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chr16:66,269,895-70,669,292

Best TWAS P=1.9e-30 · Best GWAS P=1.49e-27 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CDH1	0.08	0.09	lasso	6	0.09	8.9e-11	-7.51	-7.5	5.6e-14	0.67	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CDH3	0.07	0.04	blup	326	0.04	1.7e-05	-9.62	-10.1	8.6e-24	0.30	0.53	0.06	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NFATC3	0.05	0.02	blup	307	0.02	6.1e-04	5.24	-6.0	2.1e-09	0.05	0.83	0.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TPPP3	0.04	0.03	blup	222	0.03	2.0e-04	3.01	-6.7	3.0e-11	0.02	0.28	0.34	FALSE
5	CommonMind	Brain Pre-frontal Cortex	ZFP90	0.07	0.05	bslmm	315	0.05	3.3e-07	-10.87	-10.8	2.7e-27	0.81	0.01	0.99	FALSE
6	GTEx	Adipose Subcutaneous	SLC12A4	0.05	0.01	lasso	4	0.03	2.7e-03	4.32	6.3	2.7e-10	-0.01	0.32	0.03	FALSE
7	GTEx	Adipose Visceral Omentum	NFATC3	0.07	0.02	enet	13	0.01	1.4e-01	4.73	5.5	4.5e-08	-0.22	0.13	0.08	FALSE
8	GTEx	Adipose Visceral Omentum	C16orf86	0.10	0.00	enet	20	0.00	1.7e-01	-3.16	6.5	8.6e-11	-0.03	0.10	0.05	FALSE
9	GTEx	Artery Aorta	PLA2G15	0.11	0.03	lasso	7	0.07	1.4e-04	5.25	-7.3	1.9e-13	0.07	0.39	0.02	FALSE
10	GTEx	Artery Aorta	RANBP10	0.11	0.01	enet	11	0.04	2.0e-03	5.96	6.4	1.4e-10	0.00	0.12	0.04	FALSE
11	GTEx	Artery Tibial	NFATC3	0.13	0.15	enet	20	0.16	1.2e-12	4.72	5.8	6.6e-09	-0.24	1.00	0.00	FALSE
12	GTEx	Artery Tibial	CIRH1A	0.13	0.08	enet	22	0.08	6.1e-07	-2.23	7.4	1.0e-13	-0.32	0.85	0.08	FALSE
13	GTEx	Brain Caudate basal ganglia	PRMT7	0.33	0.29	lasso	8	0.23	3.4e-07	-5.25	-5.3	1.3e-07	0.27	0.89	0.01	FALSE
14	GTEx	Brain Caudate basal ganglia	ZFP90	0.11	0.06	enet	36	0.05	1.5e-02	-6.94	-9.2	5.2e-20	0.68	0.05	0.57	TRUE
15	GTEx	Brain Cerebellar Hemisphere	PRMT7	0.17	0.08	lasso	3	0.14	1.9e-04	-5.25	-7.5	8.9e-14	0.26	0.15	0.06	FALSE
16	GTEx	Brain Cerebellar Hemisphere	KIAA0895L	0.36	0.14	lasso	9	0.14	2.5e-04	6.78	6.2	7.2e-10	0.03	0.13	0.67	FALSE
17	GTEx	Brain Cerebellum	PRMT7	0.37	0.16	enet	25	0.23	2.2e-07	4.72	-9.2	3.3e-20	0.34	0.53	0.06	FALSE
18	GTEx	Brain Cerebellum	PSMB10	0.11	0.03	lasso	4	0.05	1.6e-02	5.24	-6.5	1.1e-10	0.19	0.05	0.52	FALSE
19	GTEx	Brain Cortex	ZFP90	0.20	0.09	lasso	4	0.13	2.3e-04	-10.64	-9.0	2.8e-19	0.90	0.04	0.89	TRUE
20	GTEx	Brain Frontal Cortex BA9	DUS2	0.17	0.19	lasso	3	0.16	4.7e-05	-5.10	-5.4	6.4e-08	0.21	0.38	0.04	FALSE
21	GTEx	Brain Hypothalamus	ZFP90	0.17	0.13	lasso	7	0.09	5.0e-03	-10.67	-10.1	3.8e-24	0.99	0.02	0.92	FALSE
22	GTEx	Cells Transformed fibroblasts	ELMO3	0.16	0.11	enet	9	0.09	1.4e-07	6.79	7.0	2.8e-12	-0.01	0.16	0.84	FALSE
23	GTEx	Cells Transformed fibroblasts	SLC12A4	0.09	0.04	enet	26	0.06	1.3e-05	5.24	5.2	2.1e-07	-0.09	0.98	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	ZFP90	0.12	0.05	enet	7	0.04	2.7e-04	-10.64	-9.3	8.6e-21	0.92	0.05	0.94	FALSE
