Best TWAS P=7.44e-18 · Best GWAS P=1.3e-20 conditioned to 8.27e-09
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Muscle Skeletal | AC009052.12 | 0.16 | 0.00 | lasso | 1 | 0.00 | 9.2e-01 | -7.3 | 7.3 | 3.9e-13 | -0.06 | 0.05 | 0.03 | TRUE |
2 | GTEx | Thyroid | AC009052.12 | 0.18 | 0.01 | enet | 35 | 0.02 | 1.1e-02 | 9.3 | 8.6 | 7.4e-18 | 0.49 | 0.00 | 0.97 | TRUE |
3 | GTEx | Whole Blood | NLRC5 | 0.18 | 0.09 | enet | 17 | 0.12 | 6.9e-11 | 5.7 | 5.9 | 4.5e-09 | 0.15 | 1.00 | 0.00 | TRUE |
4 | YFS | Blood | ZNF319 | 0.10 | 0.13 | lasso | 3 | 0.12 | 1.6e-38 | 5.5 | -5.6 | 2.6e-08 | 0.03 | 0.01 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TEPP | 0.06 | 0.02 | blup | 55 | 0.06 | 8.3e-06 | 5.4 | -5.7 | 1.2e-08 | 0.01 | 0.01 | 0.97 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCL17 | 0.03 | 0.00 | enet | 9 | 0.01 | 7.4e-03 | -7.9 | -6.4 | 1.5e-10 | -0.04 | 0.00 | 0.85 | TRUE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCL17 | 0.06 | 0.03 | enet | 7 | 0.03 | 1.9e-04 | -2.9 | -6.3 | 2.7e-10 | -0.01 | 0.07 | 0.57 | TRUE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TEPP | 0.03 | 0.02 | blup | 55 | 0.02 | 1.0e-03 | 4.6 | -6.0 | 1.4e-09 | 0.06 | 0.02 | 0.63 | TRUE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TEPP | 0.08 | 0.00 | blup | 55 | 0.02 | 5.6e-02 | 5.4 | -5.6 | 2.4e-08 | 0.05 | 0.01 | 0.70 | FALSE |
10 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CX3CL1 | 0.07 | 0.02 | enet | 8 | 0.04 | 1.9e-03 | -2.6 | -6.2 | 5.6e-10 | -0.04 | 0.01 | 0.48 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | C16orf57 | 0.13 | 0.14 | enet | 2 | 0.14 | 1.1e-13 | 5.5 | -5.5 | 2.8e-08 | 0.03 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | TEPP | 0.13 | 0.21 | lasso | 3 | 0.22 | 7.5e-21 | 5.5 | -5.6 | 2.6e-08 | 0.03 | 0.00 | 1.00 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF319 | 0.13 | 0.20 | lasso | 2 | 0.20 | 5.7e-19 | 5.5 | -5.5 | 2.9e-08 | 0.03 | 0.01 | 0.99 | FALSE |