TWAS hub - HLX

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0250	1.8e-06	0.060	0.044	0.036	0.044	0.045	8.5e-08	4.4e-06	2.9e-05	4.6e-06	3.2e-06
2	GTEx	Brain Cerebellum	0.2890	0.0980	2.1e-03	0.115	NA	0.177	NA	0.233	2.9e-04	NA	6.5e-06	NA	1.7e-07
3	GTEx	Cells Transformed fibroblasts	0.0620	0.0280	5.7e-03	-0.004	NA	-0.002	NA	-0.003	8.3e-01	NA	5.3e-01	NA	6.3e-01
4	GTEx	Esophagus Mucosa	0.1680	0.0530	2.5e-04	0.088	NA	0.056	NA	0.093	1.6e-06	NA	1.3e-04	NA	9.0e-07
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0528	0.0255	1.4e-04	0.024	0.042	0.021	NA	0.031	8.2e-04	1.4e-05	1.7e-03	NA	2.0e-04
6	TCGA	Lung Adenocarcinoma	0.0886	0.0447	4.3e-03	0.028	0.024	0.026	NA	0.025	2.6e-04	6.9e-04	4.2e-04	NA	5.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
LDL Cholesterol	5.9	9.4	17.9	-4.0	-4.0	0.1	-0.7	2.3	4.2
Lung FVC	5.1	26.0	83.5	-4.0	-5.2	9.1	-5.1	-1.8	-0.4
Major Depression (MDD)	3.9	4.7	13.6	2.5	3.7	-2.4	1.2	0.7	-0.7
Osteoarthritis (self-reported)	3.7	4.8	14.1	3.8	2.2	-1.5	-1.3	-2.1	-1.3
Medication: Blood pressure	3.2	6.1	13.2	3.2	3.6	3.2	1.5	0.2	-1.2
Handedness (chirality/laterality): Left-handed	3.0	3.6	7.6	-2.5	-1.8	0.8	1.8	2.8	0.4
Commuting to job workplace: Cycle	3.0	3.6	8.5	-2.5	-1.0	1.7	-2.9	-1.9	0.3
Breastfed as a baby	2.9	3.7	8.9	-0.6	-0.2	-1.9	2.6	3.0	1.5
Long-standing illness, disability or infirmity	2.9	4.5	7.2	2.4	2.6	-0.8	2.2	1.3	-2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.8	12.9	-1.7	-2.5	2.9	-3.6	-2.2	-0.5
Alcohol drinker status: Previous	2.8	3.2	8.1	1.1	1.4	0.4	2.9	2.6	-1.1
Medication: Co-codamol	2.7	3.1	8.4	2.9	1.8	-1.9	0.8	-0.5	-1.7
Supplements: Vitamin C	2.7	3.2	7.7	-1.7	-2.8	1.5	-1.6	-1.8	-0.5
Medication for cholesterol	2.7	4.1	10.4	-2.1	-3.2	-2.5	-1.6	-0.7	0.1
Impedance of leg (right)	2.6	12.4	46.4	1.1	2.2	-6.8	-3.0	-3.6	0.0
Blood Eosinophil Count	2.5	19.1	58.4	-1.2	0.1	-2.8	-7.6	-6.5	2.2
Waist Hip Ratio (WHR)	2.5	11.0	39.4	1.6	1.7	-6.3	-3.1	-3.2	1.0
Impedance of leg (left)	2.5	12.0	48.0	1.8	2.9	-6.9	-2.2	-2.8	0.2
Knee pain experienced in last month	2.5	4.0	8.0	2.6	2.2	1.2	-0.7	-1.5	-2.8
Coronary Artery Disease (CAD)	2.4	2.9	6.0	1.0	2.4	-0.8	1.7	2.2	1.3
Heel T-Score	2.4	19.2	42.6	-1.1	-1.9	-5.9	5.6	6.5	1.1
Mineral and other dietary supplements	2.4	3.3	8.5	-2.0	-0.8	0.0	1.1	2.3	2.9
Cholesterol lowering medication	2.4	3.6	7.8	0.2	0.5	1.9	2.8	2.6	1.6
Irritable Bowel Disease (IBD)	2.3	5.4	17.3	-1.0	-0.4	-1.0	3.2	4.2	1.6
Multivitamins +/- minerals	2.3	3.0	7.8	2.6	1.3	-0.5	-0.2	-1.1	-2.8
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.1	1.5	1.0	-2.2	-1.8	-1.4	-1.6
Ulcerative Colitis (UC)	2.2	4.1	12.2	-1.2	-0.8	0.3	2.7	3.5	1.8
Time employed in main current job	2.2	2.5	5.9	-2.4	-2.1	1.7	0.2	1.3	0.6
Impedance of whole body	2.2	11.4	58.7	1.5	1.8	-7.7	-1.0	-1.6	0.3
Impedance of arm (right)	2.1	9.7	56.4	1.1	0.6	-7.5	-0.5	0.0	0.4
Financial situation satisfaction	2.1	2.6	5.2	-2.3	-2.2	2.0	-0.4	0.1	1.2
Crohns Disease (2017)	2.0	4.3	12.1	-0.5	-0.3	-1.5	3.0	3.5	1.5
Impedance of arm (left)	2.0	9.3	54.3	1.0	0.6	-7.4	-0.1	-0.3	0.3
