0	1.3	3.9	2.0	0.9	-0.9	-0.5	-0.7
Leg fat percentage (left)	1.0	3.7	8.5	0.3	-2.9	-1.9	-1.9	-1.7
Irritability	1.0	1.7	3.4	-0.7	-1.3	-1.5	-1.8	-0.8
Prostate Cancer	0.9	1.2	2.8	0.5	-1.7	-0.3	-0.9	-1.5
HbA1C	0.9	1.0	1.9	-0.4	1.1	-0.3	1.4	1.3
Triglycerides	0.9	1.5	7.0	-2.7	0.2	-0.3	0.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.2	0.7	-0.7	-1.3	-1.5	-0.5
Blood White Count	0.9	6.3	13.2	-1.9	-1.8	-2.6	-2.2	-3.6
Medication: Atenolol	0.9	1.2	2.9	1.7	-1.1	1.2	-0.4	-0.3
Qualifications: None of the above	0.9	2.0	4.6	0.8	2.1	0.9	1.8	0.8
Arm fat percentage (right)	0.9	3.6	9.5	-0.5	-3.1	-1.6	-1.5	-1.8
Depression (self-reported)	0.9	1.0	2.9	-1.7	0.5	1.3	0.7	0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.4	2.1	0.1	0.6	0.9	0.2
Comparative body size at age 10	0.9	2.4	4.6	1.7	0.8	1.5	2.1	1.3
Qualifications: nursing, teaching	0.9	1.3	2.8	-1.1	-0.9	-0.3	-1.7	-1.3
Breast cancer (self-reported)	0.9	1.1	1.7	-1.1	-0.9	-0.8	-1.2	-1.3
Eye problems/disorders: Glaucoma	0.9	1.1	2.4	1.0	0.8	-0.1	1.5	1.1
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.9	2.2	-0.7	0.6	0.4	-0.1
Fractured/broken bones in last 5 years	0.9	1.1	2.4	1.2	0.8	0.9	0.7	1.6
Medication: Co-codamol	0.8	1.0	2.4	-0.1	-1.6	-1.0	-0.6	-1.0
High blood pressure (siblings)	0.8	1.2	2.0	0.9	1.0	1.4	0.9	1.2
Leg fat percentage (right)	0.8	2.9	7.6	0.5	-2.7	-1.6	-1.6	-1.4
Whole body fat mass	0.8	3.3	11.1	0.7	-3.3	-1.2	-1.4	-1.2
Leg fat mass (right)	0.8	2.9	9.5	1.1	-3.1	-1.3	-1.0	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.5	-1.6	-1.3	-0.8	-0.5	0.0
Arm fat percentage (left)	0.8	3.3	8.5	-0.2	-2.9	-1.6	-1.7	-1.6
Friendships satisfaction	0.8	1.0	2.1	0.8	1.5	0.2	0.9	1.2
Wears glasses or contact lenses	0.8	0.9	1.9	-1.0	-1.4	-0.5	-1.1	-0.5
Financial situation satisfaction	0.8	1.0	2.6	0.9	-0.5	0.7	1.6	1.0
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.2	-0.2	-0.6	0.1	-1.1	-1.8
Leg fat mass (left)	0.8	3.2	10.2	0.9	-3.2	-1.4	-1.1	-1.3
Sensitivity / hurt feelings	0.7	1.3	3.3	-1.8	1.0	-0.4	-1.1	-0.9
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.8	0.4	1.1	0.5	0.5	1.7
Vitamin and mineral supplements	0.7	0.9	3.5	0.3	0.3	-1.9	-0.5	-0.9
Taking other prescription medications	0.7	1.1	2.9	-0.6	-1.7	-0.3	-0.5	-1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.8	-0.4	0.4	0.6	0.4	1.7
Stomach or abdominal pain in last month	0.7	0.8	2.2	-1.5	1.1	-0.7	-0.3	0.4
Nervous feelings	0.7	1.2	2.9	1.7	-0.6	1.0	0.4	1.3
Heart attack	0.7	0.9	2.7	-0.2	-0.5	0.3	-1.2	-1.6
Noisy workplace	0.7	0.9	2.4	1.5	0.1	0.3	1.0	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.4	0.8	-1.9	0.5	0.5	-0.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.3	1.0	1.5	-0.6	0.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.7	-0.2	0.5	-1.1	-0.9	-1.3
