Hub : Genes

ZNF319

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Thyroid 0.1320 0.0480 1.2e-03 0.029 NA 0.042 NA 0.030 2.6e-03 NA 3.6e-04 NA 2.1e-03
2 YFS Blood 0.0990 0.0175 0.0e+00 0.126 0.091 0.116 0.121 0.124 3.8e-39 2.6e-28 9.0e-36 1.5e-37 1.6e-38
3 TCGA Prostate Adenocarcinoma 0.0336 0.0191 1.1e-03 0.038 0.035 0.029 NA 0.028 7.1e-05 1.3e-04 4.9e-04 NA 6.1e-04
4 TCGA Thyroid Carcinoma 0.1340 0.0480 1.6e-14 0.196 0.152 0.190 NA 0.198 9.5e-19 1.3e-14 3.4e-18 NA 5.7e-19

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.9 3.0 3.7 1.5 1.8 -1.9 1.7
Bipolar Disorder or Schizophrenia 0.4 0.9 1.2 0.7 1.1 -1.0 1.0
Depressed Affect (Nagel 2018) 0.4 0.9 1.2 -0.5 -1.0 1.0 -1.1
Depression (Nagel 2018) 0.7 1.1 1.4 0.9 -1.2 0.9 -1.2
Intelligence (Savage-Jansen 2018) 0.6 2.0 4.4 -0.9 -1.1 2.1 -1.2
Neuroticism (Nagel 2018) 0.3 0.7 1.9 1.4 0.6 -0.6 0.5
Schizophrenia (2018) 0.0 0.0 0.1 -0.3 -0.0 0.3 -0.1
Schizophrenia vs Biploar Disorder 2.7 3.6 4.7 -1.4 -2.0 2.2 -1.9
Worry (Nagel 2018) 1.4 2.9 4.6 2.1 1.6 -1.6 1.4
Alzheimer’s Disease (in mother) 0.2 0.3 0.7 0.6 0.0 -0.8 0.1
Alzheimer’s Disease (in father) 0.2 0.2 0.7 0.1 0.2 -0.8 0.3
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 -0.2 -0.4 -0.3 -0.3
Crohns Disease (2017) 0.1 0.2 0.4 0.6 0.4 -0.4 0.4
Irritable Bowel Disease (IBD) 0.1 0.3 0.6 0.3 -0.7 0.3 -0.7
Ulcerative Colitis (UC) 0.4 0.7 1.3 0.2 -1.0 0.5 -1.1
Major Depression (MDD) 2.3 2.8 3.1 -1.8 -1.6 1.7 -1.7
Reaction Time 0.7 1.4 2.3 1.5 -1.0 1.0 -1.2
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 -0.1 0.5 0.1 0.5
Breast Cancer 0.1 0.2 0.7 0.8 -0.2 0.4 -0.2
Ovarian Cancer 0.2 0.2 0.6 0.8 0.2 -0.5 0.3
Prostate Cancer 1.4 2.0 5.0 2.2 0.9 -1.0 1.0
Age at First Birth 1.3 1.9 3.3 1.8 1.3 -0.9 1.3
Bipolar Disorder (2011) 1.6 1.6 3.9 1.6 2.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.4 -0.7 -0.1 -0.2 -0.0
Coronary Artery Disease (CAD) 0.5 0.6 1.2 0.5 0.8 -1.1 0.6
Crohns Disease (2012) 1.2 2.0 2.7 1.0 1.5 -1.6 1.5
Mean Putamen Volume 0.2 0.2 0.4 -0.4 0.3 -0.6 0.3
Fasting Glucose 0.4 0.5 1.8 1.4 0.0 0.3 0.3
HbA1C 0.1 0.1 0.1 0.0 0.2 -0.3 0.3
HDL Cholesterol 0.7 1.2 2.1 0.0 1.1 -1.5 1.2
LDL Cholesterol 0.4 0.6 1.0 1.0 0.4 -0.9 0.5
Lupus 2.1 3.2 4.2 -1.4 -1.8 2.0 -1.8
Neuroticism (2016) 0.9 1.4 2.2 1.5 1.2 -0.8 1.1
Primary Biliary Cirrhosis 0.2 0.3 1.1 -1.1 -0.2 -0.0 -0.2
Rheumatoid Arthritis 0.3 0.4 0.7 -0.0 0.6 -0.8 0.7
Schizophrenia (2014) 0.0 0.1 0.2 0.1 0.4 -0.3 0.4
Triglycerides 0.3 0.5 1.1 -0.3 0.6 -1.0 0.7
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.3 -0.1 0.6 -0.4 0.6
Ulcerative Colitis 0.5 0.7 1.3 -0.3 -1.2 0.5 -1.1