Medication: Amlodipine	2.0	2.8	4.7	2.2	1.4	1.7	1.5	0.5	-2.2
Chronic bronchitis/emphysema (mother)	2.0	2.3	6.8	-2.6	-2.4	1.0	-0.5	0.4	0.2
Average weekly spirits intake	1.9	2.4	5.6	0.9	1.4	-1.0	2.4	2.1	0.5
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	6.7	-0.0	0.8	-1.8	2.6	2.1	-0.2
Glaucoma (self-reported)	1.9	2.2	10.8	0.9	0.4	-3.3	0.5	0.8	0.7
Had other major operations	1.8	2.2	5.3	0.4	0.7	-1.1	1.9	2.3	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	6.1	0.6	-0.2	-1.2	1.5	2.5	1.6
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.3	1.7	1.2	0.8	-1.3	-2.1	-1.4
Ever taken oral contraceptive pill	1.8	2.0	5.5	-0.0	-0.7	1.1	-2.0	-2.3	-0.8
Emphysema/chronic bronchitis	1.7	1.9	5.0	0.3	0.4	-2.2	-2.2	-1.1	0.3
Hypertension (Self-reported)	1.7	4.8	12.2	3.5	2.7	2.3	1.2	0.3	-1.6
Ever had prostate specific antigen (PSA) test	1.7	2.0	5.7	2.4	1.1	-0.8	1.6	1.3	0.3
Vascular/heart problems diagnosed by doctor	1.7	4.7	11.8	-3.4	-2.9	-2.2	-1.1	-0.2	1.4
Number of treatments/medications taken	1.6	2.9	9.2	3.0	1.6	1.2	1.0	0.5	-1.7
Taking other prescription medications	1.6	2.5	5.0	2.2	2.2	1.0	0.3	-0.1	-2.1
Serious illness, injury or assault to yourself	1.6	2.0	4.0	-0.5	0.4	-1.8	1.9	2.0	-0.8
Medication: Atenolol	1.6	2.0	5.4	-0.4	-0.6	1.6	-2.3	-1.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	10.6	-2.6	-2.7	1.9	-3.3	-1.6	-0.3
Birth weight of first child	1.6	2.9	7.1	1.8	2.1	-2.7	-1.1	-0.7	1.0
Eye problems/disorders: None of the above	1.6	1.8	4.2	-1.3	-0.5	2.0	0.3	1.9	0.9
Overall health rating	1.6	3.5	5.8	2.2	2.0	0.6	2.4	2.4	-0.6
Family relationship satisfaction	1.6	2.0	5.0	-1.2	-2.2	1.1	-1.1	0.4	1.6
Illnesses of father: High blood pressure	1.6	1.9	8.0	-0.6	0.7	2.8	0.8	0.1	-1.4
Frequency of depressed mood in last 2 weeks	1.5	2.1	4.6	-1.3	-2.1	1.8	0.3	1.6	0.9
High blood pressure	1.5	4.1	9.6	3.1	2.4	2.5	1.1	0.4	-1.5
Financial difficulties in last 2 years	1.5	2.1	3.5	-1.3	-1.7	0.3	1.3	1.6	1.9
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	9.8	-2.5	-3.1	2.0	-2.8	-1.4	-0.1
Qualifications: A levels/AS levels or equivalent	1.5	3.3	7.4	-2.7	-2.4	-0.5	-1.1	-1.0	2.1
Birth weight	1.5	3.2	6.8	-2.2	-1.8	-0.5	-2.6	-1.4	1.5
Medication: Omeprazole	1.5	1.8	3.8	1.2	1.7	-1.2	0.9	0.5	-1.9
Medication: Gliclazide	1.5	1.6	4.7	-0.0	0.6	-1.6	1.5	2.2	-0.2
Relative age of first facial hair	1.4	2.9	8.3	-1.8	-2.9	0.3	0.4	2.2	1.0
High blood pressure (mother)	1.4	2.0	5.9	2.4	1.4	1.2	0.6	1.1	0.8
Pain all over the body in last month	1.4	1.5	6.1	1.0	1.1	-0.7	-0.6	-0.2	-2.5
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	6.5	-2.5	-2.0	-0.3	0.6	0.4	1.5
Chest pain or discomfort	1.4	2.0	4.3	0.0	0.6	1.5	1.9	2.1	-1.3
Illnesses of siblings: Diabetes	1.4	1.7	4.5	1.3	0.0	2.1	1.3	0.6	1.4
Number of self-reported non-cancer illnesses	1.4	2.5	7.2	2.7	1.7	1.2	-0.9	-1.5	-0.5
Eye problems/disorders: Glaucoma	1.4	1.6	7.4	0.5	0.3	-2.7	1.0	0.4	0.9
Basal cell carcinoma (self-reported)	1.4	1.6	7.9	0.6	0.6	-2.8	0.9	-0.2	-0.0
Alzheimer’s Disease (in father)	1.3	1.5	3.0	0.6	0.5	-1.5	1.7	1.6	0.6