Pulse rate, automated reading	0.7	2.3	6.7	0.1	-1.3	-2.6	-1.2	-1.2
Supplements: Vitamin C	0.7	0.8	2.6	-1.6	0.5	-0.4	-0.2	1.0
Eye problems/disorders: Cataract	0.7	0.8	2.4	-0.7	-0.0	-1.5	-0.8	-0.6
Average weekly champagne plus white wine intake	0.7	1.0	1.9	1.4	0.3	1.1	-1.3	0.6
Age started oral contraceptive pill	0.7	0.8	1.5	0.1	1.1	0.8	1.2	0.9
Ever depressed for a whole week	0.7	0.8	2.5	0.7	-0.4	0.7	1.6	0.6
Cholesterol lowering medication	0.7	1.1	2.1	-0.3	1.1	0.6	1.3	1.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.0	1.7	-0.9	0.6	-0.0	-0.3
Pack years of smoking	0.7	1.1	2.6	1.6	1.2	1.0	0.5	0.3
Depressed Affect (Nagel 2018)	0.6	1.2	4.2	0.3	2.0	0.7	0.5	1.0
Schizophrenia (2018)	0.6	1.3	3.3	-1.1	-0.9	-1.8	-0.7	-0.9
Major Depression (MDD)	0.6	0.8	1.9	1.4	1.1	0.6	0.6	-0.1
Reaction Time	0.6	1.1	3.3	1.8	0.5	0.9	0.5	0.9
HDL Cholesterol	0.6	1.0	3.6	1.9	-0.8	0.7	0.1	-0.1
Lupus	0.6	0.9	2.8	-1.7	-0.2	0.6	-0.6	-0.9
Average weekly spirits intake	0.6	0.7	2.1	1.4	0.7	0.5	0.7	0.5
Current tobacco smoking	0.6	0.9	3.6	1.9	0.0	0.4	0.6	0.7
Supplements: Glucosamine	0.6	0.8	1.2	0.7	0.3	1.0	1.1	1.1
Waist circumference	0.6	2.2	8.1	0.6	-2.9	-0.9	-0.7	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.8	0.4	1.7	0.4	1.1	0.7
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	1.1	-1.0	1.2	0.3	0.6
Diabetes (self-reported)	0.6	0.9	2.7	1.7	0.5	0.5	0.8	0.6
Prospective memory result	0.6	0.8	1.8	1.4	0.4	-0.9	-0.9	-0.3
Arm fat mass (right)	0.6	2.7	8.8	0.4	-3.0	-1.2	-1.0	-1.4
Blood clot in the leg (DVT)	0.6	0.8	2.3	0.2	-1.5	-0.6	1.0	-0.4
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-0.9	-0.4	-1.1	-0.5	-1.1
Exposure to tobacco smoke outside home	0.6	0.9	2.5	-1.1	-0.1	-0.6	-1.6	-0.4
Health satisfaction	0.6	0.8	2.6	0.7	1.0	0.0	1.6	0.3
Heart disease (mother)	0.6	0.7	2.4	0.4	1.6	-0.2	0.4	0.9
Suffer from ‘nerves’	0.6	1.0	2.6	-0.1	0.7	1.1	0.8	1.6
Osteoporosis (self-reported)	0.6	0.7	1.4	-1.2	-0.5	-0.8	-1.1	-0.5
Medication: Gliclazide	0.6	0.7	2.0	1.4	-0.3	-0.2	1.1	0.1
Arm fat mass (left)	0.6	2.4	7.8	0.7	-2.8	-1.1	-1.0	-1.2
Medication: Bendroflumethiazide	0.6	1.0	1.5	1.2	-0.9	-1.0	-1.1	-0.6
Medication: Atorvastatin	0.6	0.8	1.8	1.3	-0.6	0.9	-0.1	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.7	0.4	-1.6	-0.6	0.9	-0.4
Crohns Disease (2012)	0.5	0.8	1.7	0.8	-0.8	-1.0	-0.2	-1.3
Relative age of first facial hair	0.5	1.0	2.2	-0.2	-1.1	0.2	-1.2	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.6	-1.6	0.6	-0.2	-0.1	0.0
Serious illness, injury or assault to yourself	0.5	0.6	2.3	1.5	-0.1	0.0	0.6	-0.4
High blood pressure	0.5	1.3	4.8	2.2	0.2	0.2	0.6	1.0
Body mass index (BMI)	0.5	1.9	5.8	0.8	-2.4	-1.0	-0.7	-1.3
Weight	0.5	2.6	10.2	1.1	-3.2	-0.6	-0.5	-1.1