Blood Eosinophil Count 3.4 26.0 30.9 -5.1 -5.6 4.1 -5.5
Blood Platelet Count 0.9 10.4 11.4 -3.1 -3.2 3.4 -3.2
Blood Red Count 0.1 0.6 0.8 -0.8 -0.9 0.6 -0.9
Blood White Count 0.1 0.5 0.7 -0.7 0.9 -0.6 0.7
Heel T-Score 0.7 5.7 6.4 2.3 2.5 -2.3 2.5
BMI 0.3 1.6 4.1 -2.0 -1.0 0.6 -1.0
Height 0.2 4.0 6.9 2.6 1.8 -1.6 1.8
Waist Hip Ratio (WHR) 0.6 2.7 3.9 -2.0 -1.5 1.7 -1.3
Systolic Blood Pressure 0.2 0.8 3.0 -1.7 0.0 -0.1 -0.1
Smoking Status 0.8 2.0 2.8 0.9 1.4 -1.7 1.6
Allergy or Eczema 0.2 0.6 1.1 -0.5 -1.1 0.4 -0.9
Cardiovascular Disease 0.0 0.2 0.2 -0.5 0.4 -0.3 0.4
Hypothyroidism (self reported) 0.0 0.0 0.0 -0.2 0.1 -0.2 0.2
Respiratory disease 2.3 5.1 6.6 -1.5 -2.5 2.3 -2.6
Type 2 Diabetes (T2D) (2018) 0.7 1.3 3.8 2.0 0.8 -0.2 0.8
Lung FEV1/FVC ratio 19.8 100.2 119.4 10.9 10.1 -9.1 9.8
Lung FVC 0.8 3.8 6.9 -2.6 -1.5 2.1 -1.4
Neuroticism 0.1 0.1 0.4 0.6 -0.1 -0.2 -0.2
Chronotype (morning person) 0.8 1.9 2.8 -1.7 -1.3 1.3 -1.2
Hair Pigment 0.0 0.1 0.2 0.4 0.0 0.0 -0.0
Tanning 0.0 0.3 0.9 1.0 0.3 0.3 0.2
Hand grip strength (left) 0.5 1.2 1.6 1.3 1.1 -0.7 1.2
Number of treatments/medications taken 0.6 1.1 1.5 -1.0 -1.2 0.8 -1.2
Average weekly spirits intake 1.7 2.1 2.4 -1.5 -1.4 1.5 -1.3
Sensitivity / hurt feelings 0.1 0.1 0.2 0.1 -0.3 0.4 -0.3
Frequency of depressed mood in last 2 weeks 0.6 0.8 0.9 0.8 -1.0 0.9 -0.9
Hearing difficulty/problems: Yes 0.6 0.9 1.0 1.0 1.0 -0.9 1.0
Relative age of first facial hair 0.6 1.3 2.0 -0.4 -1.4 1.2 -1.3
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 0.6 -0.2 0.0 -0.3
Ever used hormone-replacement therapy (HRT) 1.2 1.5 2.0 0.4 1.4 -1.4 1.4
Ever had hysterectomy (womb removed) 0.7 0.7 1.4 0.2 0.9 -1.2 0.8
Systolic blood pressure, automated reading 0.1 0.2 0.7 -0.8 -0.2 -0.0 -0.3
Eye problems/disorders: Diabetes related eye disease 3.3 3.7 5.6 -0.3 -2.1 2.4 -2.1
Angina 2.9 3.8 4.3 -2.1 -2.0 1.7 -2.0
Medication for hormone replacement therapy 2.0 2.2 3.0 -0.3 1.6 -1.7 1.7
Vitamin and mineral supplements 0.9 1.2 1.7 0.8 1.1 -1.3 1.1
Supplements: Zinc 0.3 0.3 0.5 0.0 0.5 -0.7 0.6
Medication: Co-codamol 0.1 0.1 0.1 -0.0 -0.2 0.3 -0.3
Medication: Metformin 0.2 0.2 0.8 -0.3 -0.2 0.9 -0.2
Diabetes (father) 0.2 0.3 0.8 0.9 0.2 -0.4 0.2
Diabetes (mother) 0.9 1.1 1.7 -0.9 -0.9 1.3 -1.0
Severe depression (siblings) 0.2 0.2 0.3 -0.5 -0.3 0.6 -0.3
Pack years adult smoking proportion 0.5 0.8 1.5 0.5 1.2 -0.2 1.2
Impedance of leg (right) 0.2 1.0 1.7 -1.3 -1.0 0.6 -0.9
Leg fat-free mass (left) 0.2 1.3 1.7 1.0 1.1 -1.3 1.0
Trunk fat percentage 0.7 2.9 6.2 -2.5 -1.5 0.8 -1.6