Supplements: Glucosamine	1.3	1.7	4.3	1.1	0.6	0.1	-0.7	-1.9	-2.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	4.4	-1.1	-2.0	2.1	-0.3	-0.5	-0.3
Medication: Lansoprazole	1.3	1.4	4.1	-2.0	-1.4	-0.9	-0.6	1.1	0.7
Forced vital capacity (FVC), Best measure	1.3	4.7	9.0	-2.3	-2.2	3.0	-2.6	-1.5	-0.2
Guilty feelings	1.3	1.9	4.6	-1.1	-1.6	0.5	-0.3	1.6	2.1
Hearing aid user	1.3	1.5	5.0	2.2	1.8	-0.5	0.3	-0.3	-0.4
Age at First Birth	1.2	1.8	3.7	0.3	-0.9	-1.1	1.5	1.9	1.5
HbA1C	1.2	1.3	2.7	-0.4	-1.6	-1.0	-1.6	-1.2	0.1
Primary Biliary Cirrhosis	1.2	1.7	4.0	-0.0	1.1	0.0	-1.9	-2.0	-1.1
Lung FEV1/FVC ratio	1.2	6.1	24.2	-1.8	-1.5	-4.9	-2.6	-0.5	-0.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.2	-0.3	-0.2	-0.1	-2.0	-2.0	0.1
Forced vital capacity (FVC)	1.2	4.5	9.6	-2.1	-2.7	3.1	-2.1	-1.3	0.3
Happiness	1.2	1.4	2.7	-1.2	-1.1	1.6	-0.6	0.6	1.6
Lung cancer (father)	1.2	1.4	3.0	1.7	1.4	0.8	1.0	-0.8	-1.2
Health satisfaction	1.2	1.5	4.1	0.3	-0.9	0.8	1.1	1.5	2.0
Alcohol intake frequency.	1.2	2.9	7.0	1.0	1.3	0.3	1.2	2.6	2.5
Leg pain on walking	1.2	1.4	4.4	2.1	0.2	-0.8	1.7	0.7	0.6
Friendships satisfaction	1.2	1.5	5.9	-0.2	0.2	-0.9	0.4	2.4	1.5
Eye problems/disorders: Cataract	1.2	1.4	3.7	-0.6	-1.9	-0.2	-0.6	-1.4	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	5.7	1.2	-0.5	2.4	1.2	0.2	-0.2
Angina	1.1	1.5	4.3	0.4	0.4	0.8	2.1	1.8	0.0
Supplements: Zinc	1.1	1.2	5.1	-0.0	-0.4	2.3	0.4	-1.0	-0.8
Hair/balding pattern: Pattern 3	1.1	1.6	3.8	2.0	1.2	-1.9	0.9	0.1	-0.5
Pulse rate	1.1	1.9	5.1	1.9	2.3	-1.0	1.1	-0.0	0.1
Blood clot in the leg (DVT)	1.1	1.4	5.2	1.2	-0.4	2.3	1.3	0.5	-0.2
Number of full brothers	1.1	1.3	3.3	0.3	-0.5	-1.7	-1.8	-1.2	-0.2
Pulse wave peak to peak time	1.1	1.2	3.6	-1.9	-0.7	-0.4	-0.1	1.8	0.0
Miserableness	1.1	1.9	8.6	0.8	0.3	0.1	0.6	2.9	1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.2	1.5	0.1	-0.5	-1.1	-1.8	-1.4
Medication: Atorvastatin	1.1	1.4	2.9	-1.3	-0.6	1.5	0.3	1.1	1.7
Number of operations (self-reported)	1.1	1.6	4.6	-1.0	-0.1	-1.6	0.8	2.1	0.9
Alzheimer’s Disease (in mother)	1.0	1.2	4.2	-0.2	-0.3	0.0	-0.6	-1.5	-2.0
Bipolar Disorder (2011)	1.0	1.0	2.9	0.3	1.7	-1.1	0.6	1.1	0.0
Crohns Disease (2012)	1.0	1.6	4.4	0.3	-0.3	-1.3	2.1	1.7	0.6
Ulcerative Colitis	1.0	1.5	3.5	-1.5	-1.2	-0.4	1.1	1.9	0.6
Blood Platelet Count	1.0	11.7	34.3	-3.0	-2.6	-1.2	-5.9	-4.3	-0.5
BMI	1.0	5.7	20.2	-2.4	-2.6	4.5	-0.7	0.8	0.9
Vitamin and mineral supplements	1.0	1.3	6.2	-0.7	0.3	-0.5	0.6	0.9	2.5
Qualifications: None of the above	1.0	2.1	5.9	2.4	2.4	-0.1	-0.1	-0.1	-1.1
Medication: Simvastatin	1.0	1.5	4.7	0.4	0.5	1.0	1.3	2.2	0.9
Pulse wave Arterial Stiffness index	1.0	1.2	3.4	1.8	0.7	0.1	0.2	-1.8	0.0
Headache pain in last month	1.0	1.7	4.2	-2.0	-1.9	0.8	-0.7	0.7	0.7
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.7	1.9	1.3	-1.2	0.5	0.2	-0.7
Neck or shoulder pain in last month	1.0	1.5	2.7	-0.8	-1.5	1.7	-0.7	-0.4	-1.5
Medication: Ibuprofen	1.0	1.2	3.4	-1.0	-1.8	1.3	-0.6	-0.6	-0.7
Mood swings	1.0	1.8	7.9	-0.8	-0.6	2.8	0.5	1.3	-0.2
