Best TWAS P=2.17e-14 · Best GWAS P=1.62e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP11-295M18.6 | 0.19 | 0.15 | lasso | 3 | 0.14 | 1.4e-05 | 5.5 | 5.3 | 1.1e-07 | -0.22 | 0.56 | 0.02 | TRUE |
| 2 | GTEx | Esophagus Mucosa | HLX | 0.17 | 0.09 | lasso | 8 | 0.09 | 9.1e-07 | -7.4 | -7.6 | 2.2e-14 | 0.95 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Heart Atrial Appendage | RP11-295M18.6 | 0.35 | 0.14 | enet | 10 | 0.22 | 3.1e-10 | 4.1 | 5.4 | 5.9e-08 | -0.38 | 0.99 | 0.00 | FALSE |
| 4 | GTEx | Muscle Skeletal | RP11-295M18.6 | 0.30 | 0.12 | lasso | 6 | 0.18 | 4.2e-17 | 4.1 | 5.3 | 1.4e-07 | -0.36 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Thyroid | RP11-295M18.6 | 0.25 | 0.22 | lasso | 4 | 0.26 | 4.7e-20 | 4.4 | 5.2 | 2.2e-07 | -0.39 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Vagina | RP11-295M18.6 | 0.33 | 0.13 | lasso | 3 | 0.08 | 6.7e-03 | 5.5 | 5.2 | 2.5e-07 | -0.24 | 0.12 | 0.06 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HLX | 0.05 | 0.02 | blup | 46 | 0.04 | 1.4e-05 | -7.5 | -6.5 | 6.9e-11 | 0.77 | 0.03 | 0.92 | FALSE |