Alcohol intake versus 10 years previously	0.5	0.7	2.4	0.2	-0.1	1.6	1.0	0.2
Exposure to tobacco smoke at home	0.5	0.6	2.4	-0.6	1.6	0.3	0.3	0.3
Birth weight of first child	0.5	0.9	1.8	1.0	0.3	0.9	1.3	1.1
Gout (self-reported)	0.5	0.7	2.8	1.7	-0.6	0.4	0.3	0.4
Medication: Allopurinol	0.5	0.7	1.3	0.8	-1.2	-0.8	-0.8	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.7	1.3	-0.5	-0.6	-0.7	0.2
Illnesses of father: Heart disease	0.5	0.7	1.7	1.3	-1.2	0.4	-0.5	-0.2
Smoking status: Current	0.5	0.8	3.0	1.7	0.1	0.3	0.4	0.7
Commuting to job workplace: Cycle	0.5	0.6	1.5	-0.3	-0.2	-0.4	-1.2	-1.2
Supplements: Calcium	0.5	0.6	1.2	0.0	0.9	1.1	0.5	0.8
Verbal and Numeric Reasoning (VNR)	0.4	1.1	2.4	0.2	-1.1	-0.9	-1.5	-0.9
Rheumatoid Arthritis	0.4	0.5	1.3	0.1	-1.0	0.5	-0.1	-1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.3	0.5	-1.1	-0.7	1.0	0.2
Angina	0.4	0.5	1.5	1.2	-0.3	0.7	0.6	0.2
Average weekly fortified wine intake	0.4	0.5	1.3	-0.2	1.2	0.3	0.8	0.5
Qualifications: CSEs or equivalent	0.4	0.6	1.8	-0.4	-1.3	-0.6	-0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	0.0	1.0	-0.7	-1.0	0.3
High blood pressure (mother)	0.4	0.5	0.9	0.9	0.8	-0.3	0.2	0.9
Had other major operations	0.4	0.5	1.2	-1.1	0.4	-0.9	-0.4	-0.2
Medication: Simvastatin	0.4	0.5	1.3	-0.4	-1.2	-1.1	-0.2	-0.2
Hip circumference	0.4	1.7	6.9	0.4	-2.6	-0.6	-0.1	-1.1
Worrier / anxious feelings	0.4	0.8	1.5	0.6	-0.6	-1.1	-1.2	-0.6
Falls in the last year	0.4	0.5	1.7	0.6	-1.3	0.3	0.2	-0.7
Breastfed as a baby	0.4	0.5	1.1	-1.0	0.4	-0.2	-0.6	-0.9
Loud music exposure frequency	0.4	0.4	1.2	0.2	1.1	0.1	0.7	0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.6	-0.4	-1.6	0.3	0.0	0.1
Medication: Amlodipine	0.4	0.5	2.3	1.5	0.5	-0.3	0.2	-0.2
Eye problems/disorders: None of the above	0.4	0.4	1.5	0.1	-1.2	0.7	-0.3	0.1
Emphysema/chronic bronchitis	0.4	0.5	1.4	-1.2	-0.7	0.2	0.7	0.0
Medication: Blood pressure	0.4	0.8	2.4	1.5	0.8	0.3	0.7	0.4
Medication: Omeprazole	0.4	0.5	1.6	1.3	-0.6	0.2	-0.5	-0.4
Had major operations	0.4	0.5	1.1	1.1	-0.5	0.5	-0.7	-0.5
Leg fat-free mass (right)	0.4	1.9	7.5	0.8	-2.7	-0.5	0.1	-1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	0.3	0.3	-0.6	-0.9	-1.0
Loneliness, isolation	0.4	0.5	1.8	0.0	1.4	0.7	0.4	0.1
Diabetes diagnosed by doctor	0.4	0.7	2.6	1.6	0.3	0.0	0.7	0.6
Leg predicted mass (right)	0.4	1.9	7.5	0.8	-2.7	-0.5	0.1	-1.1
High cholesterol (Self-reported)	0.4	0.6	1.4	0.5	0.3	0.7	1.0	1.2
Ever smoked	0.4	0.8	1.3	0.6	1.1	0.6	0.9	1.1
Diastolic blood pressure, automated reading	0.4	1.3	5.9	2.4	0.5	0.4	-0.2	0.4
Unable to work because of sickness or disability	0.4	0.5	1.1	-0.3	0.8	0.8	1.1	0.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.8	-0.6	-0.7	-1.3	-0.3	-0.8
Depression (Nagel 2018)	0.3	0.4	0.7	-0.9	0.9	-0.3	-0.5	0.5
