Hub : Genes

ZNF319

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.1320	0.0480	1.2e-03	0.029	NA	0.042	NA	0.030	2.6e-03	NA	3.6e-04	NA	2.1e-03
2	YFS	Blood	0.0990	0.0175	0.0e+00	0.126	0.091	0.116	0.121	0.124	3.8e-39	2.6e-28	9.0e-36	1.5e-37	1.6e-38
3	TCGA	Prostate Adenocarcinoma	0.0336	0.0191	1.1e-03	0.038	0.035	0.029	NA	0.028	7.1e-05	1.3e-04	4.9e-04	NA	6.1e-04
4	TCGA	Thyroid Carcinoma	0.1340	0.0480	1.6e-14	0.196	0.152	0.190	NA	0.198	9.5e-19	1.3e-14	3.4e-18	NA	5.7e-19

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.9	3.0	3.7	1.5	1.8	-1.9	1.7
Bipolar Disorder or Schizophrenia	0.4	0.9	1.2	0.7	1.1	-1.0	1.0
Depressed Affect (Nagel 2018)	0.4	0.9	1.2	-0.5	-1.0	1.0	-1.1
Depression (Nagel 2018)	0.7	1.1	1.4	0.9	-1.2	0.9	-1.2
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.4	-0.9	-1.1	2.1	-1.2
Neuroticism (Nagel 2018)	0.3	0.7	1.9	1.4	0.6	-0.6	0.5
Schizophrenia (2018)	0.0	0.0	0.1	-0.3	-0.0	0.3	-0.1
Schizophrenia vs Biploar Disorder	2.7	3.6	4.7	-1.4	-2.0	2.2	-1.9
Worry (Nagel 2018)	1.4	2.9	4.6	2.1	1.6	-1.6	1.4
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	0.6	0.0	-0.8	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.1	0.2	-0.8	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.3
Crohns Disease (2017)	0.1	0.2	0.4	0.6	0.4	-0.4	0.4
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	0.3	-0.7	0.3	-0.7
Ulcerative Colitis (UC)	0.4	0.7	1.3	0.2	-1.0	0.5	-1.1
Major Depression (MDD)	2.3	2.8	3.1	-1.8	-1.6	1.7	-1.7
Reaction Time	0.7	1.4	2.3	1.5	-1.0	1.0	-1.2
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.1	0.5	0.1	0.5
Breast Cancer	0.1	0.2	0.7	0.8	-0.2	0.4	-0.2
Ovarian Cancer	0.2	0.2	0.6	0.8	0.2	-0.5	0.3
Prostate Cancer	1.4	2.0	5.0	2.2	0.9	-1.0	1.0
Age at First Birth	1.3	1.9	3.3	1.8	1.3	-0.9	1.3
Bipolar Disorder (2011)	1.6	1.6	3.9	1.6	2.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	-0.7	-0.1	-0.2	-0.0
Coronary Artery Disease (CAD)	0.5	0.6	1.2	0.5	0.8	-1.1	0.6
Crohns Disease (2012)	1.2	2.0	2.7	1.0	1.5	-1.6	1.5
Mean Putamen Volume	0.2	0.2	0.4	-0.4	0.3	-0.6	0.3
Fasting Glucose	0.4	0.5	1.8	1.4	0.0	0.3	0.3
HbA1C	0.1	0.1	0.1	0.0	0.2	-0.3	0.3
HDL Cholesterol	0.7	1.2	2.1	0.0	1.1	-1.5	1.2
LDL Cholesterol	0.4	0.6	1.0	1.0	0.4	-0.9	0.5
Lupus	2.1	3.2	4.2	-1.4	-1.8	2.0	-1.8
Neuroticism (2016)	0.9	1.4	2.2	1.5	1.2	-0.8	1.1
Primary Biliary Cirrhosis	0.2	0.3	1.1	-1.1	-0.2	-0.0	-0.2
Rheumatoid Arthritis	0.3	0.4	0.7	-0.0	0.6	-0.8	0.7
Schizophrenia (2014)	0.0	0.1	0.2	0.1	0.4	-0.3	0.4
Triglycerides	0.3	0.5	1.1	-0.3	0.6	-1.0	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	-0.1	0.6	-0.4	0.6