25	GTEx	Esophagus Mucosa	NFATC3	0.12	0.03	enet	25	0.05	1.6e-04	4.73	8.1	3.9e-16	-0.29	0.80	0.02	FALSE
26	GTEx	Esophagus Mucosa	SLC7A6	0.09	0.00	enet	12	0.00	1.4e-01	-4.89	10.3	4.4e-25	-0.60	0.05	0.66	FALSE
27	GTEx	Esophagus Muscularis	NFATC3	0.07	0.07	enet	12	0.02	1.7e-02	4.73	5.5	4.1e-08	-0.18	0.48	0.03	FALSE
28	GTEx	Heart Left Ventricle	PRMT7	0.13	0.08	enet	10	0.10	8.3e-06	4.35	5.8	6.5e-09	-0.06	0.86	0.01	FALSE
29	GTEx	Lung	NFATC3	0.04	0.01	lasso	4	0.01	4.1e-02	-7.68	7.9	2.1e-15	-0.25	0.31	0.04	FALSE
30	GTEx	Lung	LRRC29	0.06	0.02	enet	11	0.03	4.7e-03	3.74	-5.9	2.9e-09	-0.01	0.05	0.72	FALSE
31	GTEx	Lung	ZFP90	0.11	0.07	enet	21	0.06	2.4e-05	-10.87	7.9	2.1e-15	-0.76	0.01	0.99	FALSE
32	GTEx	Muscle Skeletal	CIRH1A	0.10	0.08	enet	17	0.07	1.1e-07	-2.49	5.1	2.9e-07	-0.21	0.99	0.00	TRUE
33	GTEx	Muscle Skeletal	ZFP90	0.07	0.06	lasso	10	0.04	4.6e-05	-10.87	10.5	5.6e-26	-1.00	0.01	0.99	FALSE
34	GTEx	Nerve Tibial	NFATC3	0.08	0.06	lasso	7	0.06	3.2e-05	-5.10	5.8	5.5e-09	-0.22	0.93	0.00	FALSE
35	GTEx	Pancreas	TPPP3	0.24	0.01	lasso	4	0.00	2.0e-01	5.94	5.5	3.1e-08	-0.02	0.08	0.08	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	FAM96B	0.08	0.01	lasso	7	0.00	2.4e-01	3.96	7.1	1.4e-12	-0.09	0.07	0.04	FALSE
37	GTEx	Skin Sun Exposed Lower leg	NFATC3	0.06	0.04	enet	9	0.05	6.6e-05	-8.11	8.5	1.8e-17	-0.31	0.34	0.04	FALSE
38	GTEx	Spleen	NFATC3	0.29	0.30	lasso	2	0.25	3.3e-07	-8.13	8.1	4.4e-16	-0.18	0.46	0.04	TRUE
39	GTEx	Spleen	PRMT7	0.27	0.29	lasso	2	0.27	1.3e-07	-5.25	-5.3	1.4e-07	0.25	0.78	0.01	FALSE
40	GTEx	Spleen	ZFP90	0.31	0.25	lasso	9	0.22	3.0e-06	-10.87	11.3	1.5e-29	-0.95	0.01	0.99	TRUE
41	GTEx	Testis	NFATC3	0.23	0.16	lasso	7	0.17	6.0e-08	5.30	6.5	9.5e-11	-0.08	0.98	0.00	FALSE
42	GTEx	Testis	CIRH1A	0.33	0.11	enet	18	0.19	1.0e-08	-2.38	6.3	3.7e-10	-0.25	0.94	0.04	FALSE
43	GTEx	Testis	DUS2	0.15	0.01	enet	9	0.03	1.1e-02	5.24	5.2	2.1e-07	-0.02	0.28	0.09	FALSE
44	GTEx	Testis	ZFP90	0.14	0.14	lasso	5	0.11	1.0e-05	-10.30	-10.8	3.4e-27	0.98	0.01	0.99	FALSE
45	GTEx	Testis	WWP2	0.30	0.10	lasso	5	0.16	9.2e-08	3.42	5.3	9.7e-08	-0.05	0.01	0.98	FALSE
46	GTEx	Testis	LCAT	0.12	0.09	enet	19	0.07	5.3e-04	5.25	6.8	8.6e-12	-0.06	0.78	0.04	FALSE
47	GTEx	Testis	RP11-96D1.7	0.14	0.12	lasso	3	0.13	2.3e-06	5.30	-6.0	2.2e-09	0.05	0.97	0.00	FALSE
48	GTEx	Thyroid	NFATC3	0.12	0.13	lasso	4	0.11	1.4e-08	-5.10	5.5	4.4e-08	-0.22	1.00	0.00	FALSE
49	GTEx	Thyroid	PLA2G15	0.06	0.04	enet	5	0.04	5.7e-04	-7.99	-7.1	9.8e-13	0.28	0.76	0.01	FALSE
50	GTEx	Thyroid	NOB1	0.03	0.01	enet	6	0.02	7.7e-03	5.91	-5.8	6.8e-09	0.01	0.05	0.83	TRUE
51	GTEx	Thyroid	CTD-2033A16.3	0.03	0.02	enet	7	0.02	6.7e-03	3.81	-5.4	7.8e-08	0.01	0.08	0.73	FALSE