Hand grip strength (right) 0.9 2.6 2.9 1.4 1.6 -1.7 1.7
Townsend deprivation index at recruitment 2.0 2.8 3.5 -1.3 -1.7 1.9 -1.8
Current tobacco smoking 0.0 0.0 0.1 0.1 0.0 0.2 0.0
Average weekly fortified wine intake 0.5 0.6 1.1 1.1 0.8 -0.5 0.7
Maternal smoking around birth 0.6 0.9 1.8 -0.9 0.8 -1.3 0.7
Fed-up feelings 0.3 0.6 1.5 -0.0 -0.7 1.2 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.8 0.9 0.2 -0.1 0.2
Relative age voice broke 1.1 1.7 2.5 -0.2 -1.6 1.3 -1.6
Taking other prescription medications 1.3 2.0 3.5 -0.7 -1.9 0.9 -1.8
Age when periods started (menarche) 1.7 4.2 5.5 -2.3 -2.1 1.4 -2.2
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 2.8 1.2 1.7 -1.6 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.5 -0.7 -0.0 0.2 -0.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 0.9 0.7 -0.3 0.6
Qualifications: CSEs or equivalent 3.9 5.1 5.8 -2.4 -2.4 1.8 -2.4
Serious illness, injury or assault to yourself 0.2 0.2 0.7 -0.0 -0.3 0.8 -0.2
High blood pressure 0.1 0.4 1.3 -1.1 -0.4 -0.1 -0.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.4 -0.5 -1.2 0.9 -1.1
Multivitamins +/- minerals 1.5 1.9 2.0 -1.3 -1.4 1.4 -1.4
Stomach or abdominal pain in last month 0.6 0.7 1.5 0.5 -0.7 1.2 -0.8
Supplements: Glucosamine 1.9 2.5 3.5 -1.9 -1.4 1.6 -1.4
Diverticular disease/diverticulitis (self-reported) 2.3 2.8 3.4 -1.5 -1.7 1.9 -1.6
Medication: Atenolol 0.0 0.0 0.1 -0.4 -0.1 0.0 -0.0
Medication: Levothyroxine sodium 0.9 1.6 3.3 -0.1 1.3 -1.8 1.2
Sitting height 0.1 0.4 1.1 1.0 0.3 -0.6 0.3
Chronic bronchitis/emphysema (father) 4.8 5.6 8.6 -2.9 -2.4 1.7 -2.3
High blood pressure (mother) 0.4 0.6 1.0 1.0 0.8 -0.3 0.9
Body mass index (BMI) 0.0 0.1 0.5 -0.7 -0.1 0.2 -0.1
Impedance of leg (left) 0.1 0.3 0.6 -0.8 -0.5 0.3 -0.4
Leg predicted mass (left) 0.2 1.2 1.7 1.0 1.1 -1.3 1.0
Trunk fat mass 0.2 1.0 2.5 -1.6 -0.9 0.2 -0.9
Waist circumference 0.0 0.1 0.5 -0.7 -0.2 0.1 -0.1
Number of incorrect matches in round 0.0 0.1 0.1 0.4 -0.2 -0.2 -0.2
Past tobacco smoking 1.9 3.4 6.5 -0.8 -1.8 2.5 -1.9
Alcohol usually taken with meals 0.3 0.5 0.8 0.6 0.8 -0.4 0.9
Nervous feelings 0.2 0.5 0.8 0.9 0.5 -0.7 0.5
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 3.9 2.0 0.8 -0.8 0.9
Hearing difficulty/problems with background noise 0.5 0.8 1.1 0.8 0.8 -1.1 0.8
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 -0.2 -0.3 0.3 -0.2
Had menopause 0.4 0.4 1.2 1.1 0.5 -0.3 0.5
Had other major operations 3.1 3.8 4.5 1.5 2.0 -2.1 2.1
Forced vital capacity (FVC) 0.1 0.3 1.1 -1.0 0.2 0.4 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.0 -1.0 -0.4 0.9 -0.5