Ulcerative Colitis	0.5	0.7	1.3	-0.3	-1.2	0.5	-1.1
Blood Eosinophil Count	3.4	26.0	30.9	-5.1	-5.6	4.1	-5.5
Blood Platelet Count	0.9	10.4	11.4	-3.1	-3.2	3.4	-3.2
Blood Red Count	0.1	0.6	0.8	-0.8	-0.9	0.6	-0.9
Blood White Count	0.1	0.5	0.7	-0.7	0.9	-0.6	0.7
Heel T-Score	0.7	5.7	6.4	2.3	2.5	-2.3	2.5
BMI	0.3	1.6	4.1	-2.0	-1.0	0.6	-1.0
Height	0.2	4.0	6.9	2.6	1.8	-1.6	1.8
Waist Hip Ratio (WHR)	0.6	2.7	3.9	-2.0	-1.5	1.7	-1.3
Systolic Blood Pressure	0.2	0.8	3.0	-1.7	0.0	-0.1	-0.1
Smoking Status	0.8	2.0	2.8	0.9	1.4	-1.7	1.6
Allergy or Eczema	0.2	0.6	1.1	-0.5	-1.1	0.4	-0.9
Cardiovascular Disease	0.0	0.2	0.2	-0.5	0.4	-0.3	0.4
Hypothyroidism (self reported)	0.0	0.0	0.0	-0.2	0.1	-0.2	0.2
Respiratory disease	2.3	5.1	6.6	-1.5	-2.5	2.3	-2.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.8	2.0	0.8	-0.2	0.8
Lung FEV1/FVC ratio	19.8	100.2	119.4	10.9	10.1	-9.1	9.8
Lung FVC	0.8	3.8	6.9	-2.6	-1.5	2.1	-1.4
Neuroticism	0.1	0.1	0.4	0.6	-0.1	-0.2	-0.2
Chronotype (morning person)	0.8	1.9	2.8	-1.7	-1.3	1.3	-1.2
Hair Pigment	0.0	0.1	0.2	0.4	0.0	0.0	-0.0
Tanning	0.0	0.3	0.9	1.0	0.3	0.3	0.2
Hand grip strength (left)	0.5	1.2	1.6	1.3	1.1	-0.7	1.2
Number of treatments/medications taken	0.6	1.1	1.5	-1.0	-1.2	0.8	-1.2
Average weekly spirits intake	1.7	2.1	2.4	-1.5	-1.4	1.5	-1.3
Sensitivity / hurt feelings	0.1	0.1	0.2	0.1	-0.3	0.4	-0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	0.9	0.8	-1.0	0.9	-0.9
Hearing difficulty/problems: Yes	0.6	0.9	1.0	1.0	1.0	-0.9	1.0
Relative age of first facial hair	0.6	1.3	2.0	-0.4	-1.4	1.2	-1.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.6	-0.2	0.0	-0.3
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.0	0.4	1.4	-1.4	1.4
Ever had hysterectomy (womb removed)	0.7	0.7	1.4	0.2	0.9	-1.2	0.8
Systolic blood pressure, automated reading	0.1	0.2	0.7	-0.8	-0.2	-0.0	-0.3
Eye problems/disorders: Diabetes related eye disease	3.3	3.7	5.6	-0.3	-2.1	2.4	-2.1
Angina	2.9	3.8	4.3	-2.1	-2.0	1.7	-2.0
Medication for hormone replacement therapy	2.0	2.2	3.0	-0.3	1.6	-1.7	1.7
Vitamin and mineral supplements	0.9	1.2	1.7	0.8	1.1	-1.3	1.1
Supplements: Zinc	0.3	0.3	0.5	0.0	0.5	-0.7	0.6
Medication: Co-codamol	0.1	0.1	0.1	-0.0	-0.2	0.3	-0.3
Medication: Metformin	0.2	0.2	0.8	-0.3	-0.2	0.9	-0.2
Diabetes (father)	0.2	0.3	0.8	0.9	0.2	-0.4	0.2
Diabetes (mother)	0.9	1.1	1.7	-0.9	-0.9	1.3	-1.0
Severe depression (siblings)	0.2	0.2	0.3	-0.5	-0.3	0.6	-0.3
Pack years adult smoking proportion	0.5	0.8	1.5	0.5	1.2	-0.2	1.2
Impedance of leg (right)	0.2	1.0	1.7	-1.3	-1.0	0.6	-0.9
Leg fat-free mass (left)	0.2	1.3	1.7	1.0	1.1	-1.3	1.0
Trunk fat percentage	0.7	2.9	6.2	-2.5	-1.5	0.8	-1.6