52	GTEx	Whole Blood	ZFP90	0.13	0.09	lasso	5	0.14	5.6e-13	-10.67	11.3	1.5e-29	-0.91	0.01	0.99	FALSE
53	GTEx	Whole Blood	LCAT	0.05	0.04	lasso	4	0.05	3.2e-05	5.37	5.3	8.8e-08	-0.02	0.87	0.01	FALSE
54	METSIM	Adipose	ELMO3	0.05	0.05	blup	236	0.05	6.5e-08	2.84	5.6	2.7e-08	0.01	0.21	0.79	FALSE
55	METSIM	Adipose	NFATC3	0.03	0.00	blup	298	0.00	3.4e-01	4.73	7.6	2.1e-14	-0.32	0.08	0.03	FALSE
56	METSIM	Adipose	PLA2G15	0.03	0.01	blup	287	0.01	4.8e-03	-7.37	-8.9	7.1e-19	0.15	0.23	0.02	TRUE
57	METSIM	Adipose	RLTPR	0.04	0.00	bslmm	211	0.00	1.1e-01	-3.74	-6.4	1.4e-10	0.11	0.13	0.12	FALSE
58	METSIM	Adipose	ZFP90	0.09	0.06	lasso	7	0.07	3.0e-11	-10.87	10.9	9.8e-28	-0.98	0.01	0.99	FALSE
59	NTR	Blood	ESRP2	0.03	0.03	lasso	5	0.02	7.7e-08	5.27	-6.5	1.0e-10	0.07	1.00	0.00	FALSE
60	NTR	Blood	SLC7A6	0.03	0.03	lasso	9	0.03	6.0e-11	-5.14	7.4	1.6e-13	-0.45	1.00	0.00	FALSE
61	NTR	Blood	ZFP90	0.07	0.07	enet	14	0.07	9.4e-22	-10.64	11.5	1.9e-30	-0.99	0.01	0.99	TRUE
62	YFS	Blood	CIRH1A	0.32	0.09	enet	34	0.14	5.4e-45	-3.89	7.7	1.3e-14	-0.32	1.00	0.00	FALSE
63	YFS	Blood	LCAT	0.07	0.06	lasso	6	0.06	4.9e-20	5.74	5.8	6.1e-09	-0.03	1.00	0.00	FALSE
64	YFS	Blood	SLC7A6	0.20	0.25	lasso	8	0.26	6.1e-86	-5.25	5.5	2.9e-08	-0.26	1.00	0.00	FALSE
65	YFS	Blood	ZFP90	0.43	0.46	enet	35	0.48	2.1e-184	-10.87	11.4	5.3e-30	-0.97	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	B3GNT9	0.03	0.03	blup	26	0.02	1.3e-02	7.05	6.1	1.2e-09	0.02	0.00	0.94	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC9A5	0.01	0.00	blup	30	0.01	1.1e-02	6.75	7.9	3.3e-15	-0.03	0.01	0.77	FALSE
68	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CLEC18A	0.10	0.06	lasso	2	0.04	6.3e-03	-5.23	-5.2	1.7e-07	-0.03	0.02	0.52	FALSE
69	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PDXDC2	0.20	0.02	blup	26	0.07	1.8e-04	-4.93	-5.6	1.9e-08	-0.08	0.02	0.69	FALSE
70	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC29	0.05	0.05	blup	33	0.05	5.4e-04	6.91	-6.4	1.8e-10	-0.01	0.01	0.97	TRUE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	NFATC3	0.22	0.05	lasso	3	0.06	3.6e-04	-5.10	7.0	2.7e-12	-0.26	0.00	0.99	FALSE
72	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC7A6	0.05	0.04	enet	4	0.02	2.0e-02	-4.90	5.2	2.0e-07	-0.23	0.05	0.40	FALSE
73	The Cancer Genome Atlas	Glioblastoma Multiforme	PDXDC2	0.10	0.12	lasso	3	0.10	4.7e-04	-5.23	-5.2	1.7e-07	-0.03	0.01	0.81	FALSE