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 1.5 1.2 0.9 -0.8 0.9
Qualifications: None of the above 0.2 0.4 1.2 -1.1 0.0 0.5 0.0
Financial difficulties in last 2 years 1.0 1.3 2.1 0.1 -1.2 1.4 -1.2
Mouth/teeth dental problems 0.5 0.7 1.6 0.2 0.8 -1.2 0.8
Heart attack 0.2 0.3 0.5 -0.7 -0.5 0.2 -0.6
Allergy 1.2 2.8 3.5 1.0 1.9 -1.9 1.8
Pain all over the body in last month 0.1 0.1 0.2 -0.2 -0.4 0.3 -0.3
Diabetes (self-reported) 0.2 0.4 1.0 1.0 0.5 0.1 0.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 1.7 -0.6 -1.3 0.9 -1.2
Medication: Ramipril 0.6 0.7 2.5 -1.6 -0.4 0.0 -0.5
Medication: Simvastatin 0.0 0.1 0.2 0.2 -0.2 0.4 -0.2
Fluid intelligence score 0.1 0.2 0.4 -0.4 0.2 -0.6 0.3
Illnesses of siblings 0.3 0.4 0.8 -0.5 -0.6 0.9 -0.4
Neuroticism score 0.1 0.2 0.6 0.8 0.2 -0.2 0.1
Weight 0.0 0.1 0.3 0.1 0.4 -0.5 0.4
Impedance of arm (right) 0.7 3.1 4.5 -2.1 -1.8 1.1 -1.9
Arm fat percentage (right) 0.5 2.1 4.0 -2.0 -1.3 1.1 -1.3
Trunk fat-free mass 0.8 4.4 6.4 2.5 2.0 -1.8 2.0
Hip circumference 0.2 0.8 1.1 0.6 1.0 -1.1 1.0
Time employed in main current job 0.0 0.0 0.1 0.4 -0.1 -0.1 -0.2
Alcohol intake versus 10 years previously 0.1 0.2 0.3 -0.1 0.4 0.4 0.5
Father’s age at death 0.6 0.8 1.0 0.6 1.0 -1.0 0.9
Worrier / anxious feelings 0.1 0.3 1.0 1.0 -0.1 -0.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 3.0 -0.0 -1.6 1.7 -1.5
Falls in the last year 1.8 2.4 2.8 -1.3 -1.7 1.6 -1.6
Hair/balding pattern: Pattern 3 0.9 1.3 3.3 -1.8 -0.6 1.1 -0.6
Number of live births 1.1 1.6 2.3 -1.5 -1.1 1.2 -1.1
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 5.3 1.6 2.3 -1.5 2.3
Pulse rate 0.4 0.7 1.2 0.7 1.0 -0.5 1.1
Happiness 0.4 0.5 1.9 1.4 0.2 -0.1 0.2
Noisy workplace 1.1 1.4 3.9 2.0 0.8 -0.6 0.8
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.2 1.5 0.5 -0.9 0.5
Serious illness, injury or assault of a close relative in last 2 years 7.4 8.6 10.0 2.3 3.2 -3.0 3.2
Mouth/teeth dental problems: Dentures 0.7 1.3 3.6 -0.6 -0.7 1.9 -0.7
Asthma 0.8 1.6 2.5 -0.6 -1.4 1.6 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 -0.3 0.1 -0.6 0.2
Medication: Cholesterol lowering 0.4 0.6 0.7 -0.7 -0.8 0.7 -0.8
Depression (self-reported) 0.0 0.0 0.1 0.3 -0.2 -0.1 -0.1
Medication: Lansoprazole 0.0 0.1 0.1 0.2 0.3 0.1 0.3
Prospective memory result 1.1 1.3 3.2 1.8 0.7 -1.2 0.6
Lung cancer (father) 1.3 1.5 2.6 -1.6 -1.2 0.8 -1.2
Illnesses of mother 1.2 1.5 2.3 -0.5 -1.3 1.5 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.2 8.2 1.6 2.9 -2.5 2.8
Pulse wave Arterial Stiffness index 0.5 0.5 1.5 -1.2 0.3 -0.7 0.2
Impedance of arm (left) 0.8 3.8 6.4 -2.5 -2.0 1.0 -2.0