Hand grip strength (right)	0.9	2.6	2.9	1.4	1.6	-1.7	1.7
Townsend deprivation index at recruitment	2.0	2.8	3.5	-1.3	-1.7	1.9	-1.8
Current tobacco smoking	0.0	0.0	0.1	0.1	0.0	0.2	0.0
Average weekly fortified wine intake	0.5	0.6	1.1	1.1	0.8	-0.5	0.7
Maternal smoking around birth	0.6	0.9	1.8	-0.9	0.8	-1.3	0.7
Fed-up feelings	0.3	0.6	1.5	-0.0	-0.7	1.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.8	0.9	0.2	-0.1	0.2
Relative age voice broke	1.1	1.7	2.5	-0.2	-1.6	1.3	-1.6
Taking other prescription medications	1.3	2.0	3.5	-0.7	-1.9	0.9	-1.8
Age when periods started (menarche)	1.7	4.2	5.5	-2.3	-2.1	1.4	-2.2
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	2.8	1.2	1.7	-1.6	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.7	-0.0	0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.9	0.7	-0.3	0.6
Qualifications: CSEs or equivalent	3.9	5.1	5.8	-2.4	-2.4	1.8	-2.4
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.0	-0.3	0.8	-0.2
High blood pressure	0.1	0.4	1.3	-1.1	-0.4	-0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.4	-0.5	-1.2	0.9	-1.1
Multivitamins +/- minerals	1.5	1.9	2.0	-1.3	-1.4	1.4	-1.4
Stomach or abdominal pain in last month	0.6	0.7	1.5	0.5	-0.7	1.2	-0.8
Supplements: Glucosamine	1.9	2.5	3.5	-1.9	-1.4	1.6	-1.4
Diverticular disease/diverticulitis (self-reported)	2.3	2.8	3.4	-1.5	-1.7	1.9	-1.6
Medication: Atenolol	0.0	0.0	0.1	-0.4	-0.1	0.0	-0.0
Medication: Levothyroxine sodium	0.9	1.6	3.3	-0.1	1.3	-1.8	1.2
Sitting height	0.1	0.4	1.1	1.0	0.3	-0.6	0.3
Chronic bronchitis/emphysema (father)	4.8	5.6	8.6	-2.9	-2.4	1.7	-2.3
High blood pressure (mother)	0.4	0.6	1.0	1.0	0.8	-0.3	0.9
Body mass index (BMI)	0.0	0.1	0.5	-0.7	-0.1	0.2	-0.1
Impedance of leg (left)	0.1	0.3	0.6	-0.8	-0.5	0.3	-0.4
Leg predicted mass (left)	0.2	1.2	1.7	1.0	1.1	-1.3	1.0
Trunk fat mass	0.2	1.0	2.5	-1.6	-0.9	0.2	-0.9
Waist circumference	0.0	0.1	0.5	-0.7	-0.2	0.1	-0.1
Number of incorrect matches in round	0.0	0.1	0.1	0.4	-0.2	-0.2	-0.2
Past tobacco smoking	1.9	3.4	6.5	-0.8	-1.8	2.5	-1.9
Alcohol usually taken with meals	0.3	0.5	0.8	0.6	0.8	-0.4	0.9
Nervous feelings	0.2	0.5	0.8	0.9	0.5	-0.7	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.9	2.0	0.8	-0.8	0.9
Hearing difficulty/problems with background noise	0.5	0.8	1.1	0.8	0.8	-1.1	0.8
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.2
Had menopause	0.4	0.4	1.2	1.1	0.5	-0.3	0.5
Had other major operations	3.1	3.8	4.5	1.5	2.0	-2.1	2.1
Forced vital capacity (FVC)	0.1	0.3	1.1	-1.0	0.2	0.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	-1.0	-0.4	0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.5	1.2	0.9	-0.8	0.9