Worry (Nagel 2018)	0.3	0.6	2.1	0.6	-0.2	-0.6	-1.5	0.4
Crohns Disease (2017)	0.3	0.6	2.1	0.5	0.8	0.1	1.4	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.7	0.8	-0.5	-0.5	-0.2
BMI	0.3	1.8	3.8	1.1	-1.9	-1.4	-1.0	-0.9
Hypothyroidism (self reported)	0.3	0.6	2.6	1.6	-0.1	0.1	-0.5	-0.2
Chronotype (morning person)	0.3	0.8	2.1	-1.3	0.2	-0.0	0.5	1.5
Systolic blood pressure, automated reading	0.3	0.9	3.2	0.8	1.8	-0.1	0.6	0.1
Leg fat-free mass (left)	0.3	1.8	7.2	1.1	-2.7	-0.3	0.4	-0.7
Leg predicted mass (left)	0.3	1.8	7.2	1.0	-2.7	-0.3	0.3	-0.7
Hearing difficulty/problems with background noise	0.3	0.5	1.6	1.2	-0.8	0.1	0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.4	0.9	-0.3	1.2	-0.2	0.8
Financial difficulties in last 2 years	0.3	0.4	1.1	-0.4	1.0	0.6	0.5	-0.2
Impedance of arm (right)	0.3	1.3	5.7	-2.4	0.3	-0.2	-0.8	0.1
Happiness	0.3	0.4	0.9	-0.8	0.6	-0.9	0.1	0.2
Illnesses of mother	0.3	0.3	0.6	-0.2	-0.8	0.7	0.2	0.5
Tense / ‘highly strung’	0.3	0.4	0.8	-0.6	-0.4	-0.9	-0.9	0.4
Headache pain in last month	0.3	0.5	1.1	-1.0	-0.5	0.4	0.5	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.5	-1.2	-0.1	0.8	0.4	0.6
Glaucoma (self-reported)	0.3	0.4	1.4	0.6	0.1	0.3	1.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.0	1.4	-0.5	0.0	-0.4	-0.3
Birth weight	0.3	0.7	1.7	1.3	-0.2	0.4	1.1	0.7
Arm fat-free mass (right)	0.3	1.4	4.0	2.0	-1.4	0.4	0.8	0.3
Medication for pain relief, constipation, heartburn	0.3	0.6	1.6	-1.3	0.9	0.6	0.0	0.2
Angina (self-reported)	0.3	0.4	1.1	1.1	-0.1	0.7	0.6	0.2
Arm predicted mass (right)	0.3	1.5	4.0	2.0	-1.7	0.2	0.8	0.1
Number of full sisters	0.3	0.4	0.9	0.6	1.0	0.2	0.3	0.6
Overall health rating	0.3	0.7	1.6	-0.8	-0.2	-1.3	-0.9	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.5	0.2	0.4	0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.0	0.5	0.7	1.4	0.7	0.3
Long-standing illness, disability or infirmity	0.3	0.5	1.2	-0.1	0.2	-1.0	-0.5	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.1	-1.1	0.1	-0.3	0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	0.3	-0.6	-0.7	-0.9	-1.1
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	-1.2	-0.9	-0.4	-0.6	-0.3
Miserableness	0.3	0.6	1.1	-1.0	-0.4	-0.8	-0.8	-0.7
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.4	0.8	0.2	0.6	0.6
Mother’s age at death	0.3	0.4	1.7	-0.3	1.3	-0.2	-0.3	0.5
Medication: Blood pressure	0.3	0.5	1.1	0.4	-0.8	-0.7	-1.1	-0.1
Medication: Lisinopril	0.3	0.4	0.9	0.9	-0.5	-0.3	0.2	0.8
Basal metabolic rate	0.3	1.5	5.3	1.4	-2.3	-0.2	0.3	-0.6
Arm fat-free mass (left)	0.3	1.4	3.9	1.6	-2.0	0.0	0.5	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.7	-1.9	-0.0	-0.1	-0.3	-0.7
Neuroticism (Nagel 2018)	0.2	0.5	1.1	0.5	1.0	0.1	-0.1	1.0