Arm fat mass (right) 0.1 0.4 0.9 -1.0 -0.5 0.2 -0.5
Trunk predicted mass 0.8 4.3 6.4 2.5 2.0 -1.8 2.0
Standing height 0.3 2.6 3.6 1.9 1.4 -1.8 1.3
Length of working week for main job 0.1 0.1 0.2 -0.4 0.1 -0.4 0.1
Exposure to tobacco smoke at home 0.7 0.8 1.4 -0.8 -0.8 1.2 -0.8
Breastfed as a baby 0.2 0.3 0.6 -0.1 -0.8 0.2 -0.8
Tense / ‘highly strung’ 1.7 2.8 3.4 1.5 1.8 -1.6 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.6 0.2 -0.8 0.8 -0.8
Hair/balding pattern: Pattern 4 0.8 1.9 3.0 1.7 1.3 -1.0 1.3
Birth weight of first child 1.0 1.9 2.4 -1.2 -1.6 1.1 -1.5
Peak expiratory flow (PEF) 1.9 4.5 6.4 1.4 2.5 -1.8 2.5
Pulse wave reflection index 0.2 0.2 0.9 -0.9 -0.1 0.0 -0.2
Ever highly irritable/argumentative for 2 days 0.4 0.5 0.6 0.8 0.7 -0.6 0.8
Loud music exposure frequency 0.1 0.1 0.1 0.4 0.2 0.3 0.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.2 1.1 -0.3 -0.4 -0.3
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.4 -0.1 -1.2 1.5 -1.2
Blood clot in the leg (DVT) 0.0 0.1 0.2 -0.5 -0.1 0.1 -0.1
Medication: Paracetamol 1.8 3.0 3.6 -1.6 -1.7 1.9 -1.7
Headache pain in last month 0.3 0.6 2.0 1.4 0.4 0.2 0.4
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 1.2 0.7 -0.4 0.7
Glaucoma (self-reported) 0.1 0.1 0.4 0.7 -0.2 -0.2 -0.2
Gout (self-reported) 0.7 0.9 1.8 -1.3 -0.8 0.7 -0.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.3 0.2 0.8 -1.1 0.8
Medication: Amlodipine 0.5 0.7 1.0 -1.0 -1.0 0.3 -1.0
Medication: Ventolin 100micrograms inhaler 5.7 7.3 9.6 -1.7 -3.1 2.7 -3.0
Birth weight 3.0 6.4 8.3 -2.1 -2.8 2.2 -2.9
Chronic bronchitis/emphysema (mother) 1.1 1.3 1.7 0.5 1.3 -1.3 1.3
High blood pressure (siblings) 0.8 1.1 2.1 0.6 1.1 -1.5 1.0
Forced vital capacity (FVC), Best measure 0.1 0.5 0.9 -0.9 0.6 -0.4 0.6
Body fat percentage 0.6 2.5 5.6 -2.4 -1.4 0.9 -1.4
Leg fat percentage (right) 0.6 2.3 3.7 -1.9 -1.5 1.1 -1.5
Arm fat-free mass (right) 0.5 2.5 3.2 1.8 1.5 -1.4 1.6
Exposure to tobacco smoke outside home 2.2 2.9 4.1 1.0 1.8 -2.0 1.8
Comparative body size at age 10 0.2 0.7 1.0 0.4 -1.0 0.7 -1.0
Number of full brothers 1.1 1.4 1.7 -1.0 -1.2 1.3 -1.1
Worry too long after embarrassment 0.3 0.6 1.4 1.2 0.5 -0.6 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.7 0.8 -0.3 0.1 -0.3
Wheeze or whistling in the chest in last year 0.5 0.8 1.1 -0.6 -1.0 1.0 -1.0
Number of children fathered 0.0 0.0 0.0 0.2 0.1 0.0 0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 3.1 0.5 1.2 -1.8 1.3
Age at first live birth 3.7 6.5 7.1 2.3 2.7 -2.6 2.6
Pulse wave peak to peak time 0.5 0.5 1.8 1.3 -0.2 0.5 -0.1