Qualifications: None of the above	0.2	0.4	1.2	-1.1	0.0	0.5	0.0
Financial difficulties in last 2 years	1.0	1.3	2.1	0.1	-1.2	1.4	-1.2
Mouth/teeth dental problems	0.5	0.7	1.6	0.2	0.8	-1.2	0.8
Heart attack	0.2	0.3	0.5	-0.7	-0.5	0.2	-0.6
Allergy	1.2	2.8	3.5	1.0	1.9	-1.9	1.8
Pain all over the body in last month	0.1	0.1	0.2	-0.2	-0.4	0.3	-0.3
Diabetes (self-reported)	0.2	0.4	1.0	1.0	0.5	0.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.7	-0.6	-1.3	0.9	-1.2
Medication: Ramipril	0.6	0.7	2.5	-1.6	-0.4	0.0	-0.5
Medication: Simvastatin	0.0	0.1	0.2	0.2	-0.2	0.4	-0.2
Fluid intelligence score	0.1	0.2	0.4	-0.4	0.2	-0.6	0.3
Illnesses of siblings	0.3	0.4	0.8	-0.5	-0.6	0.9	-0.4
Neuroticism score	0.1	0.2	0.6	0.8	0.2	-0.2	0.1
Weight	0.0	0.1	0.3	0.1	0.4	-0.5	0.4
Impedance of arm (right)	0.7	3.1	4.5	-2.1	-1.8	1.1	-1.9
Arm fat percentage (right)	0.5	2.1	4.0	-2.0	-1.3	1.1	-1.3
Trunk fat-free mass	0.8	4.4	6.4	2.5	2.0	-1.8	2.0
Hip circumference	0.2	0.8	1.1	0.6	1.0	-1.1	1.0
Time employed in main current job	0.0	0.0	0.1	0.4	-0.1	-0.1	-0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.1	0.4	0.4	0.5
Father’s age at death	0.6	0.8	1.0	0.6	1.0	-1.0	0.9
Worrier / anxious feelings	0.1	0.3	1.0	1.0	-0.1	-0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.0	-0.0	-1.6	1.7	-1.5
Falls in the last year	1.8	2.4	2.8	-1.3	-1.7	1.6	-1.6
Hair/balding pattern: Pattern 3	0.9	1.3	3.3	-1.8	-0.6	1.1	-0.6
Number of live births	1.1	1.6	2.3	-1.5	-1.1	1.2	-1.1
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	5.3	1.6	2.3	-1.5	2.3
Pulse rate	0.4	0.7	1.2	0.7	1.0	-0.5	1.1
Happiness	0.4	0.5	1.9	1.4	0.2	-0.1	0.2
Noisy workplace	1.1	1.4	3.9	2.0	0.8	-0.6	0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.2	1.5	0.5	-0.9	0.5
Serious illness, injury or assault of a close relative in last 2 years	7.4	8.6	10.0	2.3	3.2	-3.0	3.2
Mouth/teeth dental problems: Dentures	0.7	1.3	3.6	-0.6	-0.7	1.9	-0.7
Asthma	0.8	1.6	2.5	-0.6	-1.4	1.6	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.3	0.1	-0.6	0.2
Medication: Cholesterol lowering	0.4	0.6	0.7	-0.7	-0.8	0.7	-0.8
Depression (self-reported)	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.1
Medication: Lansoprazole	0.0	0.1	0.1	0.2	0.3	0.1	0.3
Prospective memory result	1.1	1.3	3.2	1.8	0.7	-1.2	0.6
Lung cancer (father)	1.3	1.5	2.6	-1.6	-1.2	0.8	-1.2
Illnesses of mother	1.2	1.5	2.3	-0.5	-1.3	1.5	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.2	8.2	1.6	2.9	-2.5	2.8
Pulse wave Arterial Stiffness index	0.5	0.5	1.5	-1.2	0.3	-0.7	0.2
Impedance of arm (left)	0.8	3.8	6.4	-2.5	-2.0	1.0	-2.0