74	The Cancer Genome Atlas	Glioblastoma Multiforme	ZFP90	0.10	0.08	blup	33	0.09	8.3e-04	-9.41	-11.4	3.0e-30	0.87	0.02	0.77	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PDXDC2	0.14	0.05	enet	6	0.05	3.2e-06	-4.95	-5.3	1.1e-07	-0.01	0.02	0.97	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NFATC3	0.11	0.04	enet	4	0.04	2.8e-05	-7.74	7.4	1.4e-13	-0.25	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	NFATC3	0.23	0.05	lasso	2	0.06	8.5e-08	-7.74	7.1	1.1e-12	-0.24	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRMT7	0.19	0.14	enet	5	0.15	6.9e-17	4.74	5.7	1.6e-08	-0.13	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC7A6	0.05	0.05	blup	52	0.05	1.0e-06	-5.11	5.2	2.1e-07	-0.23	0.53	0.46	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZFP90	0.10	0.16	lasso	2	0.16	1.5e-17	-9.41	-9.4	4.8e-21	0.60	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ATP6V0D1	0.04	0.00	enet	6	0.00	9.3e-02	-0.46	5.6	2.5e-08	-0.08	0.02	0.10	TRUE
82	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CLEC18A	0.06	0.10	lasso	1	0.09	6.9e-11	-5.27	-5.3	1.4e-07	-0.03	0.05	0.95	FALSE
83	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NFATC3	0.23	0.05	enet	17	0.06	1.5e-03	-3.00	7.0	2.7e-12	-0.14	0.01	0.09	FALSE
84	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PRMT7	0.22	0.06	lasso	4	0.11	2.7e-05	4.80	6.4	1.8e-10	-0.15	0.26	0.11	FALSE
85	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NFATC3	0.26	0.09	enet	4	0.13	9.8e-06	-7.74	6.9	5.1e-12	-0.24	0.00	0.98	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	LCAT	0.07	0.00	blup	17	0.02	4.9e-03	3.44	6.1	1.0e-09	-0.08	0.00	0.34	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	NFATC3	0.18	0.05	blup	61	0.06	6.0e-07	-5.00	6.5	9.8e-11	-0.26	0.03	0.97	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMPD3	0.09	0.04	enet	14	0.06	1.4e-06	-5.47	6.6	3.1e-11	-0.22	0.71	0.04	FALSE
89	The Cancer Genome Atlas	Rectum Adenocarcinoma	CLEC18A	0.15	0.03	blup	23	0.09	4.3e-03	-4.88	-5.1	3.0e-07	0.03	0.01	0.27	FALSE
90	The Cancer Genome Atlas	Rectum Adenocarcinoma	LRRC29	0.47	-0.01	enet	18	0.03	8.3e-02	4.07	-6.9	4.5e-12	0.09	0.01	0.14	FALSE
91	The Cancer Genome Atlas	Rectum Adenocarcinoma	TSNAXIP1	0.15	0.10	enet	12	0.12	1.2e-03	1.47	5.9	4.4e-09	-0.08	0.01	0.60	FALSE
92	The Cancer Genome Atlas	Soft Tissue Sarcoma	NFATC3	0.28	0.11	enet	11	0.14	1.3e-08	4.73	7.3	2.4e-13	-0.22	0.23	0.75	FALSE
93	The Cancer Genome Atlas	Soft Tissue Sarcoma	PDXDC2	0.05	0.01	blup	26	0.03	9.5e-03	-4.88	-5.2	1.6e-07	-0.08	0.02	0.58	FALSE
94	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NFATC3	0.46	0.16	lasso	4	0.20	1.7e-07	4.73	6.5	5.8e-11	-0.23	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	NFATC3	0.09	0.02	enet	7	0.02	3.9e-03	4.73	6.0	2.5e-09	-0.22	0.02	0.91	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	PRMT7	0.27	0.15	blup	58	0.18	9.1e-18	4.80	6.0	2.1e-09	-0.19	1.00	0.00	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	SMPD3	0.03	0.03	lasso	3	0.02	4.2e-03	-7.04	7.1	1.3e-12	-0.45	0.10	0.27	FALSE