Smoking status: Current	1.0	1.6	3.7	1.0	1.0	-0.4	1.9	1.9	0.2
Body Mass Index (BMI) (2010)	0.9	1.3	4.2	-0.6	-2.1	1.5	0.1	0.7	-0.7
Fasting Glucose	0.9	1.1	2.8	0.8	0.6	-1.7	0.8	0.9	-1.2
Neuroticism (2016)	0.9	1.3	4.0	-0.8	-0.8	0.8	0.1	1.4	2.0
Rheumatoid Arthritis	0.9	1.3	2.8	-1.2	-1.7	1.0	-0.6	-0.1	1.4
Blood White Count	0.9	6.6	11.8	2.7	3.4	-1.5	0.3	-2.5	-3.4
Diabetes (father)	0.9	1.1	3.7	0.7	0.9	-0.8	-0.2	-1.1	-1.9
Fed-up feelings	0.9	1.6	6.7	-0.2	-1.4	2.6	-0.5	0.8	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	8.8	-0.6	-0.8	-3.0	0.5	1.0	-1.0
Chronic bronchitis/emphysema (father)	0.9	1.1	2.5	0.9	-1.1	-0.1	-0.8	-1.2	-1.6
Body mass index (BMI)	0.9	3.8	15.6	-2.0	-1.4	4.0	-0.7	0.8	-0.2
Alcohol usually taken with meals	0.9	1.5	5.9	-0.7	-0.1	-2.4	-0.2	-0.3	1.6
Neuroticism score	0.9	1.9	4.5	-0.7	-1.2	2.1	0.6	1.8	1.0
Depression (self-reported)	0.9	1.1	2.3	1.1	0.8	1.4	0.6	0.4	-1.5
Peak expiratory flow (PEF)	0.9	2.1	3.6	-1.8	-1.9	1.8	-0.9	0.8	-0.9
Medication: Blood pressure	0.9	1.6	3.3	1.5	1.0	1.4	1.0	0.1	-1.8
Angina (self-reported)	0.9	1.2	3.9	0.7	0.5	0.6	2.0	1.5	-0.2
Number of full sisters	0.9	1.1	2.8	0.4	1.5	0.8	1.0	-0.3	-1.7
Back pain experienced in last month	0.9	1.4	5.4	2.3	1.6	-0.1	0.4	-0.3	0.2
Illnesses of father: None of the above (group 1)	0.9	1.1	3.8	-0.7	-0.8	-1.2	-0.1	0.5	2.0
Medication: Bendroflumethiazide	0.9	1.3	2.6	0.1	0.9	1.6	-1.1	-1.1	-1.4
Depression (Nagel 2018)	0.8	1.2	3.2	-0.9	-1.8	1.6	-0.5	0.3	0.3
Height	0.8	16.2	83.4	1.9	1.9	-9.1	1.5	-1.0	-1.9
Systolic Blood Pressure	0.8	3.9	16.2	0.7	0.6	4.0	2.5	0.6	0.1
Medication: Metformin	0.8	1.1	2.6	1.3	0.6	-1.6	0.7	1.0	-0.5
Pack years adult smoking proportion	0.8	1.2	2.8	0.3	1.1	-1.4	0.9	1.7	0.4
Townsend deprivation index at recruitment	0.8	1.1	3.5	0.1	1.9	0.7	-0.4	-0.3	-1.5
Current tobacco smoking	0.8	1.4	4.0	0.5	0.5	-0.4	2.0	1.9	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.5	-0.2	-1.6	1.1	-0.1	1.5	0.4
Qualifications: CSEs or equivalent	0.8	1.0	3.3	-0.9	-0.0	1.8	0.1	1.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.9	-0.4	-0.8	0.9	-1.4	-1.7	0.6
Medication: Ramipril	0.8	1.0	2.9	0.4	0.8	1.7	0.6	-0.1	-1.4
Mouth/teeth dental problems: Dentures	0.8	1.4	5.8	0.9	1.1	0.1	0.4	-0.5	-2.4
Gout (self-reported)	0.8	1.1	2.7	-1.5	-0.7	0.6	0.6	-0.6	-1.6
Exposure to tobacco smoke outside home	0.8	1.0	2.5	-0.8	1.0	0.3	1.1	0.7	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.1	1.1	0.2	0.4	-0.9	-1.8	-0.5
Comparative height size at age 10	0.8	4.6	15.9	1.7	2.4	-4.0	1.4	-0.9	-0.5
Ever had bowel cancer screening	0.8	1.0	3.3	0.6	-0.6	-0.3	1.8	0.7	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.0	-1.5	-1.4	-0.9	-1.7	-0.4	0.1
Mother’s age at death	0.8	1.1	2.6	-0.5	-1.5	-1.6	-0.2	-0.5	-1.1
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.7	1.3	0.9	-0.4	1.6	0.7	0.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	0.6	1.3	-1.3	0.5	0.6	-1.2
Supplements: Calcium	0.8	0.9	1.5	-0.5	-0.9	0.7	-0.9	-1.1	-1.2
Schizophrenia vs Biploar Disorder	0.7	0.9	3.5	1.1	-0.3	0.5	0.2	-0.4	-1.9