Arm fat mass (right)	0.1	0.4	0.9	-1.0	-0.5	0.2	-0.5
Trunk predicted mass	0.8	4.3	6.4	2.5	2.0	-1.8	2.0
Standing height	0.3	2.6	3.6	1.9	1.4	-1.8	1.3
Length of working week for main job	0.1	0.1	0.2	-0.4	0.1	-0.4	0.1
Exposure to tobacco smoke at home	0.7	0.8	1.4	-0.8	-0.8	1.2	-0.8
Breastfed as a baby	0.2	0.3	0.6	-0.1	-0.8	0.2	-0.8
Tense / ‘highly strung’	1.7	2.8	3.4	1.5	1.8	-1.6	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.6	0.2	-0.8	0.8	-0.8
Hair/balding pattern: Pattern 4	0.8	1.9	3.0	1.7	1.3	-1.0	1.3
Birth weight of first child	1.0	1.9	2.4	-1.2	-1.6	1.1	-1.5
Peak expiratory flow (PEF)	1.9	4.5	6.4	1.4	2.5	-1.8	2.5
Pulse wave reflection index	0.2	0.2	0.9	-0.9	-0.1	0.0	-0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.6	0.8	0.7	-0.6	0.8
Loud music exposure frequency	0.1	0.1	0.1	0.4	0.2	0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.2	1.1	-0.3	-0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.4	-0.1	-1.2	1.5	-1.2
Blood clot in the leg (DVT)	0.0	0.1	0.2	-0.5	-0.1	0.1	-0.1
Medication: Paracetamol	1.8	3.0	3.6	-1.6	-1.7	1.9	-1.7
Headache pain in last month	0.3	0.6	2.0	1.4	0.4	0.2	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	1.2	0.7	-0.4	0.7
Glaucoma (self-reported)	0.1	0.1	0.4	0.7	-0.2	-0.2	-0.2
Gout (self-reported)	0.7	0.9	1.8	-1.3	-0.8	0.7	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.3	0.2	0.8	-1.1	0.8
Medication: Amlodipine	0.5	0.7	1.0	-1.0	-1.0	0.3	-1.0
Medication: Ventolin 100micrograms inhaler	5.7	7.3	9.6	-1.7	-3.1	2.7	-3.0
Birth weight	3.0	6.4	8.3	-2.1	-2.8	2.2	-2.9
Chronic bronchitis/emphysema (mother)	1.1	1.3	1.7	0.5	1.3	-1.3	1.3
High blood pressure (siblings)	0.8	1.1	2.1	0.6	1.1	-1.5	1.0
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	-0.9	0.6	-0.4	0.6
Body fat percentage	0.6	2.5	5.6	-2.4	-1.4	0.9	-1.4
Leg fat percentage (right)	0.6	2.3	3.7	-1.9	-1.5	1.1	-1.5
Arm fat-free mass (right)	0.5	2.5	3.2	1.8	1.5	-1.4	1.6
Exposure to tobacco smoke outside home	2.2	2.9	4.1	1.0	1.8	-2.0	1.8
Comparative body size at age 10	0.2	0.7	1.0	0.4	-1.0	0.7	-1.0
Number of full brothers	1.1	1.4	1.7	-1.0	-1.2	1.3	-1.1
Worry too long after embarrassment	0.3	0.6	1.4	1.2	0.5	-0.6	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	0.8	-0.3	0.1	-0.3
Wheeze or whistling in the chest in last year	0.5	0.8	1.1	-0.6	-1.0	1.0	-1.0
Number of children fathered	0.0	0.0	0.0	0.2	0.1	0.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.1	0.5	1.2	-1.8	1.3
Age at first live birth	3.7	6.5	7.1	2.3	2.7	-2.6	2.6
Pulse wave peak to peak time	0.5	0.5	1.8	1.3	-0.2	0.5	-0.1