Ulcerative Colitis (UC)	0.2	0.3	1.1	-0.2	1.0	-0.7	0.0	0.4
Breast Cancer	0.2	0.6	2.0	-1.4	-0.5	-0.8	-0.2	-0.4
Primary Biliary Cirrhosis	0.2	0.2	0.9	0.0	0.3	-0.3	-0.9	-0.3
Ulcerative Colitis	0.2	0.3	0.8	0.2	0.5	-0.1	0.5	0.9
Waist Hip Ratio (WHR)	0.2	0.7	1.5	-0.2	-0.9	1.2	0.2	1.0
Lung FEV1/FVC ratio	0.2	1.1	2.3	0.9	1.5	-0.1	-0.4	1.5
Hand grip strength (left)	0.2	0.5	1.0	0.9	1.0	0.7	0.3	0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	-0.4	-0.5	-0.5	0.3	-0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.6	0.4	-0.3	0.6	-0.3
Impedance of leg (right)	0.2	0.8	1.7	-0.5	1.3	0.3	-0.7	1.2
Hand grip strength (right)	0.2	0.5	2.4	1.5	0.6	0.2	0.0	-0.1
Fed-up feelings	0.2	0.3	0.8	-0.3	0.9	0.4	0.4	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.1	1.0	-0.7	1.0	-0.1	0.2
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.5	-0.7	-0.5	-0.5	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	1.0	0.4	-1.0	0.2	0.1	0.0
Number of incorrect matches in round	0.2	0.3	0.6	-0.6	-0.8	-0.3	-0.1	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.1	-0.6	0.4	1.0	0.2
Medication: Ramipril	0.2	0.2	0.7	0.8	0.1	0.5	-0.0	-0.4
Father’s age at death	0.2	0.2	0.4	0.6	0.2	0.2	0.4	0.7
Lung cancer (father)	0.2	0.2	0.5	-0.6	0.5	0.1	-0.1	-0.7
Impedance of arm (left)	0.2	0.9	3.2	-1.8	0.1	-0.2	-1.1	0.3
Medication: Paracetamol	0.2	0.3	0.7	-0.0	-0.7	-0.8	-0.2	-0.4
Worry too long after embarrassment	0.2	0.4	1.2	0.6	0.5	1.1	0.2	0.2
Number of children fathered	0.2	0.2	0.5	0.4	0.4	-0.1	0.4	0.7
Neck or shoulder pain in last month	0.2	0.2	0.4	-0.3	0.6	-0.5	0.5	0.2
Mean time to correctly identify matches	0.2	0.4	1.4	1.2	0.1	-0.4	-0.8	0.2
Comparative height size at age 10	0.2	1.1	2.0	1.4	-0.1	1.2	1.3	0.6
Chest pain or discomfort	0.2	0.2	0.6	-0.4	-0.6	0.3	0.1	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	0.6	0.2	0.3	0.9	-0.0
Knee pain experienced in last month	0.2	0.3	0.4	0.5	-0.6	-0.5	0.6	-0.6
Hypertension (Self-reported)	0.2	0.6	1.6	1.3	0.4	-0.1	0.6	0.8
Smoking status: Previous	0.2	0.3	0.7	-0.1	0.8	0.3	0.5	0.8
Whole body fat-free mass	0.2	1.2	3.6	1.4	-1.9	-0.1	0.5	-0.6
Mood swings	0.2	0.4	1.2	-1.1	0.7	-0.4	-0.3	-0.2
Ever had bowel cancer screening	0.2	0.2	0.4	-0.6	-0.4	-0.5	0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.9	0.3	-1.0	0.0	0.4	0.1
Medication for cholesterol	0.2	0.3	1.0	0.0	-0.0	0.8	1.0	0.1
Medication: Aspirin	0.2	0.2	0.3	0.6	-0.6	0.1	-0.5	-0.3
Whole body water mass	0.2	1.3	4.0	1.4	-2.0	-0.1	0.4	-0.6
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.7	0.1	0.5	0.5	-0.3
Medication: Paracetamol	0.2	0.4	0.8	-0.4	-0.9	-0.8	-0.0	-0.4
Number of operations (self-reported)	0.2	0.3	0.6	0.1	0.3	-0.8	-0.6	-0.7