Breast Cancer	0.7	1.8	3.9	1.7	0.8	0.9	-1.6	-2.0	-0.3
Cardiovascular Disease	0.7	2.4	7.7	2.2	1.3	2.8	0.2	0.5	0.1
Hearing difficulty/problems: Yes	0.7	1.0	2.4	0.9	1.1	0.0	1.5	0.4	-1.2
Systolic blood pressure, automated reading	0.7	2.1	9.0	0.1	0.3	3.0	1.7	0.4	-0.8
Hand grip strength (right)	0.7	1.9	7.4	-0.3	-0.8	2.7	0.1	-1.6	-0.8
Average weekly fortified wine intake	0.7	0.9	1.8	-0.2	-0.2	-1.3	1.3	1.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	5.8	-1.0	-0.9	-2.4	0.6	0.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.9	-1.4	-1.2	1.4	-1.1	0.3	-0.7
Illnesses of mother	0.7	0.8	3.1	-1.8	-1.0	-0.1	-0.5	-0.6	0.5
Length of working week for main job	0.7	0.8	2.7	-0.4	0.7	-0.4	-0.7	0.8	1.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.6	-1.1	-1.3	0.8	-1.1	-0.6	0.0
Wheeze or whistling in the chest in last year	0.7	1.3	3.5	0.4	-1.3	1.9	1.4	0.7	-0.2
Medication for pain relief, constipation, heartburn	0.7	1.1	3.1	-0.3	0.4	-1.8	-0.9	-1.4	-0.8
Had major operations	0.7	0.9	2.6	-0.5	0.4	-1.2	-0.6	1.6	0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	1.3	0.6	1.2	0.1	-0.9	-0.7
Leg fat-free mass (right)	0.7	3.5	8.6	-1.5	-1.4	2.9	2.1	1.9	-0.3
Loneliness, isolation	0.7	1.0	1.7	-0.9	-1.1	1.1	-0.2	1.3	0.9
Leg predicted mass (right)	0.7	3.7	9.7	-1.6	-1.5	3.1	2.1	1.8	-0.2
Medication: Lisinopril	0.7	0.9	2.7	0.3	0.6	1.5	0.2	0.4	-1.6
Pain experienced in last month	0.7	1.1	3.3	-1.8	-0.8	-1.6	-0.1	0.4	0.3
Depressed Affect (Nagel 2018)	0.6	1.2	5.5	-0.3	-0.5	2.3	0.3	1.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.6	-1.9	-1.6	1.6	0.3	0.4	0.2
Mean Putamen Volume	0.6	0.7	1.7	-0.5	0.7	1.3	-0.6	-1.2	-0.2
HDL Cholesterol	0.6	1.0	3.1	-0.9	0.1	-0.1	1.4	1.8	0.5
Chronotype (morning person)	0.6	1.4	3.3	1.5	1.0	-1.0	-1.8	-1.1	0.1
Hand grip strength (left)	0.6	1.7	5.9	-0.5	-0.8	2.4	0.4	-1.7	-0.7
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	1.3	0.6	-0.4	-0.8	-0.6	1.0
Leg fat-free mass (left)	0.6	3.0	7.7	-1.9	-1.6	2.8	1.4	1.2	-0.4
Hayfever, allergic rhinitis or eczema	0.6	1.2	5.2	1.1	0.1	-2.3	-0.5	-0.8	-0.3
Medication: Levothyroxine sodium	0.6	1.1	2.4	-1.2	-0.1	1.5	-1.1	-1.1	-0.4
Leg predicted mass (left)	0.6	3.1	8.1	-1.9	-1.7	2.9	1.4	1.2	-0.4
Exposure to tobacco smoke at home	0.6	0.7	2.1	-1.0	-1.4	0.6	-0.6	-0.4	0.2
Comparative body size at age 10	0.6	1.6	4.0	-1.4	-1.0	2.0	-1.6	0.3	-0.3
Number of children fathered	0.6	0.7	1.3	1.2	0.9	-0.9	-0.7	-0.2	0.6
Shortness of breath walking on level ground	0.6	0.7	1.4	1.2	-1.2	1.0	0.3	0.6	0.0
Average weekly red wine intake	0.6	0.9	2.2	-1.5	-1.4	0.0	-0.5	-1.0	0.6
Diabetes diagnosed by doctor	0.6	1.1	2.9	1.1	0.5	-0.4	1.7	1.2	-0.6
Qualifications: nursing, teaching	0.6	0.9	4.0	-0.5	-0.8	-2.0	0.1	-0.4	0.6
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.6	1.6	1.1	-0.5	0.5	0.5	0.6
High cholesterol (Self-reported)	0.6	1.1	3.3	-0.9	-0.6	1.8	-0.9	0.9	0.7
Average weekly beer plus cider intake	0.6	0.9	1.7	-0.0	0.8	1.0	-1.3	-1.0	-0.8
Age started oral contraceptive pill	0.6	0.8	3.0	0.7	-0.3	0.4	-0.8	-1.7	-0.5
Ovarian Cancer	0.5	0.6	1.0	0.6	0.9	0.8	-1.0	-1.0	-0.0