Health satisfaction 0.4 0.5 1.8 1.3 0.1 0.5 0.1
Shortness of breath walking on level ground 0.7 0.8 1.1 -0.6 -1.0 0.9 -1.0
Qualifications: College or University degree 0.5 1.5 2.9 1.7 1.1 -0.8 1.1
Eye problems/disorders: None of the above 0.8 1.0 1.4 0.3 1.1 -1.2 1.1
Mouth/teeth dental problems: Loose teeth 1.5 1.8 2.3 -1.1 -1.3 1.5 -1.4
Emphysema/chronic bronchitis 2.5 2.8 4.2 -0.7 -2.0 1.6 -1.9
Medication for pain relief, constipation, heartburn 1.3 2.2 3.0 1.7 1.6 -0.7 1.6
Neck or shoulder pain in last month 0.0 0.1 0.2 0.4 -0.1 0.1 -0.1
Medication: Blood pressure 0.1 0.2 0.6 -0.8 0.1 -0.3 0.2
Angina (self-reported) 2.9 3.8 4.6 -2.1 -2.0 1.7 -2.0
Migraine (self-reported) 0.0 0.0 0.1 0.3 0.1 -0.2 0.1
Medication: Ibuprofen 0.0 0.0 0.1 -0.4 -0.2 -0.0 -0.1
Medication: Allopurinol 0.1 0.2 0.6 -0.8 -0.1 0.2 -0.1
Medication: Omeprazole 4.0 4.7 5.4 -2.0 -2.3 2.1 -2.3
Medication: Seretide 50 evohaler 0.6 0.7 1.1 -0.6 -1.1 0.6 -1.0
Mean time to correctly identify matches 0.5 0.9 2.6 1.6 -0.5 0.5 -0.7
Heart disease (mother) 0.1 0.1 0.3 0.6 0.1 -0.1 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.1 0.3 0.0 0.2 0.1
Whole body fat mass 0.2 0.8 2.2 -1.5 -0.7 0.2 -0.7
Leg fat mass (right) 0.1 0.4 1.1 -1.0 -0.5 0.2 -0.5
Arm predicted mass (right) 0.6 3.1 3.8 1.9 1.7 -1.6 1.7
Pulse rate, automated reading 0.1 0.2 0.6 0.8 -0.1 0.3 0.0
Alcohol intake frequency. 0.3 0.8 2.0 0.1 -0.7 1.4 -0.7
Comparative height size at age 10 0.4 2.1 2.5 1.2 1.6 -1.5 1.6
Number of full sisters 1.7 2.1 3.5 -1.9 -1.5 0.6 -1.5
Suffer from ‘nerves’ 0.5 0.8 3.2 1.8 0.3 0.2 0.2
Overall health rating 0.9 1.9 2.4 -1.1 -1.5 1.2 -1.5
Chest pain or discomfort 2.4 3.4 4.8 -0.9 -2.1 2.2 -2.0
Had major operations 1.2 1.4 2.1 -1.2 -1.5 0.5 -1.4
Age at last live birth 3.4 5.0 5.8 1.7 2.4 -2.4 2.4
Family relationship satisfaction 0.9 1.1 3.6 1.9 0.5 -0.3 0.6
Leg pain on walking 0.1 0.1 0.3 -0.5 0.2 -0.6 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.7 0.4 -1.1 1.6 -1.1
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 -0.0 0.4 0.0 0.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.8 -1.3 -0.8 0.4 -0.9
Medication: Aspirin 1.5 1.9 2.5 -1.6 -1.5 0.8 -1.6
Supplements: Vitamin C 0.5 0.6 0.7 -0.6 -0.8 0.7 -0.9
Knee pain experienced in last month 0.1 0.2 0.5 -0.7 -0.4 0.4 -0.3
Hypertension (Self-reported) 0.1 0.3 0.9 -1.0 -0.1 -0.4 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.4 0.1 0.3 0.2
Illnesses of father: Heart disease 0.0 0.1 0.1 0.3 0.0 -0.3 0.1
Illnesses of siblings: Diabetes 1.4 1.7 2.2 1.5 1.4 -0.9 1.4
