Best TWAS P=2.26e-10 · Best GWAS P=6.72e-09 conditioned to 0.205
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Male) | POLI | 0.31 | 0.35 | lasso | 3 | 0.32 | 4.5e-08 | -5.8 | 5.8 | 7.6e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | POLI | 0.46 | 0.36 | enet | 18 | 0.36 | 9.9e-28 | -5.8 | 5.3 | 1.3e-07 | -0.97 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Colon Transverse | POLI | 0.24 | 0.26 | lasso | 4 | 0.25 | 4.5e-12 | -5.8 | 5.3 | 1.4e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Lung | POLI | 0.39 | 0.31 | lasso | 5 | 0.35 | 2.1e-27 | -5.8 | 5.3 | 1.1e-07 | -0.96 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Testis | POLI | 0.32 | 0.25 | lasso | 4 | 0.23 | 1.4e-10 | -5.8 | 5.2 | 1.9e-07 | -0.98 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Thyroid | POLI | 0.47 | 0.37 | enet | 14 | 0.44 | 3.3e-36 | -5.8 | 5.4 | 7.0e-08 | -0.94 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | POLI | 0.18 | 0.12 | lasso | 3 | 0.11 | 8.2e-10 | -5.8 | 5.8 | 8.4e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POLI | 0.11 | 0.11 | lasso | 4 | 0.11 | 2.1e-22 | -5.8 | 5.3 | 1.4e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POLI | 0.16 | 0.13 | lasso | 3 | 0.13 | 2.0e-14 | -5.8 | 5.7 | 1.4e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | POLI | 0.18 | 0.16 | enet | 4 | 0.16 | 1.4e-17 | -5.8 | 5.2 | 1.8e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | POLI | 0.20 | 0.17 | lasso | 6 | 0.18 | 3.6e-20 | -5.8 | 5.4 | 8.1e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | POLI | 0.08 | 0.07 | blup | 43 | 0.08 | 7.1e-10 | -5.8 | 5.4 | 5.6e-08 | -0.90 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | POLI | 0.20 | 0.17 | lasso | 4 | 0.14 | 1.6e-06 | -5.8 | 5.5 | 4.9e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLI | 0.16 | 0.17 | lasso | 7 | 0.17 | 3.5e-17 | -5.8 | 5.1 | 2.7e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Rectum Adenocarcinoma | POLI | 0.20 | 0.03 | blup | 43 | 0.05 | 3.3e-02 | -5.8 | 6.3 | 2.3e-10 | -0.79 | 0.00 | 0.56 | TRUE |
| 16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | POLI | 0.10 | 0.07 | lasso | 2 | 0.06 | 2.7e-04 | -5.8 | 5.8 | 6.1e-09 | -1.00 | 0.00 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | POLI | 0.13 | 0.11 | enet | 5 | 0.11 | 1.8e-08 | -5.8 | 5.8 | 5.6e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MBD2 | 0.23 | 0.09 | blup | 65 | 0.07 | 2.1e-03 | 5.1 | -5.4 | 7.9e-08 | 0.51 | 0.02 | 0.64 | FALSE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | POLI | 0.14 | 0.05 | lasso | 3 | 0.04 | 1.1e-02 | -5.8 | 5.2 | 2.3e-07 | -0.98 | 0.00 | 0.96 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | POLI | 0.24 | 0.28 | lasso | 2 | 0.28 | 7.3e-27 | -5.8 | 5.8 | 6.8e-09 | -1.00 | 0.00 | 1.00 | FALSE |