Lupus	0.5	0.8	1.6	-0.2	0.4	-1.2	-1.2	-1.0	0.6
Allergy or Eczema	0.5	1.2	4.4	1.2	0.3	-2.1	-1.0	-0.8	0.0
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.0	1.3	1.0	-1.4	0.8	0.6	-0.4
Maternal smoking around birth	0.5	0.8	2.2	-0.0	0.0	1.4	0.6	0.3	-1.5
Stomach or abdominal pain in last month	0.5	0.6	3.1	-0.2	0.0	1.8	-0.4	0.1	-0.8
Had menopause	0.5	0.6	1.4	-0.2	-0.6	1.2	1.1	-0.2	-0.8
Illnesses of siblings	0.5	0.7	1.7	-1.0	0.3	-1.0	-1.3	-0.6	-0.5
Father’s age at death	0.5	0.7	1.7	0.3	-0.0	-0.9	-1.0	-1.3	-0.7
Number of live births	0.5	0.7	1.7	-0.3	-0.7	1.3	-0.7	0.2	1.1
Medication: Cholesterol lowering	0.5	0.8	2.4	0.6	0.7	1.1	0.5	1.6	0.6
Arm fat mass (right)	0.5	1.9	5.0	-2.2	-1.3	1.9	-1.0	0.5	0.1
Standing height	0.5	5.3	26.6	0.8	1.1	-5.2	1.3	-1.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.6	0.2	1.3	0.4	1.0	1.1	-0.5
Loud music exposure frequency	0.5	0.6	1.1	-0.8	-0.1	-0.0	0.9	1.0	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.3	-1.5	-1.1	1.1	-0.8	-0.4	0.4
Arm fat-free mass (right)	0.5	2.4	11.4	-1.2	-0.3	3.4	0.6	-0.8	-0.7
Qualifications: College or University degree	0.5	1.6	7.1	0.3	-0.0	-2.7	0.3	0.2	1.5
Medication: Allopurinol	0.5	0.7	1.7	-0.9	-0.4	0.8	0.7	-0.5	-1.3
Heart disease (mother)	0.5	0.7	1.2	1.1	0.9	1.0	-0.2	-0.2	-1.0
Arm predicted mass (right)	0.5	2.6	12.4	-1.4	-0.5	3.5	0.7	-0.4	-0.3
Age at last live birth	0.5	0.8	2.5	-0.6	-0.5	-0.2	-1.2	-0.2	1.6
Medication: Aspirin	0.5	0.6	1.5	1.0	0.0	0.1	1.0	0.7	1.2
Smoking status: Previous	0.5	0.8	2.0	-1.4	-0.7	0.5	-0.3	-1.1	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.3	-0.6	-0.9	-1.1	-0.3	0.7	0.1
Medication: Aspirin	0.5	0.7	2.3	0.9	0.2	0.1	1.5	0.8	0.5
Fractured/broken bones in last 5 years	0.5	0.7	1.6	1.3	0.9	-0.2	0.9	0.7	0.1
Ever depressed for a whole week	0.5	0.6	1.3	-0.4	1.2	-0.0	1.0	0.3	-1.0
Pack years of smoking	0.5	0.8	1.9	0.4	0.8	-1.4	0.5	1.2	0.5
Bipolar Disorder (2018)	0.4	0.6	2.5	-0.6	-0.0	-0.8	0.1	-0.3	1.6
Reaction Time	0.4	0.7	2.6	-0.6	-0.2	1.0	-0.1	-0.5	-1.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	-0.2	0.6	0.6	-1.0	-0.8	-0.7
Blood Red Count	0.4	3.9	9.5	0.4	-0.5	-3.1	-2.1	-2.1	2.0
Hypothyroidism (self reported)	0.4	0.9	1.7	-1.3	-1.1	0.5	-1.0	-0.3	1.0
Relative age voice broke	0.4	0.6	1.4	-0.3	-1.1	1.2	-0.2	0.3	-0.9
Number of incorrect matches in round	0.4	0.7	2.0	0.6	0.3	0.4	-0.8	-1.4	-0.9
Mouth/teeth dental problems	0.4	0.5	2.5	-0.3	0.3	0.1	0.5	0.6	1.6
Heart attack	0.4	0.5	1.7	-0.0	-0.4	0.7	0.6	0.5	1.3
Allergy	0.4	0.9	2.5	-1.6	-0.4	1.5	-0.2	0.3	-0.2
Diabetes (self-reported)	0.4	0.6	1.2	0.2	0.3	-1.0	1.0	1.1	-0.5
Fluid intelligence score	0.4	0.9	4.0	-2.0	-1.0	0.2	-0.4	0.2	-0.4
Arm fat percentage (right)	0.4	1.6	4.6	-2.1	-1.5	0.8	-1.1	1.0	-0.0
Prospective memory result	0.4	0.5	2.2	1.5	0.3	0.1	0.5	-0.7	-0.4
Pulse wave reflection index	0.4	0.5	0.9	-0.1	-0.6	-0.8	-0.5	-1.0	0.7
Medication: Paracetamol	0.4	0.7	2.1	0.5	-1.4	0.7	0.1	1.0	0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	-1.4	-0.9	-0.8	-0.0	-0.4	0.9