Health satisfaction	0.4	0.5	1.8	1.3	0.1	0.5	0.1
Shortness of breath walking on level ground	0.7	0.8	1.1	-0.6	-1.0	0.9	-1.0
Qualifications: College or University degree	0.5	1.5	2.9	1.7	1.1	-0.8	1.1
Eye problems/disorders: None of the above	0.8	1.0	1.4	0.3	1.1	-1.2	1.1
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.3	-1.1	-1.3	1.5	-1.4
Emphysema/chronic bronchitis	2.5	2.8	4.2	-0.7	-2.0	1.6	-1.9
Medication for pain relief, constipation, heartburn	1.3	2.2	3.0	1.7	1.6	-0.7	1.6
Neck or shoulder pain in last month	0.0	0.1	0.2	0.4	-0.1	0.1	-0.1
Medication: Blood pressure	0.1	0.2	0.6	-0.8	0.1	-0.3	0.2
Angina (self-reported)	2.9	3.8	4.6	-2.1	-2.0	1.7	-2.0
Migraine (self-reported)	0.0	0.0	0.1	0.3	0.1	-0.2	0.1
Medication: Ibuprofen	0.0	0.0	0.1	-0.4	-0.2	-0.0	-0.1
Medication: Allopurinol	0.1	0.2	0.6	-0.8	-0.1	0.2	-0.1
Medication: Omeprazole	4.0	4.7	5.4	-2.0	-2.3	2.1	-2.3
Medication: Seretide 50 evohaler	0.6	0.7	1.1	-0.6	-1.1	0.6	-1.0
Mean time to correctly identify matches	0.5	0.9	2.6	1.6	-0.5	0.5	-0.7
Heart disease (mother)	0.1	0.1	0.3	0.6	0.1	-0.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.3	0.0	0.2	0.1
Whole body fat mass	0.2	0.8	2.2	-1.5	-0.7	0.2	-0.7
Leg fat mass (right)	0.1	0.4	1.1	-1.0	-0.5	0.2	-0.5
Arm predicted mass (right)	0.6	3.1	3.8	1.9	1.7	-1.6	1.7
Pulse rate, automated reading	0.1	0.2	0.6	0.8	-0.1	0.3	0.0
Alcohol intake frequency.	0.3	0.8	2.0	0.1	-0.7	1.4	-0.7
Comparative height size at age 10	0.4	2.1	2.5	1.2	1.6	-1.5	1.6
Number of full sisters	1.7	2.1	3.5	-1.9	-1.5	0.6	-1.5
Suffer from ‘nerves’	0.5	0.8	3.2	1.8	0.3	0.2	0.2
Overall health rating	0.9	1.9	2.4	-1.1	-1.5	1.2	-1.5
Chest pain or discomfort	2.4	3.4	4.8	-0.9	-2.1	2.2	-2.0
Had major operations	1.2	1.4	2.1	-1.2	-1.5	0.5	-1.4
Age at last live birth	3.4	5.0	5.8	1.7	2.4	-2.4	2.4
Family relationship satisfaction	0.9	1.1	3.6	1.9	0.5	-0.3	0.6
Leg pain on walking	0.1	0.1	0.3	-0.5	0.2	-0.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.7	0.4	-1.1	1.6	-1.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.0	0.4	0.0	0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.8	-1.3	-0.8	0.4	-0.9
Medication: Aspirin	1.5	1.9	2.5	-1.6	-1.5	0.8	-1.6
Supplements: Vitamin C	0.5	0.6	0.7	-0.6	-0.8	0.7	-0.9
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	-0.4	0.4	-0.3
Hypertension (Self-reported)	0.1	0.3	0.9	-1.0	-0.1	-0.4	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.4	0.1	0.3	0.2
Illnesses of father: Heart disease	0.0	0.1	0.1	0.3	0.0	-0.3	0.1
Illnesses of siblings: Diabetes	1.4	1.7	2.2	1.5	1.4	-0.9	1.4
Smoking status: Previous	1.6	2.4	4.0	0.7	1.5	-2.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	-0.3	0.5	-1.1	0.5