Smoking status: Previous 1.6 2.4 4.0 0.7 1.5 -2.0 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.1 -0.3 0.5 -1.1 0.5
Whole body fat-free mass 0.6 3.2 4.0 2.0 1.7 -1.7 1.7
Leg fat-free mass (right) 0.3 1.7 1.9 1.4 1.3 -1.4 1.2
Arm fat percentage (left) 0.6 2.4 4.6 -2.1 -1.4 1.0 -1.4
Average weekly red wine intake 0.2 0.4 0.5 -0.3 0.7 -0.6 0.7
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 0.4 -0.4 0.6 -0.4
Mood swings 0.5 0.9 1.7 -0.4 -0.9 1.3 -0.9
Loneliness, isolation 0.6 0.9 1.3 0.3 -1.0 1.1 -1.1
Long-standing illness, disability or infirmity 0.3 0.5 0.8 -0.3 -0.9 0.5 -0.9
Ever had bowel cancer screening 1.1 1.3 2.1 0.0 -1.2 1.4 -1.2
Diabetes diagnosed by doctor 0.3 0.4 1.0 1.0 0.6 0.1 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 -0.5 0.3 -0.1 0.4
Friendships satisfaction 0.7 0.9 2.8 1.7 0.5 -0.3 0.5
Qualifications: nursing, teaching 1.3 2.1 2.4 1.4 1.4 -1.5 1.4
Commuting to job workplace: Walk 1.0 1.1 2.9 1.7 0.7 -0.3 0.9
Eye problems/disorders: Cataract 0.4 0.4 0.6 -0.5 -0.7 0.7 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.1 0.1 -0.3 0.3 -0.3
Medication for cholesterol 1.4 2.1 3.1 -0.7 -1.5 1.8 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.1 -0.1 0.3 0.3 0.1
Back pain experienced in last month 0.2 0.3 0.7 0.8 0.1 0.7 0.0
Mineral and other dietary supplements 0.1 0.1 0.2 -0.1 -0.4 0.2 -0.5
Breast cancer (self-reported) 0.2 0.2 0.4 0.4 -0.3 0.6 -0.4
Asthma (self-reported) 0.4 0.9 1.5 -0.6 -0.9 1.2 -0.9
Osteoporosis (self-reported) 0.0 0.1 0.2 -0.4 -0.2 -0.1 -0.2
Osteoarthritis (self-reported) 0.4 0.6 0.7 0.9 0.7 -0.8 0.6
Medication: Aspirin 1.4 1.8 2.5 -1.5 -1.5 0.6 -1.6
Medication: Gliclazide 2.5 2.9 4.8 2.2 1.6 -1.3 1.6
Illnesses of father: None of the above (group 1) 1.0 1.2 1.6 1.2 1.2 -0.6 1.3
Smoking status: Current 0.1 0.2 0.2 0.3 0.4 -0.3 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.7 -0.3 -0.1 0.8 -0.1
Whole body water mass 0.6 3.3 4.2 2.1 1.8 -1.7 1.7
Leg predicted mass (right) 0.3 1.6 2.0 1.3 1.2 -1.4 1.2
Arm fat mass (left) 0.1 0.3 1.0 -1.0 -0.3 0.1 -0.4
Number of self-reported non-cancer illnesses 0.7 1.3 1.8 -0.9 -1.3 0.8 -1.3
Average weekly champagne plus white wine intake 0.5 0.8 1.6 -0.1 0.8 -1.3 0.8
Miserableness 0.1 0.2 0.3 -0.2 -0.6 0.3 -0.5
Guilty feelings 0.4 0.6 1.6 0.4 0.6 -1.3 0.5
Wears glasses or contact lenses 0.1 0.1 0.2 -0.5 -0.2 -0.1 -0.3
Ever taken oral contraceptive pill 1.1 1.3 2.8 -0.6 -1.0 1.7 -1.0
Hearing aid user 1.1 1.2 2.4 -1.6 -1.1 -0.5 -1.1
Mother’s age at death 4.6 5.8 6.8 1.9 2.5 -2.6 2.6
Financial situation satisfaction 0.2 0.3 1.0 1.0 0.1 -0.1 0.0
Tinnitus: Yes, now most or all of the time 0.7 0.9 1.2 -1.0 -1.1 0.4 -1.1