High blood pressure (siblings)	0.4	0.5	0.8	0.7	0.0	0.9	0.8	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.7	0.7	1.0	0.4	0.4	-0.8
Mean time to correctly identify matches	0.4	0.7	3.0	-0.5	-0.3	0.9	0.3	-0.2	-1.7
Pulse rate, automated reading	0.4	1.2	2.3	1.0	1.5	0.9	-0.7	-1.2	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	0.5	0.9	0.6	-0.0	1.1	-0.5
Whole body fat-free mass	0.4	2.1	8.9	-1.4	-0.9	3.0	0.9	0.2	-0.4
Arm fat percentage (left)	0.4	1.7	5.0	-2.2	-1.7	1.1	-0.9	0.8	-0.0
Commuting to job workplace: Walk	0.4	0.5	0.7	-0.8	-0.8	0.1	-0.4	0.8	0.8
Breast cancer (self-reported)	0.4	0.5	1.2	0.7	0.3	-0.8	1.1	0.5	-0.6
Whole body water mass	0.4	2.2	9.2	-1.5	-1.0	3.0	0.8	0.2	-0.5
Arm fat mass (left)	0.4	1.8	4.7	-2.2	-1.4	1.8	-0.9	0.2	-0.1
Arm fat-free mass (left)	0.4	1.9	8.8	-1.3	-0.2	3.0	-0.2	-0.9	-0.5
Unable to work because of sickness or disability	0.4	0.5	1.8	0.8	0.6	-0.2	0.1	0.6	-1.3
Myopia	0.4	0.6	2.4	-0.3	-0.3	0.2	0.6	0.7	1.5
Heart disease (siblings)	0.4	0.5	1.3	-0.3	-1.0	-0.2	0.3	0.5	1.1
Arm predicted mass (left)	0.4	2.2	9.9	-1.5	-0.5	3.1	-0.3	-0.8	-0.4
Intelligence (Savage-Jansen 2018)	0.3	1.1	2.7	-1.4	-1.6	0.5	-1.0	-0.7	0.2
Neuroticism (Nagel 2018)	0.3	0.7	3.1	-0.1	0.0	1.8	0.3	0.7	-0.7
Prostate Cancer	0.3	0.4	1.1	1.0	-0.2	-0.1	-0.3	-1.1	0.0
Schizophrenia (2014)	0.3	0.7	2.0	0.6	1.4	-0.3	0.9	0.4	-0.7
Respiratory disease	0.3	0.7	3.6	1.9	0.4	-0.4	0.3	0.2	0.0
Neuroticism	0.3	0.7	1.9	-0.2	-0.8	0.9	0.7	1.4	-0.2
Medication for hormone replacement therapy	0.3	0.3	1.1	0.5	0.4	-1.1	0.5	0.3	0.4
Diabetes (mother)	0.3	0.4	1.4	0.6	-0.1	-0.4	1.2	0.6	0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.0	-0.3	0.3	0.2	0.4	1.4	-0.2
Trunk fat-free mass	0.3	1.6	7.5	-1.0	-0.6	2.7	0.4	-0.5	-0.5
Noisy workplace	0.3	0.3	0.7	0.6	-0.8	-0.5	0.4	0.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.5	0.2	-0.0	-1.2	0.3	0.5	0.1
Asthma	0.3	0.6	2.2	1.5	0.7	0.3	0.7	0.3	0.4
Trunk predicted mass	0.3	1.6	7.6	-1.1	-0.7	2.8	0.4	-0.5	-0.4
Leg fat percentage (right)	0.3	1.0	2.6	-1.5	-0.4	0.3	-1.6	-0.5	-0.8
Migraine (self-reported)	0.3	0.4	1.0	-0.5	-0.5	0.2	-0.2	-0.9	-1.0
Leg fat mass (right)	0.3	1.1	3.9	-2.0	-0.8	1.1	-0.8	0.3	-0.4
Suffer from ‘nerves’	0.3	0.5	1.9	0.6	0.4	1.4	0.3	-0.4	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.9	-0.3	0.3	0.3	0.8	0.5	-1.0
Asthma (self-reported)	0.3	0.6	2.2	1.5	0.6	0.7	0.6	0.2	0.4
Average weekly champagne plus white wine intake	0.3	0.4	2.1	-0.5	-0.1	-1.4	0.0	-0.4	-0.1
Wears glasses or contact lenses	0.3	0.3	1.0	-0.1	-0.4	-0.2	-0.6	-1.0	-0.7
Alcohol drinker status: Never	0.3	0.4	1.3	0.1	0.1	0.9	-0.1	-0.0	1.2
Basal metabolic rate	0.3	1.8	7.0	-1.5	-0.9	2.6	0.6	0.2	-0.4
Irritability	0.3	0.5	1.2	-0.2	-0.4	0.4	0.7	1.1	0.8
Risk taking	0.3	0.4	0.9	0.1	0.9	-0.6	0.5	-0.7	-0.6
Diastolic blood pressure, automated reading	0.3	1.0	3.3	0.5	0.8	1.8	-0.3	0.0	-1.4
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	0.2	0.6	-0.6	0.7	0.4	1.1
Schizophrenia (2018)	0.2	0.4	0.6	0.8	0.8	-0.1	0.8	0.7	-0.0