Whole body fat-free mass	0.6	3.2	4.0	2.0	1.7	-1.7	1.7
Leg fat-free mass (right)	0.3	1.7	1.9	1.4	1.3	-1.4	1.2
Arm fat percentage (left)	0.6	2.4	4.6	-2.1	-1.4	1.0	-1.4
Average weekly red wine intake	0.2	0.4	0.5	-0.3	0.7	-0.6	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.4	-0.4	0.6	-0.4
Mood swings	0.5	0.9	1.7	-0.4	-0.9	1.3	-0.9
Loneliness, isolation	0.6	0.9	1.3	0.3	-1.0	1.1	-1.1
Long-standing illness, disability or infirmity	0.3	0.5	0.8	-0.3	-0.9	0.5	-0.9
Ever had bowel cancer screening	1.1	1.3	2.1	0.0	-1.2	1.4	-1.2
Diabetes diagnosed by doctor	0.3	0.4	1.0	1.0	0.6	0.1	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.5	0.3	-0.1	0.4
Friendships satisfaction	0.7	0.9	2.8	1.7	0.5	-0.3	0.5
Qualifications: nursing, teaching	1.3	2.1	2.4	1.4	1.4	-1.5	1.4
Commuting to job workplace: Walk	1.0	1.1	2.9	1.7	0.7	-0.3	0.9
Eye problems/disorders: Cataract	0.4	0.4	0.6	-0.5	-0.7	0.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.1	0.1	-0.3	0.3	-0.3
Medication for cholesterol	1.4	2.1	3.1	-0.7	-1.5	1.8	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.1	0.3	0.3	0.1
Back pain experienced in last month	0.2	0.3	0.7	0.8	0.1	0.7	0.0
Mineral and other dietary supplements	0.1	0.1	0.2	-0.1	-0.4	0.2	-0.5
Breast cancer (self-reported)	0.2	0.2	0.4	0.4	-0.3	0.6	-0.4
Asthma (self-reported)	0.4	0.9	1.5	-0.6	-0.9	1.2	-0.9
Osteoporosis (self-reported)	0.0	0.1	0.2	-0.4	-0.2	-0.1	-0.2
Osteoarthritis (self-reported)	0.4	0.6	0.7	0.9	0.7	-0.8	0.6
Medication: Aspirin	1.4	1.8	2.5	-1.5	-1.5	0.6	-1.6
Medication: Gliclazide	2.5	2.9	4.8	2.2	1.6	-1.3	1.6
Illnesses of father: None of the above (group 1)	1.0	1.2	1.6	1.2	1.2	-0.6	1.3
Smoking status: Current	0.1	0.2	0.2	0.3	0.4	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.3	-0.1	0.8	-0.1
Whole body water mass	0.6	3.3	4.2	2.1	1.8	-1.7	1.7
Leg predicted mass (right)	0.3	1.6	2.0	1.3	1.2	-1.4	1.2
Arm fat mass (left)	0.1	0.3	1.0	-1.0	-0.3	0.1	-0.4
Number of self-reported non-cancer illnesses	0.7	1.3	1.8	-0.9	-1.3	0.8	-1.3
Average weekly champagne plus white wine intake	0.5	0.8	1.6	-0.1	0.8	-1.3	0.8
Miserableness	0.1	0.2	0.3	-0.2	-0.6	0.3	-0.5
Guilty feelings	0.4	0.6	1.6	0.4	0.6	-1.3	0.5
Wears glasses or contact lenses	0.1	0.1	0.2	-0.5	-0.2	-0.1	-0.3
Ever taken oral contraceptive pill	1.1	1.3	2.8	-0.6	-1.0	1.7	-1.0
Hearing aid user	1.1	1.2	2.4	-1.6	-1.1	-0.5	-1.1
Mother’s age at death	4.6	5.8	6.8	1.9	2.5	-2.6	2.6
Financial situation satisfaction	0.2	0.3	1.0	1.0	0.1	-0.1	0.0
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.2	-1.0	-1.1	0.4	-1.1