Commuting to job workplace: Public transport 0.7 0.9 2.3 0.4 0.8 -1.5 0.7
Eye problems/disorders: Glaucoma 0.1 0.2 0.4 0.1 0.3 -0.6 0.4
Medication: Blood pressure 0.0 0.1 0.1 -0.3 -0.2 0.2 -0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.8 -0.5 0.8 -0.9 0.8
Supplements: Fish oil (including cod liver oil) 1.3 1.6 2.3 0.9 1.5 -1.1 1.5
High cholesterol (Self-reported) 0.3 0.5 0.6 0.7 0.8 -0.5 0.7
Medication: Bendroflumethiazide 0.8 1.3 2.3 -1.5 -0.9 1.0 -1.0
Medication: Paracetamol 2.5 3.9 5.6 -1.6 -1.9 2.4 -1.9
Medication: Lisinopril 0.8 1.0 1.7 0.4 1.3 -0.8 1.3
Medication: Atorvastatin 0.1 0.2 0.2 0.3 0.5 -0.4 0.4
Illnesses of father: High blood pressure 0.0 0.0 0.1 -0.2 0.0 -0.3 -0.1
Alcohol drinker status: Never 1.8 2.2 3.4 -0.6 -1.5 1.9 -1.6
Ever smoked 0.8 1.3 2.7 0.6 1.0 -1.6 1.1
Basal metabolic rate 0.3 1.9 2.2 1.5 1.4 -1.4 1.3
Leg fat percentage (left) 0.3 1.2 2.2 -1.5 -1.0 0.8 -1.0
Arm fat-free mass (left) 0.7 3.7 4.5 2.1 1.9 -1.7 1.9
Number of operations (self-reported) 1.1 1.7 3.2 1.0 1.1 -1.8 1.1
Average weekly beer plus cider intake 0.3 0.4 1.0 0.1 -0.5 1.0 -0.6
Irritability 0.3 0.5 1.3 1.1 0.4 0.1 0.7
Risk taking 0.2 0.3 0.5 0.5 0.7 -0.4 0.7
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.1 0.6 1.1 -1.4 1.1
Fractured/broken bones in last 5 years 1.0 1.3 2.1 0.6 1.4 -1.1 1.3
Age started oral contraceptive pill 1.8 2.2 3.6 1.9 1.2 -1.6 1.2
Diastolic blood pressure, automated reading 0.2 0.7 1.0 0.4 0.9 -1.0 0.9
Ever depressed for a whole week 0.0 0.0 0.0 0.1 -0.0 0.1 -0.0
Unable to work because of sickness or disability 0.7 0.9 2.1 0.5 -0.8 1.5 -0.7
Commuting to job workplace: Cycle 0.2 0.2 0.7 0.2 0.1 -0.8 0.1
Myopia 0.3 0.5 0.9 -0.0 -0.9 0.4 -1.0
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.6 1.3 0.6 -0.0 0.6
Cholesterol lowering medication 0.8 1.2 1.6 1.3 1.1 -1.0 1.0
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 1.7 -1.0 -1.3 1.3 -1.2
Pain experienced in last month 0.1 0.1 0.4 0.2 -0.0 -0.7 -0.1
Supplements: Calcium 0.1 0.1 0.2 0.3 0.3 -0.2 0.4
Basal cell carcinoma (self-reported) 0.3 0.4 1.3 -0.2 0.3 -1.1 0.2
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.0 -1.0 -0.8 0.4 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.6 -0.8 -0.2 0.2 -0.3
Heart disease (siblings) 0.6 0.8 1.0 0.8 0.9 -1.0 0.9
Alcohol drinker status: Previous 0.1 0.1 0.1 0.2 -0.4 0.0 -0.4
Pack years of smoking 0.4 0.6 1.0 0.4 1.0 -0.2 1.0
Impedance of whole body 0.4 2.0 4.2 -2.0 -1.3 0.7 -1.3
Leg fat mass (left) 0.0 0.1 0.4 -0.6 -0.1 -0.2 -0.1
Arm predicted mass (left) 0.7 3.5 4.2 2.0 1.9 -1.7 1.9