Average weekly beer plus cider intake	0.2	0.4	0.9	0.9	-0.3	-0.3	-0.6	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.2	-0.6	-0.7	-0.4	-0.3
Impedance of whole body	0.2	0.9	2.2	-1.5	0.5	0.0	-1.2	0.8
Arm predicted mass (left)	0.2	1.2	3.6	1.5	-1.9	-0.0	0.5	-0.2
Bipolar Disorder (2018)	0.1	0.1	0.2	0.5	-0.0	0.2	0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	-0.4	-1.1	-0.7	-0.2	-0.0
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.5	-0.1	-0.1	-0.4	-0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.4	0.6	-0.2	0.8	0.3
Neuroticism (2016)	0.1	0.2	0.4	-0.6	-0.4	0.3	0.0	-0.6
Blood Platelet Count	0.1	1.3	2.2	1.0	1.1	1.5	1.4	0.5
Blood Red Count	0.1	1.0	2.4	0.4	-1.5	-0.5	-1.3	-0.6
Heel T-Score	0.1	0.8	2.1	-0.1	1.4	-0.5	-0.7	1.1
Height	0.1	1.4	1.8	1.4	-0.8	1.3	1.1	1.3
Systolic Blood Pressure	0.1	0.4	1.8	0.5	1.3	-0.2	0.1	0.1
Cardiovascular Disease	0.1	0.2	0.4	-0.6	-0.5	-0.4	-0.7	0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	0.8	0.2	-0.4	-0.4	-0.1
Lung FVC	0.1	0.7	1.8	-0.3	1.4	0.5	1.0	0.6
Neuroticism	0.1	0.2	0.5	0.2	0.6	0.0	-0.7	0.3
Number of treatments/medications taken	0.1	0.2	0.7	0.6	-0.8	0.0	0.3	-0.1
Relative age voice broke	0.1	0.1	0.4	0.4	-0.6	-0.2	-0.1	-0.1
Sitting height	0.1	0.9	1.8	1.3	-0.1	0.8	0.8	1.2
Impedance of leg (left)	0.1	0.7	1.2	-0.7	1.0	0.1	-1.1	0.9
Past tobacco smoking	0.1	0.2	0.5	-0.3	-0.7	-0.1	-0.2	-0.5
Neuroticism score	0.1	0.2	0.6	-0.1	0.8	0.0	-0.4	0.6
Trunk fat-free mass	0.1	0.9	2.2	1.5	-1.2	0.2	0.8	-0.3
Time employed in main current job	0.1	0.2	0.3	-0.5	0.0	0.5	0.3	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.7	0.6	-0.1	0.5	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	-0.7	-0.3	0.2	-0.5	-0.1
Medication: Cholesterol lowering	0.1	0.2	0.4	0.6	-0.4	-0.3	0.2	-0.5
Trunk predicted mass	0.1	0.9	2.1	1.5	-1.2	0.1	0.7	-0.4
Standing height	0.1	0.9	2.8	0.7	-1.7	0.9	0.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	-0.3	0.1	1.0	0.0	-0.0
Pulse wave reflection index	0.1	0.2	0.4	0.5	-0.3	-0.4	-0.6	0.3
Leg pain on walking	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.4	-0.4
Medication: Aspirin	0.1	0.1	0.3	0.5	-0.6	0.1	-0.1	-0.0
Back pain experienced in last month	0.1	0.2	0.5	-0.3	-0.0	0.7	0.5	-0.2
Commuting to job workplace: Public transport	0.1	0.2	0.6	0.8	-0.2	0.4	0.1	-0.2
Risk taking	0.1	0.1	0.1	0.3	-0.4	-0.3	0.2	0.1
Pain experienced in last month	0.1	0.1	0.3	-0.6	-0.2	-0.1	-0.4	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.0	0.1	0.1	0.1	0.2	0.1	-0.4
Tanning	0.0	0.4	1.3	0.1	1.1	-0.8	-0.1	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.4	-0.4	-0.3	0.6	0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	-0.6	-0.0	0.4	-0.5	0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.4	-0.3	0.3	-0.4	0.1

Hub : Genes

JMJD5

Models

Trait associations