Commuting to job workplace: Public transport	0.7	0.9	2.3	0.4	0.8	-1.5	0.7
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	0.1	0.3	-0.6	0.4
Medication: Blood pressure	0.0	0.1	0.1	-0.3	-0.2	0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.8	-0.5	0.8	-0.9	0.8
Supplements: Fish oil (including cod liver oil)	1.3	1.6	2.3	0.9	1.5	-1.1	1.5
High cholesterol (Self-reported)	0.3	0.5	0.6	0.7	0.8	-0.5	0.7
Medication: Bendroflumethiazide	0.8	1.3	2.3	-1.5	-0.9	1.0	-1.0
Medication: Paracetamol	2.5	3.9	5.6	-1.6	-1.9	2.4	-1.9
Medication: Lisinopril	0.8	1.0	1.7	0.4	1.3	-0.8	1.3
Medication: Atorvastatin	0.1	0.2	0.2	0.3	0.5	-0.4	0.4
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.2	0.0	-0.3	-0.1
Alcohol drinker status: Never	1.8	2.2	3.4	-0.6	-1.5	1.9	-1.6
Ever smoked	0.8	1.3	2.7	0.6	1.0	-1.6	1.1
Basal metabolic rate	0.3	1.9	2.2	1.5	1.4	-1.4	1.3
Leg fat percentage (left)	0.3	1.2	2.2	-1.5	-1.0	0.8	-1.0
Arm fat-free mass (left)	0.7	3.7	4.5	2.1	1.9	-1.7	1.9
Number of operations (self-reported)	1.1	1.7	3.2	1.0	1.1	-1.8	1.1
Average weekly beer plus cider intake	0.3	0.4	1.0	0.1	-0.5	1.0	-0.6
Irritability	0.3	0.5	1.3	1.1	0.4	0.1	0.7
Risk taking	0.2	0.3	0.5	0.5	0.7	-0.4	0.7
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.1	0.6	1.1	-1.4	1.1
Fractured/broken bones in last 5 years	1.0	1.3	2.1	0.6	1.4	-1.1	1.3
Age started oral contraceptive pill	1.8	2.2	3.6	1.9	1.2	-1.6	1.2
Diastolic blood pressure, automated reading	0.2	0.7	1.0	0.4	0.9	-1.0	0.9
Ever depressed for a whole week	0.0	0.0	0.0	0.1	-0.0	0.1	-0.0
Unable to work because of sickness or disability	0.7	0.9	2.1	0.5	-0.8	1.5	-0.7
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.2	0.1	-0.8	0.1
Myopia	0.3	0.5	0.9	-0.0	-0.9	0.4	-1.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	1.3	0.6	-0.0	0.6
Cholesterol lowering medication	0.8	1.2	1.6	1.3	1.1	-1.0	1.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	1.7	-1.0	-1.3	1.3	-1.2
Pain experienced in last month	0.1	0.1	0.4	0.2	-0.0	-0.7	-0.1
Supplements: Calcium	0.1	0.1	0.2	0.3	0.3	-0.2	0.4
Basal cell carcinoma (self-reported)	0.3	0.4	1.3	-0.2	0.3	-1.1	0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	-1.0	-0.8	0.4	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.6	-0.8	-0.2	0.2	-0.3
Heart disease (siblings)	0.6	0.8	1.0	0.8	0.9	-1.0	0.9
Alcohol drinker status: Previous	0.1	0.1	0.1	0.2	-0.4	0.0	-0.4
Pack years of smoking	0.4	0.6	1.0	0.4	1.0	-0.2	1.0
Impedance of whole body	0.4	2.0	4.2	-2.0	-1.3	0.7	-1.3
Leg fat mass (left)	0.0	0.1	0.4	-0.6	-0.1	-0.2	-0.1
Arm predicted mass (left)	0.7	3.5	4.2	2.0	1.9	-1.7	1.9