Worry (Nagel 2018)	0.2	0.4	1.1	0.0	-0.1	1.1	0.7	-0.2	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.4	0.2	-0.8	0.1	-0.3	-0.8
Triglycerides	0.2	0.4	1.0	-0.1	-0.6	-0.6	-0.1	-0.9	1.0
Sensitivity / hurt feelings	0.2	0.4	0.7	0.6	0.3	0.8	-0.4	-0.3	-0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	0.8	0.7	-0.3	0.3	0.1	0.1
Trunk fat percentage	0.2	0.7	2.5	-1.6	-0.8	-0.8	-0.7	0.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.1	0.2	-0.2	0.1	-0.5	0.3	1.0
Sitting height	0.2	1.8	3.3	1.7	1.3	-1.6	1.8	-0.1	0.2
Past tobacco smoking	0.2	0.4	1.4	1.2	0.6	-0.4	-0.3	0.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.3	-0.2	-0.5	-0.4	-0.1	1.1	-0.1
Hearing difficulty/problems with background noise	0.2	0.3	1.3	-0.3	-0.3	0.3	0.5	0.4	-1.1
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	0.3	-0.1	0.5	-0.5	0.1	0.8
Weight	0.2	0.8	2.3	-1.5	-0.8	1.3	-0.0	0.3	-0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.9	0.3	0.4	-0.0	-0.9	-0.2	-0.9
Worrier / anxious feelings	0.2	0.3	1.1	0.9	-0.1	-0.2	1.1	0.2	-0.2
Falls in the last year	0.2	0.3	1.1	0.6	0.1	-0.3	-1.0	-0.5	-0.5
Tense / ‘highly strung’	0.2	0.3	1.4	-0.1	-1.2	0.3	0.5	0.5	-0.2
Hair/balding pattern: Pattern 4	0.2	0.6	2.0	0.1	0.4	0.6	0.7	-0.6	-1.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.3	0.2	0.6	-0.6	-0.6	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.7	0.1	0.9	0.5	-0.1	-0.4
Body fat percentage	0.2	0.8	2.9	-1.7	-0.8	-0.4	-1.0	0.2	-0.4
Worry too long after embarrassment	0.2	0.4	1.3	-0.6	-0.4	0.6	-1.1	0.2	-0.2
Age at first live birth	0.2	0.4	0.9	-0.4	-0.4	-0.8	-1.0	-0.7	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.7	0.1	-0.5	0.1	-0.3	-0.8	0.2
Whole body fat mass	0.2	0.9	3.5	-1.9	-0.9	0.6	-0.6	0.2	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.6	0.0	-0.3	-0.2	-0.8	0.7	-0.0
Commuting to job workplace: Public transport	0.2	0.2	0.8	0.2	-0.1	-0.4	0.1	0.3	0.9
Medication: Paracetamol	0.2	0.3	1.4	1.2	-0.2	0.4	0.1	0.6	-0.2
Ever smoked	0.2	0.3	0.7	-0.5	-0.4	0.1	0.8	0.1	-0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.0	-0.2	0.6	0.6	0.4	0.8
Leg fat mass (left)	0.2	0.9	2.9	-1.7	-0.6	1.1	-0.5	0.5	-0.4
Smoking Status	0.1	0.4	1.3	0.4	0.3	-0.4	1.1	0.5	-0.5
Hair Pigment	0.1	2.0	6.2	0.2	-1.7	2.5	-0.3	0.1	1.5
Tanning	0.1	0.8	2.3	-0.8	-0.8	1.5	0.8	0.9	0.0
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.1	-0.5	-0.4	0.6	0.6	0.2
Severe depression (siblings)	0.1	0.2	0.6	0.0	0.2	0.0	0.8	0.5	-0.2
Trunk fat mass	0.1	0.6	2.8	-1.7	-0.8	-0.1	-0.3	0.3	-0.3
Waist circumference	0.1	0.4	1.7	-0.4	0.1	-0.1	-1.3	-0.9	0.0
Nervous feelings	0.1	0.3	0.6	0.8	0.2	0.4	0.4	-0.2	-0.7
Hip circumference	0.1	0.6	1.1	-0.0	0.3	1.1	0.7	1.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.2	0.2	-0.2	0.5	-0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.6	0.3	-0.3	-0.1	-0.8	-0.2	0.0
Leg fat percentage (left)	0.1	0.5	1.4	-1.2	-0.1	0.4	-1.0	0.1	-0.8
Age when periods started (menarche)	0.0	0.1	0.3	-0.4	-0.5	-0.1	0.3	-0.2	-0.2
Illnesses of father: Heart disease	0.0	0.0	0.2	-0.0	0.1	0.1	0.4	-0.1	-0.2

Hub : Genes

HLX

Models

Trait associations